| Havana → Miami International HAV–MIA international | 106 | 0 | | 367,252 | 235 |
| Miami International → Havana MIA–HAV international | 106 | 0 | | 3,582,446 | 235 |
| Cincinnati/Northern Kentucky International → The Eastern Iowa CVG–CID | 85 | 0 | | 2,347,181 | 419 |
| Cincinnati/Northern Kentucky International → Frederick Douglass/Greater Rochester International CVG–ROC | 85 | 0 | | 1,379,481 | 461 |
| Cincinnati/Northern Kentucky International → St. Louis Lambert International CVG–STL | 85 | 0 | | 1,933,821 | 308 |
| Cincinnati/Northern Kentucky International → Tulsa International CVG–TUL | 85 | 0 | | 2,223,562 | 646 |
| St. Louis Lambert International → Eppley Airfield STL–OMA | 85 | 0 | | 872,694 | 342 |
| The Eastern Iowa → Kansas City International CID–MCI | 84 | 0 | | 1,206,227 | 238 |
| Frederick Douglass/Greater Rochester International → Cincinnati/Northern Kentucky International ROC–CVG | 84 | 0 | | 1,845,360 | 461 |
| The Eastern Iowa → Cincinnati/Northern Kentucky International CID–CVG | 83 | 0 | | 1,744,095 | 419 |
| Cincinnati/Northern Kentucky International → Philadelphia International CVG–PHL | 83 | 0 | | 2,309,527 | 507 |
| General Mitchell International → Cincinnati/Northern Kentucky International MKE–CVG | 83 | 0 | | 2,185,506 | 318 |
| Eppley Airfield → General Mitchell International OMA–MKE | 83 | 0 | | 421,303 | 426 |
| Kansas City International → The Eastern Iowa MCI–CID | 82 | 0 | | 835,185 | 238 |
| Philadelphia International → Cincinnati/Northern Kentucky International PHL–CVG | 82 | 0 | | 2,130,027 | 507 |
| Cincinnati/Northern Kentucky International → Frederick W Smith Intl/Memphis CVG–MEM | 81 | 0 | | 2,546,740 | 403 |
| Tulsa International → St. Louis Lambert International TUL–STL | 81 | 0 | | 1,459,672 | 351 |
| Frederick W Smith Intl/Memphis → Cincinnati/Northern Kentucky International MEM–CVG | 80 | 0 | | 2,098,596 | 403 |
| St. Louis Lambert International → Cincinnati/Northern Kentucky International STL–CVG | 80 | 0 | | 2,125,488 | 308 |
| Cincinnati/Northern Kentucky International → Austin-Bergstrom International CVG–AUS | 76 | 0 | | 2,123,211 | 958 |
| Austin-Bergstrom International → Cincinnati/Northern Kentucky International AUS–CVG | 75 | 0 | | 1,580,450 | 958 |
| Willow Run → Richmond International YIP–RIC | 57 | 0 | | 0 | 463 |
| Phoenix Sky Harbor International → Los Angeles International PHX–LAX | 45 | 0 | | 1,179,874 | 370 |
| Reno/Tahoe International → Phoenix Sky Harbor International RNO–PHX | 45 | 0 | | 491,454 | 601 |
| Cincinnati/Northern Kentucky International → Louis Armstrong New Orleans International CVG–MSY | 42 | 0 | | 441,930 | 701 |
| Frederick W Smith Intl/Memphis → Louis Armstrong New Orleans International MEM–MSY | 42 | 0 | | 435,764 | 349 |
| Hamilton → Newark Liberty International BDA–EWR international | 41 | 0 | | 323,436 | 779 |
| Newark Liberty International → Hamilton EWR–BDA international | 41 | 0 | | 1,079,002 | 779 |
| Louis Armstrong New Orleans International → Frederick W Smith Intl/Memphis MSY–MEM | 41 | 0 | | 265,323 | 349 |
| Richmond International → Willow Run RIC–YIP | 41 | 0 | | 567,457 | 463 |
| Nashville International → Cincinnati/Northern Kentucky International BNA–CVG | 39 | 0 | | 836,018 | 230 |
| Louis Armstrong New Orleans International → Nashville International MSY–BNA | 38 | 0 | | 252,710 | 471 |
| Los Angeles International → Phoenix Sky Harbor International LAX–PHX | 36 | 0 | | 1,180,010 | 370 |
| Phoenix Sky Harbor International → Reno/Tahoe International PHX–RNO | 35 | 0 | | 439,008 | 601 |
