| Raleigh-Durham International → Hartsfield/Jackson Atlanta International RDU–ATL | 4,595 | 679,029 | 82% | 356 | Delta Air Lines Inc., Frontier Airlines Inc., Southwest Airlines Co., Endeavor Air Inc. +4 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Laguardia RDU–LGA | 4,154 | 292,616 | 82% | 431 | Republic Airline, Endeavor Air Inc., Delta Air Lines Inc., Frontier Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → John F Kennedy International RDU–JFK | 3,553 | 270,553 | 81% | 427 | Republic Airline, Endeavor Air Inc., JetBlue Airways, Delta Air Lines Inc. +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Chicago O'Hare International RDU–ORD | 3,542 | 325,408 | 78% | 646 | United Air Lines Inc., Republic Airline, Envoy Air, American Airlines Inc. +5 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Orlando International RDU–MCO | 3,206 | 403,221 | 78% | 534 | Delta Air Lines Inc., Southwest Airlines Co., Frontier Airlines Inc., Breeze Aviation Group DBA Breeze +7 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Charlotte/Douglas International RDU–CLT | 3,069 | 409,283 | 73% | 130 | American Airlines Inc., PSA Airlines Inc., United Parcel Service, Delta Air Lines Inc. +10 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Ronald Reagan Washington Ntl RDU–DCA | 2,903 | 142,073 | 63% | 227 | Endeavor Air Inc., PSA Airlines Inc., Republic Airline, Envoy Air +6 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Nashville International RDU–BNA | 2,813 | 208,434 | 64% | 442 | Southwest Airlines Co., Republic Airline, Endeavor Air Inc., Air Canada +4 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Philadelphia International RDU–PHL | 2,807 | 243,922 | 69% | 337 | American Airlines Inc., PSA Airlines Inc., Frontier Airlines Inc., Republic Airline +9 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Newark Liberty International RDU–EWR | 2,758 | 281,616 | 79% | 416 | United Air Lines Inc., Endeavor Air Inc., Republic Airline, Spirit Air Lines +6 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → General Edward Lawrence Logan International RDU–BOS | 2,757 | 314,132 | 83% | 612 | Delta Air Lines Inc., JetBlue Airways, Frontier Airlines Inc., Republic Airline +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Miami International RDU–MIA | 2,353 | 302,695 | 82% | 700 | American Airlines Inc., Delta Air Lines Inc., Frontier Airlines Inc., Envoy Air +5 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Dallas-Fort Worth International RDU–DFW | 2,208 | 333,531 | 85% | 1,061 | American Airlines Inc., Frontier Airlines Inc., Spirit Air Lines, United Parcel Service +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Baltimore/Washington International Thurgood Marshall RDU–BWI | 1,776 | 176,556 | 64% | 256 | Southwest Airlines Co., Spirit Air Lines, Endeavor Air Inc., American Airlines Inc. +6 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Denver International RDU–DEN | 1,732 | 263,299 | 86% | 1,436 | United Air Lines Inc., Southwest Airlines Co., Frontier Airlines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Tampa International RDU–TPA | 1,699 | 191,739 | 73% | 587 | Delta Air Lines Inc., Breeze Aviation Group DBA Breeze, Southwest Airlines Co., Frontier Airlines Inc. +4 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Detroit Metro Wayne County RDU–DTW | 1,496 | 177,482 | 76% | 501 | Delta Air Lines Inc., Frontier Airlines Inc., Spirit Air Lines, Endeavor Air Inc. +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Washington Dulles International RDU–IAD | 1,470 | 141,997 | 74% | 225 | United Air Lines Inc., Republic Airline, Mesa Airlines Inc., GoJet Airlines LLC d/b/a... +9 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Fort Lauderdale/Hollywood International RDU–FLL | 1,347 | 171,996 | 80% | 680 | JetBlue Airways, Delta Air Lines Inc., Spirit Air Lines, Southwest Airlines Co. +5 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Minneapolis-St Paul Intl/Wold-Chamberlain RDU–MSP | 1,332 | 163,323 | 77% | 980 | Delta Air Lines Inc., Sun Country Airlines d/b/a..., Endeavor Air Inc., SkyWest Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → George Bush Intcntl/Houston RDU–IAH | 1,256 | 149,940 | 