| Jacksonville International → Hartsfield/Jackson Atlanta International JAX–ATL | 4,016 | 647,552 | 84% | 269 | Delta Air Lines Inc., Frontier Airlines Inc., United Parcel Service, Air Wisconsin Airlines Corp +4 | Jan 2025 – Jul 2026 |
| Jacksonville International → Chicago O'Hare International JAX–ORD | 2,074 | 193,445 | 76% | 864 | United Air Lines Inc., American Airlines Inc., Republic Airline, Envoy Air +3 | Jan 2025 – Jul 2026 |
| Jacksonville International → John F Kennedy International JAX–JFK | 1,993 | 181,221 | 83% | 829 | Endeavor Air Inc., JetBlue Airways, Delta Air Lines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Jacksonville International → Charlotte/Douglas International JAX–CLT | 1,920 | 259,852 | 76% | 328 | American Airlines Inc., PSA Airlines Inc., United Parcel Service, CFM Inc d/b/a Contour... +1 | Jan 2025 – Jul 2026 |
| Jacksonville International → Dallas-Fort Worth International JAX–DFW | 1,776 | 254,017 | 82% | 917 | American Airlines Inc., Frontier Airlines Inc., United Parcel Service, SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Philadelphia International JAX–PHL | 1,697 | 146,563 | 73% | 742 | American Airlines Inc., PSA Airlines Inc., Frontier Airlines Inc., United Parcel Service +4 | Jan 2025 – Jul 2026 |
| Jacksonville International → General Edward Lawrence Logan International JAX–BOS | 1,585 | 140,290 | 84% | 1,011 | Republic Airline, JetBlue Airways, Delta Air Lines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Jacksonville International → Miami International JAX–MIA | 1,498 | 127,221 | 76% | 335 | American Airlines Inc., Envoy Air, Republic Airline, United Parcel Service +4 | Jan 2025 – Jul 2026 |
| Jacksonville International → Ronald Reagan Washington Ntl JAX–DCA | 1,435 | 123,796 | 78% | 634 | American Airlines Inc., PSA Airlines Inc., Republic Airline, CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| Jacksonville International → Baltimore/Washington International Thurgood Marshall JAX–BWI | 1,366 | 154,555 | 70% | 663 | Southwest Airlines Co., Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Newark Liberty International JAX–EWR | 1,336 | 166,703 | 83% | 820 | United Air Lines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Jacksonville International → Laguardia JAX–LGA | 1,331 | 86,919 | 84% | 834 | Endeavor Air Inc., Republic Airline, Delta Air Lines Inc., JetBlue Airways | Jan 2025 – Jul 2026 |
| Jacksonville International → George Bush Intcntl/Houston JAX–IAH | 1,291 | 117,641 | 76% | 816 | United Air Lines Inc., Mesa Airlines Inc., SkyWest Airlines Inc., American Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| Jacksonville International → Nashville International JAX–BNA | 1,107 | 132,833 | 72% | 483 | Southwest Airlines Co., Allegiant Air, United Parcel Service, Atlas Air Inc. +3 | Jan 2025 – Jul 2026 |
| Jacksonville International → Denver International JAX–DEN | 1,018 | 141,574 | 83% | 1,446 | United Air Lines Inc., Southwest Airlines Co., Atlas Air Inc., Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Washington Dulles International JAX–IAD | 950 | 104,016 | 79% | 631 | United Air Lines Inc., Mesa Airlines Inc., Republic Airline, Allegiant Air +2 | Jan 2025 – Jul 2026 |
| Jacksonville International → Austin-Bergstrom International JAX–AUS | 646 | 60,430 | 80% | 953 | SkyWest Airlines Inc., Southwest Airlines Co., American Airlines Inc. | Mar 2025 – Jul 2026 |