| Cincinnati/Northern Kentucky International → Minneapolis-St Paul Intl/Wold-Chamberlain CVG–MSP | 32 | 0 | | 914,417 | 596 |
| Minneapolis-St Paul Intl/Wold-Chamberlain → Cincinnati/Northern Kentucky International MSP–CVG | 32 | 0 | | 969,647 | 596 |
| Camaguey → Miami International CMW–MIA international | 22 | 0 | | 83,320 | 339 |
| Miami International → Camaguey MIA–CMW international | 22 | 0 | | 761,070 | 339 |
| Laredo International → Willow Run LRD–YIP | 14 | 0 | | 137,991 | 1,354 |
| Richmond International → Gerald R Ford International RIC–GRR | 14 | 0 | | 139,494 | 570 |
| Cienfuegos → Miami International CFG–MIA international | 12 | 0 | | 41,060 | 251 |
| Gerald R Ford International → Willow Run GRR–YIP | 12 | 0 | | 0 | 111 |
| Miami International → Cienfuegos MIA–CFG international | 12 | 0 | | 404,364 | 251 |
| Richmond International → Laredo International RIC–LRD | 12 | 0 | | 172,984 | 1,458 |
| Los Angeles International → Reno/Tahoe International LAX–RNO | 10 | 0 | | 257,474 | 390 |
| Miami International → Varadero MIA–VRA international | 10 | 0 | | 339,006 | 203 |
| Varadero → Miami International VRA–MIA international | 10 | 0 | | 32,620 | 203 |
| Cincinnati/Northern Kentucky International → Baltimore/Washington International Thurgood Marshall CVG–BWI | 9 | 0 | | 284,210 | 430 |
| Baltimore/Washington International Thurgood Marshall → Cincinnati/Northern Kentucky International BWI–CVG | 8 | 0 | | 163,252 | 430 |
| Willow Run → Laredo International YIP–LRD | 8 | 0 | | 89,548 | 1,354 |
| Laredo International → Richmond International LRD–RIC | 7 | 0 | | 0 | 1,458 |
| Oscoda/Wurtsmith → Cincinnati/Northern Kentucky International OSC–CVG | 6 | 0 | | 3,965 | 379 |
| Leon/Guanajuato → Laredo International BJX–LRD international | 5 | 0 | | 0 | 468 |
| Chicago/Rockford International → Laredo International RFD–LRD | 5 | 0 | | 122,425 | 1,167 |
| Miami International → Santiago MIA–SCU international | 4 | 0 | | 89,034 | 491 |
| Willow Run → Chicago/Rockford International YIP–RFD | 4 | 0 | | 0 | 286 |
| Cincinnati/Northern Kentucky International → Dothan Regional CVG–DHN | 3 | 0 | | 3,325 | 535 |
| Laredo International → Greenville Spartanburg International LRD–GSP | 3 | 0 | | 18,019 | 1,137 |
| Laredo International → Phoenix Sky Harbor International LRD–PHX | 3 | 0 | | 2,685 | 851 |
| Miami International → Santa Clara MIA–SNU international | 3 | 0 | | 98,224 | 228 |
| Louis Armstrong New Orleans International → Cincinnati/Northern Kentucky International MSY–CVG | 3 | 0 | | 19,149 | 701 |
| Santiago → Miami International SCU–MIA international | 3 | 0 | | 7,790 | 491 |
| Santa Clara → Miami International SNU–MIA international | 3 | 0 | | 12,290 | 228 |
| Tulsa International → Cincinnati/Northern Kentucky International TUL–CVG | 3 | 0 | | 21,285 | 646 |
| Willow Run → Leon/Guanajuato YIP–BJX international | 3 | 0 | | 52,145 | 1,799 |
| Cincinnati/Northern Kentucky International → Oscoda/Wurtsmith CVG–OSC | 2 | 0 | | 0 | 379 |
| Dothan Regional → Cincinnati/Northern Kentucky International DHN–CVG | 2 | 0 | | 0 | 535 |
| Del Rio International → Willow Run DRT–YIP | 2 | 0 | | 6,183 | 1,315 |
| Rickenbacker International → Willow Run LCK–YIP | 2 | 0 | | 0 | 171 |
| Laredo International → Leon/Guanajuato LRD–BJX international | 2 | 0 | | 56,939 | 468 |
| Laredo International → Del Rio International LRD–DRT | 2 | 0 | | 0 | 154 |
| Laredo International → Rickenbacker International LRD–LCK | 2 | 0 | | 16,178 | 1,270 |
| Miami International → Miami International MIA–MIA | 2 | 0 | | 34,304 | 0 |
| Eppley Airfield → Cincinnati/Northern Kentucky International OMA–CVG | 2 | 0 | | 3,124 | 614 |
| Tucson International → Charleston Afb/Intl TUS–CHS | 2 | 0 | | 4,972 | 1,799 |
| Willow Run → Cincinnati/Northern Kentucky International YIP–CVG | 2 | 0 | | 0 | 229 |
| Willow Run → Del Rio International YIP–DRT | 2 | 0 | | 0 | 1,315 |
| Willow Run → Kansas City International YIP–MCI | 2 | 0 | | 18,500 | 621 |
| Perot Fld/Fort Worth Alliance → Laredo International AFW–LRD | 1 | 0 | | 0 | 396 |
| Austin-Bergstrom International → Dothan Regional AUS–DHN | 1 | 0 | | 3,458 | 731 |
| Central IL Rgnl/Bloomington-Normal → Florence Regional BMI–FLO | 1 | 0 | | 0 | 666 |
| Brownsville/South Padre Island International → Willow Run BRO–YIP | 1 | 0 | | 20,100 | 1,376 |
| Lovell Field → Laredo International CHA–LRD | 1 | 0 | | 0 | 987 |
| Charleston Afb/Intl → Dothan Regional CHS–DHN | 1 | 0 | | 0 | 335 |
| Charleston Afb/Intl → Willow Run CHS–YIP | 1 | 0 | | 0 | 672 |
| Cleveland-Hopkins International → Willow Run CLE–YIP | 1 | 0 | | 0 | 104 |
| Chino → Tucson International CNO–TUS | 1 | 0 | | 0 | 408 |
| Chihuahua → Laredo International CUU–LRD international | 1 | 0 | | 0 | 405 |
| Cincinnati/Northern Kentucky International → Cincinnati/Northern Kentucky International CVG–CVG | 1 | 0 | | 20,135 | 0 |
| Cincinnati/Northern Kentucky International → Valley International CVG–HRL | 1 | 0 | | 47,670 | 1,161 |
| Cincinnati/Northern Kentucky International → Los Angeles International CVG–LAX | 1 | 0 | | 4,300 | 1,900 |
| Cincinnati/Northern Kentucky International → Kansas City International CVG–MCI | 1 | 0 | | 27,128 | 539 |
| Cincinnati/Northern Kentucky International → Miami International CVG–MIA | 1 | 0 | | 1,337 | 948 |
| Cincinnati/Northern Kentucky International → Richmond International CVG–RIC | 1 | 0 | | 0 | 413 |
| Dothan Regional → Dothan Regional DHN–DHN | 1 | 0 | | 0 | 0 |
| Dothan Regional → Miami International DHN–MIA | 1 | 0 | | 0 | 493 |
| Dothan Regional → Willow Run DHN–YIP | 1 | 0 | | 0 | 761 |
| Del Rio International → Perot Fld/Fort Worth Alliance DRT–AFW | 1 | 0 | | 28,000 | 328 |
| Del Rio International → New River Valley DRT–PSK | 1 | 0 | | 7,778 | 1,285 |
| Chippewa Valley Regional → Chino EAU–CNO | 1 | 0 | | 12,000 | 1,578 |
| EL Paso International → Richmond International ELP–RIC | 1 | 0 | | 0 | 1,693 |
| EL Paso International → Tulsa International ELP–TUL | 1 | 0 | | 22,600 | 673 |
| Fort Lauderdale/Hollywood International → Miami International FLL–MIA | 1 | 0 | | 3,800 | 21 |
| Fort Lauderdale/Hollywood International → Willow Run FLL–YIP | 1 | 0 | | 0 | 1,131 |
| Florence Regional → Florence Regional FLO–FLO | 1 | 0 | | 6,000 | 0 |
| Florence Regional → Laredo International FLO–LRD | 1 | 0 | | 6,875 | 1,256 |
| Florence Regional → Willow Run FLO–YIP | 1 | 0 | | 0 | 593 |
| Gerald R Ford International → Phoenix Sky Harbor International GRR–PHX | 1 | 0 | | 7,200 | 1,574 |
| Gerald R Ford International → Richmond International GRR–RIC | 1 | 0 | | 9,900 | 570 |
| Greenville Spartanburg International → Del Rio International GSP–DRT | 1 | 0 | | 0 | 1,159 |
| Greenville Spartanburg International → Jacksonville International GSP–JAX | 1 | 0 | | 0 | 305 |
| Greenville Spartanburg International → Laredo International GSP–LRD | 1 | 0 | | 0 | 1,137 |
| Valley International → Cincinnati/Northern Kentucky International HRL–CVG | 1 | 0 | | 20,013 | 1,161 |
| Jacksonville International → Florence Regional JAX–FLO | 1 | 0 | | 0 | 279 |
| Jacksonville International → Seattle Paine Field International JAX–PAE | 1 | 0 | | 860 | 2,449 |
