| San Francisco International → Los Angeles International SFO–LAX | 12,258 | 1,416,244 | 83% | 337 | United Air Lines Inc., SkyWest Airlines Inc., Delta Air Lines Inc., Southwest Airlines Co. +13 | Jan 2025 – Jul 2026 |
| San Francisco International → San Diego International SFO–SAN | 7,107 | 792,787 | 79% | 447 | United Air Lines Inc., Southwest Airlines Co., SkyWest Airlines Inc., Horizon Air +5 | Jan 2025 – Jul 2026 |
| San Francisco International → Seattle-Tacoma International SFO–SEA | 6,747 | 815,385 | 83% | 679 | Alaska Airlines Inc., United Air Lines Inc., SkyWest Airlines Inc., Delta Air Lines Inc. +4 | Jan 2025 – Jul 2026 |
| San Francisco International → John F Kennedy International SFO–JFK | 6,570 | 957,965 | 89% | 2,586 | Delta Air Lines Inc., JetBlue Airways, American Airlines Inc., Alaska Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Harry Reid International SFO–LAS | 6,116 | 830,342 | 78% | 414 | United Air Lines Inc., Southwest Airlines Co., Alaska Airlines Inc., Frontier Airlines Inc. +7 | Jan 2025 – Jul 2026 |
| San Francisco International → Chicago O'Hare International SFO–ORD | 5,555 | 990,358 | 87% | 1,846 | United Air Lines Inc., American Airlines Inc., Alaska Airlines Inc., Eva Airways Corporation +3 | Jan 2025 – Jul 2026 |
| San Francisco International → Denver International SFO–DEN | 5,497 | 841,915 | 81% | 967 | United Air Lines Inc., Southwest Airlines Co., Frontier Airlines Inc., SkyWest Airlines Inc. +5 | Jan 2025 – Jul 2026 |
| San Francisco International → Phoenix Sky Harbor International SFO–PHX | 4,744 | 595,762 | 80% | 651 | United Air Lines Inc., American Airlines Inc., Southwest Airlines Co., SkyWest Airlines Inc. +5 | Jan 2025 – Jul 2026 |
| San Francisco International → General Edward Lawrence Logan International SFO–BOS | 4,654 | 700,477 | 86% | 2,704 | United Air Lines Inc., JetBlue Airways, Delta Air Lines Inc., Alaska Airlines Inc. +3 | Jan 2025 – Jul 2026 |
| San Francisco International → John Wayne/Orange County SFO–SNA | 4,651 | 374,004 | 82% | 372 | SkyWest Airlines Inc., United Air Lines Inc., Frontier Airlines Inc., Alaska Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Newark Liberty International SFO–EWR | 4,276 | 880,742 | 91% | 2,565 | United Air Lines Inc., Alaska Airlines Inc., Delta Air Lines Inc., JetBlue Airways | Jan 2025 – Jul 2026 |
| San Francisco International → Dallas-Fort Worth International SFO–DFW | 4,054 | 650,924 | 88% | 1,464 | American Airlines Inc., United Air Lines Inc., Frontier Airlines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Portland International SFO–PDX | 3,723 | 445,147 | 79% | 550 | United Air Lines Inc., Alaska Airlines Inc., SkyWest Airlines Inc., Horizon Air +2 | Jan 2025 – Jul 2026 |
| San Francisco International → George Bush Intcntl/Houston SFO–IAH | 3,603 | 610,784 | 85% | 1,635 | United Air Lines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Hartsfield/Jackson Atlanta International SFO–ATL | 3,477 | 543,443 | 87% | 2,139 | Delta Air Lines Inc., United Air Lines Inc., Frontier Airlines Inc., China Airlines Ltd. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Salt Lake City International SFO–SLC | 3,462 | 355,313 | 78% | 599 | Delta Air Lines Inc., SkyWest Airlines Inc., United Air Lines Inc., Frontier Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| San Francisco International → Hollywood Burbank SFO–BUR | 3,168 | 277,071 | 72% | 326 | United Air Lines Inc., SkyWest Airlines Inc., Southwest Airlines Co., Horizon Air +2 | Jan 2025 – Jul 2026 |
| San Francisco International → Vancouver SFO–YVR international | 2,991 | 382,488 | 87% | 800 | United Air Lines Inc., Air Canada, Jazz Aviation LP, Flair Airlines Ltd. +3 | Jan 2025 – Jul 2026 |
| San Francisco International → Austin-Bergstrom International SFO–AUS | 2,792 | 358,457 | 82% | 1,504 | United Air Lines Inc., Delta Air Lines Inc., Southwest Airlines Co., Alaska Airlines Inc. +5 | Jan 2025 – Jul 2026 |
| San Francisco International → Taipei SFO–TPE international | 2,783 | 611,525 | 75% | 6,469 | Eva Airways Corporation, United Air Lines Inc., China Airlines Ltd., STARLUX AIRLINES +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Washington Dulles International SFO–IAD | 2,741 | 490,673 | 87% | 2,418 | United Air Lines Inc., Alaska Airlines Inc., Jet Aviation Flight Services, Inc., Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Palm Springs International SFO–PSP | 2,700 | 168,559 | 73% | 421 | SkyWest Airlines Inc., United Air Lines Inc., Horizon Air, Frontier Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| San Francisco International → Daniel K Inouye International SFO–HNL | 2,476 | 572,934 | 88% | 2,398 | United Air Lines Inc., Alaska Airlines Inc., Hawaiian Airlines Inc., Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Minneapolis-St Paul Intl/Wold-Chamberlain SFO–MSP | 2,301 | 319,753 | 81% | 1,589 | Delta Air Lines Inc., Sun Country Airlines d/b/a..., United Air Lines Inc., SkyWest Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| San Francisco International → London SFO–LHR international | 2,174 | 528,096 | 82% | 5,368 | United Air Lines Inc., British Airways Plc, Virgin Atlantic Airways | Jan 2025 – Jul 2026 |
| San Francisco International → Seoul SFO–ICN international | 2,084 | 342,589 | 80% | 5,659 | United Air Lines Inc., Korean Air Lines Co. Ltd., Asiana Airlines Inc., AIRZETA CO Ltd. +2 | Jan 2025 – Jul 2026 |
