| Greenville Spartanburg International → Charlotte/Douglas International GSP–CLT | 3,006 | 168,796 | 82% | 75 | Piedmont Airlines, PSA Airlines Inc., American Airlines Inc., Envoy Air +5 | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Hartsfield/Jackson Atlanta International GSP–ATL | 2,849 | 334,167 | 85% | 153 | Delta Air Lines Inc., Endeavor Air Inc., United Parcel Service, Southwest Airlines Co. +5 | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Laguardia GSP–LGA | 2,040 | 105,527 | 72% | 610 | Endeavor Air Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Chicago O'Hare International GSP–ORD | 1,993 | 114,986 | 85% | 577 | Envoy Air, SkyWest Airlines Inc., GoJet Airlines LLC d/b/a..., Republic Airline +5 | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Dallas-Fort Worth International GSP–DFW | 1,136 | 126,989 | 83% | 862 | American Airlines Inc., Envoy Air, PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Philadelphia International GSP–PHL | 1,080 | 48,653 | 75% | 515 | Piedmont Airlines, PSA Airlines Inc., United Parcel Service, American Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Ronald Reagan Washington Ntl GSP–DCA | 966 | 49,314 | 76% | 396 | PSA Airlines Inc., Republic Airline, American Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Detroit Metro Wayne County GSP–DTW | 868 | 61,697 | 80% | 508 | Delta Air Lines Inc., Endeavor Air Inc., SkyWest Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Newark Liberty International GSP–EWR | 854 | 48,356 | 78% | 594 | Republic Airline, GoJet Airlines LLC d/b/a..., National Air Cargo Group... | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Washington Dulles International GSP–IAD | 852 | 37,937 | 89% | 384 | CommuteAir LLC dba CommuteAir, GoJet Airlines LLC d/b/a..., Mesa Airlines Inc., Republic Airline +1 | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Miami International GSP–MIA | 723 | 41,761 | 76% | 637 | Envoy Air, Republic Airline, Global Crossing Airlines, Inc., Amerijet International | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Baltimore/Washington International Thurgood Marshall GSP–BWI | 710 | 70,506 | 70% | 426 | Southwest Airlines Co., Global Crossing Airlines, Inc., Mesa Airlines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Nashville International GSP–BNA | 665 | 75,219 | 77% | 265 | Southwest Airlines Co., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → George Bush Intcntl/Houston GSP–IAH | 665 | 42,165 | 86% | 837 | Mesa Airlines Inc., SkyWest Airlines Inc., American Airlines Inc., PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Denver International GSP–DEN | 356 | 35,869 | 89% | 1,278 | United Air Lines Inc., SkyWest Airlines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Piedmont Triad International GSP–GSO | 352 | 0 | | 153 | Federal Express Corporation, United Parcel Service | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Frederick W Smith Intl/Memphis GSP–MEM | 248 | 0 | | 440 | Federal Express Corporation, Ameristar Air Cargo, USA Jet Airlines Inc. | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Louisville Muhammad Ali International GSP–SDF | 210 | 308 | 60% | 299 | United Parcel Service, Delta Air Lines Inc., Allegiant Air, PSA Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → William P Hobby GSP–HOU | 170 | 17,402 | 69% | 845 | Southwest Airlines Co. | Jan 2025 – Mar 2026 |