| Los Angeles International → Los Angeles International LAX–LAX | 1 | 0 | | 33,071 | 0 |
| Laredo International → Central IL Rgnl/Bloomington-Normal LRD–BMI | 1 | 0 | | 12,591 | 1,076 |
| Laredo International → Lovell Field LRD–CHA | 1 | 0 | | 11,346 | 987 |
| Laredo International → Chihuahua LRD–CUU international | 1 | 0 | | 29,428 | 405 |
| Laredo International → Laredo International LRD–LRD | 1 | 0 | | 1,590 | 0 |
| Laredo International → Chicago/Rockford International LRD–RFD | 1 | 0 | | 0 | 1,167 |
| Laredo International → San Luis Potosi LRD–SLP international | 1 | 0 | | 0 | 376 |
| Laredo International → Tucson International LRD–TUS | 1 | 0 | | 0 | 758 |
| Laredo International → Windsor LRD–YQG international | 1 | 0 | | 13,522 | 1,376 |
| Kansas City International → Cincinnati/Northern Kentucky International MCI–CVG | 1 | 0 | | 7,212 | 539 |
| Kansas City International → Miami International MCI–MIA | 1 | 0 | | 0 | 1,251 |
| Kansas City International → Tulsa International MCI–TUL | 1 | 0 | | 27,097 | 223 |
| Kansas City International → Willow Run MCI–YIP | 1 | 0 | | 10,572 | 621 |
| Frederick W Smith Intl/Memphis → Willow Run MEM–YIP | 1 | 0 | | 7,600 | 607 |
| Louis Armstrong New Orleans International → Oscoda/Wurtsmith MSY–OSC | 1 | 0 | | 0 | 1,066 |
| Oscoda/Wurtsmith → Oscoda/Wurtsmith OSC–OSC | 1 | 0 | | 0 | 0 |
| Oscoda/Wurtsmith → Willow Run OSC–YIP | 1 | 0 | | 0 | 153 |
| Seattle Paine Field International → Laredo International PAE–LRD | 1 | 0 | | 0 | 1,866 |
| Phoenix Sky Harbor International → EL Paso International PHX–ELP | 1 | 0 | | 0 | 347 |
| Phoenix Sky Harbor International → Fort Lauderdale/Hollywood International PHX–FLL | 1 | 0 | | 1,862 | 1,972 |
| Phoenix Sky Harbor International → Laredo International PHX–LRD | 1 | 0 | | 0 | 851 |
| Phoenix Sky Harbor International → Yakima Air Trml/Mcallister Field PHX–YKM | 1 | 0 | | 1,400 | 1,012 |
| New River Valley → Willow Run PSK–YIP | 1 | 0 | | 0 | 383 |
| Richmond International → Eugene F Kranz Toledo Express RIC–TOL | 1 | 0 | | 20,400 | 445 |
| Reno/Tahoe International → Cincinnati/Northern Kentucky International RNO–CVG | 1 | 0 | | 3,375 | 1,870 |
| Santiago → Fort Lauderdale/Hollywood International SCU–FLL international | 1 | 0 | | 24,600 | 502 |
| Louisville Muhammad Ali International → Cincinnati/Northern Kentucky International SDF–CVG | 1 | 0 | | 28,879 | 84 |
| Louisville Muhammad Ali International → Laredo International SDF–LRD | 1 | 0 | | 14,400 | 1,081 |
| San Luis Potosi → Laredo International SLP–LRD international | 1 | 0 | | 11,936 | 376 |
| St. Louis Lambert International → Louisville Muhammad Ali International STL–SDF | 1 | 0 | | 28,879 | 254 |
| Eugene F Kranz Toledo Express → Richmond International TOL–RIC | 1 | 0 | | 0 | 445 |
| Tulsa International → Cleveland-Hopkins International TUL–CLE | 1 | 0 | | 22,600 | 837 |
| Tulsa International → Reno/Tahoe International TUL–RNO | 1 | 0 | | 3,388 | 1,322 |
| Willow Run → Brownsville/South Padre Island International YIP–BRO | 1 | 0 | | 0 | 1,376 |
| Willow Run → EL Paso International YIP–ELP | 1 | 0 | | 0 | 1,447 |
| Willow Run → Frederick W Smith Intl/Memphis YIP–MEM | 1 | 0 | | 7,630 | 607 |
| Willow Run → Oscoda/Wurtsmith YIP–OSC | 1 | 0 | | 0 | 153 |
| Willow Run → Louisville Muhammad Ali International YIP–SDF | 1 | 0 | | 2,500 | 304 |
| Willow Run → Willow Run YIP–YIP | 1 | 0 | | 0 | 0 |
| Yakima Air Trml/Mcallister Field → Laredo International YKM–LRD | 1 | 0 | | 0 | 1,743 |
| Windsor → Willow Run YQG–YIP international | 1 | 0 | | 0 | 28 |