| Jacksonville International → Detroit Metro Wayne County JAX–DTW | 626 | 74,285 | 79% | 813 | Delta Air Lines Inc., SkyWest Airlines Inc., Air Wisconsin Airlines Corp | Jan 2025 – Jul 2026 |
| Jacksonville International → Louisville Muhammad Ali International JAX–SDF | 557 | 68 | 80% | 577 | United Parcel Service, CFM Inc d/b/a Contour..., Envoy Air | Jan 2025 – Jul 2026 |
| Jacksonville International → Luis Munoz Marin International JAX–SJU | 508 | 36,272 | 76% | 1,288 | United Parcel Service, Frontier Airlines Inc., JetBlue Airways | Jan 2025 – Jul 2026 |
| Jacksonville International → St. Louis Lambert International JAX–STL | 505 | 55,715 | 69% | 753 | Southwest Airlines Co., National Air Cargo Group..., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Chicago Midway International JAX–MDW | 410 | 49,742 | 75% | 848 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Jacksonville International → Minneapolis-St Paul Intl/Wold-Chamberlain JAX–MSP | 391 | 51,118 | 84% | 1,173 | Delta Air Lines Inc., Sun Country Airlines d/b/a..., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Dallas Love Field JAX–DAL | 345 | 47,694 | 85% | 906 | Southwest Airlines Co., Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Phoenix Sky Harbor International JAX–PHX | 323 | 45,065 | 86% | 1,785 | American Airlines Inc., Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → William P Hobby JAX–HOU | 290 | 29,314 | 65% | 815 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Jacksonville International → Norfolk International JAX–ORF | 288 | 32,904 | 83% | 543 | Breeze Aviation Group DBA Breeze, Allegiant Air, Endeavor Air Inc., United Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Jacksonville International → Indianapolis International JAX–IND | 264 | 13,501 | 83% | 687 | Federal Express Corporation, Allegiant Air, Republic Airline, Atlas Air Inc. +3 | Jan 2025 – Jul 2026 |
| Jacksonville International → Akron-Canton Regional JAX–CAK | 262 | 30,198 | 73% | 719 | Allegiant Air, Breeze Aviation Group DBA Breeze, Eastern Air Express, LLC (EAX) | May 2025 – Jul 2026 |
| Jacksonville International → Frederick W Smith Intl/Memphis JAX–MEM | 241 | 0 | | 574 | Federal Express Corporation, United Parcel Service | Jan 2025 – Jul 2026 |
| Jacksonville International → Tweed/New Haven JAX–HVN | 189 | 19,256 | 68% | 891 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Feb 2025 – Jul 2026 |
| Jacksonville International → Southwest Florida International JAX–RSW | 182 | 421 | 62% | 273 | United Parcel Service, American Airlines Inc., Sun Country Airlines d/b/a..., United Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Jacksonville International → Pittsburgh International JAX–PIT | 175 | 24,150 | 80% | 694 | Allegiant Air, Breeze Aviation Group DBA Breeze, Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Orlando International JAX–MCO | 174 | 20,292 | 85% | 144 | Southwest Airlines Co., JetBlue Airways, American Airlines Inc., United Air Lines Inc. +8 | Jan 2025 – Jul 2026 |
| Jacksonville International → Cincinnati/Northern Kentucky International JAX–CVG | 138 | 19,842 | 83% | 613 | Allegiant Air, ABX Air Inc, Atlas Air Inc., Air Transport International +2 | Jan 2025 – Jul 2026 |