| San Francisco International → Philadelphia International SFO–PHL | 2,029 | 320,264 | 85% | 2,522 | American Airlines Inc., United Air Lines Inc., Delta Air Lines Inc., Alaska Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Toronto SFO–YYZ international | 2,004 | 271,563 | 86% | 2,259 | Air Canada, United Air Lines Inc., Porter Airlines Limited (PACL), Jet Aviation Flight Services, Inc. +2 | Jan 2025 – Jul 2026 |
| San Francisco International → Reno/Tahoe International SFO–RNO | 1,912 | 155,429 | 75% | 192 | SkyWest Airlines Inc., United Air Lines Inc., Alaska Airlines Inc., Scott Aviation, LLC d/b/a... +2 | Jan 2025 – Jul 2026 |
| San Francisco International → Boise Air Trml/Gowen Field SFO–BOI | 1,829 | 117,017 | 78% | 522 | SkyWest Airlines Inc., United Air Lines Inc., Horizon Air | Jan 2025 – Jul 2026 |
| San Francisco International → Detroit Metro Wayne County SFO–DTW | 1,786 | 258,077 | 83% | 2,079 | Delta Air Lines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Mexico City SFO–MEX international | 1,775 | 226,640 | 80% | 1,881 | United Air Lines Inc., Aeromexico | Jan 2025 – Jul 2026 |
| San Francisco International → Miami International SFO–MIA | 1,733 | 275,809 | 90% | 2,585 | American Airlines Inc., United Air Lines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Kahului SFO–OGG | 1,701 | 247,199 | 84% | 2,338 | United Air Lines Inc., Alaska Airlines Inc., Hawaiian Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Santa Barbara Municipal SFO–SBA | 1,621 | 123,506 | 64% | 262 | United Air Lines Inc., SkyWest Airlines Inc., Scott Aviation, LLC d/b/a..., ADVANCED AIR, LLC | Jan 2025 – Jul 2026 |
| San Francisco International → Hong Kong SFO–HKG international | 1,620 | 460,212 | 85% | 6,927 | Cathay Pacific Airways Ltd., United Air Lines Inc., Atlas Air Inc., VistaJet Limited | Jan 2025 – Jul 2026 |
| San Francisco International → Charlotte/Douglas International SFO–CLT | 1,479 | 243,753 | 86% | 2,296 | American Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Tokyo SFO–NRT international | 1,462 | 300,919 | 82% | 5,124 | United Air Lines Inc., Japan Air Lines Co. Ltd., ZIPAIR Tokyo Inc., All Nippon Airways Co. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Roberts Fld/Redmond Municipal SFO–RDM | 1,420 | 105,952 | 66% | 462 | United Air Lines Inc., SkyWest Airlines Inc., Horizon Air | Jan 2025 – Jul 2026 |
| San Francisco International → Orlando International SFO–MCO | 1,394 | 216,685 | 85% | 2,446 | United Air Lines Inc., Alaska Airlines Inc., Frontier Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Sacramento International SFO–SMF | 1,372 | 66,722 | 72% | 86 | SkyWest Airlines Inc., United Air Lines Inc., Alaska Airlines Inc., Delta Air Lines Inc. +3 | Jan 2025 – Jul 2026 |
| San Francisco International → Ontario International SFO–ONT | 1,316 | 148,374 | 72% | 363 | United Air Lines Inc., Frontier Airlines Inc., SkyWest Airlines Inc., Air Transport International +2 | Jan 2025 – Jul 2026 |
| San Francisco International → California Redwood Coast-Humboldt County SFO–ACV | 1,258 | 66,779 | 78% | 250 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Fresno Yosemite International SFO–FAT | 1,256 | 57,617 | 77% | 158 | SkyWest Airlines Inc., Alaska Airlines Inc., Delta Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| San Francisco International → Fort Lauderdale/Hollywood International SFO–FLL | 1,247 | 182,635 | 89% | 2,584 | JetBlue Airways, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Nashville International SFO–BNA | 1,160 | 144,883 | 78% | 1,969 | United Air Lines Inc., Southwest Airlines Co., SkyWest Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Ellison Onizuka Kona International AT Keahole SFO–KOA | 1,148 | 192,028 | 81% | 2,368 | United Air Lines Inc., Alaska Airlines Inc., Jet Aviation Flight Services, Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Frankfurt SFO–FRA international | 1,141 | 303,078 | 86% | 5,699 | United Air Lines Inc., Lufthansa German Airlines, Condor Flugdienst, National Air Cargo Group... | Jan 2025 – Jul 2026 |
| San Francisco International → San Luis Obispo County Regional SFO–SBP | 1,133 | 61,162 | 66% | 191 | SkyWest Airlines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → San Jose del Cabo SFO–SJD international | 1,131 | 146,726 | 78% | 1,248 | United Air Lines Inc., Alaska Airlines Inc., VistaJet Limited | Jan 2025 – Jul 2026 |
| San Francisco International → Henderson Executive SFO–HND international | 1,102 | 225,872 | 86% | 5,160 | United Air Lines Inc., Japan Air Lines Co. Ltd., All Nippon Airways Co., American Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Ronald Reagan Washington Ntl SFO–DCA | 1,079 | 156,221 | 88% | 2,442 | United Air Lines Inc., Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Baltimore/Washington International Thurgood Marshall SFO–BWI | 1,052 | 150,600 | 83% | 2,457 | United Air Lines Inc., Southwest Airlines Co., Delta Air Lines Inc., American Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Spokane International SFO–GEG | 1,035 | 62,671 | 78% | 733 | SkyWest Airlines Inc., Horizon Air, United Air Lines Inc., Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Singapore SFO–SIN international | 1,025 | 255,088 | 83% | 8,440 | United Air Lines Inc., Singapore Airlines Ltd. | Jan 2025 – Jul 2026 |
