| Charleston Afb/Intl → Hartsfield/Jackson Atlanta International CHS–ATL | 3,286 | 451,700 | 85% | 259 | Delta Air Lines Inc., Endeavor Air Inc., SkyWest Airlines Inc., Alaska Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Charlotte/Douglas International CHS–CLT | 2,623 | 248,772 | 76% | 168 | American Airlines Inc., PSA Airlines Inc., Envoy Air, Piedmont Airlines +4 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Laguardia CHS–LGA | 2,116 | 138,058 | 80% | 641 | Republic Airline, Endeavor Air Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Chicago O'Hare International CHS–ORD | 2,035 | 172,243 | 76% | 760 | United Air Lines Inc., Envoy Air, Republic Airline, American Airlines Inc. +3 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Ronald Reagan Washington Ntl CHS–DCA | 1,676 | 107,618 | 72% | 444 | PSA Airlines Inc., American Airlines Inc., Republic Airline, Envoy Air +2 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → John F Kennedy International CHS–JFK | 1,635 | 125,103 | 76% | 636 | Endeavor Air Inc., JetBlue Airways, Republic Airline, Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Newark Liberty International CHS–EWR | 1,290 | 152,111 | 76% | 628 | United Air Lines Inc., Spirit Air Lines, Republic Airline | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Baltimore/Washington International Thurgood Marshall CHS–BWI | 1,214 | 133,785 | 70% | 472 | Southwest Airlines Co., Spirit Air Lines, Sun Country Airlines d/b/a..., TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Dallas-Fort Worth International CHS–DFW | 1,190 | 151,977 | 82% | 987 | American Airlines Inc., Envoy Air, PSA Airlines Inc., Frontier Airlines Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Philadelphia International CHS–PHL | 1,159 | 106,950 | 81% | 550 | American Airlines Inc., PSA Airlines Inc., Piedmont Airlines, Frontier Airlines Inc. +4 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → General Edward Lawrence Logan International CHS–BOS | 1,116 | 126,688 | 84% | 818 | JetBlue Airways, Delta Air Lines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Washington Dulles International CHS–IAD | 1,024 | 82,064 | 79% | 442 | United Air Lines Inc., Republic Airline, Mesa Airlines Inc., CommuteAir LLC dba CommuteAir +4 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Miami International CHS–MIA | 999 | 96,163 | 73% | 489 | American Airlines Inc., Envoy Air, Republic Airline, Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Nashville International CHS–BNA | 983 | 111,528 | 69% | 439 | Southwest Airlines Co., Federal Express Corporation, Allegiant Air, SkyWest Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Detroit Metro Wayne County CHS–DTW | 866 | 59,823 | 79% | 667 | Endeavor Air Inc., Delta Air Lines Inc., SkyWest Airlines Inc., Spirit Air Lines +1 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → George Bush Intcntl/Houston CHS–IAH | 682 | 52,951 | 81% | 925 | Mesa Airlines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Denver International CHS–DEN | 633 | 84,697 | 85% | 1,449 | United Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Fort Lauderdale/Hollywood International CHS–FLL | 508 | 55,999 | 67% | 470 | JetBlue Airways, Spirit Air Lines, Breeze Aviation Group DBA Breeze, American Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Tampa International CHS–TPA | 410 | 44,654 | 81% | 370 | Breeze Aviation Group DBA Breeze, American Airlines Inc., JetBlue Airways | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Minneapolis-St Paul Intl/Wold-Chamberlain CHS–MSP | 391 | 47,215 | 85% | 1,087 | Delta Air Lines Inc., Endeavor Air Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Chicago Midway International CHS–MDW | 365 | 41,114 | 69% | 745 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Dallas Love Field CHS–DAL | 360 | 46,682 | 82% | 977 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Seattle-Tacoma International CHS–SEA | 346 | 48,415 | 80% | 2,415 | Alaska Airlines Inc., Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Rhode Island TF Green International CHS–PVD | 318 | 34,774 | 80% | 771 | Breeze Aviation Group DBA Breeze, JetBlue Airways | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Akron-Canton Regional CHS–CAK | 316 | 33,869 | 79% | 558 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Orlando International CHS–MCO | 293 | 31,364 | 78% | 317 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co., American Airlines Inc., JetBlue Airways +3 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Bradley International CHS–BDL | 284 | 29,503 | 80% | 743 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Louis Armstrong New Orleans International CHS–MSY | 284 | 27,347 | 79% | 635 | Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a..., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Westchester County CHS–HPN | 259 | 24,920 | 71% | 663 | Breeze Aviation Group DBA Breeze, JetBlue Airways, Global Crossing Airlines, Inc., CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Cincinnati/Northern Kentucky International CHS–CVG | 249 | 27,854 | 74% | 497 | Breeze Aviation Group DBA Breeze, Allegiant Air, Endeavor Air Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Pittsburgh International CHS–PIT | 245 | 26,053 | 78% | 524 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Tweed/New Haven CHS–HVN | 231 | 25,458 | 76% | 699 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → William P Hobby CHS–HOU | 193 | 22,001 | 70% | 928 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Southwest Florida International CHS–RSW | 166 | 15,169 | 67% | 450 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → John Glenn Columbus International CHS–CMH | 165 | 16,403 | 73% | 514 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co., Republic Airline | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → St. Louis Lambert International CHS–STL | 160 | 17,297 | 68% | 706 | Southwest Airlines Co., Eastern Air Express, LLC (EAX) | Mar 2025 – Jul 2026 |
| Charleston Afb/Intl → Long Island Mac Arthur CHS–ISP | 155 | 16,138 | 79% | 666 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Portland International Jetport CHS–PWM | 133 | 15,425 | 86% | 909 | Breeze Aviation Group DBA Breeze, CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → West Palm Beach/Palm Beach CHS–PBI | 131 | 12,594 | 70% | 428 | Breeze Aviation Group DBA Breeze, American Airlines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Norfolk International CHS–ORF | 129 | 14,406 | 82% | 351 | Breeze Aviation Group DBA Breeze, PSA Airlines Inc., Southwest Airlines Co., Republic Airline | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Austin-Bergstrom International CHS–AUS | 127 | 15,730 | 78% | 1,055 | Southwest Airlines Co. | Mar 2025 – Jul 2026 |
