| Pittsburgh International → Chicago O'Hare International PIT–ORD | 3,958 | 322,734 | 74% | 413 | Republic Airline, United Air Lines Inc., American Airlines Inc., SkyWest Airlines Inc. +4 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Laguardia PIT–LGA | 3,277 | 185,583 | 77% | 335 | Republic Airline, Endeavor Air Inc., SkyWest Airlines Inc., Delta Air Lines Inc. +5 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Hartsfield/Jackson Atlanta International PIT–ATL | 2,707 | 364,213 | 80% | 526 | Delta Air Lines Inc., Southwest Airlines Co., Eastern Air Express, LLC (EAX), Breeze Aviation Group DBA Breeze +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Newark Liberty International PIT–EWR | 2,276 | 133,253 | 79% | 319 | Republic Airline, GoJet Airlines LLC d/b/a..., Spirit Air Lines, United Air Lines Inc. +10 | Jan 2025 – Jul 2026 |
| Pittsburgh International → John F Kennedy International PIT–JFK | 2,210 | 133,816 | 67% | 340 | Republic Airline, Endeavor Air Inc., JetBlue Airways, Delta Air Lines Inc. +6 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Orlando International PIT–MCO | 2,194 | 296,377 | 78% | 834 | Southwest Airlines Co., Spirit Air Lines, Frontier Airlines Inc., Republic Airline +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Philadelphia International PIT–PHL | 2,185 | 124,833 | 70% | 268 | Piedmont Airlines, American Airlines Inc., Republic Airline, PSA Airlines Inc. +8 | Jan 2025 – Jul 2026 |
| Pittsburgh International → General Edward Lawrence Logan International PIT–BOS | 2,098 | 168,005 | 76% | 496 | Republic Airline, JetBlue Airways, Delta Air Lines Inc., American Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Charlotte/Douglas International PIT–CLT | 1,930 | 247,056 | 78% | 366 | American Airlines Inc., PSA Airlines Inc., Delta Air Lines Inc., Piedmont Airlines +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Denver International PIT–DEN | 1,651 | 229,713 | 82% | 1,290 | United Air Lines Inc., Southwest Airlines Co., Frontier Airlines Inc., JetBlue Airways | Jan 2025 – Jul 2026 |
| Pittsburgh International → Detroit Metro Wayne County PIT–DTW | 1,573 | 95,807 | 76% | 201 | Endeavor Air Inc., SkyWest Airlines Inc., Republic Airline, Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Dallas-Fort Worth International PIT–DFW | 1,473 | 196,612 | 76% | 1,067 | American Airlines Inc., Envoy Air, United Air Lines Inc., United Parcel Service | Jan 2025 – Jul 2026 |
| Pittsburgh International → Washington Dulles International PIT–IAD | 1,452 | 102,514 | 73% | 182 | Republic Airline, United Air Lines Inc., Mesa Airlines Inc., CommuteAir LLC dba CommuteAir +6 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Ronald Reagan Washington Ntl PIT–DCA | 1,426 | 75,436 | 67% | 204 | Republic Airline, PSA Airlines Inc., Envoy Air, American Airlines Inc. +5 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Minneapolis-St Paul Intl/Wold-Chamberlain PIT–MSP | 1,277 | 90,007 | 75% | 726 | Endeavor Air Inc., Delta Air Lines Inc., SkyWest Airlines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Pittsburgh International → Chicago Midway International PIT–MDW | 1,106 | 118,704 | 66% | 402 | Southwest Airlines Co., Delta Air Lines Inc., Global Crossing Airlines, Inc., CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| Pittsburgh