| MC Ghee Tyson → Hartsfield/Jackson Atlanta International TYS–ATL | 2,922 | 283,373 | 87% | 152 | Delta Air Lines Inc., Endeavor Air Inc., American Airlines Inc., United Air Lines Inc. +3 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Charlotte/Douglas International TYS–CLT | 2,726 | 137,348 | 82% | 176 | Piedmont Airlines, PSA Airlines Inc., American Airlines Inc., SkyWest Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Chicago O'Hare International TYS–ORD | 2,610 | 150,305 | 82% | 475 | SkyWest Airlines Inc., PSA Airlines Inc., GoJet Airlines LLC d/b/a..., United Air Lines Inc. +2 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Dallas-Fort Worth International TYS–DFW | 1,666 | 208,833 | 82% | 772 | American Airlines Inc., PSA Airlines Inc., Envoy Air, SkyWest Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Washington Dulles International TYS–IAD | 1,350 | 64,401 | 79% | 420 | CommuteAir LLC dba CommuteAir, Allegiant Air, Mesa Airlines Inc., PSA Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → George Bush Intcntl/Houston TYS–IAH | 1,325 | 64,343 | 89% | 771 | CommuteAir LLC dba CommuteAir, Mesa Airlines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Laguardia TYS–LGA | 1,052 | 56,890 | 74% | 647 | Endeavor Air Inc., Republic Airline, American Airlines Inc. | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Philadelphia International TYS–PHL | 999 | 47,007 | 77% | 555 | Piedmont Airlines, PSA Airlines Inc., Allegiant Air, Delta Air Lines Inc. +1 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Denver International TYS–DEN | 995 | 109,903 | 84% | 1,162 | United Air Lines Inc., SkyWest Airlines Inc., Frontier Airlines Inc., Southwest Airlines Co. +1 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Ronald Reagan Washington Ntl TYS–DCA | 977 | 47,914 | 71% | 437 | PSA Airlines Inc., Republic Airline, American Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Detroit Metro Wayne County TYS–DTW | 920 | 55,020 | 82% | 443 | Endeavor Air Inc., Delta Air Lines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Orlando Sanford International TYS–SFB | 635 | 96,058 | 84% | 511 | Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → St. Pete-Clearwater International TYS–PIE | 518 | 77,178 | 82% | 550 | Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Minneapolis-St Paul Intl/Wold-Chamberlain TYS–MSP | 486 | 32,086 | 87% | 792 | Endeavor Air Inc., Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Miami International TYS–MIA | 484 | 33,759 | 83% | 724 | Envoy Air, American Airlines Inc., Republic Airline, Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Fort Lauderdale/Hollywood International TYS–FLL | 476 | 73,645 | 84% | 709 | Allegiant Air, Jet Aviation Flight Services, Inc., Envoy Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Louisville Muhammad Ali International TYS–SDF | 372 | 82 | 16% | 189 | United Parcel Service, Federal Express Corporation, Jet Aviation Flight Services, Inc., Global Crossing Airlines, Inc. +3 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Nashville International TYS–BNA | 312 | 31,760 | 73% | 152 | Southwest Airlines Co., SkyWest Airlines Inc., American Airlines Inc., Republic Airline +6 | Apr 2025 – Jul 2026 |
