| Cleveland-Hopkins International → Chicago O'Hare International CLE–ORD | 4,741 | 414,478 | 76% | 316 | United Air Lines Inc., SkyWest Airlines Inc., Envoy Air, Republic Airline +5 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Hartsfield/Jackson Atlanta International CLE–ATL | 3,346 | 451,734 | 76% | 554 | Delta Air Lines Inc., Frontier Airlines Inc., Endeavor Air Inc., Southwest Airlines Co. +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Laguardia CLE–LGA | 2,784 | 162,787 | 73% | 419 | Republic Airline, Endeavor Air Inc., Frontier Airlines Inc., United Air Lines Inc. +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Newark Liberty International CLE–EWR | 2,170 | 207,031 | 76% | 404 | United Air Lines Inc., Republic Airline, GoJet Airlines LLC d/b/a..., United Parcel Service +4 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Orlando International CLE–MCO | 2,097 | 328,063 | 81% | 895 | Frontier Airlines Inc., United Air Lines Inc., Southwest Airlines Co., Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Detroit Metro Wayne County CLE–DTW | 1,920 | 102,639 | 72% | 95 | SkyWest Airlines Inc., Endeavor Air Inc., Delta Air Lines Inc., Republic Airline +5 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Denver International CLE–DEN | 1,827 | 274,390 | 85% | 1,201 | United Air Lines Inc., Southwest Airlines Co., Frontier Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Charlotte/Douglas International CLE–CLT | 1,761 | 200,968 | 73% | 430 | American Airlines Inc., PSA Airlines Inc., Frontier Airlines Inc., Envoy Air +4 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Philadelphia International CLE–PHL | 1,759 | 85,695 | 71% | 363 | Piedmont Airlines, PSA Airlines Inc., American Airlines Inc., United Parcel Service +5 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → John F Kennedy International CLE–JFK | 1,653 | 95,423 | 72% | 425 | Endeavor Air Inc., Republic Airline, JetBlue Airways, Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → General Edward Lawrence Logan International CLE–BOS | 1,611 | 131,970 | 76% | 563 | Republic Airline, JetBlue Airways, Frontier Airlines Inc., Delta Air Lines Inc. +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Dallas-Fort Worth International CLE–DFW | 1,567 | 216,811 | 79% | 1,021 | American Airlines Inc., Frontier Airlines Inc., Envoy Air, PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Ronald Reagan Washington Ntl CLE–DCA | 1,503 | 72,127 | 70% | 310 | PSA Airlines Inc., Envoy Air, Republic Airline, American Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Washington Dulles International CLE–IAD | 1,448 | 120,443 | 75% | 287 | United Air Lines Inc., Mesa Airlines Inc., Republic Airline, GoJet Airlines LLC d/b/a... +4 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Minneapolis-St Paul Intl/Wold-Chamberlain CLE–MSP | 1,221 | 89,731 | 78% | 622 | Delta Air Lines Inc., Endeavor Air Inc., SkyWest Airlines Inc., Sun Country Airlines d/b/a... +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Fort Lauderdale/Hollywood International CLE–FLL | 1,211 | 179,674 | 77% | 1,062 | United Air Lines Inc., Frontier Airlines Inc., Spirit Air Lines, JetBlue Airways +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Chicago