81% | 1,042 | United Air Lines Inc., Mesa Airlines Inc., Frontier Airlines Inc., American Airlines Inc. +4 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Austin-Bergstrom International RDU–AUS | 1,214 | 103,858 | 76% | 1,162 | Endeavor Air Inc., Southwest Airlines Co., American Airlines Inc., Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Chicago Midway International RDU–MDW | 939 | 111,269 | 73% | 632 | Southwest Airlines Co., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Seattle-Tacoma International RDU–SEA | 899 | 131,556 | 85% | 2,354 | Alaska Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → San Francisco International RDU–SFO | 878 | 124,235 | 83% | 2,400 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Pittsburgh International RDU–PIT | 852 | 49,150 | 68% | 328 | Republic Airline, Breeze Aviation Group DBA Breeze, Envoy Air, Southwest Airlines Co. +4 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Los Angeles International RDU–LAX | 832 | 113,900 | 79% | 2,239 | American Airlines Inc., Delta Air Lines Inc., Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... +1 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Phoenix Sky Harbor International RDU–PHX | 823 | 122,878 | 85% | 1,891 | American Airlines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → St. Louis Lambert International RDU–STL | 657 | 70,624 | 65% | 668 | Southwest Airlines Co., Republic Airline, Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Toronto RDU–YYZ international | 657 | 37,850 | 76% | 540 | Jazz Aviation LP, Chartright Air Inc., Air Canada | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Harry Reid International RDU–LAS | 619 | 90,786 | 84% | 2,026 | Delta Air Lines Inc., Southwest Airlines Co., Frontier Airlines Inc., KaiserAir, Inc. +4 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Indianapolis International RDU–IND | 531 | 25,867 | 77% | 489 | Endeavor Air Inc., Federal Express Corporation, Frontier Airlines Inc., Republic Airline +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Frederick W Smith Intl/Memphis RDU–MEM | 468 | 9,715 | 80% | 634 | Federal Express Corporation, Breeze Aviation Group DBA Breeze, United Parcel Service, American Airlines Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Luis Munoz Marin International RDU–SJU | 458 | 65,661 | 83% | 1,432 | JetBlue Airways, Frontier Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Louisville Muhammad Ali International RDU–SDF | 436 | 9,344 | 64% | 416 | United Parcel Service, Breeze Aviation Group DBA Breeze, Republic Airline, American Airlines Inc. +4 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Dallas Love Field RDU–DAL | 422 | 55,422 | 81% | 1,052 | Southwest Airlines Co., Ameristar Air Cargo, Breeze Aviation Group DBA Breeze, Delta Air Lines Inc. +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Tweed/New Haven RDU–HVN | 403 | 48,282 | 74% | 490 | TEM Enterprises dba Avelo Airlines, Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Montreal RDU–YUL international | 397 | 21,055 | 70% | 713 | Jazz Aviation LP, Air Canada, Delta Air Lines Inc. | Apr 2025 – Jul 2026 |
| Raleigh-Durham International → Kansas City International RDU–MCI | 390 | 24,009 | 71% | 904 | Endeavor Air Inc., Southwest Airlines Co., Eastern Air Express, LLC (EAX), Alaska Airlines Inc. | Feb 2025 – Jul 2026 |
| Raleigh-Durham International → Southwest Florida International RDU–RSW | 381 | 41,388 | 78% | 667 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, American Airlines Inc., Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Salt Lake City International RDU–SLC | 379 | 56,622 | 82% | 1,824 | Delta Air Lines Inc., Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Bradley International RDU–BDL | 367 | 41,861 | 83% | 532 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, Delta Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Rhode Island TF Green International RDU–PVD | 361 | 38,872 | 78% | 566 | Breeze Aviation Group DBA Breeze, Allegiant Air, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → London RDU–LHR international | 353 | 71,301 | 74% | 3,872 | American Airlines Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → William P Hobby RDU–HOU | 352 | 42,243 | 72% | 1,050 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Louis Armstrong New Orleans International RDU–MSY | 348 | 34,095 | 75% | 779 | Breeze Aviation Group DBA Breeze, Spirit Air Lines, Southwest Airlines Co., Frontier Airlines Inc. +3 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Mexico City RDU–MEX international | 319 | 24,613 | 78% | 1,675 | Aerolitoral | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Cincinnati/Northern Kentucky International RDU–CVG | 309 | 18,316 | 79% | 390 | Endeavor Air Inc., Breeze Aviation Group DBA Breeze, Republic Airline | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Keflavik/Reykjavik RDU–KEF international | 293 | 41,552 | 80% | 3,016 | Icelandair | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Frederick Douglass/Greater Rochester International RDU–ROC | 287 | 31,948 | 73% | 503 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Paris RDU–CDG international | 278 | 72,529 | 84% | 4,053 | Compagnie Natl Air France | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Wilmington International RDU–ILM | 257 | 170 | 32% | 122 | Federal Express Corporation, Endeavor Air Inc., American Airlines Inc., Sun Country Airlines d/b/a... +1 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Coastal Carolina Regional RDU–EWN | 256 | 48 | 96% | 113 | Federal Express Corporation, Piedmont Airlines | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → West Palm Beach/Palm Beach RDU–PBI | 253 | 28,784 | 83% | 638 | Breeze Aviation Group DBA Breeze, JetBlue Airways | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Albany International RDU–ALB | 245 | 27,717 | 77% | 544 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Frankfurt RDU–FRA international | 229 | 51,831 | 87% | 4,277 | Lufthansa German Airlines | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Westchester County RDU–HPN | 217 | 20,071 | 71% | 452 | Breeze Aviation Group DBA Breeze, Tradewind Aviation, Global Crossing Airlines, Inc., CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Cleveland-Hopkins International RDU–CLE | 210 | 29,003 | 68% | 416 | Frontier Airlines Inc., CFM Inc d/b/a Contour..., United Parcel Service, Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → San Diego International RDU–SAN | 205 | 26,274 | 82% | 2,193 | Breeze Aviation Group DBA Breeze, Alaska Airlines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Panama City RDU–PTY international | 199 | 27,260 | 82% | 1,845 | Compania Panamena (Copa) | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → John Glenn Columbus International RDU–CMH | 195 | 21,143 | 80% | 362 | Breeze Aviation Group DBA Breeze, Delta Air Lines Inc., Sun Country Airlines d/b/a..., Endeavor Air Inc. +3 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Akron-Canton Regional RDU–CAK | 188 | 17,817 | 69% | 376 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Long Island Mac Arthur RDU–ISP | 175 | 18,391 | 83% | 459 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Syracuse Hancock International RDU–SYR | 157 | 17,094 | 74% | 519 | Breeze Aviation Group DBA Breeze, Frontier Airlines Inc., Southwest Airlines Co., Global Crossing Airlines, Inc. +6 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Ogdensburg International RDU–OGS | 143 | 11,743 | 60% | 632 | Breeze Aviation Group DBA Breeze | Sep 2025 – Jul 2026 |
| Raleigh-Durham International → Patrick Leahy Burlington International RDU–BTV | 140 | 16,181 | 86% | 663 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Cancun RDU–CUN international | 136 | 15,046 | 65% | 1,133 | Aeromexico, American Airlines Inc., Delta Air Lines Inc., Frontier Airlines Inc. +4 | Jan 2025 – May 2026 |
| Raleigh-Durham International → Manchester Boston Regional RDU–MHT | 127 | 14,082 | 73% | 625 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Jacksonville International RDU–JAX | 123 | 11,546 | 69% | 408 | Breeze Aviation Group DBA Breeze, Delta Air Lines Inc., United Parcel Service, CFM Inc d/b/a Contour... +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Pensacola International RDU–PNS | 111 | 9,656 | 68% | 613 | Breeze Aviation Group DBA Breeze, United Parcel Service | Apr 2025 – Jul 2026 |