| Charleston Afb/Intl → Albany International CHS–ALB | 114 | 10,437 | 67% | 760 | Breeze Aviation Group DBA Breeze | Jun 2025 – Jul 2026 |
| Charleston Afb/Intl → Frederick Douglass/Greater Rochester International CHS–ROC | 112 | 10,447 | 76% | 717 | Breeze Aviation Group DBA Breeze | May 2025 – Jul 2026 |
| Charleston Afb/Intl → Ted Stevens Anchorage International CHS–ANC | 111 | 0 | | 3,605 | Atlas Air Inc., National Air Cargo Group... | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → New York Stewart International CHS–SWF | 105 | 11,497 | 80% | 677 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Syracuse Hancock International CHS–SYR | 105 | 9,924 | 69% | 736 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Toronto CHS–YYZ international | 105 | 5,363 | 68% | 744 | Jazz Aviation LP, Chartright Air Inc. | Mar 2025 – Jul 2026 |
| Charleston Afb/Intl → Manchester Boston Regional CHS–MHT | 94 | 9,744 | 76% | 836 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Los Angeles International CHS–LAX | 76 | 8,733 | 84% | 2,206 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Louisville Muhammad Ali International CHS–SDF | 76 | 6,982 | 68% | 485 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co., Republic Airline, Allegiant Air | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Richmond International CHS–RIC | 72 | 3,975 | 40% | 353 | Breeze Aviation Group DBA Breeze, JetBlue Airways, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → MC Connell Air Force Base CHS–IAB | 70 | 0 | | 1,025 | Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Patrick Leahy Burlington International CHS–BTV | 61 | 6,670 | 80% | 880 | Breeze Aviation Group DBA Breeze | May 2025 – Jul 2026 |
| Charleston Afb/Intl → Taranto CHS–TAR international | 59 | 0 | | 5,147 | Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Atlantic City International CHS–ACY | 30 | 2,741 | 63% | 545 | Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Feb 2025 – Jul 2026 |
| Charleston Afb/Intl → Indianapolis International CHS–IND | 28 | 3,747 | 78% | 585 | Allegiant Air, American Airlines Inc., United Air Lines Inc., Republic Airline | May 2025 – Jul 2026 |
| Charleston Afb/Intl → Cancun CHS–CUN international | 27 | 1,963 | 53% | 918 | Breeze Aviation Group DBA Breeze | Jan 2026 – Jul 2026 |
| Charleston Afb/Intl → Charleston Afb/Intl CHS–CHS | 24 | 0 | 0% | 0 | Atlas Air Inc., SkyWest Airlines Inc. | Jan 2025 – Jun 2026 |
| Charleston Afb/Intl → Savannah/Hilton Head International CHS–SAV | 20 | 1,722 | 76% | 86 | Southwest Airlines Co., JetBlue Airways, Endeavor Air Inc., Delta Air Lines Inc. +8 | Feb 2025 – Jul 2026 |
| Charleston Afb/Intl → Hamilton CHS–BDA international | 13 | 235 | 25% | 896 | BermudAir | Sep 2025 – Oct 2025 |
| Charleston Afb/Intl → Raleigh-Durham International CHS–RDU | 11 | 661 | 56% | 217 | Endeavor Air Inc., Breeze Aviation Group DBA Breeze, Republic Airline, PSA Airlines Inc. +2 | Feb 2025 – Jul 2026 |
| Charleston Afb/Intl → Kansas City International CHS–MCI | 10 | 1,345 | 84% | 930 | Southwest Airlines Co., Envoy Air, United Air Lines Inc. | Jun 2025 – Jul 2026 |