Midway International CLE–MDW | 1,104 | 116,748 | 67% | 307 | Southwest Airlines Co., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Nashville International CLE–BNA | 1,032 | 114,436 | 68% | 448 | Southwest Airlines Co., Frontier Airlines Inc., Spirit Air Lines, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → George Bush Intcntl/Houston CLE–IAH | 1,023 | 118,191 | 78% | 1,091 | United Air Lines Inc., Mesa Airlines Inc., National Air Cargo Group... | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Tampa International CLE–TPA | 1,020 | 165,472 | 80% | 927 | Frontier Airlines Inc., United Air Lines Inc., Southwest Airlines Co., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Phoenix Sky Harbor International CLE–PHX | 982 | 144,857 | 81% | 1,737 | Southwest Airlines Co., Frontier Airlines Inc., American Airlines Inc., Delta Air Lines Inc. +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Harry Reid International CLE–LAS | 979 | 160,478 | 82% | 1,824 | Frontier Airlines Inc., Southwest Airlines Co., American Airlines Inc., Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Baltimore/Washington International Thurgood Marshall CLE–BWI | 962 | 96,989 | 63% | 314 | Southwest Airlines Co., United Air Lines Inc., Atlas Air Inc., Endeavor Air Inc. +1 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Southwest Florida International CLE–RSW | 922 | 140,987 | 78% | 1,025 | Frontier Airlines Inc., United Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Miami International CLE–MIA | 866 | 110,990 | 78% | 1,080 | American Airlines Inc., Frontier Airlines Inc., Envoy Air, Republic Airline +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Los Angeles International CLE–LAX | 762 | 102,244 | 78% | 2,052 | United Air Lines Inc., American Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → St. Louis Lambert International CLE–STL | 699 | 75,890 | 71% | 487 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → San Francisco International CLE–SFO | 579 | 77,398 | 79% | 2,161 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Louisville Muhammad Ali International CLE–SDF | 548 | 96 | 53% | 304 | United Parcel Service, Delta Air Lines Inc., USA Jet Airlines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Toronto CLE–YYZ international | 509 | 24,352 | 65% | 193 | Jazz Aviation LP, Chartright Air Inc., Delta Air Lines Inc., United Air Lines Inc. +1 | Feb 2025 – Jul 2026 |
| Cleveland-Hopkins International → Seattle-Tacoma International CLE–SEA | 449 | 64,398 | 82% | 2,021 | Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Frederick W Smith Intl/Memphis CLE–MEM | 415 | 171 | 39% | 623 | Federal Express Corporation, Delta Air Lines Inc., United Parcel Service, Mesa Airlines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Salt Lake City International CLE–SLC | 362 | 37,910 | 81% | 1,565 | Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Cancun CLE–CUN international | 340 | 43,246 | 60% | 1,434 | Frontier Airlines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Dubois Municipal CLE–DUB international | 262 | 32,848 | 68% | 3,466 | Aer Lingus Plc | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Indianapolis International CLE–IND | 219 | 