| Greenville Spartanburg International → Liege GSP–LGG international | 159 | 0 | | 4,321 | Atlas Air Inc., Air Atlanta Icelandic, National Air Cargo Group... | Apr 2025 – Jul 2026 |
| Greenville Spartanburg International → Tampa International GSP–TPA | 159 | 17,622 | 84% | 477 | Breeze Aviation Group DBA Breeze, Allegiant Air, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Fort Lauderdale/Hollywood International GSP–FLL | 147 | 22,253 | 85% | 620 | Allegiant Air, Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Orlando Sanford International GSP–SFB | 133 | 19,710 | 81% | 426 | Allegiant Air | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → St. Pete-Clearwater International GSP–PIE | 129 | 18,208 | 78% | 482 | Allegiant Air | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Rhode Island TF Green International GSP–PVD | 117 | 12,287 | 77% | 751 | Breeze Aviation Group DBA Breeze, CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Orlando International GSP–MCO | 111 | 11,264 | 74% | 449 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co. | Mar 2025 – Jul 2026 |
| Greenville Spartanburg International → Southwest Florida International GSP–RSW | 108 | 11,270 | 77% | 577 | Breeze Aviation Group DBA Breeze, American Airlines Inc., CFM Inc d/b/a Contour... | May 2025 – Jul 2026 |
| Greenville Spartanburg International → Tweed/New Haven GSP–HVN | 107 | 14,046 | 81% | 671 | TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Bradley International GSP–BDL | 104 | 11,154 | 78% | 709 | Breeze Aviation Group DBA Breeze | Apr 2025 – Jul 2026 |
| Greenville Spartanburg International → Sarasota/Bradenton International GSP–SRQ | 104 | 12,437 | 66% | 517 | Allegiant Air | Feb 2025 – Jul 2026 |
| Greenville Spartanburg International → Pittsburgh International GSP–PIT | 75 | 8,203 | 81% | 401 | Breeze Aviation Group DBA Breeze, Endeavor Air Inc., Republic Airline | Feb 2025 – Jul 2026 |
| Greenville Spartanburg International → Los Angeles International GSP–LAX | 72 | 8,299 | 83% | 2,057 | Breeze Aviation Group DBA Breeze, National Air Cargo Group... | Apr 2025 – Jul 2026 |
| Greenville Spartanburg International → Indianapolis International GSP–IND | 38 | 234 | 79% | 401 | Federal Express Corporation, Allegiant Air, GoJet Airlines LLC d/b/a..., Envoy Air | Jun 2025 – May 2026 |
| Greenville Spartanburg International → Ted Stevens Anchorage International GSP–ANC | 28 | 0 | | 3,420 | Amerijet International, National Air Cargo Group... | Jan 2025 – Nov 2025 |
| Greenville Spartanburg International → John Glenn Columbus International GSP–CMH | 27 | 2,978 | 82% | 354 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, Republic Airline | Mar 2025 – Jul 2026 |
| Greenville Spartanburg International → Bogota GSP–BOG international | 25 | 0 | | 2,141 | Amerijet International | Mar 2025 – Nov 2025 |
| Greenville Spartanburg International → Laredo International GSP–LRD | 16 | 0 | | 1,137 | Tatonduk Outfitters..., USA Jet Airlines Inc., Gulf And Caribbean Cargo, Kalitta Charters II | Jan 2025 – Jun 2026 |
| Greenville Spartanburg International → Columbia Metro GSP–CAE | 14 | 144 | 90% | 91 | United Parcel Service, CommuteAir LLC dba CommuteAir, Delta Air Lines Inc., Federal Express Corporation | Jun 2025 – Jul 2026 |
| Greenville Spartanburg International → Cincinnati/Northern Kentucky International GSP–CVG | 10 | 943 | 73% | 317 | Breeze Aviation Group DBA Breeze, Envoy Air | Feb 2025 – Jul 2026 |