International → Nashville International PIT–BNA | 1,095 | 121,472 | 68% | 462 | Southwest Airlines Co., Allegiant Air, Air Canada, Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Baltimore/Washington International Thurgood Marshall PIT–BWI | 1,091 | 116,202 | 66% | 210 | Southwest Airlines Co., Delta Air Lines Inc., United Air Lines Inc., Global Crossing Airlines, Inc. +6 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Fort Lauderdale/Hollywood International PIT–FLL | 1,079 | 151,160 | 82% | 994 | Spirit Air Lines, Southwest Airlines Co., JetBlue Airways, Atlas Air Inc. +4 | Jan 2025 – Jul 2026 |
| Pittsburgh International → George Bush Intcntl/Houston PIT–IAH | 1,039 | 105,533 | 76% | 1,117 | United Air Lines Inc., Mesa Airlines Inc., SkyWest Airlines Inc., American Airlines Inc. +3 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Tampa International PIT–TPA | 953 | 106,383 | 69% | 873 | Southwest Airlines Co., Breeze Aviation Group DBA Breeze, Spirit Air Lines, Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Raleigh-Durham International PIT–RDU | 855 | 49,669 | 68% | 328 | Republic Airline, Breeze Aviation Group DBA Breeze, Envoy Air, Delta Air Lines Inc. +4 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Phoenix Sky Harbor International PIT–PHX | 804 | 115,555 | 85% | 1,814 | American Airlines Inc., Southwest Airlines Co., Allegiant Air, JetBlue Airways +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Dubois Regional PIT–DUJ | 769 | 1,943 | 28% | 84 | Southern Airways Express,... | Jan 2025 – Jul 2026 |
| Pittsburgh International → Harry Reid International PIT–LAS | 721 | 100,694 | 80% | 1,910 | Southwest Airlines Co., Spirit Air Lines, American Airlines Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Miami International PIT–MIA | 710 | 91,111 | 81% | 1,013 | American Airlines Inc., Southwest Airlines Co., Envoy Air, Republic Airline +2 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Southwest Florida International PIT–RSW | 576 | 68,639 | 75% | 966 | Southwest Airlines Co., Breeze Aviation Group DBA Breeze, American Airlines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Pittsburgh International → Louisville Muhammad Ali International PIT–SDF | 557 | 1,788 | 43% | 335 | United Parcel Service, Breeze Aviation Group DBA Breeze, Republic Airline, Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Pittsburgh International → San Francisco International PIT–SFO | 551 | 71,337 | 78% | 2,254 | United Air Lines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Los Angeles International PIT–LAX | 527 | 66,356 | 76% | 2,136 | American Airlines Inc., United Air Lines Inc., Breeze Aviation Group DBA Breeze, Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → St. Louis Lambert International PIT–STL | 506 | 48,727 | 63% | 554 | Southwest Airlines Co., United Air Lines Inc., Global Crossing Airlines, Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Pittsburgh International → State College PIT–SCE | 501 | 0 | 0% | 128 | Federal Express Corporation, Eastern Air Express, LLC (EAX) | Jan 2025 – May 2026 |
| Pittsburgh International → Seattle-Tacoma International PIT–SEA | 468 | 64,914 | 79% | 2,125 | Alaska Airlines Inc., Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Bradford Regional PIT–BFD | 461 | 1,258 | 30% | 123 | Southern Airways Express,... | Jan 2025 – Jul 2026 |
