| James M Cox Dayton International → Chicago O'Hare International DAY–ORD | 3,095 | 144,442 | 78% | 240 | GoJet Airlines LLC d/b/a..., PSA Airlines Inc., SkyWest Airlines Inc., Envoy Air +4 | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Hartsfield/Jackson Atlanta International DAY–ATL | 1,406 | 129,418 | 84% | 432 | Delta Air Lines Inc., Endeavor Air Inc., Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Charlotte/Douglas International DAY–CLT | 1,360 | 76,838 | 77% | 370 | PSA Airlines Inc., Piedmont Airlines, Republic Airline | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Dallas-Fort Worth International DAY–DFW | 1,317 | 81,926 | 83% | 861 | PSA Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Washington Dulles International DAY–IAD | 944 | 38,532 | 81% | 367 | CommuteAir LLC dba CommuteAir, GoJet Airlines LLC d/b/a..., Republic Airline, PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Ronald Reagan Washington Ntl DAY–DCA | 927 | 43,897 | 72% | 391 | PSA Airlines Inc., American Airlines Inc. | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Denver International DAY–DEN | 363 | 38,044 | 87% | 1,085 | United Air Lines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Philadelphia International DAY–PHL | 357 | 15,874 | 62% | 477 | PSA Airlines Inc., Piedmont Airlines, Allegiant Air, Republic Airline | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Frederick W Smith Intl/Memphis DAY–MEM | 252 | 0 | 0% | 461 | Federal Express Corporation, Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → St. Pete-Clearwater International DAY–PIE | 106 | 16,038 | 87% | 831 | Allegiant Air, CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Punta Gorda DAY–PGD | 94 | 14,809 | 88% | 904 | Allegiant Air | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Orlando Sanford International DAY–SFB | 81 | 12,054 | 85% | 785 | Allegiant Air | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Laguardia DAY–LGA | 55 | 2,067 | 52% | 549 | Endeavor Air Inc., Republic Airline | Jan 2025 – Sep 2025 |
| James M Cox Dayton International → Myrtle Beach International DAY–MYR | 20 | 2,560 | 76% | 520 | Allegiant Air | May 2026 – Jul 2026 |
| James M Cox Dayton International → James M Cox Dayton International DAY–DAY | 12 | 0 | 0% | 0 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → John Glenn Columbus International DAY–CMH | 9 | 188 | 29% | 71 | Republic Airline, PSA Airlines Inc., SkyWest Airlines Inc. | Jan 2025 – May 2026 |
| James M Cox Dayton International → Gulfport-Biloxi International DAY–GPT | 9 | 1,234 | 74% | 710 | Sun Country Airlines d/b/a... | Jan 2025 – Jun 2026 |
| James M Cox Dayton International → Atlantic City International DAY–ACY | 7 | 952 | 73% | 515 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → South Bend International DAY–SBN | 5 | 241 | 75% | 166 | PSA Airlines Inc., GoJet Airlines LLC d/b/a... | Jan 2025 – Jun 2026 |
| James M Cox Dayton International → Detroit Metro Wayne County DAY–DTW | 4 | 375 | 84% | 166 | Endeavor Air Inc., Delta Air Lines Inc. | Jul 2025 – Jun 2026 |
| James M Cox Dayton International → Richmond International DAY–RIC | 4 | 57 | 12% | 407 | Republic Airline, Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Jan 2025 – Mar 2026 |