| Jacksonville International → Bradley International JAX–BDL | 130 | 13,951 | 78% | 935 | Breeze Aviation Group DBA Breeze, Endeavor Air Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Raleigh-Durham International JAX–RDU | 122 | 11,475 | 70% | 408 | Breeze Aviation Group DBA Breeze, United Parcel Service, American Airlines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Jacksonville International → Fort Lauderdale/Hollywood International JAX–FLL | 115 | 10,481 | 58% | 319 | JetBlue Airways, Breeze Aviation Group DBA Breeze, Atlas Air Inc., Delta Air Lines Inc. +3 | Jan 2025 – Jul 2026 |
| Jacksonville International → Rhode Island TF Green International JAX–PVD | 115 | 10,937 | 70% | 963 | Breeze Aviation Group DBA Breeze, Republic Airline | Jan 2025 – Jul 2026 |
| Jacksonville International → Harry Reid International JAX–LAS | 108 | 12,757 | 86% | 1,964 | Breeze Aviation Group DBA Breeze, American Airlines Inc., Jet Aviation Flight Services, Inc., Atlas Air Inc. +2 | Jan 2025 – Jul 2026 |
| Jacksonville International → Gerald R Ford International JAX–GRR | 106 | 14,124 | 75% | 880 | Allegiant Air, SkyWest Airlines Inc., United Air Lines Inc. | May 2025 – Jul 2026 |
| Jacksonville International → MC Ghee Tyson JAX–TYS | 105 | 13,074 | 69% | 390 | Allegiant Air | Jan 2025 – Jul 2026 |
| Jacksonville International → Alexandria International JAX–AEX | 100 | 6,342 | 47% | 646 | Eastern Air Express, LLC (EAX), Global Crossing Airlines, Inc., Air Wisconsin Airlines Corp | Jan 2025 – Jul 2026 |
| Jacksonville International → Toronto JAX–YYZ international | 94 | 6,011 | 74% | 916 | Jazz Aviation LP, Air Canada, Chartright Air Inc. | Apr 2025 – Jul 2026 |
| Jacksonville International → John Glenn Columbus International JAX–CMH | 86 | 9,312 | 79% | 658 | Breeze Aviation Group DBA Breeze, United Air Lines Inc., Southwest Airlines Co., Republic Airline | Feb 2025 – Jul 2026 |
| Jacksonville International → Los Angeles International JAX–LAX | 86 | 10,368 | 87% | 2,152 | Breeze Aviation Group DBA Breeze, American Airlines Inc., Global Jet Aruba V.B.A...., National Air Cargo Group... | Jan 2025 – Jul 2026 |
| Jacksonville International → Bishop International JAX–FNT | 83 | 12,792 | 86% | 867 | Allegiant Air | Jan 2025 – Jul 2026 |
| Jacksonville International → Westchester County JAX–HPN | 82 | 7,205 | 64% | 855 | Breeze Aviation Group DBA Breeze | Sep 2025 – May 2026 |
| Jacksonville International → Harrisburg International JAX–MDT | 74 | 10,897 | 82% | 724 | Allegiant Air, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Jacksonville International → Louis Armstrong New Orleans International JAX–MSY | 70 | 6,441 | 66% | 512 | Breeze Aviation Group DBA Breeze, Eastern Air Express, LLC (EAX), Atlas Air Inc., Sun Country Airlines d/b/a... +1 | Jan 2025 – May 2026 |
| Jacksonville International → Richmond International JAX–RIC | 68 | 7,143 | 81% | 545 | Breeze Aviation Group DBA Breeze, Endeavor Air Inc., Tropic Ocean Airways LLC, United Parcel Service +2 | Feb 2025 – Jul 2026 |
| Jacksonville International → Valley International JAX–HRL | 58 | 6,171 | 64% | 1,014 | Global Crossing Airlines, Inc., Eastern Air Express, LLC (EAX) | Feb 2025 – Jul 2026 |
| Jacksonville International → Des Moines International JAX–DSM | 52 | 6,672 | 72% | 1,012 | Allegiant Air, Republic Airline | May 2025 – Jul 2026 |