| Pittsburgh International → Toronto PIT–YYZ international | 458 | 23,114 | 66% | 222 | Jazz Aviation LP, Delta Air Lines Inc., PSA Airlines Inc., Chartright Air Inc. +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Lancaster PIT–LNS | 382 | 1,806 | 52% | 210 | Southern Airways Express,... | Jan 2025 – Jun 2026 |
| Pittsburgh International → Dallas Love Field PIT–DAL | 360 | 49,335 | 82% | 1,060 | Southwest Airlines Co., Ameristar Air Cargo, Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Pittsburgh International → Salt Lake City International PIT–SLC | 359 | 39,927 | 81% | 1,660 | Delta Air Lines Inc., Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Sarasota/Bradenton International PIT–SRQ | 338 | 48,278 | 83% | 912 | Southwest Airlines Co., Allegiant Air | Jan 2025 – Jul 2026 |
| Pittsburgh International → Austin-Bergstrom International PIT–AUS | 323 | 36,051 | 70% | 1,210 | Southwest Airlines Co., Allegiant Air, American Airlines Inc., JetBlue Airways +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Lakeland Linder International PIT–LAL | 322 | 0 | | 868 | Sun Country Airlines d/b/a..., Air Transport International, ABX Air Inc | Jan 2025 – Jul 2026 |
| Pittsburgh International → William P Hobby PIT–HOU | 318 | 32,830 | 63% | 1,131 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Pittsburgh International → London PIT–LHR international | 292 | 52,500 | 85% | 3,720 | British Airways Plc | Jan 2025 – Jul 2026 |
| Pittsburgh International → Perot Fld/Fort Worth Alliance PIT–AFW | 275 | 0 | | 1,077 | Sun Country Airlines d/b/a..., Air Transport International | Jan 2025 – May 2026 |
| Pittsburgh International → Charleston Afb/Intl PIT–CHS | 247 | 25,901 | 77% | 524 | Breeze Aviation Group DBA Breeze, Spirit Air Lines, Allegiant Air, Republic Airline | Jan 2025 – Jul 2026 |
| Pittsburgh International → Myrtle Beach International PIT–MYR | 219 | 28,735 | 71% | 475 | Allegiant Air, Spirit Air Lines, Southwest Airlines Co., Breeze Aviation Group DBA Breeze | Apr 2025 – Jul 2026 |
| Pittsburgh International → Frederick W Smith Intl/Memphis PIT–MEM | 209 | 56 | 26% | 652 | Federal Express Corporation, Republic Airline | Jan 2025 – Jul 2026 |
| Pittsburgh International → Indianapolis International PIT–IND | 204 | 487 | 52% | 326 | Federal Express Corporation, Republic Airline, American Airlines Inc., Delta Air Lines Inc. +2 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Jacksonville International PIT–JAX | 177 | 24,251 | 80% | 694 | Allegiant Air, Breeze Aviation Group DBA Breeze, Atlas Air Inc., Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Punta Gorda PIT–PGD | 177 | 28,103 | 88% | 941 | Allegiant Air | Jan 2025 – Jul 2026 |
| Pittsburgh International → Orlando Sanford International PIT–SFB | 173 | 27,880 | 89% | 810 | Allegiant Air | Jan 2025 – Jul 2026 |
| Pittsburgh International → St. Pete-Clearwater International PIT–PIE | 164 | 26,825 | 92% | 878 | Allegiant Air, Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Richmond International PIT–RIC | 163 | 496 | 60% | 258 | United Parcel Service, Breeze Aviation Group DBA Breeze, PSA Airlines Inc., SkyWest Airlines Inc. +3 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Montreal PIT–YUL international | 162 | 10,262 | 83% | 476 | Jazz Aviation LP, Delta Air Lines Inc., Air Canada | Apr 2025 – Jul 2026 |
