| Istanbul → John F Kennedy International IST–JFK international | 1,124 | 312,539 | 88% | 48,829,931 | 4,999 |
| John F Kennedy International → Istanbul JFK–IST international | 1,066 | 302,860 | 85% | 23,678,113 | 4,999 |
| Istanbul → Chicago O'Hare International IST–ORD international | 876 | 189,102 | 86% | 67,626,440 | 5,472 |
| Chicago O'Hare International → Istanbul ORD–IST international | 786 | 186,715 | 85% | 32,782,304 | 5,472 |
| Istanbul → Los Angeles International IST–LAX international | 699 | 199,820 | 85% | 23,919,260 | 6,850 |
| Los Angeles International → Istanbul LAX–IST international | 698 | 192,802 | 83% | 21,472,970 | 6,850 |
| Washington Dulles International → Istanbul IAD–IST international | 650 | 178,655 | 85% | 7,939,242 | 5,223 |
| Istanbul → Washington Dulles International IST–IAD international | 648 | 179,464 | 86% | 21,704,544 | 5,223 |
| Miami International → Istanbul MIA–IST international | 599 | 168,943 | 86% | 18,933,739 | 5,966 |
| Istanbul → Miami International IST–MIA international | 598 | 166,792 | 85% | 19,101,006 | 5,966 |
| George Bush Intcntl/Houston → Istanbul IAH–IST international | 545 | 121,532 | 85% | 25,970,132 | 6,370 |
| Hartsfield/Jackson Atlanta International → Istanbul ATL–IST international | 534 | 107,638 | 80% | 29,996,150 | 5,757 |
| Istanbul → San Francisco International IST–SFO international | 518 | 142,841 | 84% | 12,813,440 | 6,704 |
| San Francisco International → Istanbul SFO–IST international | 517 | 140,080 | 82% | 6,074,580 | 6,704 |
| Istanbul → Hartsfield/Jackson Atlanta International IST–ATL international | 463 | 107,120 | 80% | 18,236,582 | 5,757 |
| Istanbul → George Bush Intcntl/Houston IST–IAH international | 461 | 122,162 | 85% | 13,981,843 | 6,370 |
| Dallas-Fort Worth International → Istanbul DFW–IST international | 442 | 111,781 | 81% | 9,181,788 | 6,274 |
| Istanbul → Dallas-Fort Worth International IST–DFW international | 433 | 112,478 | 83% | 10,562,744 | 6,274 |
| Istanbul → Seattle-Tacoma International IST–SEA international | 357 | 98,818 | 84% | 8,410,336 | 6,070 |
| Seattle-Tacoma International → Istanbul SEA–IST international | 356 | 94,726 | 81% | 4,027,148 | 6,070 |
| Detroit Metro Wayne County → Istanbul DTW–IST international | 323 | 81,802 | 80% | 2,960,141 | 5,297 |
| Istanbul → Detroit Metro Wayne County IST–DTW international | 323 | 82,122 | 80% | 8,623,198 | 5,297 |
| Newark Liberty International → Istanbul EWR–IST international | 313 | 88,118 | 87% | 4,528,562 | 5,012 |
| Istanbul → Newark Liberty International IST–EWR international | 312 | 88,145 | 86% | 7,305,351 | 5,012 |
| General Edward Lawrence Logan International → Istanbul BOS–IST international | 306 | 82,647 | 84% | 3,923,502 | 4,812 |
| Istanbul → General Edward Lawrence Logan International IST–BOS international | 305 | 82,221 | 83% | 7,981,142 | 4,812 |
| Denver International → Istanbul DEN–IST international | 188 | 45,603 | 75% | 1,172,100 | 6,128 |
| Istanbul → Denver International IST–DEN international | 187 | 49,084 | 81% | 4,610,476 | 6,128 |
| Miami International → Maastricht MIA–MST international | 119 | 0 | | 295,049 | 4,698 |
| Quito → Miami International UIO–MIA international | 113 | 0 | | 1,505,538 | 1,787 |
| Chicago O'Hare International → Quito ORD–UIO international | 104 | 0 | | 11,521 | 2,957 |
| Liege → Chicago O'Hare International LGG–ORD international | 69 | 0 | | 1,326,271 | 4,205 |
| Mexico City → George Bush Intcntl/Houston NLU–IAH international | 49 | 0 | | 0 | 742 |
| Chicago O'Hare International → Hartsfield/Jackson Atlanta International ORD–ATL | 49 | 0 | | 2,301,706 | 606 |
| John F Kennedy International → Chicago O'Hare International JFK–ORD | 47 | 0 | | 1,152,356 | 740 |
| Liege → John F Kennedy International LGG–JFK international | 45 | 0 | | 1,561,782 | 3,713 |
| Miami International → Hartsfield/Jackson Atlanta International MIA–ATL | 42 | 0 | | 1,279,023 | 594 |