| Jacksonville International → Scott Afb/Midamerica St. Louis JAX–BLV | 48 | 7,385 | 86% | 723 | Allegiant Air | Mar 2025 – Jul 2026 |
| Jacksonville International → West Palm Beach/Palm Beach JAX–PBI | 47 | 222 | 34% | 280 | United Parcel Service, Jet Aviation Flight Services, Inc., American Airlines Inc., JetBlue Airways +2 | Jan 2025 – Jul 2026 |
| Jacksonville International → EL Paso International JAX–ELP | 42 | 3,872 | 53% | 1,461 | Global Crossing Airlines, Inc., Eastern Air Express, LLC (EAX), Eastern Airlines f/k/a... | Apr 2025 – Jul 2026 |
| Jacksonville International → Tampa International JAX–TPA | 39 | 3,971 | 86% | 181 | American Airlines Inc., United Parcel Service, Delta Air Lines Inc., JetBlue Airways +6 | Jan 2025 – Jul 2026 |
| Jacksonville International → San Diego International JAX–SAN | 34 | 4,101 | 88% | 2,088 | Breeze Aviation Group DBA Breeze | Mar 2025 – Jul 2026 |
| Jacksonville International → Guatemala City JAX–GUA international | 32 | 3,224 | 65% | 1,230 | Global Crossing Airlines, Inc. | Nov 2025 – Jul 2026 |
| Jacksonville International → New Castle JAX–ILG | 23 | 3,012 | 71% | 721 | TEM Enterprises dba Avelo Airlines | May 2025 – Jan 2026 |
| Jacksonville International → San Pedro Sula JAX–SAP international | 22 | 1,582 | 42% | 1,108 | Global Crossing Airlines, Inc. | Nov 2025 – Jul 2026 |
| Jacksonville International → Wichita Dwight D Eisenhower Ntl JAX–ICT | 21 | 0 | | 1,026 | Ameristar Air Cargo, USA Jet Airlines Inc. | Jun 2025 – Jul 2026 |
| Jacksonville International → Gulfport-Biloxi International JAX–GPT | 18 | 2,259 | 67% | 439 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Jacksonville International → Kansas City International JAX–MCI | 14 | 957 | 76% | 954 | USA Jet Airlines Inc., Southwest Airlines Co., American Airlines Inc., Ameristar Air Cargo +3 | Jun 2025 – Apr 2026 |
| Jacksonville International → Charleston Afb/Intl JAX–CHS | 12 | 1,152 | 67% | 192 | Southwest Airlines Co., Delta Air Lines Inc., Endeavor Air Inc., JetBlue Airways +3 | Apr 2025 – Jul 2026 |
| Jacksonville International → Jacksonville International JAX–JAX | 11 | 0 | 0% | 0 | SkyWest Airlines Inc., Atlas Air Inc., Ameristar Air Cargo | Mar 2025 – Jul 2026 |
| Jacksonville International → Tapachula JAX–TAP international | 11 | 1,321 | 81% | 1,275 | Eastern Air Express, LLC (EAX), Global Crossing Airlines, Inc. | Apr 2026 – Jul 2026 |
| Jacksonville International → Tallahassee International JAX–TLH | 10 | 529 | 73% | 158 | Envoy Air, Delta Air Lines Inc., Federal Express Corporation, Piedmont Airlines | Jan 2025 – Apr 2026 |
| Jacksonville International → Villahermosa JAX–VSA international | 10 | 393 | 28% | 1,108 | Global Crossing Airlines, Inc. | May 2026 – Jul 2026 |
| Jacksonville International → Miami-Opa Locka Executive JAX–OPF | 9 | 228 | 35% | 328 | Global Crossing Airlines, Inc., CFM Inc d/b/a Contour..., Jet Aviation Flight Services, Inc. | Sep 2025 – May 2026 |
| Jacksonville International → Smyrna JAX–MQY | 8 | 17 | 12% | 471 | CFM Inc d/b/a Contour... | Feb 2025 – Jun 2026 |
| Jacksonville International → Daytona Beach International JAX–DAB | 7 | 363 | 38% | 99 | Sun Country Airlines d/b/a..., JetBlue Airways, Delta Air Lines Inc., CFM Inc d/b/a Contour... +2 | Feb 2025 – Jul 2026 |