| Greenville Spartanburg International → Greenville Spartanburg International GSP–GSP | 10 | 0 | 0% | 0 | SkyWest Airlines Inc., Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Westchester County GSP–HPN | 10 | 922 | 67% | 630 | Breeze Aviation Group DBA Breeze | May 2025 – Sep 2025 |
| Greenville Spartanburg International → Willow Run GSP–YIP | 9 | 0 | | 512 | USA Jet Airlines Inc., Ameristar Air Cargo | Oct 2025 – Jul 2026 |
| Greenville Spartanburg International → Gulfport-Biloxi International GSP–GPT | 8 | 906 | 61% | 505 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Jacksonville International GSP–JAX | 7 | 31 | 9% | 305 | Ameristar Air Cargo, Kalitta Charters II, National Air Cargo Group..., Air Wisconsin Airlines Corp | Mar 2025 – Jun 2026 |
| Greenville Spartanburg International → Atlantic City International GSP–ACY | 6 | 926 | 83% | 526 | Sun Country Airlines d/b/a... | Mar 2025 – Jun 2026 |
| Greenville Spartanburg International → Raleigh-Durham International GSP–RDU | 6 | 560 | 79% | 205 | Delta Air Lines Inc., Endeavor Air Inc., Ameristar Air Cargo, Breeze Aviation Group DBA Breeze +1 | Jan 2025 – Jan 2026 |
| Greenville Spartanburg International → Baton Rouge Metro, Ryan Field GSP–BTR | 5 | 561 | 84% | 601 | Breeze Aviation Group DBA Breeze, Endeavor Air Inc., Delta Air Lines Inc., Allegiant Air | Mar 2025 – Mar 2026 |
| Greenville Spartanburg International → John F Kennedy International GSP–JFK | 5 | 591 | 50% | 608 | National Air Cargo Group..., Endeavor Air Inc., Delta Air Lines Inc. | Dec 2025 – Dec 2025 |
| Greenville Spartanburg International → Tallahassee International GSP–TLH | 5 | 431 | 66% | 334 | Breeze Aviation Group DBA Breeze, Delta Air Lines Inc., Envoy Air | Nov 2025 – May 2026 |
| Greenville Spartanburg International → Asheville Regional GSP–AVL | 4 | 177 | 51% | 42 | JetBlue Airways, Delta Air Lines Inc., GoJet Airlines LLC d/b/a..., Piedmont Airlines | Feb 2025 – Jul 2026 |
| Greenville Spartanburg International → Minneapolis-St Paul Intl/Wold-Chamberlain GSP–MSP | 4 | 150 | 22% | 902 | Sun Country Airlines d/b/a..., American Airlines Inc., Allegiant Air | Mar 2025 – Mar 2026 |
| Greenville Spartanburg International → Louis Armstrong New Orleans International GSP–MSY | 4 | 353 | 57% | 578 | American Airlines Inc., Delta Air Lines Inc., Sun Country Airlines d/b/a..., Southwest Airlines Co. | Aug 2025 – Jan 2026 |
| Greenville Spartanburg International → St. Louis Lambert International GSP–STL | 4 | 100 | 38% | 524 | GoJet Airlines LLC d/b/a..., Global Crossing Airlines, Inc., Envoy Air, SkyWest Airlines Inc. | Jun 2025 – Jul 2026 |
| Greenville Spartanburg International → General Edward Lawrence Logan International GSP–BOS | 3 | 212 | 59% | 795 | Delta Air Lines Inc., JetBlue Airways | Jul 2025 – Jan 2026 |
| Greenville Spartanburg International → General Mitchell International GSP–MKE | 3 | 60 | 32% | 634 | SkyWest Airlines Inc., Envoy Air | Dec 2025 – May 2026 |
| Greenville Spartanburg International → Oakland County International GSP–PTK | 3 | 0 | | 540 | Gulf And Caribbean Cargo | Jan 2026 – Jan 2026 |
| Greenville Spartanburg International → Chicago/Rockford International GSP–RFD | 3 | 0 | | 626 | Tatonduk Outfitters..., Amerijet International | Jan 2025 – Jul 2026 |
| Greenville Spartanburg International → Richmond International GSP–RIC | 3 | 74 | 22% | 328 | Endeavor Air Inc., Sun Country Airlines d/b/a..., Republic Airline | Feb 2025 – May 2026 |