827 | 51% | 261 | Federal Express Corporation, Delta Air Lines Inc., Southwest Airlines Co., Republic Airline +2 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Raleigh-Durham International CLE–RDU | 207 | 28,120 | 66% | 416 | Frontier Airlines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Erie Intl/Tom Ridge Field CLE–ERI | 189 | 47 | 94% | 98 | Federal Express Corporation, Piedmont Airlines | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Paulding Northwest Atlanta CLE–PUJ international | 118 | 17,516 | 64% | 1,764 | Frontier Airlines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Sarasota/Bradenton International CLE–SRQ | 118 | 16,531 | 68% | 967 | Frontier Airlines Inc., Southwest Airlines Co., Delta Air Lines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Montreal CLE–YUL international | 93 | 6,238 | 88% | 495 | Jazz Aviation LP, Delta Air Lines Inc. | May 2026 – Jul 2026 |
| Cleveland-Hopkins International → Myrtle Beach International CLE–MYR | 83 | 10,575 | 67% | 557 | Frontier Airlines Inc., Spirit Air Lines, Sun Country Airlines d/b/a... | Mar 2025 – Jul 2026 |
| Cleveland-Hopkins International → Harrisburg International CLE–MDT | 47 | 0 | | 280 | Federal Express Corporation | Jun 2025 – Jul 2026 |
| Cleveland-Hopkins International → Austin-Bergstrom International CLE–AUS | 43 | 6,772 | 74% | 1,174 | Frontier Airlines Inc., American Airlines Inc., United Air Lines Inc. | Jan 2025 – Mar 2026 |
| Cleveland-Hopkins International → Luis Munoz Marin International CLE–SJU | 35 | 5,720 | 76% | 1,839 | Frontier Airlines Inc. | Jan 2025 – Jan 2026 |
| Cleveland-Hopkins International → Pittsburgh International CLE–PIT | 28 | 839 | 60% | 106 | United Parcel Service, Republic Airline, Delta Air Lines Inc., Endeavor Air Inc. +3 | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → West Palm Beach/Palm Beach CLE–PBI | 19 | 2,613 | 64% | 1,020 | Frontier Airlines Inc. | Jan 2025 – Mar 2026 |
| Cleveland-Hopkins International → Willow Run CLE–YIP | 16 | 0 | | 104 | USA Jet Airlines Inc., Ameristar Air Cargo, Kalitta Charters II | Feb 2025 – Jun 2026 |
| Cleveland-Hopkins International → General Mitchell International CLE–MKE | 15 | 669 | 59% | 328 | Delta Air Lines Inc., United Parcel Service, CFM Inc d/b/a Contour..., SkyWest Airlines Inc. +3 | Mar 2025 – Jul 2026 |
| Cleveland-Hopkins International → Cleveland-Hopkins International CLE–CLE | 14 | 0 | 0% | 0 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → Tweed/New Haven CLE–HVN | 13 | 1,446 | 60% | 466 | TEM Enterprises dba Avelo Airlines | Jun 2026 – Jul 2026 |
| Cleveland-Hopkins International → Concord CLE–USA | 13 | 1,445 | 60% | 420 | TEM Enterprises dba Avelo Airlines | Jun 2026 – Jul 2026 |
| Cleveland-Hopkins International → Atlantic City International CLE–ACY | 12 | 1,543 | 69% | 406 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Cleveland-Hopkins International → John Glenn Columbus International CLE–CMH | 11 | 702 | 49% | 112 | Republic Airline, American Airlines Inc., Sun Country Airlines d/b/a..., Delta Air Lines Inc. +3 | Jan 2025 – Jun 2026 |
| Cleveland-Hopkins International → Gulfport-Biloxi International CLE–GPT | 11 | 1,316 | 64% | 859 | Sun Country Airlines d/b/a... | Feb 2025 – Jun 2026 |