| Jacksonville International → Gainesville Regional JAX–GNV | 7 | 292 | 42% | 65 | Envoy Air, Piedmont Airlines, Sun Country Airlines d/b/a... | Feb 2025 – Jul 2026 |
| Jacksonville International → General Mitchell International JAX–MKE | 6 | 69 | 17% | 924 | Air Wisconsin Airlines Corp, SkyWest Airlines Inc., United Air Lines Inc. | Jun 2025 – Jul 2026 |
| Jacksonville International → Willow Run JAX–YIP | 6 | 0 | | 816 | USA Jet Airlines Inc., Ameristar Air Cargo | Apr 2026 – Jul 2026 |
| Jacksonville International → Columbia Metro JAX–CAE | 5 | 309 | 58% | 240 | United Parcel Service, American Airlines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Jacksonville International → Greenville Spartanburg International JAX–GSP | 5 | 349 | 37% | 305 | National Air Cargo Group..., United Parcel Service, Delta Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jun 2026 |
| Jacksonville International → Pensacola International JAX–PNS | 5 | 0 | | 327 | United Parcel Service | Mar 2025 – Jun 2026 |
| Jacksonville International → Atlantic City International JAX–ACY | 4 | 373 | 50% | 738 | Sun Country Airlines d/b/a... | Mar 2025 – Feb 2026 |
| Jacksonville International → Addison JAX–ADS | 4 | 0 | | 906 | Ameristar Air Cargo | Mar 2026 – May 2026 |
| Jacksonville International → Birmingham-Shuttlesworth International JAX–BHM | 4 | 287 | 85% | 364 | United Parcel Service, Delta Air Lines Inc., Global Crossing Airlines, Inc. | Apr 2025 – Jul 2026 |
| Jacksonville International → Buffalo Niagara International JAX–BUF | 4 | 359 | 44% | 874 | Delta Air Lines Inc., Allegiant Air, United Air Lines Inc., Southwest Airlines Co. | Jan 2026 – Jan 2026 |
| Jacksonville International → Savannah/Hilton Head International JAX–SAV | 4 | 318 | 62% | 116 | United Parcel Service, American Airlines Inc., Delta Air Lines Inc., Southwest Airlines Co. | May 2025 – Mar 2026 |
| Jacksonville International → Southwest Georgia Regional JAX–ABY | 3 | 0 | | 164 | United Parcel Service | Apr 2025 – Mar 2026 |
| Jacksonville International → Columbia Regional JAX–COU | 3 | 361 | 65% | 828 | Sun Country Airlines d/b/a..., Allegiant Air | Dec 2025 – Dec 2025 |
| Jacksonville International → Columbus JAX–CSG | 3 | 0 | 0% | 236 | Air Wisconsin Airlines Corp, CFM Inc d/b/a Contour... | Feb 2025 – Jul 2026 |
| Jacksonville International → Long Island Mac Arthur JAX–ISP | 3 | 394 | 74% | 859 | Allegiant Air, JetBlue Airways | Jul 2025 – Oct 2025 |
| Jacksonville International → Lawson Army Airfield (Fort Benning) JAX–LSF | 3 | 307 | 96% | 232 | Global Crossing Airlines, Inc. | Nov 2025 – Mar 2026 |
| Jacksonville International → Melbourne Orlando International JAX–MLB | 3 | 75 | 17% | 177 | Sun Country Airlines d/b/a..., Envoy Air | Jan 2025 – May 2026 |
| Jacksonville International → Myrtle Beach International JAX–MYR | 3 | 0 | 0% | 273 | Sun Country Airlines d/b/a... | Apr 2026 – Jul 2026 |
| Jacksonville International → San Antonio International JAX–SAT | 3 | 413 | 83% | 1,006 | Southwest Airlines Co., United Air Lines Inc. | Apr 2025 – Mar 2026 |
| Jacksonville International → Seattle-Tacoma International JAX–SEA | 3 | 343 | 60% | 2,442 | Atlas Air Inc., American Airlines Inc., Delta Air Lines Inc. | Oct 2025 – Jul 2026 |
| Jacksonville International → Valdosta Regional JAX–VLD | 3 | 160 | 75% | 96 | Endeavor Air Inc. | Mar 2025 – Jan 2026 |