| Pittsburgh International → West Palm Beach/Palm Beach PIT–PBI | 144 | 22,393 | 86% | 952 | Allegiant Air, Spirit Air Lines, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Rhode Island TF Green International PIT–PVD | 117 | 10,728 | 68% | 467 | Breeze Aviation Group DBA Breeze, Delta Air Lines Inc., CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| Pittsburgh International → Bradley International PIT–BDL | 107 | 10,979 | 75% | 406 | Breeze Aviation Group DBA Breeze, United Parcel Service, American Airlines Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Savannah/Hilton Head International PIT–SAV | 107 | 13,629 | 79% | 579 | Allegiant Air | Jan 2025 – Jul 2026 |
| Pittsburgh International → Key West International PIT–EYW | 96 | 12,712 | 75% | 1,102 | Allegiant Air | Jan 2025 – Jul 2026 |
| Pittsburgh International → Melbourne Orlando International PIT–MLB | 95 | 14,645 | 85% | 854 | Allegiant Air | Jan 2025 – Jul 2026 |
| Pittsburgh International → Keflavik/Reykjavik PIT–KEF international | 94 | 11,637 | 73% | 2,794 | Icelandair | Apr 2025 – Jul 2026 |
| Pittsburgh International → Eglin Afb/Destin-Ft Walton Beach PIT–VPS | 88 | 12,806 | 83% | 775 | Allegiant Air, Southwest Airlines Co. | Apr 2025 – Jul 2026 |
| Pittsburgh International → Cleveland-Hopkins International PIT–CLE | 79 | 1,174 | 52% | 106 | Federal Express Corporation, United Parcel Service, Delta Air Lines Inc., Southwest Airlines Co. +7 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Greenville Spartanburg International PIT–GSP | 79 | 8,983 | 83% | 401 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co., Republic Airline, American Airlines Inc. +1 | Feb 2025 – Jul 2026 |
| Pittsburgh International → Portland International Jetport PIT–PWM | 78 | 8,086 | 76% | 554 | Breeze Aviation Group DBA Breeze, Republic Airline | May 2025 – Jul 2026 |
| Pittsburgh International → Norfolk International PIT–ORF | 72 | 6,278 | 73% | 330 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co. | May 2025 – Jul 2026 |
| Pittsburgh International → San Diego International PIT–SAN | 71 | 9,018 | 90% | 2,106 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co., Delta Air Lines Inc. | Mar 2025 – Jul 2026 |
| Pittsburgh International → Paulding Northwest Atlanta PIT–PUJ international | 69 | 10,384 | 84% | 1,667 | Allegiant Air, American Airlines Inc. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Cancun PIT–CUN international | 64 | 9,484 | 82% | 1,396 | Allegiant Air, American Airlines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Louis Armstrong New Orleans International PIT–MSY | 59 | 5,676 | 75% | 918 | Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a..., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Pittsburgh International → Cincinnati/Northern Kentucky International PIT–CVG | 56 | 556 | 36% | 256 | Federal Express Corporation, Delta Air Lines Inc., Sun Country Airlines d/b/a..., United Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Dubois Municipal PIT–DUB international | 38 | 4,266 | 61% | 3,444 | Aer Lingus Plc | May 2026 – Jul 2026 |
| Pittsburgh International → John Glenn Columbus International PIT–CMH | 25 | 880 | 39% | 145 | Republic Airline, Delta Air Lines Inc., American Airlines Inc., NEW PACIFIC AIRLINES +6 | Jan 2025 – Jul 2026 |