| Charleston Afb/Intl → Myrtle Beach International CHS–MYR | 10 | 1,051 | 77% | 84 | Breeze Aviation Group DBA Breeze, American Airlines Inc., Spirit Air Lines, Piedmont Airlines +1 | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Gulfport-Biloxi International CHS–GPT | 9 | 1,066 | 64% | 559 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Charleston Afb/Intl → Frederick W Smith Intl/Memphis CHS–MEM | 6 | 258 | 59% | 589 | Federal Express Corporation, Allegiant Air, Atlas Air Inc., United Air Lines Inc. | May 2025 – Jul 2026 |
| Charleston Afb/Intl → Seattle Paine Field International CHS–PAE | 6 | 0 | | 2,419 | Atlas Air Inc. | Jan 2025 – Jun 2026 |
| Charleston Afb/Intl → Columbia Metro CHS–CAE | 5 | 43 | 10% | 95 | Republic Airline, CommuteAir LLC dba CommuteAir, Sun Country Airlines d/b/a... | Apr 2025 – Jul 2026 |
| Charleston Afb/Intl → Laredo International CHS–LRD | 5 | 0 | | 1,217 | Ameristar Air Cargo, USA Jet Airlines Inc., Lynden Air Cargo Airlines | Apr 2025 – Jun 2026 |
| Charleston Afb/Intl → Jacksonville International CHS–JAX | 4 | 318 | 95% | 192 | Endeavor Air Inc., Breeze Aviation Group DBA Breeze, Republic Airline | Jun 2025 – Jul 2026 |
| Charleston Afb/Intl → Rickenbacker International CHS–LCK | 4 | 462 | 64% | 503 | Allegiant Air | May 2025 – Aug 2025 |
| Charleston Afb/Intl → General Mitchell International CHS–MKE | 4 | 308 | 56% | 814 | American Airlines Inc., Southwest Airlines Co., Republic Airline | Feb 2026 – Jul 2026 |
| Charleston Afb/Intl → Hilton Head CHS–HHH | 3 | 72 | 34% | 60 | Republic Airline, Envoy Air | Jul 2025 – Jun 2026 |
| Charleston Afb/Intl → General Downing - Peoria International CHS–PIA | 3 | 234 | 57% | 756 | Allegiant Air, Envoy Air, United Air Lines Inc. | Oct 2025 – Jul 2026 |
| Charleston Afb/Intl → San Antonio International CHS–SAT | 3 | 478 | 92% | 1,114 | American Airlines Inc., Southwest Airlines Co. | Jul 2025 – Jul 2026 |
| Charleston Afb/Intl → Willow Run CHS–YIP | 3 | 0 | | 672 | USA Jet Airlines Inc., Kalitta Charters II | May 2025 – Jun 2026 |
| Charleston Afb/Intl → Lehigh Valley International CHS–ABE | 2 | 136 | 89% | 592 | Endeavor Air Inc., Republic Airline | Dec 2025 – Dec 2025 |
| Charleston Afb/Intl → Augusta Regional AT Bush Field CHS–AGS | 2 | 291 | 82% | 116 | Delta Air Lines Inc. | Nov 2025 – Mar 2026 |
| Charleston Afb/Intl → Lovell Field CHS–CHA | 2 | 293 | 91% | 331 | Delta Air Lines Inc., Southwest Airlines Co. | Jul 2025 – Oct 2025 |
| Charleston Afb/Intl → Cleveland-Hopkins International CHS–CLE | 2 | 31 | 13% | 595 | SkyWest Airlines Inc., Southwest Airlines Co. | Jul 2025 – Mar 2026 |
| Charleston Afb/Intl → University Of Illinois/Willard CHS–CMI | 2 | 106 | 70% | 672 | Envoy Air | Jan 2026 – Mar 2026 |
| Charleston Afb/Intl → City Of Colorado Springs Municipal CHS–COS | 2 | 310 | 95% | 1,438 | United Air Lines Inc., Southwest Airlines Co. | Apr 2025 – Mar 2026 |
| Charleston Afb/Intl → EL Paso International CHS–ELP | 2 | 0 | | 1,538 | Lynden Air Cargo Airlines | Sep 2025 – Dec 2025 |
| Charleston Afb/Intl → Claremore Regional CHS–GCM international | 2 | 260 | 69% | 940 | JetBlue Airways, United Air Lines Inc. | Nov 2025 – Apr 2026 |
| Charleston Afb/Intl → Greenville CHS–GDC | 2 | 0 | | 186 | Ameristar Air Cargo | Jun 2025 – Jul 2026 |
| Charleston Afb/Intl → Okc Will Rogers International CHS–OKC | 2 | 315 | 92% | 1,020 | American Airlines Inc. | Oct 2025 – Jun 2026 |
| Charleston Afb/Intl → Providenciales CHS–PLS international | 2 | 4 | 14% | 902 | VistaJet Limited | Feb 2026 – Mar 2026 |