| San Francisco International → Rogue Valley Intl/Medford SFO–MFR | 1,023 | 78,233 | 69% | 329 | SkyWest Airlines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Mahlon Sweet Field SFO–EUG | 996 | 90,309 | 68% | 451 | United Air Lines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Manila SFO–MNL international | 977 | 302,753 | 86% | 6,987 | United Air Lines Inc., Philippine Airlines Inc., VistaJet Limited | Jan 2025 – Jul 2026 |
| San Francisco International → Tucson International SFO–TUS | 949 | 59,741 | 82% | 751 | SkyWest Airlines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Calgary SFO–YYC international | 925 | 126,534 | 86% | 1,019 | Westjet, United Air Lines Inc., Jazz Aviation LP | Jan 2025 – Jul 2026 |
| San Francisco International → Lihue SFO–LIH | 896 | 122,187 | 83% | 2,446 | United Air Lines Inc., Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Raleigh-Durham International SFO–RDU | 885 | 128,733 | 86% | 2,400 | United Air Lines Inc., American Airlines Inc., Alaska Airlines Inc., JetBlue Airways +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Redding Regional SFO–RDD | 865 | 39,292 | 68% | 199 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Paris SFO–CDG international | 841 | 207,735 | 85% | 5,584 | Compagnie Natl Air France, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → San Salvador SFO–SAL international | 834 | 120,346 | 82% | 2,640 | Taca International Airlines | Jan 2025 – Jul 2026 |
| San Francisco International → Cancun SFO–CUN international | 790 | 119,928 | 85% | 2,407 | United Air Lines Inc., Alaska Airlines Inc., VistaJet Limited | Jan 2025 – Jul 2026 |
| San Francisco International → St. Louis Lambert International SFO–STL | 752 | 85,833 | 84% | 1,735 | Southwest Airlines Co., SkyWest Airlines Inc., United Air Lines Inc., American Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Puerto Vallarta SFO–PVR international | 740 | 98,168 | 80% | 1,554 | United Air Lines Inc., Alaska Airlines Inc., Scott Aviation, LLC d/b/a..., Aeromexico | Jan 2025 – Jul 2026 |
| San Francisco International → Monterey Regional SFO–MRY | 735 | 27,710 | 63% | 77 | SkyWest Airlines Inc., American Airlines Inc., Gestair, S.A. | Jan 2025 – Jul 2026 |
| San Francisco International → Albuquerque International Sunport SFO–ABQ | 712 | 50,837 | 77% | 896 | SkyWest Airlines Inc., United Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| San Francisco International → Munich SFO–MUC international | 710 | 177,429 | 77% | 5,879 | United Air Lines Inc., Lufthansa German Airlines, VistaJet Limited | Jan 2025 – Jul 2026 |
| San Francisco International → Tampa International SFO–TPA | 702 | 100,626 | 84% | 2,393 | United Air Lines Inc., Alaska Airlines Inc., JetBlue Airways, Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Tri-Cities SFO–PSC | 593 | 32,761 | 76% | 620 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Seattle Paine Field International SFO–PAE | 592 | 37,779 | 84% | 710 | Horizon Air | Jan 2025 – Jul 2026 |
| San Francisco International → Sydney SFO–SYD international | 591 | 110,983 | 72% | 7,416 | United Air Lines Inc., Qantas Airways Ltd. | Jan 2025 – Jul 2026 |
| San Francisco International → Cleveland-Hopkins International SFO–CLE | 583 | 79,939 | 81% | 2,161 | United Air Lines Inc., American Airlines Inc., Alaska Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Montreal SFO–YUL international | 582 | 80,144 | 85% | 2,539 | Air Canada, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Meadows Field SFO–BFL | 577 | 29,332 | 70% | 238 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Pittsburgh International SFO–PIT | 562 | 75,955 | 82% | 2,254 | United Air Lines Inc., American Airlines Inc., Alaska Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Amsterdam SFO–AMS international | 556 | 139,766 | 84% | 5,473 | Klm Royal Dutch Airlines, United Air Lines Inc., Luxaviation EA | Jan 2025 – Jul 2026 |
| San Francisco International → Panama City SFO–PTY international | 551 | 73,842 | 80% | 3,320 | Compania Panamena (Copa), United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Indianapolis International SFO–IND | 530 | 69,931 | 83% | 1,943 | United Air Lines Inc., Delta Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| San Francisco International → Auckland SFO–AKL international | 529 | 114,049 | 79% | 6,516 | Air New Zealand, United Air Lines Inc., Qantas Airways Ltd. | Jan 2025 – Jul 2026 |
| San Francisco International → Zurich SFO–ZRH international | 529 | 135,213 | 84% | 5,841 | Swiss International Airlines, United Air Lines Inc., VistaJet Limited | Jan 2025 – Jul 2026 |
| San Francisco International → Louis Armstrong New Orleans International SFO–MSY | 524 | 70,089 | 81% | 1,911 | United Air Lines Inc., American Airlines Inc., Delta Air Lines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| San Francisco International → Hampton Roads Executive SFO–PVG international | 521 | 146,267 | 83% | 6,151 | United Air Lines Inc., China Eastern Airlines | Jan 2025 – Jul 2026 |
| San Francisco International → Istanbul SFO–IST international | 517 | 140,080 | 82% | 6,704 | Turk Hava Yollari A.O. | Jan 2025 – Jul 2026 |