| Liege → Miami International LGG–MIA international | 38 | 0 | | 738,938 | 4,688 |
| John F Kennedy International → Toronto JFK–YYZ international | 37 | 0 | | 2,125,787 | 366 |
| Chicago O'Hare International → George Bush Intcntl/Houston ORD–IAH | 34 | 0 | | 1,665,996 | 925 |
| Hartsfield/Jackson Atlanta International → Toronto ATL–YYZ international | 29 | 0 | | 739,129 | 739 |
| Chicago O'Hare International → Toronto ORD–YYZ international | 17 | 0 | | 800,310 | 436 |
| John F Kennedy International → Quito JFK–UIO international | 12 | 0 | | 0 | 2,822 |
| John F Kennedy International → Hartsfield/Jackson Atlanta International JFK–ATL | 8 | 0 | | 0 | 760 |
| George Bush Intcntl/Houston → Dallas-Fort Worth International IAH–DFW | 6 | 827 | 46% | 0 | 224 |
| Amsterdam → Miami International AMS–MIA international | 3 | 0 | | 43,817 | 4,633 |
| John F Kennedy International → George Bush Intcntl/Houston JFK–IAH | 2 | 0 | | 0 | 1,417 |
| Miami International → Liege MIA–LGG international | 2 | 0 | | 0 | 4,688 |
| Chicago O'Hare International → Dallas-Fort Worth International ORD–DFW | 2 | 0 | | 23,135 | 802 |
| Bogota → Miami International BOG–MIA international | 1 | 0 | | 0 | 1,506 |
| General Edward Lawrence Logan International → John F Kennedy International BOS–JFK | 1 | 299 | 86% | 0 | 187 |
| Cancun → General Edward Lawrence Logan International CUN–BOS international | 1 | 0 | 0% | 0 | 1,734 |
| Dallas-Fort Worth International → Frankfurt DFW–FRA international | 1 | 0 | 0% | 0 | 5,142 |
| Dallas-Fort Worth International → Quito DFW–UIO international | 1 | 0 | | 0 | 2,574 |
| Detroit Metro Wayne County → Chicago O'Hare International DTW–ORD | 1 | 357 | 100% | 0 | 235 |
| Newark Liberty International → Halifax EWR–YHZ international | 1 | 0 | 0% | 0 | 614 |
| Fort Lauderdale/Hollywood International → Istanbul FLL–IST international | 1 | 0 | 0% | 0 | 5,946 |
| Fort Lauderdale/Hollywood International → Miami International FLL–MIA | 1 | 315 | 90% | 0 | 21 |
| Istanbul → Fort Lauderdale/Hollywood International IST–FLL international | 1 | 0 | 0% | 0 | 5,946 |
| John F Kennedy International → Newark Liberty International JFK–EWR | 1 | 316 | 96% | 0 | 21 |
| John F Kennedy International → Washington Dulles International JFK–IAD | 1 | 317 | 91% | 0 | 228 |
| Keflavik/Reykjavik → Dallas-Fort Worth International KEF–DFW international | 1 | 269 | 90% | 0 | 3,742 |
| Keflavik/Reykjavik → Washington Dulles International KEF–IAD international | 1 | 290 | 97% | 0 | 2,798 |
| Chicago O'Hare International → Amsterdam ORD–AMS international | 1 | 0 | 0% | 0 | 4,120 |
| Chicago O'Hare International → Miami International ORD–MIA | 1 | 0 | | 0 | 1,197 |
| Chicago O'Hare International → Goose Bay ORD–YYR international | 1 | 271 | 78% | 60,817 | 1,490 |
| Chicago O'Hare International → St. John'S ORD–YYT international | 1 | 0 | 0% | 0 | 1,756 |
| Oslo → Los Angeles International OSL–LAX international | 1 | 265 | 76% | 0 | 5,345 |
| Edgar County → John F Kennedy International PRG–JFK international | 1 | 131 | 38% | 0 | 4,081 |
| San Francisco International → Copenhagen SFO–CPH international | 1 | 297 | 90% | 20,495 | 5,487 |
| Salt Lake City International → Denver International SLC–DEN | 1 | 0 | 0% | 0 | 391 |
| Shannon → Chicago O'Hare International SNN–ORD international | 1 | 0 | | 0 | 3,590 |
| Edmonton → Los Angeles International YEG–LAX international | 1 | 311 | 95% | 0 | 1,358 |
| Edmonton → Seattle-Tacoma International YEG–SEA international | 1 | 280 | 85% | 0 | 559 |
| Montreal → Hartsfield/Jackson Atlanta International YUL–ATL international | 1 | 258 | 86% | 0 | 994 |
| Montreal → George Bush Intcntl/Houston YUL–IAH international | 1 | 221 | 74% | 0 | 1,584 |
| Toronto → Hartsfield/Jackson Atlanta International YYZ–ATL international | 1 | 0 | | 47,216 | 739 |
| Toronto → Chicago O'Hare International YYZ–ORD international | 1 | 0 | 0% | 0 | 436 |