| Pittsburgh International → Atlantic City International PIT–ACY | 18 | 2,447 | 73% | 308 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Pittsburgh International → Buffalo Niagara International PIT–BUF | 14 | 1,215 | 69% | 186 | Southwest Airlines Co., Air Canada, Delta Air Lines Inc., KaiserAir, Inc. +3 | Jan 2025 – Jun 2026 |
| Pittsburgh International → Pittsburgh International PIT–PIT | 13 | 0 | 0% | 0 | SkyWest Airlines Inc., CFM Inc d/b/a Contour... | Feb 2025 – Mar 2026 |
| Pittsburgh International → General Mitchell International PIT–MKE | 9 | 271 | 25% | 431 | Delta Air Lines Inc., Southwest Airlines Co., United Air Lines Inc., Endeavor Air Inc. | Feb 2025 – Jul 2026 |
| Pittsburgh International → St. Louis Downtown PIT–CPS | 8 | 207 | 31% | 546 | Delta Air Lines Inc., CFM Inc d/b/a Contour..., Allegiant Air, Global Crossing Airlines, Inc. +1 | Feb 2025 – Jul 2026 |
| Pittsburgh International → Okc Will Rogers International PIT–OKC | 8 | 418 | 46% | 1,010 | SkyWest Airlines Inc., American Airlines Inc. | Jun 2025 – Jun 2026 |
| Pittsburgh International → Gulfport-Biloxi International PIT–GPT | 7 | 786 | 60% | 855 | Sun Country Airlines d/b/a... | Feb 2025 – Jul 2026 |
| Pittsburgh International → Frederick Douglass/Greater Rochester International PIT–ROC | 7 | 471 | 70% | 224 | Republic Airline, Endeavor Air Inc., American Airlines Inc., Delta Air Lines Inc. +2 | Jan 2025 – Jun 2026 |
| Pittsburgh International → Harrisburg International PIT–MDT | 6 | 176 | 99% | 184 | United Parcel Service, American Airlines Inc., Federal Express Corporation, GoJet Airlines LLC d/b/a... | Feb 2025 – Jul 2026 |
| Pittsburgh International → Akron-Canton Regional PIT–CAK | 5 | 51 | 6% | 70 | Sun Country Airlines d/b/a..., Eastern Air Express, LLC (EAX), Breeze Aviation Group DBA Breeze | Jul 2025 – Jul 2026 |
| Pittsburgh International → Westchester County PIT–HPN | 5 | 157 | 51% | 344 | Delta Air Lines Inc., Jet Aviation Flight Services, Inc., Envoy Air | Feb 2025 – Feb 2026 |
| Pittsburgh International → Syracuse Hancock International PIT–SYR | 5 | 238 | 45% | 279 | Southwest Airlines Co., United Parcel Service, Delta Air Lines Inc., Republic Airline | Jan 2025 – Mar 2026 |
| Pittsburgh International → Erie Intl/Tom Ridge Field PIT–ERI | 4 | 155 | 84% | 110 | Piedmont Airlines, Southern Airways Express,..., PSA Airlines Inc. | Jan 2025 – Mar 2026 |
| Pittsburgh International → Rickenbacker International PIT–LCK | 4 | 0 | | 150 | Federal Express Corporation, United Parcel Service | Jan 2025 – Apr 2026 |
| Pittsburgh International → Liege PIT–LGG international | 4 | 0 | | 3,979 | Atlas Air Inc. | May 2025 – Jun 2026 |
| Pittsburgh International → Morgantown Muni/Walter L Bill Hart Field PIT–MGW | 4 | 0 | 0% | 61 | SkyWest Airlines Inc. | Apr 2025 – Jun 2026 |
| Pittsburgh International → Albany International PIT–ALB | 3 | 137 | 100% | 367 | United Parcel Service, Southwest Airlines Co. | Jul 2025 – Jul 2026 |
| Pittsburgh International → Laurence G Hanscom Field PIT–BED | 3 | 0 | 0% | 484 | Delta Air Lines Inc., Global Crossing Airlines, Inc., Republic Airline | Mar 2025 – Mar 2026 |
| Pittsburgh International → Birmingham-Shuttlesworth International PIT–BHM | 3 | 209 | 53% | 598 | Delta Air Lines Inc., SkyWest Airlines Inc., Southwest Airlines Co. | Jul 2025 – Jun 2026 |