| San Francisco International → Chicago Midway International SFO–MDW | 482 | 70,240 | 85% | 1,855 | Southwest Airlines Co., Jet Aviation Flight Services, Inc., Delta Air Lines Inc., Jet Story +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Beijing SFO–PEK international | 468 | 110,130 | 78% | 5,913 | United Air Lines Inc., Air China | Jan 2025 – Jul 2026 |
| San Francisco International → Bozeman Yellowstone International SFO–BZN | 454 | 44,714 | 80% | 807 | United Air Lines Inc., Horizon Air, SkyWest Airlines Inc., Jet Aviation Flight Services, Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Cincinnati/Northern Kentucky International SFO–CVG | 444 | 12,941 | 89% | 2,036 | Air Transport International, Breeze Aviation Group DBA Breeze, ABX Air Inc, Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → San Antonio International SFO–SAT | 444 | 33,448 | 83% | 1,482 | SkyWest Airlines Inc., United Air Lines Inc., American Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Monterrey SFO–MTY international | 383 | 21,623 | 73% | 1,539 | SkyWest Airlines Inc., United Air Lines Inc., Aeromexico | Jan 2025 – Jul 2026 |
| San Francisco International → Kansas City International SFO–MCI | 368 | 33,549 | 84% | 1,499 | SkyWest Airlines Inc., United Air Lines Inc., American Airlines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| San Francisco International → Eppley Airfield SFO–OMA | 368 | 26,316 | 76% | 1,433 | SkyWest Airlines Inc., United Air Lines Inc., American Airlines Inc., Alaska Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → San Jose SFO–SJO international | 364 | 49,083 | 81% | 3,039 | United Air Lines Inc. | May 2025 – Jul 2026 |
| San Francisco International → Melbourne SFO–MEL international | 359 | 72,813 | 79% | 7,853 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Osaka SFO–KIX international | 356 | 80,190 | 81% | 5,413 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Aspen-Pitkin County/Sardy Field SFO–ASE | 350 | 15,949 | 65% | 848 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Papeete SFO–PPT international | 345 | 75,521 | 73% | 4,188 | United Air Lines Inc., French bee | Jan 2025 – Jul 2026 |
| San Francisco International → Dubois Municipal SFO–DUB international | 338 | 72,507 | 70% | 5,098 | Aer Lingus Plc, VistaJet Limited | Jan 2025 – Jul 2026 |
| San Francisco International → Jackson Hole SFO–JAC | 334 | 28,449 | 69% | 737 | United Air Lines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → John Glenn Columbus International SFO–CMH | 319 | 36,651 | 84% | 2,120 | United Air Lines Inc., Southwest Airlines Co. | Mar 2025 – Jul 2026 |
| San Francisco International → Copenhagen SFO–CPH international | 313 | 74,991 | 83% | 5,487 | Scandinavian Airlines Sys., Turk Hava Yollari A.O. | Jan 2025 – Jul 2026 |
| San Francisco International → Southwest Oregon Regional SFO–OTH | 311 | 17,512 | 79% | 412 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Ted Stevens Anchorage International SFO–ANC | 310 | 35,099 | 68% | 2,018 | Alaska Airlines Inc., United Air Lines Inc., AIRZETA CO Ltd., Jet Aviation Flight Services, Inc. | Feb 2025 – Jul 2026 |
| San Francisco International → Rome SFO–FCO international | 301 | 69,171 | 82% | 6,264 | United Air Lines Inc., Italia Transporto Aereo... | Jan 2025 – Jul 2026 |
| San Francisco International → Friedman Memorial SFO–SUN | 291 | 13,232 | 65% | 587 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Brisbane SFO–BNE international | 287 | 57,787 | 73% | 7,063 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Delhi SFO–DEL international | 286 | 62,320 | 67% | 7,707 | National Aviation Company... | Jan 2025 – Apr 2026 |
| San Francisco International → Dubai SFO–DXB international | 266 | 90,772 | 67% | 8,101 | Emirates | Jan 2025 – Apr 2026 |
| San Francisco International → Frederick W Smith Intl/Memphis SFO–MEM | 254 | 335 | 79% | 1,807 | Federal Express Corporation, Delta Air Lines Inc., United Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| San Francisco International → Barcelona SFO–BCN international | 252 | 60,205 | 88% | 5,971 | United Air Lines Inc., Iberia Air Lines Of Spain, LEVEL | Mar 2025 – Jul 2026 |
| San Francisco International → Carlsbad SFO–CLD | 248 | 8,542 | 49% | 422 | SkyWest Airlines Inc. | Mar 2026 – Jul 2026 |
| San Francisco International → Kalispell SFO–FCA | 248 | 14,375 | 80% | 844 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → San Francisco International SFO–SFO | 238 | 0 | 0% | 0 | SkyWest Airlines Inc., ABX Air Inc | Jan 2025 – Jul 2026 |
| San Francisco International → Doha SFO–DOH international | 233 | 69,966 | 92% | 8,085 | Qatar Airways (Q.C.S.C) | Jan 2025 – Jun 2026 |
| San Francisco International → Bishop SFO–BIH | 226 | 9,265 | 58% | 221 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Lisbon SFO–LIS international | 211 | 51,772 | 83% | 5,681 | TAP-TAP Air Portugal | Jan 2025 – Jul 2026 |
| San Francisco International → San Bernardino International SFO–SBD | 208 | 22,949 | 81% | 377 | Breeze Aviation Group DBA Breeze, Air Transport International | Jan 2025 – Jul 2026 |
| San Francisco International → Guadalajara SFO–GDL international | 185 | 25,020 | 83% | 1,642 | Aeromexico | Jan 2025 – Jun 2026 |
| San Francisco International → Nadi SFO–NAN international | 165 | 40,603 | 77% | 5,457 | Air Pacific Ltd. | Jan 2025 – Jul 2026 |
| San Francisco International → Dallas Love Field SFO–DAL | 156 | 19,812 | 85% | 1,476 | Southwest Airlines Co., Delta Air Lines Inc., Jet Aviation Flight Services, Inc., Jet Aviation Business Jets AG | Jan 2025 – Jul 2026 |