| Greenville Spartanburg International → Lehigh Valley International GSP–ABE | 2 | 140 | 92% | 543 | Endeavor Air Inc. | May 2026 – Jul 2026 |
| Greenville Spartanburg International → Perot Fld/Fort Worth Alliance GSP–AFW | 2 | 75 | 99% | 876 | Envoy Air, USA Jet Airlines Inc. | Feb 2025 – May 2026 |
| Greenville Spartanburg International → Austin-Bergstrom International GSP–AUS | 2 | 152 | 63% | 957 | American Airlines Inc., Global Crossing Airlines, Inc. | Feb 2025 – Jun 2026 |
| Greenville Spartanburg International → Laurence G Hanscom Field GSP–BED | 2 | 188 | 47% | 788 | Delta Air Lines Inc. | Oct 2025 – Nov 2025 |
| Greenville Spartanburg International → Charleston Afb/Intl GSP–CHS | 2 | 150 | 41% | 186 | Delta Air Lines Inc., Sun Country Airlines d/b/a... | Feb 2025 – Feb 2026 |
| Greenville Spartanburg International → Easterwood Field GSP–CLL | 2 | 129 | 70% | 874 | Breeze Aviation Group DBA Breeze, PSA Airlines Inc. | Mar 2025 – Mar 2026 |
| Greenville Spartanburg International → City Of Colorado Springs Municipal GSP–COS | 2 | 142 | 65% | 1,271 | SkyWest Airlines Inc., United Air Lines Inc. | Feb 2025 – Dec 2025 |
| Greenville Spartanburg International → Del Rio International GSP–DRT | 2 | 0 | | 1,159 | Ameristar Air Cargo, Kalitta Charters II | Jun 2026 – Jun 2026 |
| Greenville Spartanburg International → Wichita Dwight D Eisenhower Ntl GSP–ICT | 2 | 283 | 87% | 869 | United Air Lines Inc., Southwest Airlines Co. | Aug 2025 – Jul 2026 |
| Greenville Spartanburg International → Rickenbacker International GSP–LCK | 2 | 0 | | 341 | National Air Cargo Group... | Jun 2026 – Jun 2026 |
| Greenville Spartanburg International → Blue Grass GSP–LEX | 2 | 38 | 30% | 254 | SkyWest Airlines Inc., Republic Airline | Jan 2026 – Mar 2026 |
| Greenville Spartanburg International → Cincinnati Muni/Lunken Field GSP–LUK | 2 | 9 | 14% | 315 | CFM Inc d/b/a Contour..., SkyWest Airlines Inc. | Dec 2025 – Dec 2025 |
| Greenville Spartanburg International → Okc Will Rogers International GSP–OKC | 2 | 108 | 48% | 871 | Global Crossing Airlines, Inc., SkyWest Airlines Inc. | Jun 2025 – Mar 2026 |
| Greenville Spartanburg International → Providenciales GSP–PLS international | 2 | 12 | 34% | 1,087 | CFM Inc d/b/a Contour... | Dec 2025 – Jan 2026 |
| Greenville Spartanburg International → Portsmouth International AT Pease GSP–PSM | 2 | 0 | | 832 | Antonov Company | Jul 2025 – Sep 2025 |
| Greenville Spartanburg International → Rapid City Regional GSP–RAP | 2 | 0 | 0% | 1,276 | SkyWest Airlines Inc. | Jun 2026 – Jul 2026 |
| Greenville Spartanburg International → Teterboro GSP–TEB | 2 | 4 | 25% | 606 | CFM Inc d/b/a Contour..., FlexFlight AsP | Sep 2025 – Jul 2026 |
| Greenville Spartanburg International → MC Ghee Tyson GSP–TYS | 2 | 67 | 67% | 118 | CommuteAir LLC dba CommuteAir | Nov 2025 – Nov 2025 |
| Greenville Spartanburg International → Augusta Regional AT Bush Field GSP–AGS | 1 | 0 | 0% | 106 | Sun Country Airlines d/b/a... | Apr 2026 – Apr 2026 |
| Greenville Spartanburg International → Albany International GSP–ALB | 1 | 84 | 76% | 706 | Delta Air Lines Inc. | Mar 2025 – Mar 2026 |
| Greenville Spartanburg International → Appleton International GSP–ATW | 1 | 0 | 0% | 728 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| Greenville Spartanburg International → Oconee County Regional GSP–CEU | 1 | 2 | 22% | 41 | Chartright Air Inc. | Oct 2025 – Oct 2025 |
| Greenville Spartanburg International → Cape Girardeau Regional GSP–CGI | 1 | 112 | 62% | 442 | Allegiant Air | Nov 2025 – Nov 2025 |