| Pittsburgh International → Columbia Metro PIT–CAE | 3 | 370 | 69% | 454 | Delta Air Lines Inc. | Jan 2025 – Jun 2026 |
| Pittsburgh International → Green Bay/Austin Straubel International PIT–GRB | 3 | 246 | 75% | 488 | Delta Air Lines Inc., Endeavor Air Inc. | Oct 2025 – Oct 2025 |
| Pittsburgh International → Piedmont Triad International PIT–GSO | 3 | 128 | 68% | 303 | United Parcel Service, Breeze Aviation Group DBA Breeze, SkyWest Airlines Inc. | Apr 2025 – Jul 2026 |
| Pittsburgh International → John Murtha Johnstown/Cambria County PIT–JST | 3 | 0 | 0% | 75 | SkyWest Airlines Inc. | Mar 2025 – Apr 2026 |
| Pittsburgh International → Kansas City International PIT–MCI | 3 | 226 | 43% | 773 | Southwest Airlines Co. | Jul 2025 – Apr 2026 |
| Pittsburgh International → Dane County Rgnl/Truax Field PIT–MSN | 3 | 35 | 14% | 504 | Delta Air Lines Inc., SkyWest Airlines Inc., Republic Airline | Jul 2025 – Jul 2026 |
| Pittsburgh International → Eppley Airfield PIT–OMA | 3 | 141 | 40% | 821 | Southwest Airlines Co., Republic Airline | Jun 2025 – Mar 2026 |
| Pittsburgh International → South Bend International PIT–SBN | 3 | 273 | 60% | 328 | Delta Air Lines Inc., Global Crossing Airlines, Inc., Mesa Airlines Inc. | Feb 2025 – May 2026 |
| Pittsburgh International → Sacramento International PIT–SMF | 3 | 138 | 42% | 2,191 | NEW PACIFIC AIRLINES, Global Crossing Airlines, Inc., United Air Lines Inc. | Sep 2025 – Jun 2026 |
| Pittsburgh International → Northwest Arkansas Ntl PIT–XNA | 3 | 299 | 80% | 816 | American Airlines Inc., Republic Airline | Jan 2025 – Jun 2026 |
| Pittsburgh International → Youngstown/Warren Regional PIT–YNG | 3 | 39 | 8% | 58 | Eastern Air Express, LLC (EAX) | Mar 2026 – Apr 2026 |
| Pittsburgh International → Ottawa PIT–YOW international | 3 | 141 | 51% | 406 | Delta Air Lines Inc., Tradewind Aviation | Jan 2025 – Jun 2026 |
| Pittsburgh International → Augusta Regional AT Bush Field PIT–AGS | 2 | 4 | 22% | 500 | Chartright Air Inc. | Apr 2025 – Jan 2026 |
| Pittsburgh International → Corpus Christi International PIT–CRP | 2 | 226 | 90% | 1,318 | Southwest Airlines Co., Mesa Airlines Inc. | Sep 2025 – Oct 2025 |
| Pittsburgh International → West Virginia International Yeager PIT–CRW | 2 | 0 | 0% | 163 | SkyWest Airlines Inc., Sun Country Airlines d/b/a... | May 2025 – Sep 2025 |
| Pittsburgh International → Tweed/New Haven PIT–HVN | 2 | 72 | 24% | 388 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Apr 2026 |
| Pittsburgh International → Blue Grass PIT–LEX | 2 | 0 | 0% | 289 | CFM Inc d/b/a Contour..., SkyWest Airlines Inc. | Apr 2026 – Jul 2026 |
| Pittsburgh International → Kansas City Downtown/Wheeler Field PIT–MKC | 2 | 82 | 46% | 769 | Breeze Aviation Group DBA Breeze, Republic Airline | Dec 2025 – Mar 2026 |
| Pittsburgh International → Smyrna PIT–MQY | 2 | 0 | 0% | 461 | CFM Inc d/b/a Contour... | Apr 2025 – Jul 2026 |
| Pittsburgh International → Ocala Intl-Jim Taylor Field PIT–OCF | 2 | 4 | 29% | 788 | Chartright Air Inc. | Jan 2026 – Jan 2026 |
| Pittsburgh International → Reno/Tahoe International PIT–RNO | 2 | 304 | 82% | 2,081 | Sun Country Airlines d/b/a... | Dec 2025 – Jun 2026 |
| Pittsburgh International → Roanoke/Blacksburg Regional (Woodrum Field) PIT–ROA | 2 | 58 | 76% | 219 | United Parcel Service, Republic Airline | May 2025 – Jun 2026 |