| San Francisco International → Missoula Montana SFO–MSO | 131 | 7,977 | 84% | 769 | SkyWest Airlines Inc., United Air Lines Inc. | Apr 2025 – Jul 2026 |
| San Francisco International → Provo Municipal SFO–PVU | 127 | 15,254 | 88% | 601 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| San Francisco International → Wilmington Air Park SFO–ILN | 124 | 0 | | 2,078 | Air Transport International | Nov 2025 – Jul 2026 |
| San Francisco International → Edmonton SFO–YEG international | 119 | 8,299 | 86% | 1,163 | Jazz Aviation LP, Westjet, Virgin Atlantic Airways | Apr 2025 – Jul 2026 |
| San Francisco International → Mumbai SFO–BOM international | 111 | 20,256 | 55% | 8,401 | National Aviation Company... | Jan 2025 – Feb 2026 |
| San Francisco International → Eagle County Regional SFO–EGE | 110 | 4,883 | 63% | 847 | SkyWest Airlines Inc. | Jan 2025 – Apr 2026 |
| San Francisco International → Paris SFO–ORY international | 107 | 36,919 | 85% | 5,593 | French bee | Jan 2025 – May 2026 |
| San Francisco International → Perot Fld/Fort Worth Alliance SFO–AFW | 97 | 0 | | 1,447 | Air Transport International | Jan 2025 – Mar 2026 |
| San Francisco International → Guangzhou SFO–CAN international | 96 | 31,850 | 92% | 6,897 | China Southern Airlines | Jan 2025 – Jul 2026 |
| San Francisco International → Wuhan SFO–WUH international | 96 | 31,118 | 89% | 6,479 | China Southern Airlines | Jan 2025 – Jul 2026 |
| San Francisco International → Bangalore SFO–BLR international | 89 | 16,750 | 56% | 8,691 | National Aviation Company... | Jan 2025 – Feb 2026 |
| San Francisco International → Liberia SFO–LIR international | 89 | 11,515 | 77% | 2,946 | United Air Lines Inc., Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Madrid SFO–MAD international | 78 | 17,711 | 85% | 5,812 | Iberia Air Lines Of Spain, United Air Lines Inc., VistaJet Limited | May 2025 – Jul 2026 |
| San Francisco International → Richmond International SFO–RIC | 74 | 8,547 | 83% | 2,449 | Breeze Aviation Group DBA Breeze, JetBlue Airways, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Louisville Muhammad Ali International SFO–SDF | 73 | 8,428 | 84% | 1,990 | Breeze Aviation Group DBA Breeze, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Southwest Florida International SFO–RSW | 52 | 6,277 | 72% | 2,481 | United Air Lines Inc., American Airlines Inc., JetBlue Airways | Jan 2025 – Mar 2026 |
| San Francisco International → Christchurch SFO–CHC international | 48 | 9,121 | 77% | 6,912 | United Air Lines Inc. | Jan 2025 – Mar 2026 |
| San Francisco International → Adelaide SFO–ADL international | 45 | 5,996 | 52% | 8,068 | United Air Lines Inc. | Dec 2025 – Mar 2026 |
| San Francisco International → Montrose Regional SFO–MTJ | 45 | 2,099 | 61% | 791 | SkyWest Airlines Inc., Southwest Airlines Co. | Jan 2025 – Apr 2026 |
| San Francisco International → Warsaw SFO–WAW international | 40 | 7,736 | 71% | 5,868 | Polskie Linie Lotnicze | May 2026 – Jul 2026 |
| San Francisco International → Yampa Valley SFO–HDN | 36 | 2,001 | 70% | 838 | SkyWest Airlines Inc., Southwest Airlines Co. | Jan 2025 – Mar 2026 |
| San Francisco International → Guatemala City SFO–GUA international | 32 | 4,605 | 81% | 2,514 | Taca International Airlines | Jun 2026 – Jul 2026 |
| San Francisco International → Ixtapa/Zihuatanejo SFO–ZIH international | 21 | 3,021 | 83% | 1,874 | Alaska Airlines Inc. | Jan 2025 – Apr 2026 |
| San Francisco International → Okc Will Rogers International SFO–OKC | 18 | 1,820 | 78% | 1,384 | Delta Air Lines Inc., American Airlines Inc., United Air Lines Inc., SkyWest Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| San Francisco International → Mineta San Jose International SFO–SJC | 17 | 72 | 2% | 30 | Sun Country Airlines d/b/a..., Alaska Airlines Inc., Delta Air Lines Inc., Jet Aviation Flight Services, Inc. | Feb 2025 – Jul 2026 |
| San Francisco International → Loreto SFO–LTO international | 16 | 1,937 | 71% | 1,029 | Alaska Airlines Inc. | Jan 2025 – Apr 2026 |
| San Francisco International → Oakland San Francisco Bay SFO–OAK | 16 | 656 | 23% | 11 | Alaska Airlines Inc., Delta Air Lines Inc., Hawaiian Airlines Inc., Sun Country Airlines d/b/a... +2 | Feb 2025 – Mar 2026 |
| San Francisco International → Teller SFO–TER international | 16 | 3,933 | 85% | 4,918 | TAP-TAP Air Portugal | Jun 2025 – Jul 2026 |
| San Francisco International → Belize City SFO–BZE international | 14 | 1,665 | 72% | 2,484 | United Air Lines Inc. | Jan 2025 – Apr 2026 |
| San Francisco International → Charles M Schulz/Sonoma County SFO–STS | 13 | 198 | 21% | 66 | SkyWest Airlines Inc. | Jan 2025 – May 2026 |
| San Francisco International → Van Nuys SFO–VNY | 13 | 42 | 39% | 320 | Scott Aviation, LLC d/b/a..., ADVANCED AIR, LLC | Mar 2025 – Mar 2026 |
| San Francisco International → Grand Junction Regional SFO–GJT | 10 | 534 | 50% | 759 | SkyWest Airlines Inc., United Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jun 2026 |
| San Francisco International → Boeing Fld/King County International SFO–BFI | 9 | 170 | 16% | 684 | Delta Air Lines Inc., Alaska Airlines Inc. | Feb 2025 – Jul 2026 |
| San Francisco International → Teterboro SFO–TEB | 8 | 20 | 18% | 2,569 | Jet Aviation Flight Services, Inc., Scott Aviation, LLC d/b/a... | Mar 2025 – Jul 2026 |