| Greenville Spartanburg International → Charlottesville-Albemarle GSP–CHO | 1 | 74 | 97% | 307 | Republic Airline | Jul 2026 – Jul 2026 |
| Greenville Spartanburg International → The Eastern Iowa GSP–CID | 1 | 0 | 0% | 705 | SkyWest Airlines Inc. | Mar 2025 – Jun 2026 |
| Greenville Spartanburg International → Cleveland-Hopkins International GSP–CLE | 1 | 69 | 100% | 450 | Endeavor Air Inc. | Jul 2025 – Jun 2026 |
| Greenville Spartanburg International → University Of Illinois/Willard GSP–CMI | 1 | 130 | 74% | 486 | Southwest Airlines Co. | Mar 2026 – Mar 2026 |
| Greenville Spartanburg International → Columbia Regional GSP–COU | 1 | 100 | 67% | 616 | Global Crossing Airlines, Inc. | Jan 2025 – Mar 2026 |
| Greenville Spartanburg International → Dallas Love Field GSP–DAL | 1 | 0 | 0% | 852 | Ameristar Air Cargo | Jan 2026 – Jan 2026 |
| Greenville Spartanburg International → James M Cox Dayton International GSP–DAY | 1 | 135 | 75% | 362 | Allegiant Air | Feb 2025 – Oct 2025 |
| Greenville Spartanburg International → Dupage GSP–DPA | 1 | 2 | 25% | 584 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Greenville Spartanburg International → Fayetteville Rgnl/Grannis Field GSP–FAY | 1 | 48 | 96% | 189 | Piedmont Airlines | Jul 2026 – Jul 2026 |
| Greenville Spartanburg International → Fort Worth Meacham International GSP–FTW | 1 | 0 | 0% | 882 | Global Crossing Airlines, Inc. | Mar 2026 – Mar 2026 |
| Greenville Spartanburg International → Claremore Regional GSP–GCM international | 1 | 13 | 87% | 1,076 | CFM Inc d/b/a Contour... | Dec 2025 – Dec 2025 |
| Greenville Spartanburg International → Greenville GSP–GDC | 1 | 0 | | 13 | Ameristar Air Cargo | Sep 2025 – Sep 2025 |
| Greenville Spartanburg International → Gainesville Regional GSP–GNV | 1 | 63 | 58% | 359 | Breeze Aviation Group DBA Breeze | Mar 2026 – Mar 2026 |
| Greenville Spartanburg International → Gerald R Ford International GSP–GRR | 1 | 35 | 70% | 579 | GoJet Airlines LLC d/b/a... | Dec 2025 – Dec 2025 |
| Greenville Spartanburg International → Gary/Chicago International GSP–GYY | 1 | 112 | 62% | 543 | Allegiant Air | Nov 2025 – Nov 2025 |
| Greenville Spartanburg International → Hilton Head GSP–HHH | 1 | 66 | 87% | 204 | Republic Airline | Aug 2025 – Aug 2025 |
| Greenville Spartanburg International → Hahn GSP–HHN international | 1 | 0 | | 4,414 | National Air Cargo Group... | Jan 2025 – Nov 2025 |
| Greenville Spartanburg International → Katowice GSP–KTW international | 1 | 0 | | 4,861 | Amerijet International | Dec 2025 – Dec 2025 |
| Greenville Spartanburg International → Bill And Hillary Clinton Ntl/Adams Field GSP–LIT | 1 | 126 | 73% | 569 | American Airlines Inc. | Apr 2025 – Jun 2026 |
| Greenville Spartanburg International → Lancaster GSP–LNS | 1 | 128 | 93% | 485 | Breeze Aviation Group DBA Breeze | Mar 2026 – Mar 2026 |
| Greenville Spartanburg International → Lagos GSP–LOS international | 1 | 0 | | 5,712 | Amerijet International | Jan 2026 – Jan 2026 |
| Greenville Spartanburg International → Lublin GSP–LUZ international | 1 | 0 | | 4,967 | Amerijet International | Sep 2025 – Sep 2025 |
| Greenville Spartanburg International → Madrid GSP–MAD international | 1 | 5 | 36% | 4,182 | Gestair, S.A. | Feb 2025 – May 2026 |
| Greenville Spartanburg International → Kansas City International GSP–MCI | 1 | 147 | 98% | 753 | United Air Lines Inc. | Jul 2026 – Jul 2026 |
| Greenville Spartanburg International → Middle Georgia Regional GSP–MCN | 1 | 0 | 0% | 173 | Sun Country Airlines d/b/a... | Jul 2026 – Jul 2026 |
| Greenville Spartanburg International → Chicago Midway International GSP–MDW | 1 | 157 | 90% | 562 | Southwest Airlines Co. | Nov 2025 – Nov 2025 |
| Greenville Spartanburg International → Quad Cities International GSP–MLI | 1 | 59 | 78% | 638 | Envoy Air | Jun 2026 – Jun 2026 |
| Greenville Spartanburg International → Smyrna GSP–MQY | 1 | 0 | 0% | 254 | CFM Inc d/b/a Contour... | Aug 2025 – Aug 2025 |
| Greenville Spartanburg International → Oakland San Francisco Bay GSP–OAK | 1 | 42 | 23% | 2,224 | Sun Country Airlines d/b/a... | Feb 2026 – Feb 2026 |
| Greenville Spartanburg International → Miami-Opa Locka Executive GSP–OPF | 1 | 0 | 0% | 630 | Global Crossing Airlines, Inc. | Mar 2026 – Mar 2026 |
| Greenville Spartanburg International → Owensboro/Daviess County Regional GSP–OWB | 1 | 0 | 0% | 339 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| Greenville Spartanburg International → General Downing - Peoria International GSP–PIA | 1 | 61 | 94% | 570 | Envoy Air | May 2026 – May 2026 |
| Greenville Spartanburg International → Chicago Executive GSP–PWK | 1 | 1 | 12% | 585 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Greenville Spartanburg International → Portland International Jetport GSP–PWM | 1 | 6 | 4% | 877 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Greenville Spartanburg International → Rocky Mount/Wilson Regional GSP–RWI | 1 | 0 | | 253 | Gulf And Caribbean Cargo | Jun 2026 – Jun 2026 |
| Greenville Spartanburg International → San Salvador GSP–SAL international | 1 | 0 | | 1,537 | National Air Cargo Group... | Jan 2026 – Jan 2026 |
| Greenville Spartanburg International → Salisbury-Ocean City Wicomico Regional GSP–SBY | 1 | 48 | 96% | 442 | Piedmont Airlines | May 2026 – May 2026 |
| Greenville Spartanburg International → Shreveport Regional GSP–SHV | 1 | 73 | 96% | 690 | PSA Airlines Inc. | Jan 2025 – Aug 2025 |
| Greenville Spartanburg International → Mineta San Jose International GSP–SJC | 1 | 40 | 29% | 2,211 | Breeze Aviation Group DBA Breeze | Feb 2026 – Feb 2026 |
| Greenville Spartanburg International → Saltillo GSP–SLW international | 1 | 0 | | 1,288 | Ameristar Air Cargo | Jan 2025 – Jan 2026 |
| Greenville Spartanburg International → Sheppard Afb/Wichita Falls Municipal GSP–SPS | 1 | 76 | 100% | 930 | PSA Airlines Inc. | Apr 2026 – Apr 2026 |
| Greenville Spartanburg International → New York Stewart International GSP–SWF | 1 | 117 | 63% | 634 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |
| Greenville Spartanburg International → Syracuse Hancock International GSP–SYR | 1 | 193 | 96% | 655 | JetBlue Airways | Jan 2025 – Sep 2025 |
| Greenville Spartanburg International → Nashville GSP–TN8 | 1 | 30 | 100% | 278 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| Greenville Spartanburg International → Tupelo Regional GSP–TUP | 1 | 95 | 63% | 376 | Global Crossing Airlines, Inc. | Mar 2025 – Mar 2026 |
| Greenville Spartanburg International → Cherry Capital GSP–TVC | 1 | 2 | 25% | 702 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Greenville Spartanburg International → Vero Beach Regional GSP–VRB | 1 | 99 | 72% | 510 | Breeze Aviation Group DBA Breeze | Aug 2025 – Aug 2025 |
| Greenville Spartanburg International → Northwest Arkansas Ntl GSP–XNA | 1 | 0 | 0% | 687 | Global Crossing Airlines, Inc. | Mar 2025 – Mar 2026 |