| Cleveland-Hopkins International → Louis Armstrong New Orleans International CLE–MSY | 11 | 1,001 | 55% | 917 | Frontier Airlines Inc., Sun Country Airlines d/b/a..., Delta Air Lines Inc., American Airlines Inc. | Sep 2025 – Jul 2026 |
| Cleveland-Hopkins International → Gerald R Ford International CLE–GRR | 5 | 365 | 62% | 214 | American Airlines Inc., SkyWest Airlines Inc., United Air Lines Inc. | Mar 2025 – Jul 2026 |
| Cleveland-Hopkins International → Laughlin/Bullhead International CLE–IFP | 5 | 891 | 96% | 1,818 | Sun Country Airlines d/b/a... | Mar 2025 – Jul 2026 |
| Cleveland-Hopkins International → Oakland County International CLE–PTK | 5 | 137 | 38% | 118 | Gulf And Caribbean Cargo, United Air Lines Inc. | Apr 2025 – Jun 2026 |
| Cleveland-Hopkins International → San Antonio International CLE–SAT | 5 | 243 | 53% | 1,240 | Delta Air Lines Inc., American Airlines Inc. | Mar 2025 – Mar 2026 |
| Cleveland-Hopkins International → Buffalo Niagara International CLE–BUF | 4 | 216 | 39% | 192 | Delta Air Lines Inc., Sun Country Airlines d/b/a..., Republic Airline | Mar 2025 – May 2026 |
| Cleveland-Hopkins International → Cincinnati/Northern Kentucky International CLE–CVG | 4 | 304 | 46% | 221 | Southwest Airlines Co., Delta Air Lines Inc., United Air Lines Inc. | Feb 2025 – Jul 2026 |
| Cleveland-Hopkins International → James M Cox Dayton International CLE–DAY | 4 | 84 | 17% | 162 | Sun Country Airlines d/b/a..., CommuteAir LLC dba CommuteAir, Envoy Air | Mar 2025 – Jun 2026 |
| Cleveland-Hopkins International → Laredo International CLE–LRD | 4 | 0 | | 1,382 | USA Jet Airlines Inc., Ameristar Air Cargo | Dec 2025 – Jul 2026 |
| Cleveland-Hopkins International → Kansas City International CLE–MCI | 4 | 330 | 63% | 694 | American Airlines Inc., USA Jet Airlines Inc., United Air Lines Inc., Southwest Airlines Co. | Jun 2025 – Jul 2026 |
| Cleveland-Hopkins International → Nice CLE–NCE international | 4 | 27 | 48% | 4,313 | VistaJet Limited | Oct 2025 – Apr 2026 |
| Cleveland-Hopkins International → Okc Will Rogers International CLE–OKC | 4 | 486 | 83% | 948 | American Airlines Inc., Delta Air Lines Inc. | Aug 2025 – Jun 2026 |
| Cleveland-Hopkins International → Tulsa International CLE–TUL | 4 | 566 | 85% | 837 | American Airlines Inc. | Mar 2025 – Jun 2026 |
| Cleveland-Hopkins International → Birmingham-Shuttlesworth International CLE–BHM | 3 | 134 | 37% | 604 | Chartright Air Inc., Delta Air Lines Inc., Sun Country Airlines d/b/a... | Jan 2026 – Jul 2026 |
| Cleveland-Hopkins International → Akron-Canton Regional CLE–CAK | 3 | 0 | 0% | 40 | Sun Country Airlines d/b/a..., SkyWest Airlines Inc. | Feb 2025 – Apr 2026 |
| Cleveland-Hopkins International → Lovell Field CLE–CHA | 3 | 339 | 65% | 476 | Delta Air Lines Inc., Sun Country Airlines d/b/a... | Dec 2025 – Jul 2026 |
| Cleveland-Hopkins International → Charleston Afb/Intl CLE–CHS | 3 | 433 | 76% | 595 | American Airlines Inc., Delta Air Lines Inc., Spirit Air Lines | Aug 2025 – Aug 2025 |
| Cleveland-Hopkins International → Green Bay/Austin Straubel International CLE–GRB | 3 | 167 | 52% | 382 | Delta Air Lines Inc. | Sep 2025 – Jan 2026 |
| Cleveland-Hopkins International → Blue Grass CLE–LEX | 3 | 2 | 1% | 275 | SkyWest Airlines Inc., Chartright Air Inc. | Nov 2025 – Dec 2025 |