| San Francisco International → City Of Colorado Springs Municipal SFO–COS | 6 | 895 | 75% | 964 | United Air Lines Inc., Alaska Airlines Inc., SkyWest Airlines Inc. | Jun 2025 – Jul 2026 |
| San Francisco International → Rick Husband Amarillo International SFO–AMA | 5 | 863 | 95% | 1,161 | American Airlines Inc., Southwest Airlines Co. | Apr 2025 – Jun 2026 |
| San Francisco International → Gainesville Regional SFO–GNV | 5 | 0 | 0% | 2,356 | SkyWest Airlines Inc. | Mar 2025 – Mar 2026 |
| San Francisco International → London SFO–LTN international | 5 | 13 | 19% | 5,350 | VistaJet Limited, Air Alsie A/S, Concierge U Ltd. d/b/a Jet... | Jan 2025 – Jul 2026 |
| San Francisco International → Portland International Jetport SFO–PWM | 5 | 787 | 95% | 2,723 | United Air Lines Inc. | Jun 2026 – Jul 2026 |
| San Francisco International → Chicago/Rockford International SFO–RFD | 5 | 1,031 | 87% | 1,784 | United Air Lines Inc. | Jan 2026 – Jul 2026 |
| San Francisco International → Roswell Air Center SFO–ROW | 5 | 72 | 17% | 1,048 | SkyWest Airlines Inc., United Air Lines Inc. | Jan 2026 – Jun 2026 |
| San Francisco International → Buffalo Niagara International SFO–BUF | 4 | 459 | 78% | 2,309 | JetBlue Airways, American Airlines Inc., Delta Air Lines Inc. | Apr 2025 – Jul 2026 |
| San Francisco International → William P Hobby SFO–HOU | 4 | 250 | 42% | 1,649 | Southwest Airlines Co., Delta Air Lines Inc., United Air Lines Inc. | Mar 2025 – Apr 2026 |
| San Francisco International → Jacksonville International SFO–JAX | 4 | 654 | 91% | 2,365 | United Air Lines Inc. | Mar 2025 – Jul 2026 |
| San Francisco International → Long Beach (Daugherty Field) SFO–LGB | 4 | 203 | 37% | 354 | United Air Lines Inc., Ameristar Air Cargo, Delta Air Lines Inc. | Jun 2025 – Jul 2026 |
| San Francisco International → Queretaro SFO–QRO international | 4 | 519 | 80% | 1,772 | United Air Lines Inc., Aeromexico | Aug 2025 – Mar 2026 |
| San Francisco International → The Eastern Iowa SFO–CID | 3 | 377 | 63% | 1,650 | United Air Lines Inc. | Mar 2026 – Apr 2026 |
| San Francisco International → Farnborough SFO–FAB international | 3 | 13 | 32% | 5,368 | VistaJet Limited, Air Alsie A/S | Jun 2025 – Jun 2026 |
| San Francisco International → Idaho Falls Regional SFO–IDA | 3 | 117 | 43% | 678 | SkyWest Airlines Inc., United Air Lines Inc. | Mar 2025 – Dec 2025 |
| San Francisco International → Harrisburg International SFO–MDT | 3 | 407 | 89% | 2,438 | United Air Lines Inc., American Airlines Inc. | Jun 2025 – Jul 2026 |
| San Francisco International → General Mitchell International SFO–MKE | 3 | 282 | 68% | 1,845 | American Airlines Inc., Delta Air Lines Inc. | Jun 2025 – Apr 2026 |
| San Francisco International → Dane County Rgnl/Truax Field SFO–MSN | 3 | 478 | 87% | 1,772 | United Air Lines Inc., American Airlines Inc. | Aug 2025 – Apr 2026 |
| San Francisco International → Northolt SFO–NHT international | 3 | 9 | 21% | 5,365 | VistaJet Limited | Dec 2025 – Mar 2026 |
| San Francisco International → Rhode Island TF Green International SFO–PVD | 3 | 329 | 74% | 2,691 | JetBlue Airways, Delta Air Lines Inc., Southwest Airlines Co. | Jul 2025 – Feb 2026 |
| San Francisco International → Tulsa International SFO–TUL | 3 | 367 | 99% | 1,465 | American Airlines Inc., Delta Air Lines Inc., Federal Express Corporation | Mar 2025 – May 2026 |
| San Francisco International → Athens SFO–ATH international | 2 | 8 | 29% | 6,808 | VistaJet Limited | Sep 2025 – Sep 2025 |
| San Francisco International → Bradley International SFO–BDL | 2 | 343 | 86% | 2,625 | Delta Air Lines Inc., United Air Lines Inc. | Apr 2025 – Jul 2026 |
| San Francisco International → Rocky Mountain Metro SFO–BJC | 2 | 15 | 48% | 944 | Jet Aviation Flight Services, Inc., Scott Aviation, LLC d/b/a... | Dec 2025 – Mar 2026 |
| San Francisco International → Charleston Afb/Intl SFO–CHS | 2 | 132 | 45% | 2,396 | JetBlue Airways, Breeze Aviation Group DBA Breeze | Jul 2025 – Jul 2026 |
| San Francisco International → Des Moines International SFO–DSM | 2 | 309 | 82% | 1,549 | United Air Lines Inc., Southwest Airlines Co. | Feb 2025 – Jul 2026 |
| San Francisco International → Seoul SFO–GMP international | 2 | 11 | 39% | 5,640 | VistaJet Limited | Mar 2025 – Jul 2026 |
| San Francisco International → Robert Gray Army Airfield SFO–GRK | 2 | 331 | 97% | 1,469 | American Airlines Inc., United Air Lines Inc. | Aug 2025 – Jun 2026 |
| San Francisco International → Gerald R Ford International SFO–GRR | 2 | 334 | 97% | 1,966 | American Airlines Inc. | Jul 2025 – Jul 2026 |
| San Francisco International → Sao Paulo SFO–GRU international | 2 | 1 | 7% | 6,472 | United Air Lines Inc., VistaJet Limited | Sep 2025 – Sep 2025 |
| San Francisco International → Wichita Dwight D Eisenhower Ntl SFO–ICT | 2 | 145 | 55% | 1,364 | American Airlines Inc., SkyWest Airlines Inc. | Jun 2025 – May 2026 |
| San Francisco International → Keflavik/Reykjavik SFO–KEF international | 2 | 270 | 93% | 4,204 | Jet Aviation Flight Services, Inc., United Air Lines Inc. | Apr 2025 – Jul 2026 |
| San Francisco International → Midland International Air And Space Port SFO–MAF | 2 | 0 | 0% | 1,209 | SkyWest Airlines Inc. | Aug 2025 – Jun 2026 |
| San Francisco International → Middle Georgia Regional SFO–MCN | 2 | 0 | 0% | 2,203 | SkyWest Airlines Inc. | Jul 2025 – Jun 2026 |