| Pittsburgh International → Mineta San Jose International PIT–SJC | 2 | 233 | 82% | 2,236 | KaiserAir, Inc., Delta Air Lines Inc. | Jan 2025 – Dec 2025 |
| Pittsburgh International → Teterboro PIT–TEB | 2 | 39 | 80% | 325 | CFM Inc d/b/a Contour... | Oct 2025 – Jan 2026 |
| Pittsburgh International → Tulsa International PIT–TUL | 2 | 279 | 81% | 899 | American Airlines Inc. | Mar 2025 – Jun 2026 |
| Pittsburgh International → MC Ghee Tyson PIT–TYS | 2 | 185 | 49% | 382 | American Airlines Inc., Sun Country Airlines d/b/a... | Jul 2025 – Jul 2026 |
| Pittsburgh International → Willow Run PIT–YIP | 2 | 0 | 0% | 209 | USA Jet Airlines Inc., Republic Airline | Feb 2026 – Apr 2026 |
| Pittsburgh International → Winnipeg PIT–YWG international | 2 | 110 | 77% | 1,050 | Air Canada, Delta Air Lines Inc. | Jan 2025 – Mar 2026 |
| Pittsburgh International → Lehigh Valley International PIT–ABE | 1 | 0 | 0% | 252 | CFM Inc d/b/a Contour... | Jun 2025 – Apr 2026 |
| Pittsburgh International → Allegheny County PIT–AGC | 1 | 0 | 0% | 19 | CFM Inc d/b/a Contour... | Dec 2025 – Dec 2025 |
| Pittsburgh International → Stockholm PIT–ARN international | 1 | 66 | 23% | 4,131 | Delta Air Lines Inc. | Nov 2025 – Nov 2025 |
| Pittsburgh International → Asheville Regional PIT–AVL | 1 | 0 | 0% | 371 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Pittsburgh International → Wilkes-Barre/Scranton International PIT–AVP | 1 | 25 | 50% | 243 | CommuteAir LLC dba CommuteAir | Jul 2026 – Jul 2026 |
| Pittsburgh International → Boeing Fld/King County International PIT–BFI | 1 | 55 | 76% | 2,124 | Delta Air Lines Inc. | Jan 2026 – Jan 2026 |
| Pittsburgh International → Bangor International PIT–BGR | 1 | 0 | 0% | 652 | Republic Airline | Aug 2025 – Aug 2025 |
| Pittsburgh International → Bratislava PIT–BTS international | 1 | 0 | 0% | 4,523 | Jet Aviation Flight... | Aug 2025 – Aug 2025 |
| Pittsburgh International → Lovell Field PIT–CHA | 1 | 159 | 94% | 464 | Delta Air Lines Inc. | Jul 2026 – Jul 2026 |
| Pittsburgh International → Charlottesville-Albemarle PIT–CHO | 1 | 0 | 0% | 188 | Republic Airline | Feb 2025 – Feb 2026 |
| Pittsburgh International → Easterwood Field PIT–CLL | 1 | 52 | 29% | 1,134 | Allegiant Air | Dec 2025 – Dec 2025 |
| Pittsburgh International → City Of Colorado Springs Municipal PIT–COS | 1 | 154 | 93% | 1,306 | United Air Lines Inc. | Jun 2025 – Aug 2025 |
| Pittsburgh International → Columbus PIT–CSG | 1 | 125 | 74% | 609 | Delta Air Lines Inc. | Apr 2026 – Apr 2026 |
| Pittsburgh International → Daytona Beach International PIT–DAB | 1 | 0 | 0% | 781 | Republic Airline | Nov 2025 – Nov 2025 |
| Pittsburgh International → EL Paso International PIT–ELP | 1 | 36 | 53% | 1,572 | Global Crossing Airlines, Inc. | Jun 2025 – Jun 2026 |
| Pittsburgh International → Fort Wayne International PIT–FWA | 1 | 66 | 87% | 263 | Envoy Air | Mar 2025 – Aug 2025 |
| Pittsburgh International → Gerald R Ford International PIT–GRR | 1 | 52 | 30% | 320 | Southwest Airlines Co. | Feb 2025 – Feb 2026 |
| Pittsburgh International → Cape Cod Gateway PIT–HYA | 1 | 21 | 100% | 526 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Pittsburgh International → Laughlin/Bullhead International PIT–IFP | 1 | 173 | 93% | 1,901 | Sun Country Airlines d/b/a... | Apr 2026 – Apr 2026 |