| Raleigh-Durham International → Buffalo Niagara International RDU–BUF | 110 | 13,887 | 65% | 487 | Frontier Airlines Inc., Air Canada, Southwest Airlines Co., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Portland International Jetport RDU–PWM | 104 | 11,177 | 78% | 700 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Daytona Beach International RDU–DAB | 103 | 8,782 | 62% | 480 | Breeze Aviation Group DBA Breeze | Feb 2025 – Jul 2026 |
| Raleigh-Durham International → Key West International RDU–EYW | 88 | 6,507 | 55% | 800 | Breeze Aviation Group DBA Breeze, CFM Inc d/b/a Contour... | Oct 2025 – Jul 2026 |
| Raleigh-Durham International → Paulding Northwest Atlanta RDU–PUJ international | 80 | 9,316 | 77% | 1,351 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, American Airlines Inc. | Feb 2025 – Jul 2026 |
| Raleigh-Durham International → Dubois Municipal RDU–DUB international | 79 | 10,498 | 72% | 3,602 | Aer Lingus Plc | Apr 2026 – Jul 2026 |
| Raleigh-Durham International → Columbia Metro RDU–CAE | 75 | 96 | 27% | 188 | United Parcel Service, Delta Air Lines Inc., Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Sarasota/Bradenton International RDU–SRQ | 70 | 6,785 | 71% | 625 | Breeze Aviation Group DBA Breeze | Jan 2025 – May 2026 |
| Raleigh-Durham International → Portsmouth International AT Pease RDU–PSM | 69 | 7,169 | 75% | 654 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Aug 2025 – Jul 2026 |
| Raleigh-Durham International → Piedmont Triad International RDU–GSO | 60 | 51 | 10% | 67 | Federal Express Corporation, United Parcel Service, Endeavor Air Inc., Global Crossing Airlines, Inc. +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Norfolk International RDU–ORF | 60 | 768 | 53% | 160 | Federal Express Corporation, Delta Air Lines Inc., Republic Airline, Endeavor Air Inc. +5 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Gerald R Ford International RDU–GRR | 53 | 5,910 | 65% | 603 | TEM Enterprises dba Avelo Airlines, United Air Lines Inc. | May 2025 – Jan 2026 |
| Raleigh-Durham International → Vancouver RDU–YVR international | 53 | 5,985 | 70% | 2,404 | Air Canada, Air Canada rouge LP | Jun 2025 – Jul 2026 |
| Raleigh-Durham International → Rickenbacker International RDU–LCK | 50 | 0 | | 354 | Federal Express Corporation | Aug 2025 – Jul 2026 |
| Raleigh-Durham International → Atlantic City International RDU–ACY | 38 | 2,905 | 46% | 338 | Sun Country Airlines d/b/a..., Breeze Aviation Group DBA Breeze, Spirit Air Lines | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → New Castle RDU–ILG | 38 | 3,301 | 48% | 315 | TEM Enterprises dba Avelo Airlines, Global Crossing Airlines, Inc. | Mar 2025 – May 2026 |
| Raleigh-Durham International → Hamilton RDU–BDA international | 35 | 814 | 30% | 843 | BermudAir | Sep 2025 – Jan 2026 |
| Raleigh-Durham International → San Antonio International RDU–SAT | 30 | 2,942 | 72% | 1,224 | Breeze Aviation Group DBA Breeze, American Airlines Inc., United Parcel Service, Endeavor Air Inc. +2 | Apr 2025 – Jul 2026 |
| Raleigh-Durham International → Calgary RDU–YYC international | 28 | 2,888 | 63% | 2,031 | Westjet | Jun 2025 – Oct 2025 |
| Raleigh-Durham International → Dane County Rgnl/Truax Field RDU–MSN | 27 | 2,958 | 82% | 753 | Breeze Aviation Group DBA Breeze, Envoy Air, United Air Lines Inc. | Jan 2026 – Jul 2026 |
| Raleigh-Durham International → New York Stewart International RDU–SWF | 26 | 3,111 | 88% | 463 | Breeze Aviation Group DBA Breeze, American Airlines Inc. | Nov 2025 – Jul 2026 |
| Raleigh-Durham International → Vero Beach Regional RDU–VRB | 26 | 2,177 | 61% | 574 | Breeze Aviation Group DBA Breeze | May 2026 – Jul 2026 |
| Raleigh-Durham International → Bangor International RDU–BGR | 25 | 2,841 | 83% | 809 | Breeze Aviation Group DBA Breeze | May 2026 – Jul 2026 |
| Raleigh-Durham International → Tallahassee International RDU–TLH | 22 | 1,470 | 50% | 496 | Breeze Aviation Group DBA Breeze, Global Crossing Airlines, Inc., Eastern Air Express, LLC (EAX), American Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Richmond International RDU–RIC | 20 | 1,890 | 74% | 139 | Delta Air Lines Inc., JetBlue Airways, Endeavor Air Inc., Breeze Aviation Group DBA Breeze +8 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → John Wayne/Orange County RDU–SNA | 19 | 2,323 | 89% | 2,213 | Breeze Aviation Group DBA Breeze | May 2026 – Jul 2026 |