| San Francisco International → Gerlach SFO–NV5 | 2 | 7 | 44% | 275 | Scott Aviation, LLC d/b/a... | Aug 2025 – Aug 2025 |
| San Francisco International → Norfolk International SFO–ORF | 2 | 248 | 93% | 2,520 | American Airlines Inc., United Air Lines Inc. | Jul 2025 – Jul 2026 |
| San Francisco International → Pocatello Regional SFO–PIH | 2 | 150 | 64% | 631 | Delta Air Lines Inc., SkyWest Airlines Inc. | Aug 2025 – Jul 2026 |
| San Francisco International → Sacramento Executive SFO–SAC | 2 | 4 | 14% | 78 | Jet Aviation Flight Services, Inc. | Jul 2025 – Jul 2026 |
| San Francisco International → South Bend International SFO–SBN | 2 | 212 | 75% | 1,929 | Delta Air Lines Inc., SkyWest Airlines Inc. | Nov 2025 – Mar 2026 |
| San Francisco International → Philipsburg SFO–SXM international | 2 | 10 | 37% | 3,803 | DCA, VistaJet Limited | Apr 2025 – Feb 2026 |
| San Francisco International → Northwest Arkansas Ntl SFO–XNA | 2 | 157 | 47% | 1,550 | United Air Lines Inc. | Mar 2025 – Jun 2026 |
| San Francisco International → Yakima Air Trml/Mcallister Field SFO–YKM | 2 | 245 | 85% | 625 | Alaska Airlines Inc., Delta Air Lines Inc. | Mar 2025 – Mar 2026 |
| San Francisco International → Winnipeg SFO–YWG international | 2 | 166 | 94% | 1,505 | Scott Aviation, LLC d/b/a..., Air Canada | Dec 2025 – Apr 2026 |
| San Francisco International → Lehigh Valley International SFO–ABE | 1 | 100 | 98% | 2,500 | American Airlines Inc. | May 2026 – May 2026 |
| San Francisco International → Abilene Regional SFO–ABI | 1 | 76 | 60% | 1,332 | United Air Lines Inc. | May 2026 – May 2026 |
| San Francisco International → Acapulco SFO–ACA international | 1 | 166 | 100% | 1,990 | Aeromexico | Oct 2025 – Oct 2025 |
| San Francisco International → Atlantic City International SFO–ACY | 1 | 151 | 95% | 2,562 | JetBlue Airways | Oct 2025 – Oct 2025 |
| San Francisco International → Albany International SFO–ALB | 1 | 155 | 97% | 2,559 | JetBlue Airways | Jul 2025 – Sep 2025 |
| San Francisco International → Centennial SFO–APA | 1 | 2 | 25% | 957 | Scott Aviation, LLC d/b/a... | Nov 2025 – Nov 2025 |
| San Francisco International → Stockholm SFO–ARN international | 1 | 5 | 42% | 5,360 | AVCON JET MALTA LTD | Jan 2025 – Apr 2026 |
| San Francisco International → Phoenix SFO–AZA | 1 | 115 | 69% | 673 | United Air Lines Inc. | Aug 2025 – Aug 2025 |
| San Francisco International → Hamilton SFO–BDA international | 1 | 1 | 7% | 3,242 | VistaJet Limited | Nov 2025 – Nov 2025 |
| San Francisco International → Birmingham-Shuttlesworth International SFO–BHM | 1 | 175 | 97% | 2,013 | Delta Air Lines Inc. | Jul 2025 – Mar 2026 |
| San Francisco International → Birmingham SFO–BHX international | 1 | 461 | 98% | 5,281 | British Airways Plc | Jun 2026 – Jun 2026 |
| San Francisco International → Billings Logan International SFO–BIL | 1 | 123 | 82% | 909 | United Air Lines Inc. | Jan 2025 – Aug 2025 |
| San Francisco International → Bismarck Municipal SFO–BIS | 1 | 0 | 0% | 1,271 | SkyWest Airlines Inc. | Jun 2026 – Jun 2026 |
| San Francisco International → Leon/Guanajuato SFO–BJX international | 1 | 175 | 97% | 1,696 | Aeromexico | Dec 2025 – Dec 2025 |
| San Francisco International → New Bight SFO–CAT international | 1 | 2 | 14% | 2,899 | VistaJet Limited | Jul 2026 – Jul 2026 |
| San Francisco International → Canberra SFO–CBR international | 1 | 238 | 86% | 7,562 | United Air Lines Inc. | Oct 2025 – Oct 2025 |
| San Francisco International → Lovell Field SFO–CHA | 1 | 154 | 86% | 2,068 | Delta Air Lines Inc. | Nov 2025 – Nov 2025 |
| San Francisco International → North Central West Virginia SFO–CKB | 1 | 0 | 0% | 2,268 | SkyWest Airlines Inc. | Feb 2025 – Mar 2026 |
| San Francisco International → Easterwood Field SFO–CLL | 1 | 134 | 75% | 1,562 | United Air Lines Inc. | Jul 2025 – Jun 2026 |
| San Francisco International → St. Louis Downtown SFO–CPS | 1 | 0 | 0% | 1,748 | Delta Air Lines Inc. | Jun 2026 – Jun 2026 |
| San Francisco International → Duluth International SFO–DLH | 1 | 1 | 7% | 1,661 | Jet Aviation Flight Services, Inc. | Feb 2026 – Feb 2026 |
| San Francisco International → EL Paso International SFO–ELP | 1 | 133 | 80% | 993 | United Air Lines Inc. | Jan 2025 – Jun 2026 |
| San Francisco International → Eastsound SFO–ESD | 1 | 1 | 17% | 766 | Kenmore Air Harbor | Aug 2025 – Aug 2025 |
| San Francisco International → Hector International SFO–FAR | 1 | 124 | 98% | 1,450 | United Air Lines Inc. | Jul 2025 – May 2026 |
| San Francisco International → Figari SFO–FSC international | 1 | 4 | 29% | 6,187 | VistaJet Limited | Aug 2025 – Aug 2025 |
| San Francisco International → Joe Foss Field SFO–FSD | 1 | 159 | 88% | 1,403 | Delta Air Lines Inc. | May 2025 – Feb 2026 |
| San Francisco International → Fort Worth Meacham International SFO–FTW | 1 | 2 | 14% | 1,449 | Jet Aviation Flight Services, Inc. | Jan 2026 – Jan 2026 |
| San Francisco International → Claremore Regional SFO–GCM international | 1 | 3 | 21% | 2,768 | Air Hamburg... | Apr 2026 – Apr 2026 |
| San Francisco International → Great Falls International SFO–GTF | 1 | 0 | 0% | 880 | SkyWest Airlines Inc. | Jan 2026 – Jan 2026 |
| San Francisco International → Guam International SFO–GUM | 1 | 330 | 94% | 5,812 | United Air Lines Inc. | Apr 2025 – Apr 2026 |