| Cleveland-Hopkins International → Lehigh Valley International CLE–ABE | 2 | 44 | 19% | 339 | GoJet Airlines LLC d/b/a..., Sun Country Airlines d/b/a... | Jun 2025 – Jun 2026 |
| Cleveland-Hopkins International → Albuquerque International Sunport CLE–ABQ | 2 | 344 | 98% | 1,411 | Southwest Airlines Co. | Mar 2025 – Apr 2026 |
| Cleveland-Hopkins International → Perot Fld/Fort Worth Alliance CLE–AFW | 2 | 0 | | 1,029 | USA Jet Airlines Inc. | Jun 2026 – Jul 2026 |
| Cleveland-Hopkins International → Boeing Fld/King County International CLE–BFI | 2 | 120 | 44% | 2,020 | JetBlue Airways, Delta Air Lines Inc. | Oct 2025 – Jan 2026 |
| Cleveland-Hopkins International → Fort Wayne International CLE–FWA | 2 | 44 | 19% | 177 | Piedmont Airlines, Sun Country Airlines d/b/a... | Oct 2025 – Apr 2026 |
| Cleveland-Hopkins International → William P Hobby CLE–HOU | 2 | 1 | 1% | 1,106 | Chartright Air Inc., Delta Air Lines Inc. | Jan 2025 – Mar 2026 |
| Cleveland-Hopkins International → Capital Region International CLE–LAN | 2 | 0 | 0% | 169 | United Parcel Service, CommuteAir LLC dba CommuteAir | Feb 2025 – Jan 2026 |
| Cleveland-Hopkins International → MC Ghee Tyson CLE–TYS | 2 | 135 | 75% | 403 | Chartright Air Inc., Delta Air Lines Inc. | Aug 2025 – May 2026 |
| Cleveland-Hopkins International → Hamilton CLE–YHM international | 2 | 3 | 25% | 157 | Hamilton Jetport Limited | Feb 2026 – Jul 2026 |
| Cleveland-Hopkins International → Nantucket Memorial CLE–ACK | 1 | 1 | 12% | 613 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Cleveland-Hopkins International → Addison CLE–ADS | 1 | 2 | 22% | 1,009 | Jet Aviation Flight Services, Inc. | Sep 2025 – Sep 2025 |
| Cleveland-Hopkins International → Augusta Regional AT Bush Field CLE–AGS | 1 | 122 | 68% | 555 | Delta Air Lines Inc. | Nov 2025 – Nov 2025 |
| Cleveland-Hopkins International → Rick Husband Amarillo International CLE–AMA | 1 | 159 | 92% | 1,156 | American Airlines Inc. | Apr 2025 – Aug 2025 |
| Cleveland-Hopkins International → Kalamazoo/Battle Creek International CLE–AZO | 1 | 0 | 0% | 199 | SkyWest Airlines Inc. | Jun 2026 – Jun 2026 |
| Cleveland-Hopkins International → Bradley International CLE–BDL | 1 | 0 | | 476 | United Parcel Service | Dec 2025 – Dec 2025 |
| Cleveland-Hopkins International → Laurence G Hanscom Field CLE–BED | 1 | 60 | 83% | 549 | Delta Air Lines Inc. | Feb 2025 – Nov 2025 |
| Cleveland-Hopkins International → Bangor International CLE–BGR | 1 | 5 | 62% | 698 | Gainjet Aviation SA | Dec 2025 – Dec 2025 |
| Cleveland-Hopkins International → Burke Lakefront CLE–BKL | 1 | 0 | 0% | 12 | Delta Air Lines Inc. | Apr 2026 – Apr 2026 |
| Cleveland-Hopkins International → Columbia Metro CLE–CAE | 1 | 180 | 100% | 517 | Delta Air Lines Inc. | Feb 2025 – Jul 2026 |
| Cleveland-Hopkins International → Outlaw Field CLE–CKV | 1 | 4 | 50% | 446 | Chartright Air Inc. | Jan 2026 – Jan 2026 |
| Cleveland-Hopkins International → Central Wisconsin CLE–CWA | 1 | 34 | 45% | 459 | Endeavor Air Inc. | Mar 2026 – Mar 2026 |
| Cleveland-Hopkins International → Dallas Love Field CLE–DAL | 1 | 140 | 98% | 1,015 | Southwest Airlines Co. | Dec 2025 – Dec 2025 |