| Jacksonville International → Augusta Regional AT Bush Field JAX–AGS | 2 | 340 | 92% | 199 | Delta Air Lines Inc. | Jul 2025 – Oct 2025 |
| Jacksonville International → Athens/Ben Epps JAX–AHN | 2 | 164 | 75% | 256 | Delta Air Lines Inc. | Nov 2025 – Nov 2025 |
| Jacksonville International → Baton Rouge Metro, Ryan Field JAX–BTR | 2 | 143 | 53% | 563 | Eastern Air Express, LLC (EAX), Breeze Aviation Group DBA Breeze | Jul 2025 – Mar 2026 |
| Jacksonville International → Charlottesville-Albemarle JAX–CHO | 2 | 230 | 68% | 559 | Delta Air Lines Inc., Breeze Aviation Group DBA Breeze | Dec 2025 – Dec 2025 |
| Jacksonville International → Robert Gray Army Airfield JAX–GRK | 2 | 11 | 6% | 959 | Eastern Air Express, LLC (EAX), Air Wisconsin Airlines Corp | Nov 2025 – Jun 2026 |
| Jacksonville International → Pensacola Naval Air Station (Forrest Sherman Field) JAX–NPA | 2 | 174 | 49% | 335 | Global Crossing Airlines, Inc. | Oct 2025 – Oct 2025 |
| Jacksonville International → Okc Will Rogers International JAX–OKC | 2 | 31 | 25% | 982 | SkyWest Airlines Inc., Air Wisconsin Airlines Corp | Mar 2025 – Jul 2026 |
| Jacksonville International → Seattle Paine Field International JAX–PAE | 2 | 0 | | 2,449 | Gulf And Caribbean Cargo, Kalitta Charters II | Apr 2026 – Jun 2026 |
| Jacksonville International → Sarasota/Bradenton International JAX–SRQ | 2 | 120 | 33% | 220 | Sun Country Airlines d/b/a..., Southwest Airlines Co. | Apr 2025 – Feb 2026 |
| Jacksonville International → Syracuse Hancock International JAX–SYR | 2 | 207 | 75% | 923 | JetBlue Airways, Breeze Aviation Group DBA Breeze | Jan 2026 – Mar 2026 |
| Jacksonville International → Southern California Logistics JAX–VCV | 2 | 297 | 92% | 2,091 | Eastern Air Express, LLC (EAX), Global Crossing Airlines, Inc. | Jun 2025 – Jul 2026 |
| Jacksonville International → Abilene Regional JAX–ABI | 1 | 53 | 37% | 1,069 | Eastern Air Express, LLC (EAX) | Jul 2026 – Jul 2026 |
| Jacksonville International → Waco Regional JAX–ACT | 1 | 170 | 99% | 923 | American Airlines Inc. | Sep 2025 – Sep 2025 |
| Jacksonville International → Perot Fld/Fort Worth Alliance JAX–AFW | 1 | 0 | | 934 | USA Jet Airlines Inc. | Jun 2026 – Jun 2026 |
| Jacksonville International → Albany International JAX–ALB | 1 | 3 | 38% | 951 | CFM Inc d/b/a Contour... | Jun 2026 – Jun 2026 |
| Jacksonville International → Rick Husband Amarillo International JAX–AMA | 1 | 167 | 95% | 1,205 | Southwest Airlines Co. | Aug 2025 – Aug 2025 |
| Jacksonville International → Naples Municipal JAX–APF | 1 | 0 | 0% | 299 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| Jacksonville International → Asheville Regional JAX–AVL | 1 | 3 | 38% | 344 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Jacksonville International → Brindisi JAX–BDS international | 1 | 0 | 0% | 5,348 | Glock Aviation GmbH | Jul 2026 – Jul 2026 |
| Jacksonville International → Hancock County/Bar Harbor JAX–BHB | 1 | 2 | 25% | 1,207 | Jet Aviation Flight Services, Inc. | Jul 2026 – Jul 2026 |
| Jacksonville International → Burke Lakefront JAX–BKL | 1 | 0 | 0% | 760 | Republic Airline | May 2026 – May 2026 |
| Jacksonville International → Brunswick Golden Isles JAX–BQK | 1 | 38 | 50% | 55 | Endeavor Air Inc. | Feb 2025 – May 2026 |