| Raleigh-Durham International → Montego Bay RDU–MBJ international | 15 | 1,130 | 49% | 1,197 | TEM Enterprises dba Avelo Airlines | Feb 2025 – Jan 2026 |
| Raleigh-Durham International → Roanoke/Blacksburg Regional (Woodrum Field) RDU–ROA | 12 | 169 | 26% | 120 | United Parcel Service, Endeavor Air Inc., Republic Airline, Global Crossing Airlines, Inc. +1 | Feb 2025 – Jun 2026 |
| Raleigh-Durham International → South Bend International RDU–SBN | 10 | 565 | 51% | 572 | Breeze Aviation Group DBA Breeze, Air Wisconsin Airlines Corp, Endeavor Air Inc., Delta Air Lines Inc. +3 | Jan 2025 – May 2026 |
| Raleigh-Durham International → Birmingham-Shuttlesworth International RDU–BHM | 9 | 954 | 77% | 480 | Breeze Aviation Group DBA Breeze | Mar 2025 – Jul 2026 |
| Raleigh-Durham International → Gulfport-Biloxi International RDU–GPT | 9 | 969 | 58% | 705 | Sun Country Airlines d/b/a... | Jan 2025 – May 2026 |
| Raleigh-Durham International → Lehigh Valley International RDU–ABE | 8 | 76 | 100% | 376 | Federal Express Corporation, Endeavor Air Inc. | Mar 2025 – Jul 2026 |
| Raleigh-Durham International → Charleston Afb/Intl RDU–CHS | 8 | 681 | 56% | 217 | Breeze Aviation Group DBA Breeze, Alaska Airlines Inc., Delta Air Lines Inc., Southwest Airlines Co. +1 | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Huntsville Intl-Carl T Jones Field RDU–HSV | 8 | 0 | | 460 | United Parcel Service | Jul 2025 – Jul 2026 |
| Raleigh-Durham International → Laurence G Hanscom Field RDU–BED | 7 | 135 | 14% | 607 | Global Crossing Airlines, Inc., Breeze Aviation Group DBA Breeze | Jan 2025 – Apr 2026 |
| Raleigh-Durham International → Greenville Spartanburg International RDU–GSP | 7 | 541 | 73% | 205 | United Parcel Service, Delta Air Lines Inc., American Airlines Inc., Global Crossing Airlines, Inc. +1 | Feb 2025 – Mar 2026 |
| Raleigh-Durham International → Lovell Field RDU–CHA | 5 | 183 | 29% | 366 | Sun Country Airlines d/b/a..., Delta Air Lines Inc., CFM Inc d/b/a Contour..., Republic Airline | Jun 2025 – Jul 2026 |
| Raleigh-Durham International → Okc Will Rogers International RDU–OKC | 5 | 317 | 50% | 1,058 | American Airlines Inc., Republic Airline, Breeze Aviation Group DBA Breeze | Jan 2025 – May 2026 |
| Raleigh-Durham International → Augusta Regional AT Bush Field RDU–AGS | 4 | 56 | 18% | 250 | Endeavor Air Inc. | Apr 2026 – Apr 2026 |
| Raleigh-Durham International → Topeka Regional RDU–FOE | 4 | 55 | 8% | 951 | Global Crossing Airlines, Inc. | Nov 2025 – Feb 2026 |
| Raleigh-Durham International → Harrisburg International RDU–MDT | 4 | 11 | 79% | 318 | United Parcel Service, Jet Aviation Flight Services, Inc. | Dec 2025 – Feb 2026 |
| Raleigh-Durham International → General Mitchell International RDU–MKE | 4 | 135 | 33% | 689 | Southwest Airlines Co., Air Wisconsin Airlines Corp | Feb 2025 – May 2026 |
| Raleigh-Durham International → Oakland San Francisco Bay RDU–OAK | 4 | 429 | 57% | 2,390 | American Airlines Inc., Delta Air Lines Inc., Global Crossing Airlines, Inc. | Jan 2025 – Jan 2026 |
| Raleigh-Durham International → Raleigh-Durham International RDU–RDU | 4 | 0 | 0% | 0 | SkyWest Airlines Inc. | Mar 2025 – Jul 2026 |
| Raleigh-Durham International → Ottawa RDU–YOW international | 4 | 210 | 46% | 672 | Air Canada | Jan 2026 – Apr 2026 |
| Raleigh-Durham International → Muskegon County RDU–MKG | 3 | 1 | 7% | 641 | ACM AIR CHARTER GmbH | Feb 2026 – Feb 2026 |
| Raleigh-Durham International → Tampico RDU–TAM international | 3 | 267 | 90% | 1,481 | Aerolitoral | Dec 2025 – May 2026 |
| Raleigh-Durham International → Perot Fld/Fort Worth Alliance RDU–AFW | 2 | 0 | 0% | 1,075 | Eastern Airlines f/k/a..., Omni Air International LLC | Nov 2025 – Mar 2026 |
| Raleigh-Durham International → Asheville Regional RDU–AVL | 2 | 1 | 6% | 214 | CFM Inc d/b/a Contour... | Jun 2026 – Jun 2026 |
| Raleigh-Durham International → Bridgeport/Sikorsky RDU–BDR | 2 | 5 | 31% | 476 | Tradewind Aviation | Oct 2025 – Feb 2026 |
| Raleigh-Durham International → Columbia Regional RDU–COU | 2 | 96 | 91% | 766 | CFM Inc d/b/a Contour..., Envoy Air | Mar 2025 – Mar 2026 |