| Cleveland-Hopkins International → Delhi CLE–DEL international | 1 | 3 | 21% | 7,432 | VistaJet Limited | Jun 2026 – Jun 2026 |
| Cleveland-Hopkins International → Duluth International CLE–DLH | 1 | 79 | 42% | 635 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |
| Cleveland-Hopkins International → Mahlon Sweet Field CLE–EUG | 1 | 165 | 87% | 2,090 | TEM Enterprises dba Avelo Airlines | Oct 2025 – Oct 2025 |
| Cleveland-Hopkins International → Key West International CLE–EYW | 1 | 87 | 48% | 1,161 | Allegiant Air | Jan 2026 – Jan 2026 |
| Cleveland-Hopkins International → Hector International CLE–FAR | 1 | 103 | 94% | 833 | Delta Air Lines Inc. | Jun 2026 – Jun 2026 |
| Cleveland-Hopkins International → Bishop International CLE–FNT | 1 | 0 | 0% | 145 | SkyWest Airlines Inc. | Dec 2025 – Dec 2025 |
| Cleveland-Hopkins International → Joe Foss Field CLE–FSD | 1 | 0 | 0% | 774 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Cleveland-Hopkins International → Spokane International CLE–GEG | 1 | 71 | 41% | 1,797 | Southwest Airlines Co. | Jun 2026 – Jun 2026 |
| Cleveland-Hopkins International → Piedmont Triad International CLE–GSO | 1 | 64 | 84% | 380 | PSA Airlines Inc. | Jun 2025 – Jan 2026 |
| Cleveland-Hopkins International → Greenville Spartanburg International CLE–GSP | 1 | 124 | 72% | 450 | American Airlines Inc. | Mar 2026 – Mar 2026 |
| Cleveland-Hopkins International → Westchester County CLE–HPN | 1 | 70 | 97% | 425 | Delta Air Lines Inc. | May 2025 – May 2026 |
| Cleveland-Hopkins International → Valley International CLE–HRL | 1 | 0 | 0% | 1,381 | Global Crossing Airlines, Inc. | May 2026 – May 2026 |
| Cleveland-Hopkins International → Wichita Dwight D Eisenhower Ntl CLE–ICT | 1 | 126 | 66% | 870 | American Airlines Inc. | May 2026 – May 2026 |
| Cleveland-Hopkins International → Jacksonville International CLE–JAX | 1 | 114 | 89% | 753 | American Airlines Inc. | Sep 2025 – Sep 2025 |
| Cleveland-Hopkins International → Klagenfurt CLE–KLU international | 1 | 0 | 0% | 4,491 | Glock Aviation GmbH | Feb 2026 – Feb 2026 |
| Cleveland-Hopkins International → Paris CLE–LBG international | 1 | 1 | 7% | 3,934 | Albinati aviation Limited | May 2026 – May 2026 |
| Cleveland-Hopkins International → Long Beach (Daugherty Field) CLE–LGB | 1 | 66 | 28% | 2,043 | United Air Lines Inc. | May 2026 – May 2026 |
| Cleveland-Hopkins International → Bill And Hillary Clinton Ntl/Adams Field CLE–LIT | 1 | 125 | 73% | 729 | American Airlines Inc. | Jul 2025 – Aug 2025 |
| Cleveland-Hopkins International → Midland International Air And Space Port CLE–MAF | 1 | 165 | 94% | 1,300 | Southwest Airlines Co. | Jun 2026 – Jun 2026 |
| Cleveland-Hopkins International → Montgomery Regional (Dannelly Field) CLE–MGM | 1 | 128 | 97% | 676 | Delta Air Lines Inc. | Jul 2026 – Jul 2026 |
| Cleveland-Hopkins International → Smyrna CLE–MQY | 1 | 0 | | 450 | USA Jet Airlines Inc. | Dec 2025 – Dec 2025 |
| Cleveland-Hopkins International → Dane County Rgnl/Truax Field CLE–MSN | 1 | 151 | 91% | 402 | United Air Lines Inc. | Apr 2026 – Apr 2026 |
| Cleveland-Hopkins International → Norfolk International CLE–ORF | 1 | 0 | 0% | 435 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Cleveland-Hopkins International → St. Pete-Clearwater International CLE–PIE | 1 | 73 | 41% | 932 | United Air Lines Inc. | Jul 2026 – Jul 2026 |