| Jacksonville International → Baker Bay JAX–BS3 international | 1 | 0 | 0% | 383 | Tropic Ocean Airways LLC | May 2026 – May 2026 |
| Jacksonville International → Cape Girardeau Regional JAX–CGI | 1 | 0 | 0% | 647 | CFM Inc d/b/a Contour... | Nov 2025 – Nov 2025 |
| Jacksonville International → Cleveland-Hopkins International JAX–CLE | 1 | 71 | 93% | 753 | Endeavor Air Inc. | Jul 2025 – Jul 2026 |
| Jacksonville International → City Of Colorado Springs Municipal JAX–COS | 1 | 143 | 95% | 1,425 | United Air Lines Inc. | May 2026 – May 2026 |
| Jacksonville International → Corpus Christi International JAX–CRP | 1 | 125 | 91% | 972 | Southwest Airlines Co. | Jul 2026 – Jul 2026 |
| Jacksonville International → Roscoe Turner JAX–CRX | 1 | 6 | 75% | 504 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Jacksonville International → Northwest Florida Beaches International JAX–ECP | 1 | 69 | 91% | 244 | Envoy Air | Jun 2025 – Dec 2025 |
| Jacksonville International → Road Town JAX–EIS international | 1 | 21 | 70% | 1,359 | CFM Inc d/b/a Contour... | Nov 2025 – Nov 2025 |
| Jacksonville International → Florence Regional JAX–FLO | 1 | 0 | | 279 | Kalitta Charters II | Jun 2026 – Jun 2026 |
| Jacksonville International → Greenville JAX–GDC | 1 | 0 | 0% | 296 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Jacksonville International → Great Harbour Cay JAX–GHC international | 1 | 4 | 50% | 404 | Tradewind Aviation | Dec 2025 – Dec 2025 |
| Jacksonville International → Piedmont Triad International JAX–GSO | 1 | 9 | 6% | 400 | Eastern Air Express, LLC (EAX) | Nov 2025 – Nov 2025 |
| Jacksonville International → Huntsville Intl-Carl T Jones Field JAX–HSV | 1 | 5 | 62% | 411 | CFM Inc d/b/a Contour... | May 2025 – Jun 2026 |
| Jacksonville International → Laughlin/Bullhead International JAX–IFP | 1 | 110 | 59% | 1,930 | Sun Country Airlines d/b/a... | Feb 2025 – Aug 2025 |
| Jacksonville International → Wilmington International JAX–ILM | 1 | 0 | 0% | 342 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Jacksonville International → Inverness JAX–INV international | 1 | 8 | 57% | 4,029 | VistaJet Limited | Aug 2025 – Aug 2025 |
| Jacksonville International → Kingston JAX–KIN international | 1 | 110 | 71% | 918 | Caribbean Sun Airlines,... | Nov 2025 – Nov 2025 |
| Jacksonville International → Laredo International JAX–LRD | 1 | 0 | | 1,093 | Tatonduk Outfitters... | Jun 2026 – Jun 2026 |
| Jacksonville International → Madrid JAX–MAD international | 1 | 2 | 14% | 4,317 | Skyfirst Limited | Feb 2026 – Feb 2026 |
| Jacksonville International → Montego Bay JAX–MBJ international | 1 | 68 | 100% | 859 | Global Crossing Airlines, Inc. | Jan 2025 – Dec 2025 |
| Jacksonville International → Middle Georgia Regional JAX–MCN | 1 | 0 | 0% | 190 | Sun Country Airlines d/b/a... | May 2025 – May 2026 |
| Jacksonville International → Managua JAX–MGA international | 1 | 3 | 30% | 1,295 | Jet Aviation Flight Services, Inc. | Apr 2026 – Apr 2026 |
| Jacksonville International → Montgomery Regional (Dannelly Field) JAX–MGM | 1 | 19 | 38% | 304 | Piedmont Airlines | May 2026 – May 2026 |
| Jacksonville International → Marsh Harbour JAX–MHH international | 1 | 7 | 88% | 393 | Tradewind Aviation | Jan 2026 – Jan 2026 |
| Jacksonville International → Manchester Boston Regional JAX–MHT | 1 | 0 | 0% | 1,028 | Southwest Airlines Co. | Jul 2026 – Jul 2026 |