| Pittsburgh International → Smith Reynolds PIT–INT | 1 | 0 | 0% | 301 | SkyWest Airlines Inc. | Jan 2025 – Jan 2026 |
| Pittsburgh International → Williamsport Regional PIT–IPT | 1 | 9 | 100% | 181 | Southern Airways Express,... | Jun 2025 – Nov 2025 |
| Pittsburgh International → Kirksville Regional PIT–IRK | 1 | 0 | 0% | 651 | CFM Inc d/b/a Contour... | Jan 2026 – Jan 2026 |
| Pittsburgh International → Long Island Mac Arthur PIT–ISP | 1 | 0 | 0% | 375 | Southwest Airlines Co. | Dec 2025 – Dec 2025 |
| Pittsburgh International → Lubbock Preston Smith International PIT–LBB | 1 | 171 | 99% | 1,278 | American Airlines Inc. | Jun 2026 – Jun 2026 |
| Pittsburgh International → Long Beach (Daugherty Field) PIT–LGB | 1 | 55 | 76% | 2,126 | Delta Air Lines Inc. | Apr 2025 – Oct 2025 |
| Pittsburgh International → Milan PIT–LIN international | 1 | 11 | 79% | 4,305 | VistaJet Limited | Jul 2025 – May 2026 |
| Pittsburgh International → Bill And Hillary Clinton Ntl/Adams Field PIT–LIT | 1 | 174 | 97% | 768 | Delta Air Lines Inc. | Jul 2026 – Jul 2026 |
| Pittsburgh International → Lincoln PIT–LNK | 1 | 38 | 35% | 867 | Breeze Aviation Group DBA Breeze | Feb 2026 – Feb 2026 |
| Pittsburgh International → Marco Island PIT–MRK | 1 | 2 | 25% | 1,002 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| Pittsburgh International → Monterrey PIT–MTY international | 1 | 145 | 60% | 1,528 | Aeroenlaces Nacionales,... | Jul 2026 – Jul 2026 |
| Pittsburgh International → Cherry Point PIT–N1C | 1 | 0 | | 427 | Atlas Air Inc. | Jul 2026 – Jul 2026 |
| Pittsburgh International → Porto PIT–OPO international | 1 | 7 | 50% | 3,635 | VistaJet Limited | Mar 2026 – Mar 2026 |
| Pittsburgh International → Portsmouth International AT Pease PIT–PSM | 1 | 2 | 25% | 517 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| Pittsburgh International → Provo Municipal PIT–PVU | 1 | 159 | 88% | 1,653 | Delta Air Lines Inc. | Jul 2026 – Jul 2026 |
| Pittsburgh International → Chicago/Rockford International PIT–RFD | 1 | 0 | | 476 | United Parcel Service | Dec 2025 – Dec 2025 |
| Pittsburgh International → Rochester International PIT–RST | 1 | 72 | 95% | 671 | Endeavor Air Inc. | Jul 2026 – Jul 2026 |
| Pittsburgh International → San Jose PIT–SJO international | 1 | 0 | | 2,114 | Sun Country Airlines d/b/a... | Dec 2025 – Dec 2025 |
| Pittsburgh International → Moore County PIT–SOP | 1 | 4 | 50% | 365 | Chartright Air Inc. | May 2026 – May 2026 |
| Pittsburgh International → Sheppard Afb/Wichita Falls Municipal PIT–SPS | 1 | 166 | 97% | 1,099 | American Airlines Inc. | Aug 2025 – Aug 2025 |
| Pittsburgh International → Tallahassee International PIT–TLH | 1 | 181 | 91% | 733 | Delta Air Lines Inc. | Jan 2025 – Oct 2025 |
| Pittsburgh International → Nashville PIT–TN8 | 1 | 8 | 62% | 468 | CFM Inc d/b/a Contour... | Sep 2025 – Sep 2025 |
| Pittsburgh International → Tri-Cities PIT–TRI | 1 | 123 | 72% | 301 | Delta Air Lines Inc. | Aug 2025 – Aug 2025 |
| Pittsburgh International → Tucson International PIT–TUS | 1 | 115 | 66% | 1,798 | Southwest Airlines Co. | Mar 2025 – Aug 2025 |
| Pittsburgh International → Concord PIT–USA | 1 | 29 | 97% | 353 | CFM Inc d/b/a Contour... | Jan 2025 – Dec 2025 |
| Pittsburgh International → Hamilton PIT–YHM international | 1 | 6 | 86% | 186 | Chartright Air Inc. | Nov 2025 – Nov 2025 |