| Charleston Afb/Intl → Roanoke/Blacksburg Regional (Woodrum Field) CHS–ROA | 2 | 151 | 70% | 305 | Breeze Aviation Group DBA Breeze | Nov 2025 – Jan 2026 |
| Charleston Afb/Intl → Santiago CHS–SCL international | 2 | 0 | | 4,599 | LATAM Airlines Group SA... | Jun 2026 – Jul 2026 |
| Charleston Afb/Intl → Shreveport Regional CHS–SHV | 2 | 251 | 94% | 804 | American Airlines Inc., Envoy Air | Feb 2026 – May 2026 |
| Charleston Afb/Intl → Miami Executive CHS–TMB | 2 | 2 | 9% | 500 | Jet Aviation Flight Services, Inc., Tradewind Aviation | Jan 2026 – Mar 2026 |
| Charleston Afb/Intl → Waco Regional CHS–ACT | 1 | 75 | 99% | 1,009 | Envoy Air | Dec 2025 – Dec 2025 |
| Charleston Afb/Intl → Perot Fld/Fort Worth Alliance CHS–AFW | 1 | 47 | 65% | 1,003 | Delta Air Lines Inc. | Jan 2025 – Oct 2025 |
| Charleston Afb/Intl → Naples Municipal CHS–APF | 1 | 6 | 100% | 476 | Chartright Air Inc. | Mar 2026 – Mar 2026 |
| Charleston Afb/Intl → Athens CHS–ATH international | 1 | 1 | 7% | 5,539 | VistaJet Limited | Feb 2026 – Feb 2026 |
| Charleston Afb/Intl → Augusta State CHS–AUG | 1 | 2 | 25% | 962 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| Charleston Afb/Intl → Wilkes-Barre/Scranton International CHS–AVP | 1 | 42 | 55% | 629 | Republic Airline | Jan 2025 – Sep 2025 |
| Charleston Afb/Intl → Laurence G Hanscom Field CHS–BED | 1 | 2 | 17% | 815 | Air Alsie A/S | Aug 2025 – Aug 2025 |
| Charleston Afb/Intl → Boeing Fld/King County International CHS–BFI | 1 | 2 | 17% | 2,415 | Scott Aviation, LLC d/b/a... | Dec 2025 – Dec 2025 |
| Charleston Afb/Intl → Hancock County/Bar Harbor CHS–BHB | 1 | 1 | 12% | 1,015 | CFM Inc d/b/a Contour... | Jun 2026 – Jun 2026 |
| Charleston Afb/Intl → Bogota CHS–BOG international | 1 | 0 | | 1,977 | National Air Cargo Group... | Apr 2026 – Apr 2026 |
| Charleston Afb/Intl → Brunswick Golden Isles CHS–BQK | 1 | 1 | 7% | 141 | Jet Aviation Flight Services, Inc. | Mar 2026 – Mar 2026 |
| Charleston Afb/Intl → Baton Rouge Metro, Ryan Field CHS–BTR | 1 | 44 | 63% | 674 | Mesa Airlines Inc. | Apr 2025 – Feb 2026 |
| Charleston Afb/Intl → Cuyahoga County CHS–CGF | 1 | 2 | 25% | 603 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Charleston Afb/Intl → Cape Girardeau Regional CHS–CGI | 1 | 106 | 68% | 617 | Allegiant Air | Oct 2025 – Oct 2025 |
| Charleston Afb/Intl → North Central West Virginia CHS–CKB | 1 | 74 | 49% | 441 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| Charleston Afb/Intl → Dothan Regional CHS–DHN | 1 | 0 | | 335 | Kalitta Charters II | Jun 2026 – Jun 2026 |
| Charleston Afb/Intl → Dyess Air Force Base CHS–DYS | 1 | 61 | 34% | 1,154 | Allegiant Air | Feb 2026 – Feb 2026 |
| Charleston Afb/Intl → Coastal Carolina Regional CHS–EWN | 1 | 41 | 82% | 228 | Piedmont Airlines | May 2026 – May 2026 |
| Charleston Afb/Intl → Hector International CHS–FAR | 1 | 153 | 85% | 1,310 | Allegiant Air | Aug 2025 – Aug 2025 |
| Charleston Afb/Intl → Fayetteville Rgnl/Grannis Field CHS–FAY | 1 | 76 | 100% | 159 | PSA Airlines Inc. | Jun 2026 – Jun 2026 |
| Charleston Afb/Intl → Fort Wayne International CHS–FWA | 1 | 69 | 91% | 626 | Envoy Air | Feb 2026 – Feb 2026 |
| Charleston Afb/Intl → Guadalajara CHS–GDL international | 1 | 0 | | 1,666 | National Air Cargo Group... | Sep 2025 – Sep 2025 |