| Jacksonville International → Nassau JAX–NAS international | 1 | 0 | 0% | 457 | Global Crossing Airlines, Inc. | Apr 2025 – Nov 2025 |
| Jacksonville International → Mexico City JAX–NLU international | 1 | 180 | 100% | 1,310 | Global Crossing Airlines, Inc. | Aug 2025 – Aug 2025 |
| Jacksonville International → Ocala Intl-Jim Taylor Field JAX–OCF | 1 | 0 | 0% | 96 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| Jacksonville International → Eppley Airfield JAX–OMA | 1 | 173 | 96% | 1,088 | Allegiant Air | Jan 2025 – Jul 2026 |
| Jacksonville International → Puebla JAX–PBC international | 1 | 6 | 55% | 1,303 | Volkswagen AirSevice GmbH... | Nov 2025 – Nov 2025 |
| Jacksonville International → St. Pete-Clearwater International JAX–PIE | 1 | 0 | 0% | 188 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |
| Jacksonville International → Mercedita JAX–PSE | 1 | 21 | 13% | 1,282 | Allegiant Air | Oct 2025 – Oct 2025 |
| Jacksonville International → Oakland County International JAX–PTK | 1 | 2 | 14% | 845 | Jet Aviation Flight Services, Inc. | Sep 2025 – Sep 2025 |
| Jacksonville International → Provo Municipal JAX–PVU | 1 | 93 | 68% | 1,812 | Breeze Aviation Group DBA Breeze | Feb 2026 – Feb 2026 |
| Jacksonville International → March Arb JAX–RIV | 1 | 87 | 48% | 2,086 | Allegiant Air | Aug 2025 – Aug 2025 |
| Jacksonville International → State College JAX–SCE | 1 | 34 | 68% | 746 | Air Wisconsin Airlines Corp | Jun 2026 – Jun 2026 |
| Jacksonville International → Orlando Sanford International JAX–SFB | 1 | 0 | 0% | 122 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |
| Jacksonville International → Mineta San Jose International JAX–SJC | 1 | 180 | 95% | 2,341 | Atlas Air Inc. | Sep 2025 – Sep 2025 |
| Jacksonville International → Salt Lake City International JAX–SLC | 1 | 0 | 0% | 1,834 | SkyWest Airlines Inc. | Jun 2026 – Jun 2026 |
| Jacksonville International → Salina Regional JAX–SLN | 1 | 0 | 0% | 1,071 | SkyWest Airlines Inc. | Apr 2026 – Apr 2026 |
| Jacksonville International → Stella Maris JAX–SML international | 1 | 6 | 86% | 619 | Island Wings Ltd. Dba... | Nov 2025 – Nov 2025 |
| Jacksonville International → Shannon JAX–SNN international | 1 | 2 | 12% | 3,881 | International Jet Management GmbH | Feb 2026 – Feb 2026 |
| Jacksonville International → Abraham Lincoln Capital JAX–SPI | 1 | 76 | 100% | 786 | Envoy Air | Apr 2026 – Apr 2026 |
| Jacksonville International → London JAX–STN international | 1 | 181 | 96% | 4,273 | Atlas Air Inc. | Oct 2025 – Oct 2025 |
| Jacksonville International → Tulsa International JAX–TUL | 1 | 0 | | 909 | USA Jet Airlines Inc. | May 2025 – Sep 2025 |
| Jacksonville International → Tucson International JAX–TUS | 1 | 0 | 0% | 1,728 | SkyWest Airlines Inc. | Mar 2026 – Mar 2026 |
| Jacksonville International → Thomasville Regional JAX–TVI | 1 | 0 | 0% | 133 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| Jacksonville International → Eglin Afb/Destin-Ft Walton Beach JAX–VPS | 1 | 68 | 53% | 288 | American Airlines Inc. | Jan 2026 – Jan 2026 |
| Jacksonville International → Youngstown/Warren Regional JAX–YNG | 1 | 13 | 8% | 745 | Eastern Air Express, LLC (EAX) | Mar 2025 – Dec 2025 |
| Jacksonville International → Zurich JAX–ZRH international | 1 | 4 | 31% | 4,723 | Mjet GmbH | Feb 2026 – Feb 2026 |