| Raleigh-Durham International → James M Cox Dayton International RDU–DAY | 2 | 116 | 39% | 406 | TEM Enterprises dba Avelo Airlines | Mar 2025 – Mar 2026 |
| Raleigh-Durham International → EL Paso International RDU–ELP | 2 | 283 | 67% | 1,606 | Delta Air Lines Inc., TEM Enterprises dba Avelo Airlines | Dec 2025 – Jul 2026 |
| Raleigh-Durham International → Fort Worth Meacham International RDU–FTW | 2 | 162 | 64% | 1,081 | CommuteAir LLC dba CommuteAir, Allegiant Air | Sep 2025 – Mar 2026 |
| Raleigh-Durham International → Green Bay/Austin Straubel International RDU–GRB | 2 | 3 | 4% | 772 | CFM Inc d/b/a Contour..., SkyWest Airlines Inc. | Jun 2026 – Jul 2026 |
| Raleigh-Durham International → Robert Gray Army Airfield RDU–GRK | 2 | 56 | 21% | 1,147 | PSA Airlines Inc., TEM Enterprises dba Avelo Airlines | Aug 2025 – Mar 2026 |
| Raleigh-Durham International → Lakeland Linder International RDU–LAL | 2 | 0 | 0% | 576 | TEM Enterprises dba Avelo Airlines | Jan 2025 – Dec 2025 |
| Raleigh-Durham International → Eppley Airfield RDU–OMA | 2 | 252 | 70% | 997 | Sun Country Airlines d/b/a..., Southwest Airlines Co. | Jun 2025 – Jun 2026 |
| Raleigh-Durham International → General Downing - Peoria International RDU–PIA | 2 | 67 | 30% | 678 | Eastern Air Express, LLC (EAX), Envoy Air | Jul 2025 – Mar 2026 |
| Raleigh-Durham International → Mineta San Jose International RDU–SJC | 2 | 5 | 3% | 2,379 | Jet Aviation Flight Services, Inc., Global Crossing Airlines, Inc. | Feb 2025 – Jul 2026 |
| Raleigh-Durham International → Sacramento International RDU–SMF | 2 | 92 | 26% | 2,345 | Allegiant Air, Global Crossing Airlines, Inc. | Mar 2026 – Mar 2026 |
| Raleigh-Durham International → Santiago RDU–STI international | 2 | 328 | 92% | 1,239 | United Air Lines Inc. | Dec 2025 – Jan 2026 |
| Raleigh-Durham International → Teterboro RDU–TEB | 2 | 5 | 24% | 429 | Gestair, S.A., Tradewind Aviation | Apr 2025 – Apr 2026 |
| Raleigh-Durham International → MC Ghee Tyson RDU–TYS | 2 | 143 | 47% | 292 | American Airlines Inc., United Air Lines Inc. | Jan 2025 – Jan 2026 |
| Raleigh-Durham International → Concord RDU–USA | 2 | 7 | 3% | 113 | CFM Inc d/b/a Contour..., TEM Enterprises dba Avelo Airlines | Apr 2025 – Feb 2026 |
| Raleigh-Durham International → Northwest Arkansas Ntl RDU–XNA | 2 | 0 | 0% | 868 | TEM Enterprises dba Avelo Airlines, Republic Airline | Feb 2025 – Jan 2026 |
| Raleigh-Durham International → Acapulco RDU–ACA international | 1 | 49 | 49% | 1,842 | Aerolitoral | Apr 2026 – Apr 2026 |
| Raleigh-Durham International → Nantucket Memorial RDU–ACK | 1 | 0 | 0% | 600 | ACM AIR CHARTER GmbH | Aug 2025 – Aug 2025 |
| Raleigh-Durham International → Waco Regional RDU–ACT | 1 | 109 | 62% | 1,100 | Southwest Airlines Co. | Mar 2025 – Mar 2026 |
| Raleigh-Durham International → Athens/Ben Epps RDU–AHN | 1 | 0 | 0% | 290 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Raleigh-Durham International → Naples Municipal RDU–APF | 1 | 6 | 100% | 693 | Chartright Air Inc. | Mar 2026 – Mar 2026 |
| Raleigh-Durham International → Wilkes-Barre/Scranton International RDU–AVP | 1 | 91 | 66% | 412 | Breeze Aviation Group DBA Breeze | Mar 2026 – Mar 2026 |
| Raleigh-Durham International → Boca Raton RDU–BCT | 1 | 2 | 15% | 659 | CFM Inc d/b/a Contour... | Dec 2025 – Dec 2025 |
| Raleigh-Durham International → Scottsbluff/Western Nebraska Rgnl/Wm B Heilig Field RDU–BFF | 1 | 164 | 99% | 1,395 | United Air Lines Inc. | Aug 2025 – Aug 2025 |
| Raleigh-Durham International → Boeing Fld/King County International RDU–BFI | 1 | 0 | 0% | 2,354 | Global Crossing Airlines, Inc. | Mar 2025 – Mar 2026 |
| Raleigh-Durham International → Boise Air Trml/Gowen Field RDU–BOI | 1 | 135 | 84% | 2,045 | Delta Air Lines Inc. | Oct 2025 – Oct 2025 |
| Raleigh-Durham International → Charlottesville-Albemarle RDU–CHO | 1 | 0 | 0% | 157 | Global Crossing Airlines, Inc. | Jan 2025 – Feb 2026 |
| Raleigh-Durham International → North Central West Virginia RDU–CKB | 1 | 0 | 0% | 249 | Global Crossing Airlines, Inc. | Mar 2025 – Jan 2026 |
| Raleigh-Durham International → University Of Illinois/Willard RDU–CMI | 1 | 187 | 80% | 592 | Delta Air Lines Inc. | Sep 2025 – Sep 2025 |