| San Francisco International → Helsinki SFO–HEL international | 1 | 2 | 14% | 5,435 | Avcon Jet AG | Oct 2025 – Oct 2025 |
| San Francisco International → Hahn SFO–HHN international | 1 | 0 | | 5,669 | National Air Cargo Group... | Jun 2026 – Jun 2026 |
| San Francisco International → Westchester County SFO–HPN | 1 | 67 | 93% | 2,584 | Delta Air Lines Inc. | Mar 2025 – Jan 2026 |
| San Francisco International → Huntsville Intl-Carl T Jones Field SFO–HSV | 1 | 162 | 99% | 1,990 | Delta Air Lines Inc. | Jul 2026 – Jul 2026 |
| San Francisco International → Hayward Executive SFO–HWD | 1 | 0 | 0% | 14 | Jet Aviation Flight Services, Inc. | Jul 2025 – Jul 2026 |
| San Francisco International → Laughlin/Bullhead International SFO–IFP | 1 | 0 | 0% | 468 | Sun Country Airlines d/b/a... | Mar 2026 – Mar 2026 |
| San Francisco International → Lakeland Linder International SFO–LAL | 1 | 0 | | 2,420 | Air Transport International | Feb 2026 – Feb 2026 |
| San Francisco International → Laramie Regional SFO–LAR | 1 | 0 | 0% | 927 | Alaska Airlines Inc. | Oct 2025 – Oct 2025 |
| San Francisco International → Lincoln SFO–LNK | 1 | 0 | 0% | 1,387 | SkyWest Airlines Inc. | Jan 2025 – Jan 2026 |
| San Francisco International → Manchester Boston Regional SFO–MHT | 1 | 5 | 56% | 2,676 | Scott Aviation, LLC d/b/a... | Aug 2025 – Aug 2025 |
| San Francisco International → Kansas City Downtown/Wheeler Field SFO–MKC | 1 | 65 | 34% | 1,506 | American Airlines Inc. | May 2025 – Aug 2025 |
| San Francisco International → Martha'S Vineyard SFO–MVY | 1 | 33 | 24% | 2,737 | JetBlue Airways | Sep 2025 – Sep 2025 |
| San Francisco International → Mazatlan SFO–MZT international | 1 | 116 | 70% | 1,381 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Francisco International → Nassau SFO–NAS international | 1 | 3 | 23% | 2,765 | Air Hamburg... | Nov 2025 – Nov 2025 |
| San Francisco International → Nagoya SFO–NGO international | 1 | 4 | 29% | 5,324 | VistaJet Limited | Apr 2026 – Apr 2026 |
| San Francisco International → Okinawa SFO–OKA international | 1 | 330 | 91% | 6,125 | Cathay Pacific Airways Ltd. | Feb 2026 – Feb 2026 |
| San Francisco International → Porto SFO–OPO international | 1 | 3 | 21% | 5,583 | Glock Aviation GmbH | Nov 2025 – Nov 2025 |
| San Francisco International → Oslo SFO–OSL international | 1 | 1 | 8% | 5,196 | Air Alsie A/S | Jan 2026 – Jan 2026 |
| San Francisco International → Perugia SFO–PEG international | 1 | 6 | 43% | 6,198 | VistaJet Limited | Sep 2025 – Sep 2025 |
| San Francisco International → Page Municipal SFO–PGA | 1 | 29 | 97% | 604 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| San Francisco International → Beijing SFO–PKX international | 1 | 123 | 45% | 5,949 | United Air Lines Inc. | Jan 2026 – Jan 2026 |
| San Francisco International → Palma Mallorca SFO–PMI international | 1 | 5 | 36% | 6,085 | VistaJet Limited | Aug 2025 – Aug 2025 |
| San Francisco International → Palermo SFO–PMO international | 1 | 6 | 43% | 6,497 | VistaJet Limited | Jul 2026 – Jul 2026 |
| San Francisco International → Sarasota/Bradenton International SFO–SRQ | 1 | 175 | 98% | 2,410 | United Air Lines Inc. | Oct 2025 – Oct 2025 |
| San Francisco International → St. Paul Downtown Holman Field SFO–STP | 1 | 1 | 7% | 1,597 | Jet Aviation Flight Services, Inc. | Sep 2025 – Sep 2025 |
| San Francisco International → Stuttgart SFO–STR international | 1 | 2 | 15% | 5,791 | DCA | Jan 2025 – Nov 2025 |
| San Francisco International → Travis Air Force Base SFO–SUU | 1 | 0 | | 51 | Kalitta Air LLC | Dec 2025 – Dec 2025 |
| San Francisco International → Syracuse Hancock International SFO–SYR | 1 | 126 | 75% | 2,440 | Delta Air Lines Inc. | Mar 2025 – Jul 2026 |
| San Francisco International → Truckee SFO–TKF | 1 | 9 | 56% | 169 | Jet Aviation Flight Services, Inc. | Dec 2025 – Dec 2025 |
| San Francisco International → Tallahassee International SFO–TLH | 1 | 169 | 72% | 2,223 | Delta Air Lines Inc. | Oct 2025 – Oct 2025 |
| San Francisco International → Tallinn SFO–TLL international | 1 | 3 | 21% | 5,490 | VistaJet Limited | Nov 2025 – Nov 2025 |
| San Francisco International → Toulon/Hyeres SFO–TLN international | 1 | 2 | 14% | 6,008 | VistaJet Limited | Jun 2025 – Mar 2026 |
| San Francisco International → Tel Aviv SFO–TLV international | 1 | 2 | 14% | 7,422 | VistaJet Limited | Oct 2025 – Oct 2025 |
| San Francisco International → Taipei SFO–TSA international | 1 | 6 | 43% | 6,455 | VistaJet Limited | Feb 2025 – Nov 2025 |
| San Francisco International → MC Ghee Tyson SFO–TYS | 1 | 150 | 89% | 2,120 | Delta Air Lines Inc. | Mar 2026 – Mar 2026 |
| San Francisco International → Concord SFO–USA | 1 | 6 | 43% | 2,306 | Jet Aviation Flight Services, Inc. | May 2026 – May 2026 |
| San Francisco International → St. Lucia SFO–UVF international | 1 | 3 | 21% | 4,090 | Global Jet Austria, GmbH | Apr 2026 – Apr 2026 |
| San Francisco International → Verona SFO–VRN international | 1 | 2 | 14% | 6,022 | VistaJet Limited | May 2026 – May 2026 |
| San Francisco International → Ottawa SFO–YOW international | 1 | 74 | 44% | 2,446 | Air Canada | May 2026 – May 2026 |
| San Francisco International → Saint John SFO–YSJ international | 1 | 7 | 54% | 2,919 | Air Hamburg... | Mar 2026 – Mar 2026 |
| San Francisco International → Zaragoza SFO–ZAZ international | 1 | 1 | 7% | 5,843 | Gestair, S.A. | Jan 2025 – Sep 2025 |