| MC Ghee Tyson → Frederick W Smith Intl/Memphis TYS–MEM | 283 | 2,814 | 60% | 342 | Federal Express Corporation, Allegiant Air, United Parcel Service | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Orlando International TYS–MCO | 258 | 33,353 | 82% | 532 | Southwest Airlines Co., Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Punta Gorda TYS–PGD | 220 | 32,040 | 81% | 624 | Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Baltimore/Washington International Thurgood Marshall TYS–BWI | 151 | 16,022 | 78% | 464 | Southwest Airlines Co., Endeavor Air Inc., Global Crossing Airlines, Inc., PSA Airlines Inc. | Oct 2025 – Jul 2026 |
| MC Ghee Tyson → Dallas Love Field TYS–DAL | 150 | 18,682 | 82% | 762 | Southwest Airlines Co., TEM Enterprises dba Avelo Airlines | Feb 2025 – Jul 2026 |
| MC Ghee Tyson → General Edward Lawrence Logan International TYS–BOS | 146 | 22,192 | 84% | 830 | Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Newark Liberty International TYS–EWR | 144 | 23,007 | 89% | 631 | Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Phoenix Sky Harbor International TYS–PHX | 122 | 19,950 | 91% | 1,599 | Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Eglin Afb/Destin-Ft Walton Beach TYS–VPS | 121 | 16,441 | 77% | 395 | Allegiant Air | Mar 2025 – Jul 2026 |
| MC Ghee Tyson → Harry Reid International TYS–LAS | 120 | 18,835 | 89% | 1,739 | Allegiant Air, Delta Air Lines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Sarasota/Bradenton International TYS–SRQ | 107 | 13,939 | 72% | 586 | Allegiant Air | Feb 2025 – Jul 2026 |
| MC Ghee Tyson → Jacksonville International TYS–JAX | 106 | 13,857 | 73% | 390 | Allegiant Air | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Key West International TYS–EYW | 85 | 10,323 | 69% | 787 | Allegiant Air | Oct 2025 – Jul 2026 |
| MC Ghee Tyson → Austin-Bergstrom International TYS–AUS | 80 | 11,313 | 81% | 882 | Allegiant Air, Global Crossing Airlines, Inc., CommuteAir LLC dba CommuteAir, American Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Indianapolis International TYS–IND | 74 | 47 | 9% | 297 | Federal Express Corporation, Sun Country Airlines d/b/a..., Endeavor Air Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → William P Hobby TYS–HOU | 58 | 8,265 | 81% | 782 | Allegiant Air, Jet Aviation Flight Services, Inc., CommuteAir LLC dba CommuteAir, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Chicago Midway International TYS–MDW | 58 | 8,416 | 80% | 459 | Allegiant Air, Delta Air Lines Inc. | May 2025 – Jul 2026 |
| MC Ghee Tyson → Tweed/New Haven TYS–HVN | 56 | 6,659 | 73% | 709 | TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Tri-State/Milton J Ferguson Field TYS–HTS | 44 | 0 | | 193 | Federal Express Corporation | Feb 2025 – Jul 2026 |
| MC Ghee Tyson → Gulf Shores TYS–GUF | 26 | 2,835 | 61% | 436 | Allegiant Air | May 2025 – Jul 2026 |
| MC Ghee Tyson → Alexandria International TYS–AEX | 17 | 236 | 22% | 582 | Air Wisconsin Airlines Corp, Eastern Air Express, LLC (EAX), Global Crossing Airlines, Inc. | Sep 2025 – Jul 2026 |
| MC Ghee Tyson → South Bend International TYS–SBN | 15 | 950 | 46% | 426 | Allegiant Air, SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Rickenbacker International TYS–LCK | 14 | 0 | | 282 | Federal Express Corporation | Apr 2025 – Jul 2026 |
| MC Ghee Tyson → MC Ghee Tyson TYS–TYS | 14 | 0 | 0% | 0 | SkyWest Airlines Inc. | Feb 2025 – Jul 2026 |
| MC Ghee Tyson → Gulfport-Biloxi International TYS–GPT | 9 | 863 | 52% | 475 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Okc Will Rogers International TYS–OKC | 9 | 750 | 65% | 766 | American Airlines Inc., Delta Air Lines Inc., SkyWest Airlines Inc., CommuteAir LLC dba CommuteAir +2 | Feb 2025 – May 2026 |
| MC Ghee Tyson → Tampa International TYS–TPA | 9 | 1,031 | 67% | 547 | Southwest Airlines Co., Allegiant Air | Sep 2025 – Jul 2026 |
| MC Ghee Tyson → Birmingham-Shuttlesworth International TYS–BHM | 6 | 446 | 73% | 221 | Endeavor Air Inc., Delta Air Lines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Atlantic City International TYS–ACY | 5 | 530 | 57% | 574 | Sun Country Airlines d/b/a... | May 2025 – Jul 2026 |
| MC Ghee Tyson → Scott Afb/Midamerica St. Louis TYS–BLV | 5 | 583 | 65% | 373 | Allegiant Air | Jan 2025 – Aug 2025 |
| MC Ghee Tyson → Lovell Field TYS–CHA | 5 | 274 | 76% | 87 | Endeavor Air Inc., Delta Air Lines Inc., SkyWest Airlines Inc., Piedmont Airlines | Mar 2025 – Jul 2026 |
| MC Ghee Tyson → Easterwood Field TYS–CLL | 5 | 286 | 63% | 801 | Ameristar Air Cargo, CommuteAir LLC dba CommuteAir, Global Crossing Airlines, Inc., Breeze Aviation Group DBA Breeze | Jan 2025 – Feb 2026 |
| MC Ghee Tyson → Gainesville Regional TYS–GNV | 5 | 436 | 80% | 433 | Delta Air Lines Inc., Endeavor Air Inc., Breeze Aviation Group DBA Breeze, Air Wisconsin Airlines Corp | Jan 2025 – Mar 2026 |
| MC Ghee Tyson → Northwest Arkansas Ntl TYS–XNA | 5 | 346 | 52% | 578 | Endeavor Air Inc., Delta Air Lines Inc., Global Crossing Airlines, Inc., Sun Country Airlines d/b/a... +1 | Jan 2025 – Jul 2026 |
| MC Ghee Tyson → Athens/Ben Epps TYS–AHN | 4 | 263 | 60% | 134 | Delta Air Lines Inc. | Sep 2025 – Feb 2026 |
| MC Ghee Tyson → Asheville Regional TYS–AVL | 4 | 83 | 42% | 86 | GoJet Airlines LLC d/b/a..., CFM Inc d/b/a Contour..., Envoy Air, SkyWest Airlines Inc. | May 2025 – Jun 2026 |
| MC Ghee Tyson → Hector International TYS–FAR | 4 | 0 | 0% | 1,013 | SkyWest Airlines Inc., Sun Country Airlines d/b/a... | Dec 2025 – Jun 2026 |
| MC Ghee Tyson → Golden Triangle Regional TYS–GTR | 4 | 337 | 61% | 308 | Delta Air Lines Inc., Southwest Airlines Co. | Sep 2025 – Apr 2026 |
| MC Ghee Tyson → Huntsville Intl-Carl T Jones Field TYS–HSV | 4 | 145 | 82% | 177 | United Parcel Service, CommuteAir LLC dba CommuteAir, PSA Airlines Inc., Piedmont Airlines | Jan 2025 – May 2026 |
| MC Ghee Tyson → Blue Grass TYS–LEX | 4 | 143 | 49% | 157 | SkyWest Airlines Inc., Envoy Air, PSA Airlines Inc. | Nov 2025 – Jul 2026 |
| MC Ghee Tyson → General Mitchell International TYS–MKE | 4 | 0 | 0% | 535 | Air Wisconsin Airlines Corp, SkyWest Airlines Inc., Sun Country Airlines d/b/a... | May 2025 – May 2026 |
| MC Ghee Tyson → Savannah/Hilton Head International TYS–SAV | 4 | 249 | 66% | 300 | Allegiant Air, CFM Inc d/b/a Contour..., SkyWest Airlines Inc., Southwest Airlines Co. | Nov 2025 – Jul 2026 |
| MC Ghee Tyson → Baton Rouge Metro, Ryan Field TYS–BTR | 3 | 138 | 51% | 551 | Delta Air Lines Inc., Breeze Aviation Group DBA Breeze, Air Wisconsin Airlines Corp | Jan 2025 – Apr 2026 |
| MC Ghee Tyson → Columbia Metro TYS–CAE | 3 | 147 | 50% | 208 | Delta Air Lines Inc., PSA Airlines Inc. | Dec 2025 – Mar 2026 |
| MC Ghee Tyson → John Glenn Columbus International TYS–CMH | 3 | 93 | 33% | 295 | Endeavor Air Inc., Delta Air Lines Inc., GoJet Airlines LLC d/b/a... | Mar 2025 – Jul 2026 |
| MC Ghee Tyson → Louis Armstrong New Orleans International TYS–MSY | 3 | 61 | 14% | 541 | Sun Country Airlines d/b/a..., PSA Airlines Inc. | Aug 2025 – May 2026 |
| MC Ghee Tyson → Richmond International TYS–RIC | 3 | 97 | 69% | 389 | PSA Airlines Inc., Tatonduk Outfitters... | Apr 2025 – Feb 2026 |
| MC Ghee Tyson → San Antonio International TYS–SAT | 3 | 465 | 85% | 947 | American Airlines Inc., Sun Country Airlines d/b/a... | Sep 2025 – Jun 2026 |
| MC Ghee Tyson → Tuscaloosa Ntl TYS–TCL | 3 | 138 | 51% | 272 | Delta Air Lines Inc., Air Wisconsin Airlines Corp | Jan 2026 – Feb 2026 |
| MC Ghee Tyson → Tri-Cities TYS–TRI | 3 | 126 | 60% | 100 | Endeavor Air Inc., Envoy Air | Feb 2025 – Jul 2026 |
| MC Ghee Tyson → Willow Run TYS–YIP | 3 | 0 | 0% | 445 | USA Jet Airlines Inc., Air Wisconsin Airlines Corp | Jan 2026 – Jul 2026 |
| MC Ghee Tyson → Toronto TYS–YYZ international | 3 | 7 | 4% | 590 | Chartright Air Inc., Sun Country Airlines d/b/a... | Aug 2025 – May 2026 |
| MC Ghee Tyson → Fairhope TYS–AL6 | 2 | 4 | 25% | 432 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| MC Ghee Tyson → Bradley International TYS–BDL | 2 | 159 | 63% | 741 | Delta Air Lines Inc., TEM Enterprises dba Avelo Airlines | Feb 2025 – Jan 2026 |
| MC Ghee Tyson → Columbia Regional TYS–COU | 2 | 89 | 56% | 498 | Delta Air Lines Inc., Air Wisconsin Airlines Corp | Feb 2025 – Apr 2026 |
| MC Ghee Tyson → Cincinnati/Northern Kentucky International TYS–CVG | 2 | 0 | 0% | 226 | SkyWest Airlines Inc., Sun Country Airlines d/b/a... | Sep 2025 – Jun 2026 |
| MC Ghee Tyson → James M Cox Dayton International TYS–DAY | 2 | 99 | 86% | 282 | GoJet Airlines LLC d/b/a..., PSA Airlines Inc. | Mar 2025 – Mar 2026 |
| MC Ghee Tyson → Gerald R Ford International TYS–GRR | 2 | 65 | 57% | 495 | PSA Airlines Inc., SkyWest Airlines Inc. | Mar 2025 – Jun 2026 |
| MC Ghee Tyson → Greenville Spartanburg International TYS–GSP | 2 | 95 | 95% | 118 | GoJet Airlines LLC d/b/a..., Piedmont Airlines | Feb 2025 – Jan 2026 |
| MC Ghee Tyson → Valley International TYS–HRL | 2 | 139 | 40% | 1,043 | Global Crossing Airlines, Inc. | Aug 2025 – May 2026 |
| MC Ghee Tyson → Niagara Falls International TYS–IAG | 2 | 0 | | 571 | USA Jet Airlines Inc. | Feb 2026 – Feb 2026 |
| MC Ghee Tyson → Laughlin/Bullhead International TYS–IFP | 2 | 341 | 92% | 1,717 | Sun Country Airlines d/b/a... | Feb 2025 – Mar 2026 |
| MC Ghee Tyson → John F Kennedy International TYS–JFK | 2 | 73 | 41% | 647 | Endeavor Air Inc., Delta Air Lines Inc. | Sep 2025 – Dec 2025 |
| MC Ghee Tyson → Los Angeles International TYS–LAX | 2 | 84 | 23% | 1,949 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| MC Ghee Tyson → General Downing - Peoria International TYS–PIA | 2 | 65 | 50% | 456 | Envoy Air, SkyWest Airlines Inc. | Aug 2025 – Jul 2026 |
| MC Ghee Tyson → Raleigh-Durham International TYS–RDU | 2 | 101 | 50% | 292 | Endeavor Air Inc., American Airlines Inc. | Feb 2025 – Nov 2025 |
| MC Ghee Tyson → Reno/Tahoe International TYS–RNO | 2 | 308 | 83% | 1,965 | Sun Country Airlines d/b/a... | Mar 2025 – Feb 2026 |
| MC Ghee Tyson → Shreveport Regional TYS–SHV | 2 | 195 | 86% | 609 | American Airlines Inc., PSA Airlines Inc. | Jun 2025 – Nov 2025 |
| MC Ghee Tyson → St. Louis Lambert International TYS–STL | 2 | 53 | 82% | 405 | PSA Airlines Inc., USA Jet Airlines Inc. | Jun 2025 – Mar 2026 |
| MC Ghee Tyson → University-Oxford TYS–UOX | 2 | 0 | 0% | 329 | SkyWest Airlines Inc. | Feb 2025 – Mar 2026 |
| MC Ghee Tyson → Lehigh Valley International TYS–ABE | 1 | 48 | 63% | 572 | Endeavor Air Inc. | Dec 2025 – Dec 2025 |
| MC Ghee Tyson → Albuquerque International Sunport TYS–ABQ | 1 | 126 | 92% | 1,275 | Southwest Airlines Co. | Jul 2026 – Jul 2026 |
| MC Ghee Tyson → Scottsbluff/Western Nebraska Rgnl/Wm B Heilig Field TYS–BFF | 1 | 0 | 0% | 1,134 | SkyWest Airlines Inc. | Dec 2025 – Dec 2025 |
| MC Ghee Tyson → Central IL Rgnl/Bloomington-Normal TYS–BMI | 1 | 0 | 0% | 419 | Sun Country Airlines d/b/a... | Apr 2026 – Apr 2026 |
| MC Ghee Tyson → Brownsville/South Padre Island International TYS–BRO | 1 | 0 | | 1,048 | USA Jet Airlines Inc. | Jan 2026 – Jan 2026 |
| MC Ghee Tyson → Patrick Leahy Burlington International TYS–BTV | 1 | 0 | 0% | 827 | SkyWest Airlines Inc. | Jun 2026 – Jun 2026 |
| MC Ghee Tyson → Hollywood Burbank TYS–BUR | 1 | 2 | 14% | 1,942 | Jet Aviation Flight Services, Inc. | May 2026 – May 2026 |
| MC Ghee Tyson → Charleston Afb/Intl TYS–CHS | 1 | 114 | 60% | 302 | Allegiant Air | Jul 2025 – Mar 2026 |
| MC Ghee Tyson → The Eastern Iowa TYS–CID | 1 | 86 | 68% | 590 | United Air Lines Inc. | Sep 2025 – Sep 2025 |
| MC Ghee Tyson → Carlsbad TYS–CLD | 1 | 6 | 67% | 1,900 | Scott Aviation, LLC d/b/a... | Aug 2025 – Aug 2025 |
| MC Ghee Tyson → City Of Colorado Springs Municipal TYS–COS | 1 | 128 | 93% | 1,157 | Southwest Airlines Co. | Feb 2025 – Jun 2026 |
| MC Ghee Tyson → Corpus Christi International TYS–CRP | 1 | 43 | 57% | 967 | Mesa Airlines Inc. | Jun 2026 – Jun 2026 |
| MC Ghee Tyson → Duluth International TYS–DLH | 1 | 0 | 0% | 871 | SkyWest Airlines Inc. | Mar 2026 – Mar 2026 |
| MC Ghee Tyson → Northwest Florida Beaches International TYS–ECP | 1 | 6 | 75% | 390 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| MC Ghee Tyson → Kalispell TYS–FCA | 1 | 0 | 0% | 1,763 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| MC Ghee Tyson → Fort Wayne International TYS–FWA | 1 | 66 | 87% | 362 | Envoy Air | Feb 2025 – Jun 2026 |
| MC Ghee Tyson → Canton TYS–GA6 | 1 | 0 | 0% | 106 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| MC Ghee Tyson → Piedmont Triad International TYS–GSO | 1 | 49 | 98% | 228 | Piedmont Airlines | Mar 2025 – Feb 2026 |
| MC Ghee Tyson → Hilton Head TYS–HHH | 1 | 4 | 25% | 311 | Jet Aviation Flight Services, Inc. | May 2026 – May 2026 |
| MC Ghee Tyson → Wichita Dwight D Eisenhower Ntl TYS–ICT | 1 | 0 | 0% | 756 | SkyWest Airlines Inc. | Apr 2026 – Apr 2026 |
| MC Ghee Tyson → Laredo International TYS–LRD | 1 | 0 | | 1,073 | USA Jet Airlines Inc. | Jan 2026 – Jan 2026 |
| MC Ghee Tyson → Las Cruces International TYS–LRU | 1 | 150 | 81% | 1,334 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |
| MC Ghee Tyson → Lynchburg Rgnl/Preston Glenn Field TYS–LYH | 1 | 0 | 0% | 286 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| MC Ghee Tyson → Midland International Air And Space Port TYS–MAF | 1 | 161 | 94% | 1,078 | American Airlines Inc. | Jun 2026 – Jun 2026 |
| MC Ghee Tyson → Harrisburg International TYS–MDT | 1 | 29 | 58% | 497 | Piedmont Airlines | May 2025 – Jul 2026 |
| MC Ghee Tyson → MC Allen International TYS–MFE | 1 | 0 | | 1,073 | Ameristar Air Cargo | Sep 2025 – Sep 2025 |
| MC Ghee Tyson → Montgomery Regional (Dannelly Field) TYS–MGM | 1 | 70 | 92% | 278 | Endeavor Air Inc. | Apr 2026 – Apr 2026 |
| MC Ghee Tyson → Mitchell Municipal TYS–MHE | 1 | 18 | 95% | 926 | CFM Inc d/b/a Contour... | Nov 2025 – Nov 2025 |
| MC Ghee Tyson → Quad Cities International TYS–MLI | 1 | 8 | 62% | 524 | CFM Inc d/b/a Contour... | Jun 2025 – Jun 2026 |
| MC Ghee Tyson → Morristown Municipal TYS–MMU | 1 | 1 | 12% | 623 | CFM Inc d/b/a Contour... | Apr 2025 – Jun 2026 |
| MC Ghee Tyson → Taylorsville TYS–NC2 | 1 | 0 | 0% | 316 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| MC Ghee Tyson → Miami-Opa Locka Executive TYS–OPF | 1 | 4 | 50% | 717 | CFM Inc d/b/a Contour... | Feb 2025 – May 2026 |
| MC Ghee Tyson → Norfolk International TYS–ORF | 1 | 0 | 0% | 441 | CFM Inc d/b/a Contour... | Mar 2025 – Nov 2025 |
| MC Ghee Tyson → Owensboro/Daviess County Regional TYS–OWB | 1 | 0 | 0% | 221 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| MC Ghee Tyson → Waterbury-Oxford TYS–OXC | 1 | 0 | 0% | 705 | Jet Aviation Flight Services, Inc. | Jun 2026 – Jun 2026 |
| MC Ghee Tyson → West Palm Beach/Palm Beach TYS–PBI | 1 | 172 | 96% | 670 | Allegiant Air | Jul 2026 – Jul 2026 |
| MC Ghee Tyson → Pensacola International TYS–PNS | 1 | 0 | 0% | 412 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| MC Ghee Tyson → Oakland County International TYS–PTK | 1 | 4 | 50% | 474 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| MC Ghee Tyson → Rhode Island TF Green International TYS–PVD | 1 | 142 | 79% | 790 | Allegiant Air | Jun 2026 – Jun 2026 |
| MC Ghee Tyson → Roanoke/Blacksburg Regional (Woodrum Field) TYS–ROA | 1 | 0 | | 247 | United Parcel Service | Jan 2025 – Aug 2025 |
| MC Ghee Tyson → Southwest Florida International TYS–RSW | 1 | 69 | 91% | 653 | Endeavor Air Inc. | Jan 2026 – Jan 2026 |
| MC Ghee Tyson → Phoenix TYS–SCF | 1 | 2 | 12% | 1,591 | Jet Aviation Flight Services, Inc. | May 2026 – May 2026 |
| MC Ghee Tyson → San Francisco International TYS–SFO | 1 | 93 | 52% | 2,120 | United Air Lines Inc. | Jan 2026 – Jan 2026 |
| MC Ghee Tyson → St. Simons Island TYS–SSI | 1 | 7 | 88% | 355 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| MC Ghee Tyson → Syracuse Hancock International TYS–SYR | 1 | 52 | 47% | 656 | Delta Air Lines Inc. | Apr 2025 – Dec 2025 |
| MC Ghee Tyson → Teterboro TYS–TEB | 1 | 2 | 25% | 641 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| MC Ghee Tyson → Tulsa International TYS–TUL | 1 | 113 | 66% | 667 | American Airlines Inc. | Apr 2025 – Apr 2026 |
| MC Ghee Tyson → Concord TYS–USA | 1 | 84 | 46% | 187 | TEM Enterprises dba Avelo Airlines | Feb 2026 – Feb 2026 |
| MC Ghee Tyson → Van Nuys TYS–VNY | 1 | 7 | 78% | 1,950 | Scott Aviation, LLC d/b/a... | Sep 2025 – Sep 2025 |