| Cleveland-Hopkins International → Rhode Island TF Green International CLE–PVD | 1 | 166 | 71% | 540 | United Air Lines Inc. | Feb 2025 – Oct 2025 |
| Cleveland-Hopkins International → Chicago Executive CLE–PWK | 1 | 2 | 33% | 316 | Scott Aviation, LLC d/b/a... | Mar 2026 – Mar 2026 |
| Cleveland-Hopkins International → Portland International Jetport CLE–PWM | 1 | 22 | 16% | 609 | Southwest Airlines Co. | Jun 2025 – Mar 2026 |
| Cleveland-Hopkins International → Richmond International CLE–RIC | 1 | 0 | 0% | 362 | Republic Airline | Jul 2025 – Sep 2025 |
| Cleveland-Hopkins International → Reno/Tahoe International CLE–RNO | 1 | 111 | 71% | 1,987 | Allegiant Air | Jul 2026 – Jul 2026 |
| Cleveland-Hopkins International → Frederick Douglass/Greater Rochester International CLE–ROC | 1 | 65 | 86% | 245 | Republic Airline | Apr 2025 – Feb 2026 |
| Cleveland-Hopkins International → Rochester International CLE–RST | 1 | 0 | 0% | 569 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Cleveland-Hopkins International → Savannah/Hilton Head International CLE–SAV | 1 | 24 | 18% | 641 | Southwest Airlines Co. | Apr 2025 – Mar 2026 |
| Cleveland-Hopkins International → State College CLE–SCE | 1 | 0 | 0% | 213 | SkyWest Airlines Inc. | Apr 2026 – Apr 2026 |
| Cleveland-Hopkins International → Brown Field Municipal CLE–SDM | 1 | 0 | | 2,021 | USA Jet Airlines Inc. | Aug 2025 – Aug 2025 |
| Cleveland-Hopkins International → Springfield-Branson Ntl CLE–SGF | 1 | 0 | 0% | 681 | Sun Country Airlines d/b/a... | Oct 2025 – Oct 2025 |
| Cleveland-Hopkins International → Mineta San Jose International CLE–SJC | 1 | 194 | 55% | 2,144 | United Air Lines Inc. | Nov 2025 – Nov 2025 |
| Cleveland-Hopkins International → Saltillo CLE–SLW international | 1 | 0 | | 1,546 | USA Jet Airlines Inc. | Mar 2026 – Mar 2026 |
| Cleveland-Hopkins International → Sacramento International CLE–SMF | 1 | 71 | 40% | 2,097 | United Air Lines Inc. | Apr 2026 – Apr 2026 |
| Cleveland-Hopkins International → John Wayne/Orange County CLE–SNA | 1 | 157 | 95% | 2,032 | United Air Lines Inc. | Apr 2026 – Apr 2026 |
| Cleveland-Hopkins International → London CLE–STN international | 1 | 186 | 67% | 3,759 | United Air Lines Inc. | Oct 2025 – Oct 2025 |
| Cleveland-Hopkins International → Witham Field CLE–SUA | 1 | 7 | 54% | 985 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Cleveland-Hopkins International → Syracuse Hancock International CLE–SYR | 1 | 74 | 97% | 317 | Republic Airline | Sep 2025 – Sep 2025 |
| Cleveland-Hopkins International → Teterboro CLE–TEB | 1 | 0 | 0% | 408 | Chartright Air Inc. | Dec 2025 – Dec 2025 |
| Cleveland-Hopkins International → Tel Aviv CLE–TLV international | 1 | 10 | 71% | 5,976 | VistaJet Limited | Oct 2025 – Oct 2025 |
| Cleveland-Hopkins International → Tupelo Regional CLE–TUP | 1 | 0 | | 621 | Gulf And Caribbean Cargo | Jun 2026 – Jun 2026 |
| Cleveland-Hopkins International → Thunder Bay CLE–YQT international | 1 | 1 | 12% | 604 | Chartright Air Inc. | Jan 2026 – Jan 2026 |
| Cleveland-Hopkins International → Zagreb CLE–ZAG international | 1 | 5 | 38% | 4,595 | Jet Story | Mar 2026 – Mar 2026 |