| Raleigh-Durham International → City Of Colorado Springs Municipal RDU–COS | 1 | 59 | 38% | 1,436 | Caribbean Sun Airlines,... | Apr 2025 – Mar 2026 |
| Raleigh-Durham International → St. Louis Downtown RDU–CPS | 1 | 48 | 32% | 654 | Air Canada | Jan 2026 – Jan 2026 |
| Raleigh-Durham International → Columbus RDU–CSG | 1 | 62 | 57% | 422 | Breeze Aviation Group DBA Breeze | May 2025 – May 2026 |
| Raleigh-Durham International → Fort Drum RDU–DQK | 1 | 0 | 0% | 587 | TEM Enterprises dba Avelo Airlines | Sep 2025 – Sep 2025 |
| Raleigh-Durham International → Des Moines International RDU–DSM | 1 | 0 | 0% | 892 | Republic Airline | Nov 2025 – Nov 2025 |
| Raleigh-Durham International → Evansville Regional RDU–EVV | 1 | 0 | 0% | 506 | Chartright Air Inc. | Sep 2025 – Sep 2025 |
| Raleigh-Durham International → Fayetteville Rgnl/Grannis Field RDU–FAY | 1 | 54 | 77% | 61 | SkyWest Airlines Inc. | Jul 2025 – Jun 2026 |
| Raleigh-Durham International → Rome RDU–FCO international | 1 | 76 | 36% | 4,688 | Omni Air International LLC | Jun 2026 – Jun 2026 |
| Raleigh-Durham International → Republic RDU–FRG | 1 | 52 | 38% | 444 | JetBlue Airways | Jan 2025 – Apr 2026 |
| Raleigh-Durham International → Joe Foss Field RDU–FSD | 1 | 71 | 65% | 1,091 | Delta Air Lines Inc. | Jul 2026 – Jul 2026 |
| Raleigh-Durham International → Greensboro RDU–GA7 | 1 | 0 | 0% | 293 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Raleigh-Durham International → Cartersville RDU–GA9 | 1 | 0 | 0% | 364 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Raleigh-Durham International → Spokane International RDU–GEG | 1 | 128 | 80% | 2,133 | Delta Air Lines Inc. | Mar 2025 – Jan 2026 |
| Raleigh-Durham International → Governors Harbour RDU–GHB international | 1 | 1 | 12% | 744 | Glock Aviation GmbH | Jan 2026 – Jan 2026 |
| Raleigh-Durham International → Valley International RDU–HRL | 1 | 0 | 0% | 1,298 | Global Crossing Airlines, Inc. | Jan 2025 – Oct 2025 |
| Raleigh-Durham International → Terre Haute Regional RDU–HUF | 1 | 0 | 0% | 528 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Raleigh-Durham International → Wichita Dwight D Eisenhower Ntl RDU–ICT | 1 | 42 | 55% | 1,040 | Endeavor Air Inc. | Oct 2025 – Oct 2025 |
| Raleigh-Durham International → Charleston Executive RDU–JZI | 1 | 0 | 0% | 432 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Raleigh-Durham International → Capital Region International RDU–LAN | 1 | 50 | 39% | 568 | American Airlines Inc. | Feb 2025 – Dec 2025 |
| Raleigh-Durham International → Blue Grass RDU–LEX | 1 | 47 | 26% | 355 | Global Crossing Airlines, Inc. | Mar 2025 – Dec 2025 |
| Raleigh-Durham International → Lisbon RDU–LIS international | 1 | 9 | 64% | 3,745 | Axis Aviation GmbH | Dec 2025 – Dec 2025 |
| Raleigh-Durham International → Lincoln RDU–LNK | 1 | 80 | 53% | 1,032 | Global Crossing Airlines, Inc. | Jun 2025 – Mar 2026 |
| Raleigh-Durham International → Lynchburg Rgnl/Preston Glenn Field RDU–LYH | 1 | 45 | 90% | 103 | Piedmont Airlines | Jan 2025 – Jul 2026 |
| Raleigh-Durham International → Midland International Air And Space Port RDU–MAF | 1 | 123 | 70% | 1,369 | Southwest Airlines Co. | Oct 2025 – Oct 2025 |
| Raleigh-Durham International → Kansas City Downtown/Wheeler Field RDU–MKC | 1 | 37 | 20% | 896 | Sun Country Airlines d/b/a... | Apr 2025 – May 2026 |
| Raleigh-Durham International → Quad Cities International RDU–MLI | 1 | 73 | 49% | 740 | Eastern Air Express, LLC (EAX) | Mar 2026 – Mar 2026 |
| Raleigh-Durham International → Missoula Montana RDU–MSO | 1 | 0 | 0% | 1,966 | TEM Enterprises dba Avelo Airlines | Oct 2025 – Oct 2025 |
| Raleigh-Durham International → Montrose Regional RDU–MTJ | 1 | 0 | 0% | 1,609 | TEM Enterprises dba Avelo Airlines | Jul 2025 – Nov 2025 |
| Raleigh-Durham International → Monterrey RDU–MTY international | 1 | 84 | 85% | 1,441 | Aerolitoral | Sep 2025 – Sep 2025 |
| Raleigh-Durham International → Martha'S Vineyard RDU–MVY | 1 | 1 | 12% | 583 | Tradewind Aviation | Jun 2025 – Aug 2025 |
| Raleigh-Durham International → Nassau RDU–NAS international | 1 | 1 | 7% | 751 | VistaJet Limited | Jul 2026 – Jul 2026 |
| Raleigh-Durham International → Albert J Ellis RDU–OAJ | 1 | 0 | 0% | 98 | TEM Enterprises dba Avelo Airlines | Mar 2025 – Oct 2025 |
| Raleigh-Durham International → Kahului RDU–OGG | 1 | 98 | 36% | 4,721 | Omni Air International LLC | Nov 2025 – Nov 2025 |
| Raleigh-Durham International → Miami-Opa Locka Executive RDU–OPF | 1 | 5 | 36% | 692 | Global Jet Luxembourg, Sa | Feb 2026 – Feb 2026 |
| Raleigh-Durham International → Owensboro/Daviess County Regional RDU–OWB | 1 | 0 | 0% | 482 | CFM Inc d/b/a Contour... | Nov 2025 – Nov 2025 |
| Raleigh-Durham International → Barkley Regional RDU–PAH | 1 | 105 | 58% | 562 | Allegiant Air | Mar 2026 – Mar 2026 |
| Raleigh-Durham International → Dekalb-Peachtree RDU–PDK | 1 | 15 | 79% | 342 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Raleigh-Durham International → Portland International RDU–PDX | 1 | 115 | 72% | 2,363 | Delta Air Lines Inc. | Dec 2025 – Dec 2025 |
| Raleigh-Durham International → Perugia RDU–PEG international | 1 | 2 | 14% | 4,657 | Glock Aviation GmbH | Oct 2025 – Oct 2025 |
| Raleigh-Durham International → Pitt-Greenville RDU–PGV | 1 | 46 | 92% | 80 | Piedmont Airlines | Jun 2026 – Jun 2026 |
| Raleigh-Durham International → Newport News/Williamsburg International RDU–PHF | 1 | 0 | 0% | 154 | Sun Country Airlines d/b/a... | Aug 2025 – Aug 2025 |
| Raleigh-Durham International → Hattiesburg/Laurel Regional RDU–PIB | 1 | 0 | 0% | 679 | TEM Enterprises dba Avelo Airlines | Oct 2025 – Oct 2025 |
| Raleigh-Durham International → St. Pete-Clearwater International RDU–PIE | 1 | 0 | 0% | 595 | Sun Country Airlines d/b/a... | Aug 2025 – Aug 2025 |
| Raleigh-Durham International → Palm Springs International RDU–PSP | 1 | 188 | 99% | 2,135 | American Airlines Inc. | Jul 2026 – Jul 2026 |
| Raleigh-Durham International → Pueblo Memorial RDU–PUB | 1 | 163 | 93% | 1,426 | Southwest Airlines Co. | Dec 2025 – Dec 2025 |
| Raleigh-Durham International → Kennesaw RDU–QMA | 1 | 0 | | 354 | Ameristar Air Cargo | Dec 2025 – Dec 2025 |
| Raleigh-Durham International → Queretaro RDU–QRO international | 1 | 92 | 93% | 1,668 | Aerolitoral | Feb 2025 – Jul 2026 |
| Raleigh-Durham International → Reno/Tahoe International RDU–RNO | 1 | 166 | 89% | 2,241 | Sun Country Airlines d/b/a... | May 2026 – May 2026 |
| Raleigh-Durham International → Savannah/Hilton Head International RDU–SAV | 1 | 172 | 99% | 293 | Delta Air Lines Inc. | Feb 2025 – Jul 2026 |
| Raleigh-Durham International → Salina Regional RDU–SLN | 1 | 0 | 0% | 1,056 | SkyWest Airlines Inc. | Jul 2026 – Jul 2026 |
| Raleigh-Durham International → Shannon RDU–SNN international | 1 | 244 | 90% | 3,502 | American Airlines Inc. | Dec 2025 – Dec 2025 |
| Raleigh-Durham International → Cyril E King RDU–STT | 1 | 0 | 0% | 1,474 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| Raleigh-Durham International → Witham Field RDU–SUA | 1 | 1 | 12% | 605 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Raleigh-Durham International → Tel Aviv RDU–TLV international | 1 | 5 | 36% | 6,093 | VistaJet Limited | Dec 2025 – Dec 2025 |
| Raleigh-Durham International → Trenton Mercer RDU–TTN | 1 | 14 | 88% | 373 | CFM Inc d/b/a Contour... | Nov 2025 – Nov 2025 |
| Raleigh-Durham International → South Andos RDU–TZN international | 1 | 8 | 50% | 810 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| Raleigh-Durham International → Jesse Viertel Memorial RDU–VER international | 1 | 73 | 74% | 1,566 | Aerolitoral | Aug 2025 – Aug 2025 |
| Raleigh-Durham International → Valencia RDU–VLC international | 1 | 2 | 14% | 4,158 | VistaJet Limited | Mar 2026 – Mar 2026 |
| Raleigh-Durham International → Van Nuys RDU–VNY | 1 | 5 | 42% | 2,239 | Scott Aviation, LLC d/b/a... | Oct 2025 – Oct 2025 |
| Raleigh-Durham International → Edmonton RDU–YEG international | 1 | 0 | 0% | 2,064 | Global Crossing Airlines, Inc. | Mar 2025 – Dec 2025 |
| Raleigh-Durham International → Willow Run RDU–YIP | 1 | 0 | 0% | 508 | Southwest Airlines Co. | Mar 2026 – Mar 2026 |
| Raleigh-Durham International → Yakima Air Trml/Mcallister Field RDU–YKM | 1 | 137 | 86% | 2,267 | Delta Air Lines Inc. | Mar 2026 – Mar 2026 |
| Raleigh-Durham International → St. John'S RDU–YYT international | 1 | 267 | 91% | 1,560 | Lufthansa German Airlines | Feb 2026 – Feb 2026 |