| James M Cox Dayton International → Shreveport Regional DAY–SHV | 4 | 259 | 88% | 743 | PSA Airlines Inc. | Sep 2025 – Jun 2026 |
| James M Cox Dayton International → Lehigh Valley International DAY–ABE | 3 | 144 | 33% | 466 | Allegiant Air, PSA Airlines Inc., Sun Country Airlines d/b/a... | Oct 2025 – Mar 2026 |
| James M Cox Dayton International → St. Louis Downtown DAY–CPS | 3 | 52 | 40% | 332 | CFM Inc d/b/a Contour..., Republic Airline | Jan 2026 – Feb 2026 |
| James M Cox Dayton International → Cincinnati/Northern Kentucky International DAY–CVG | 3 | 336 | 72% | 64 | Delta Air Lines Inc., Alaska Airlines Inc. | Mar 2025 – Dec 2025 |
| James M Cox Dayton International → Des Moines International DAY–DSM | 3 | 170 | 62% | 508 | Allegiant Air, CFM Inc d/b/a Contour..., PSA Airlines Inc. | Nov 2025 – Mar 2026 |
| James M Cox Dayton International → Fort Wayne International DAY–FWA | 3 | 0 | 0% | 90 | Sun Country Airlines d/b/a... | Feb 2025 – Jun 2026 |
| James M Cox Dayton International → Greenville Spartanburg International DAY–GSP | 3 | 194 | 63% | 362 | CommuteAir LLC dba CommuteAir, Allegiant Air, PSA Airlines Inc. | Feb 2025 – Jul 2026 |
| James M Cox Dayton International → Arnold Palmer Regional DAY–LBE | 3 | 0 | 0% | 256 | Sun Country Airlines d/b/a... | Aug 2025 – Mar 2026 |
| James M Cox Dayton International → Laredo International DAY–LRD | 3 | 0 | | 1,220 | USA Jet Airlines Inc., Gulf And Caribbean Cargo | Mar 2025 – Jul 2026 |
| James M Cox Dayton International → Kansas City International DAY–MCI | 3 | 102 | 50% | 561 | PSA Airlines Inc., SkyWest Airlines Inc. | Nov 2025 – Jun 2026 |
| James M Cox Dayton International → General Mitchell International DAY–MKE | 3 | 63 | 22% | 284 | Air Wisconsin Airlines Corp, Allegiant Air | Jan 2025 – Nov 2025 |
| James M Cox Dayton International → Okc Will Rogers International DAY–OKC | 3 | 149 | 69% | 796 | PSA Airlines Inc., SkyWest Airlines Inc. | Mar 2025 – Jun 2026 |
| James M Cox Dayton International → Baltimore/Washington International Thurgood Marshall DAY–BWI | 2 | 127 | 63% | 406 | Breeze Aviation Group DBA Breeze, PSA Airlines Inc. | Jan 2025 – Mar 2026 |
| James M Cox Dayton International → Columbia Metro DAY–CAE | 2 | 109 | 68% | 445 | Delta Air Lines Inc., Piedmont Airlines | Mar 2025 – Jan 2026 |
| James M Cox Dayton International → The Eastern Iowa DAY–CID | 2 | 0 | 0% | 415 | SkyWest Airlines Inc., Republic Airline | Jan 2025 – Apr 2026 |
| James M Cox Dayton International → Gerald R Ford International DAY–GRR | 2 | 32 | 44% | 217 | CFM Inc d/b/a Contour..., PSA Airlines Inc. | May 2025 – Mar 2026 |
| James M Cox Dayton International → Laughlin/Bullhead International DAY–IFP | 2 | 353 | 95% | 1,690 | Sun Country Airlines d/b/a... | Jun 2025 – Jul 2026 |
| James M Cox Dayton International → Indianapolis International DAY–IND | 2 | 0 | 0% | 111 | Federal Express Corporation, Sun Country Airlines d/b/a... | Mar 2025 – Apr 2026 |
| James M Cox Dayton International → Jacksonville International DAY–JAX | 2 | 0 | 0% | 664 | Ameristar Air Cargo, National Air Cargo Group... | Dec 2025 – Mar 2026 |
| James M Cox Dayton International → Dane County Rgnl/Truax Field DAY–MSN | 2 | 70 | 48% | 347 | PSA Airlines Inc., Republic Airline | Oct 2025 – Jan 2026 |
| James M Cox Dayton International → Minneapolis-St Paul Intl/Wold-Chamberlain DAY–MSP | 2 | 0 | 0% | 574 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| James M Cox Dayton International → Oakland County International DAY–PTK | 2 | 0 | | 195 | Gulf And Caribbean Cargo | Mar 2025 – Jan 2026 |
| James M Cox Dayton International → Raleigh-Durham International DAY–RDU | 2 | 113 | 37% | 406 | Eastern Air Express, LLC (EAX), Allegiant Air | Mar 2025 – Mar 2026 |
| James M Cox Dayton International → St. Louis Lambert International DAY–STL | 2 | 23 | 23% | 339 | GoJet Airlines LLC d/b/a... | Aug 2025 – May 2026 |
| James M Cox Dayton International → MC Ghee Tyson DAY–TYS | 2 | 96 | 55% | 282 | Delta Air Lines Inc., PSA Airlines Inc. | Mar 2025 – Jul 2026 |
| James M Cox Dayton International → Willow Run DAY–YIP | 2 | 0 | 0% | 166 | USA Jet Airlines Inc., Republic Airline | Jan 2025 – Apr 2026 |
| James M Cox Dayton International → Waterloo Regional DAY–ALO | 1 | 0 | 0% | 464 | Sun Country Airlines d/b/a... | Jan 2026 – Jan 2026 |
| James M Cox Dayton International → Patrick Leahy Burlington International DAY–BTV | 1 | 0 | 0% | 649 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| James M Cox Dayton International → Buffalo Niagara International DAY–BUF | 1 | 86 | 58% | 354 | TEM Enterprises dba Avelo Airlines | Jan 2025 – Mar 2026 |
| James M Cox Dayton International → Akron-Canton Regional DAY–CAK | 1 | 32 | 49% | 162 | PSA Airlines Inc. | Jul 2026 – Jul 2026 |
| James M Cox Dayton International → City Of Colorado Springs Municipal DAY–COS | 1 | 0 | 0% | 1,097 | SkyWest Airlines Inc. | Feb 2025 – Aug 2025 |
| James M Cox Dayton International → Dallas Love Field DAY–DAL | 1 | 95 | 63% | 855 | Eastern Air Express, LLC (EAX) | Mar 2026 – Mar 2026 |
| James M Cox Dayton International → Duluth International DAY–DLH | 1 | 0 | 0% | 624 | SkyWest Airlines Inc. | Jul 2026 – Jul 2026 |
| James M Cox Dayton International → Newark Liberty International DAY–EWR | 1 | 0 | 0% | 533 | Global Crossing Airlines, Inc. | Jan 2025 – Mar 2026 |
| James M Cox Dayton International → Valley International DAY–HRL | 1 | 0 | 0% | 1,220 | Global Crossing Airlines, Inc. | Mar 2026 – Mar 2026 |
| James M Cox Dayton International → George Bush Intcntl/Houston DAY–IAH | 1 | 54 | 83% | 929 | PSA Airlines Inc. | Apr 2025 – Jul 2026 |
| James M Cox Dayton International → Wichita Dwight D Eisenhower Ntl DAY–ICT | 1 | 0 | | 730 | Gulf And Caribbean Cargo | Dec 2025 – Dec 2025 |
| James M Cox Dayton International → Wilmington International DAY–ILM | 1 | 39 | 65% | 522 | Ameristar Air Cargo | Mar 2026 – Mar 2026 |
| James M Cox Dayton International → Purdue University DAY–LAF | 1 | 0 | 0% | 148 | Republic Airline | Jan 2026 – Jan 2026 |
| James M Cox Dayton International → Lubbock Preston Smith International DAY–LBB | 1 | 51 | 67% | 1,064 | PSA Airlines Inc. | Feb 2025 – Apr 2026 |
| James M Cox Dayton International → Bill And Hillary Clinton Ntl/Adams Field DAY–LIT | 1 | 36 | 47% | 567 | PSA Airlines Inc. | Feb 2025 – Apr 2026 |
| James M Cox Dayton International → Orlando International DAY–MCO | 1 | 0 | 0% | 808 | Republic Airline | Nov 2025 – Nov 2025 |
| James M Cox Dayton International → Louis Armstrong New Orleans International DAY–MSY | 1 | 176 | 95% | 764 | Sun Country Airlines d/b/a... | Feb 2026 – Feb 2026 |
| James M Cox Dayton International → Dekalb-Peachtree DAY–PDK | 1 | 0 | 0% | 416 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| James M Cox Dayton International → Portland International DAY–PDX | 1 | 0 | 0% | 1,972 | Global Crossing Airlines, Inc. | Mar 2026 – Mar 2026 |
| James M Cox Dayton International → Phoenix Sky Harbor International DAY–PHX | 1 | 0 | | 1,600 | USA Jet Airlines Inc. | Aug 2025 – Aug 2025 |
| James M Cox Dayton International → Rhode Island TF Green International DAY–PVD | 1 | 38 | 20% | 682 | TEM Enterprises dba Avelo Airlines | Feb 2025 – Nov 2025 |
| James M Cox Dayton International → Reno/Tahoe International DAY–RNO | 1 | 149 | 80% | 1,882 | Sun Country Airlines d/b/a... | Feb 2025 – Jan 2026 |
| James M Cox Dayton International → Southwest Florida International DAY–RSW | 1 | 2 | 25% | 932 | Chartright Air Inc. | Jan 2026 – Jan 2026 |
| James M Cox Dayton International → San Diego International DAY–SAN | 1 | 1 | 12% | 1,893 | Scott Aviation, LLC d/b/a... | Mar 2025 – Aug 2025 |
| James M Cox Dayton International → San Antonio International DAY–SAT | 1 | 0 | | 1,079 | Gulf And Caribbean Cargo | Oct 2025 – Oct 2025 |
| James M Cox Dayton International → State College DAY–SCE | 1 | 0 | 0% | 342 | Republic Airline | Jan 2025 – Feb 2026 |
| James M Cox Dayton International → Springfield-Branson Ntl DAY–SGF | 1 | 9 | 75% | 529 | Hamilton Jetport Limited | May 2026 – May 2026 |
| James M Cox Dayton International → Shenandoah Valley Regional DAY–SHD | 1 | 0 | 0% | 308 | SkyWest Airlines Inc. | Jul 2026 – Jul 2026 |
| James M Cox Dayton International → Sheppard Afb/Wichita Falls Municipal DAY–SPS | 1 | 45 | 59% | 888 | PSA Airlines Inc. | Jun 2026 – Jun 2026 |
| James M Cox Dayton International → London DAY–STN international | 1 | 1 | 7% | 3,921 | Voluxis Limited | Oct 2025 – Oct 2025 |
| James M Cox Dayton International → Tuscaloosa Ntl DAY–TCL | 1 | 8 | 89% | 497 | Hamilton Jetport Limited | Oct 2025 – Oct 2025 |
| James M Cox Dayton International → Tallahassee International DAY–TLH | 1 | 58 | 54% | 655 | Breeze Aviation Group DBA Breeze | Jan 2025 – Dec 2025 |
| James M Cox Dayton International → Eugene F Kranz Toledo Express DAY–TOL | 1 | 0 | | 119 | Ameristar Air Cargo | Mar 2025 – Aug 2025 |
| James M Cox Dayton International → Tampa International DAY–TPA | 1 | 69 | 38% | 828 | Allegiant Air | Mar 2026 – Mar 2026 |
| James M Cox Dayton International → Tri-Cities DAY–TRI | 1 | 55 | 72% | 256 | PSA Airlines Inc. | Sep 2025 – Sep 2025 |
| James M Cox Dayton International → Tucson International DAY–TUS | 1 | 216 | 74% | 1,583 | National Air Cargo Group... | Dec 2025 – Dec 2025 |
| James M Cox Dayton International → Concord DAY–USA | 1 | 0 | 0% | 366 | TEM Enterprises dba Avelo Airlines | Mar 2026 – Mar 2026 |
| James M Cox Dayton International → Windsor DAY–YQG international | 1 | 0 | | 176 | USA Jet Airlines Inc. | Jan 2026 – Jan 2026 |