| Charleston Afb/Intl → Gerald R Ford International CHS–GRR | 1 | 146 | 97% | 750 | United Air Lines Inc. | May 2025 – Nov 2025 |
| Charleston Afb/Intl → Greenville Spartanburg International CHS–GSP | 1 | 0 | | 186 | Tatonduk Outfitters... | Apr 2025 – Jul 2026 |
| Charleston Afb/Intl → Huntsville Intl-Carl T Jones Field CHS–HSV | 1 | 89 | 56% | 406 | Delta Air Lines Inc. | Jun 2025 – Jan 2026 |
| Charleston Afb/Intl → Wichita Dwight D Eisenhower Ntl CHS–ICT | 1 | 112 | 67% | 1,034 | United Air Lines Inc. | Aug 2025 – Aug 2025 |
| Charleston Afb/Intl → Wilmington International CHS–ILM | 1 | 0 | 0% | 155 | Republic Airline | Mar 2026 – Mar 2026 |
| Charleston Afb/Intl → Bill And Hillary Clinton Ntl/Adams Field CHS–LIT | 1 | 166 | 95% | 712 | Southwest Airlines Co. | Jun 2025 – May 2026 |
| Charleston Afb/Intl → Lancaster CHS–LNS | 1 | 48 | 35% | 540 | Breeze Aviation Group DBA Breeze | Mar 2026 – Mar 2026 |
| Charleston Afb/Intl → Cincinnati Muni/Lunken Field CHS–LUK | 1 | 77 | 71% | 493 | Breeze Aviation Group DBA Breeze | Nov 2025 – Nov 2025 |
| Charleston Afb/Intl → Harrisburg International CHS–MDT | 1 | 57 | 75% | 535 | PSA Airlines Inc. | Nov 2025 – Nov 2025 |
| Charleston Afb/Intl → MC Allen International CHS–MFE | 1 | 0 | | 1,188 | Ameristar Air Cargo | Oct 2025 – Oct 2025 |
| Charleston Afb/Intl → Smyrna CHS–MQY | 1 | 1 | 8% | 427 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Charleston Afb/Intl → Coles County Memorial CHS–MTO | 1 | 105 | 58% | 646 | Allegiant Air | Oct 2025 – Oct 2025 |
| Charleston Afb/Intl → Miami-Opa Locka Executive CHS–OPF | 1 | 4 | 50% | 482 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| Charleston Afb/Intl → Dekalb-Peachtree CHS–PDK | 1 | 0 | 0% | 255 | Jet Aviation Flight Services, Inc. | Jan 2026 – Jan 2026 |
| Charleston Afb/Intl → Portsmouth International AT Pease CHS–PSM | 1 | 135 | 99% | 863 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Charleston Afb/Intl → Phoenix CHS–SCF | 1 | 4 | 44% | 1,839 | Jet Aviation Flight Services, Inc. | Jun 2026 – Jun 2026 |
| Charleston Afb/Intl → Orlando Sanford International CHS–SFB | 1 | 133 | 75% | 293 | Allegiant Air | Sep 2025 – Sep 2025 |
| Charleston Afb/Intl → San Jose CHS–SJO international | 1 | 12 | 100% | 1,598 | Jet Aviation Flight Services, Inc. | Dec 2025 – Dec 2025 |
| Charleston Afb/Intl → Salt Lake City International CHS–SLC | 1 | 162 | 93% | 1,840 | Southwest Airlines Co. | Jun 2025 – Aug 2025 |
| Charleston Afb/Intl → Sheppard Afb/Wichita Falls Municipal CHS–SPS | 1 | 75 | 99% | 1,067 | PSA Airlines Inc. | Jun 2026 – Jun 2026 |
| Charleston Afb/Intl → St. Paul Downtown Holman Field CHS–STP | 1 | 5 | 38% | 1,084 | Air Hamburg... | Jan 2026 – Jan 2026 |
| Charleston Afb/Intl → Cyril E King CHS–STT | 1 | 9 | 60% | 1,371 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Charleston Afb/Intl → Teterboro CHS–TEB | 1 | 5 | 50% | 640 | Jet Aviation Flight Services, Inc. | Mar 2026 – Mar 2026 |
| Charleston Afb/Intl → Tulsa International CHS–TUL | 1 | 159 | 92% | 931 | American Airlines Inc. | Jul 2025 – Jun 2026 |
| Charleston Afb/Intl → Texarkana Rgnl-Webb Field CHS–TXK | 1 | 68 | 89% | 809 | Envoy Air | Nov 2025 – Nov 2025 |
| Charleston Afb/Intl → Concord CHS–USA | 1 | 0 | 0% | 176 | TEM Enterprises dba Avelo Airlines | Aug 2025 – Aug 2025 |
| Charleston Afb/Intl → Warsaw CHS–WAR | 1 | 8 | 62% | 660 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |