| Portland International Jetport → Laguardia PWM–LGA | 1,542 | 96,210 | 81% | 269 | Republic Airline, Endeavor Air Inc., American Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Portland International Jetport → Chicago O'Hare International PWM–ORD | 1,439 | 119,272 | 83% | 900 | Republic Airline, United Air Lines Inc., SkyWest Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Portland International Jetport → Newark Liberty International PWM–EWR | 1,340 | 80,902 | 78% | 284 | Republic Airline, GoJet Airlines LLC d/b/a..., United Air Lines Inc., Federal Express Corporation +1 | Jan 2025 – Jul 2026 |
| Portland International Jetport → Baltimore/Washington International Thurgood Marshall PWM–BWI | 1,327 | 169,231 | 81% | 452 | Southwest Airlines Co., American Airlines Inc., Allegiant Air | Jan 2025 – Jul 2026 |
| Portland International Jetport → Philadelphia International PWM–PHL | 1,263 | 88,324 | 83% | 364 | Piedmont Airlines, American Airlines Inc., PSA Airlines Inc., Tradewind Aviation +2 | Jan 2025 – Jul 2026 |
| Portland International Jetport → Washington Dulles International PWM–IAD | 1,133 | 64,542 | 80% | 493 | Republic Airline, GoJet Airlines LLC d/b/a..., United Air Lines Inc., CommuteAir LLC dba CommuteAir +6 | Jan 2025 – Jul 2026 |
| Portland International Jetport → Ronald Reagan Washington Ntl PWM–DCA | 1,112 | 93,895 | 81% | 482 | American Airlines Inc., PSA Airlines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Portland International Jetport → John F Kennedy International PWM–JFK | 995 | 68,546 | 70% | 273 | Endeavor Air Inc., JetBlue Airways, Republic Airline | Jan 2025 – Jul 2026 |
| Portland International Jetport → Charlotte/Douglas International PWM–CLT | 696 | 95,457 | 84% | 813 | American Airlines Inc., PSA Airlines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Portland International Jetport → Detroit Metro Wayne County PWM–DTW | 654 | 56,134 | 87% | 668 | Delta Air Lines Inc., SkyWest Airlines Inc., Republic Airline, Endeavor Air Inc. | Jan 2025 – Jul 2026 |
| Portland International Jetport → Hartsfield/Jackson Atlanta International PWM–ATL | 632 | 97,358 | 85% | 1,027 | Delta Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Portland International Jetport → Presque Isle International PWM–PQI | 501 | 0 | | 237 | Federal Express Corporation | Jan 2025 – Jul 2026 |
| Portland International Jetport → Orlando International PWM–MCO | 296 | 34,911 | 82% | 1,214 | Breeze Aviation Group DBA Breeze, JetBlue Airways, Frontier Airlines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Portland International Jetport → Frederick W Smith Intl/Memphis PWM–MEM | 239 | 0 | 0% | 1,205 | Federal Express Corporation, SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Portland International Jetport → Denver International PWM–DEN | 213 | 31,971 | 91% | 1,782 | United Air Lines Inc. | May 2025 – Jul 2026 |
| Portland International Jetport → Minneapolis-St Paul Intl/Wold-Chamberlain PWM–MSP | 209 | 33,478 | 88% | 1,136 | Delta Air Lines Inc., Sun Country Airlines d/b/a... | Mar 2025 – Jul 2026 |
| Portland International Jetport → Nashville International PWM–BNA | 161 | 21,605 | 86% | 1,010 | Southwest Airlines Co., SkyWest Airlines Inc., Air Hamburg..., Federal Express Corporation | Apr 2025 – Jul 2026 |
| Portland International Jetport → Chicago Midway International PWM–MDW | 151 | 22,430 | 91% | 895 | Southwest Airlines Co., Flying Service N.V. | Jun 2025 – Jul 2026 |
| Portland International Jetport → Dallas-Fort Worth International PWM–DFW | 144 | 22,049 | 89% | 1,622 | American Airlines Inc. | Jun 2025 – Jul 2026 |
| Portland International Jetport → Charleston Afb/Intl PWM–CHS | 130 | 14,948 | 84% | 909 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Portland International Jetport → Tampa International PWM–TPA | 110 | 11,664 | 80% | 1,277 | Breeze Aviation Group DBA Breeze, Air Hamburg... | Jan 2025 – Jul 2026 |
| Portland International Jetport → Raleigh-Durham International PWM–RDU | 104 | 12,090 | 85% | 700 | Breeze Aviation Group DBA Breeze, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Portland International Jetport → Southwest Florida International PWM–RSW | 96 | 10,695 | 81% | 1,343 | Breeze Aviation Group DBA Breeze | Jan 2025 – May 2026 |
| Portland International Jetport → Pittsburgh International PWM–PIT | 76 | 8,127 | 78% | 554 | Breeze Aviation Group DBA Breeze | May 2025 – Jul 2026 |
| Portland International Jetport → John Glenn Columbus International PWM–CMH | 70 | 7,683 | 80% | 696 | Breeze Aviation Group DBA Breeze | May 2025 – Jul 2026 |
| Portland International Jetport → Bangor International PWM–BGR | 63 | 513 | 88% | 109 | Federal Express Corporation, Endeavor Air Inc., Piedmont Airlines, American Airlines Inc. +2 | Jan 2025 – Jul 2026 |
| Portland International Jetport → Norfolk International PWM–ORF | 59 | 5,119 | 64% | 560 | Breeze Aviation Group DBA Breeze, PSA Airlines Inc., Southwest Airlines Co., Republic Airline | May 2025 – Jul 2026 |
| Portland International Jetport → Sarasota/Bradenton International PWM–SRQ | 51 | 5,710 | 82% | 1,313 | Breeze Aviation Group DBA Breeze | Jan 2025 – Apr 2026 |
| Portland International Jetport → Westchester County PWM–HPN | 13 | 636 | 77% | 249 | Tradewind Aviation, Allegiant Air, CFM Inc d/b/a Contour..., Jet Aviation Flight Services, Inc. +2 | Aug 2025 – Jul 2026 |
| Portland International Jetport → George Bush Intcntl/Houston PWM–IAH | 12 | 1,034 | 87% | 1,667 | SkyWest Airlines Inc., United Air Lines Inc. | Jun 2025 – Jul 2026 |
| Portland International Jetport → Fort Lauderdale/Hollywood International PWM–FLL | 10 | 1,018 | 63% | 1,332 | JetBlue Airways | Apr 2026 – Apr 2026 |
| Portland International Jetport → Tweed/New Haven PWM–HVN | 10 | 410 | 30% | 211 | TEM Enterprises dba Avelo Airlines, Tradewind Aviation | May 2025 – Feb 2026 |
| Portland International Jetport → Akron-Canton Regional PWM–CAK | 9 | 875 | 71% | 600 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Portland International Jetport → Cincinnati/Northern Kentucky International PWM–CVG | 9 | 976 | 79% | 810 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Portland International Jetport → Nantucket Memorial PWM–ACK | 7 | 28 | 50% | 166 | Tradewind Aviation, CFM Inc d/b/a Contour... | Jul 2025 – Jul 2026 |
| Portland International Jetport → East Hampton PWM–HTO | 6 | 21 | 44% | 210 | Tradewind Aviation | Jun 2025 – Jul 2026 |
| Portland International Jetport → Los Angeles International PWM–LAX | 6 | 619 | 62% | 2,642 | United Air Lines Inc., Southwest Airlines Co. | Jun 2026 – Jul 2026 |
| Portland International Jetport → San Francisco International PWM–SFO | 5 | 666 | 80% | 2,723 | United Air Lines Inc. | Jun 2026 – Jul 2026 |
| Portland International Jetport → Atlantic City International PWM–ACY | 4 | 147 | 26% | 364 | Sun Country Airlines d/b/a..., CFM Inc d/b/a Contour... | Jun 2025 – Jul 2026 |
| Portland International Jetport → General Edward Lawrence Logan International PWM–BOS | 4 | 118 | 52% | 95 | Tradewind Aviation, Air Canada, PSA Airlines Inc. | Jul 2025 – May 2026 |
| Portland International Jetport → Buffalo Niagara International PWM–BUF | 3 | 74 | 97% | 427 | Federal Express Corporation, Republic Airline | Sep 2025 – Jul 2026 |
| Portland International Jetport → Indianapolis International PWM–IND | 3 | 91 | 23% | 869 | Allegiant Air, Breeze Aviation Group DBA Breeze, Republic Airline | Mar 2025 – Jul 2026 |
| Portland International Jetport → Martha'S Vineyard PWM–MVY | 3 | 5 | 21% | 156 | Tradewind Aviation | Jun 2025 – Jul 2026 |
| Portland International Jetport → Rhode Island TF Green International PWM–PVD | 3 | 0 | | 144 | Federal Express Corporation | Jan 2025 – Jul 2026 |
| Portland International Jetport → Portland International Jetport PWM–PWM | 3 | 0 | 0% | 0 | SkyWest Airlines Inc. | May 2025 – May 2026 |
| Portland International Jetport → Syracuse Hancock International PWM–SYR | 3 | 65 | 46% | 294 | Federal Express Corporation, PSA Airlines Inc., Republic Airline | Aug 2025 – Dec 2025 |
| Portland International Jetport → Teterboro PWM–TEB | 3 | 6 | 25% | 272 | Tradewind Aviation | Feb 2025 – Jun 2026 |
| Portland International Jetport → Lehigh Valley International PWM–ABE | 2 | 11 | 69% | 335 | Tradewind Aviation | Jun 2025 – Jan 2026 |
| Portland International Jetport → Albany International PWM–ALB | 2 | 225 | 88% | 187 | Delta Air Lines Inc., Republic Airline | Jan 2025 – Jul 2026 |
| Portland International Jetport → Hamilton PWM–BDA international | 2 | 5 | 19% | 836 | Air Hamburg..., VistaJet Limited | Mar 2026 – Apr 2026 |
| Portland International Jetport → Bradley International PWM–BDL | 2 | 0 | 0% | 169 | Federal Express Corporation, Sun Country Airlines d/b/a... | Feb 2025 – Jul 2026 |
| Portland International Jetport → Patrick Leahy Burlington International PWM–BTV | 2 | 67 | 44% | 153 | SkyWest Airlines Inc., Republic Airline | Jan 2026 – Feb 2026 |
| Portland International Jetport → Cleveland-Hopkins International PWM–CLE | 2 | 104 | 41% | 609 | Delta Air Lines Inc., Southwest Airlines Co. | Dec 2025 – Apr 2026 |
| Portland International Jetport → Piedmont Triad International PWM–GSO | 2 | 183 | 90% | 729 | Air Alsie A/S, American Airlines Inc. | Aug 2025 – Feb 2026 |
| Portland International Jetport → Greenville Spartanburg International PWM–GSP | 2 | 147 | 65% | 877 | American Airlines Inc., SkyWest Airlines Inc. | Mar 2026 – Jun 2026 |
| Portland International Jetport → Richmond International PWM–RIC | 2 | 163 | 80% | 561 | American Airlines Inc., Republic Airline | Jun 2025 – May 2026 |
| Portland International Jetport → Roanoke/Blacksburg Regional (Woodrum Field) PWM–ROA | 2 | 0 | | 670 | Federal Express Corporation | May 2025 – Nov 2025 |
| Portland International Jetport → Louisville Muhammad Ali International PWM–SDF | 2 | 175 | 70% | 890 | Southwest Airlines Co., Republic Airline | Jul 2025 – Jul 2026 |
| Portland International Jetport → MC Ghee Tyson PWM–TYS | 2 | 361 | 100% | 906 | American Airlines Inc. | Jun 2025 – Mar 2026 |
| Portland International Jetport → Watertown International PWM–ART | 1 | 6 | 75% | 286 | Tradewind Aviation | Aug 2025 – Aug 2025 |
| Portland International Jetport → Birmingham-Shuttlesworth International PWM–BHM | 1 | 0 | | 1,126 | Federal Express Corporation | May 2026 – May 2026 |
| Portland International Jetport → Columbia Metro PWM–CAE | 1 | 187 | 98% | 887 | American Airlines Inc. | Sep 2025 – Sep 2025 |
| Portland International Jetport → Lovell Field PWM–CHA | 1 | 156 | 99% | 992 | Delta Air Lines Inc. | Jul 2026 – Jul 2026 |
| Portland International Jetport → City Of Colorado Springs Municipal PWM–COS | 1 | 161 | 97% | 1,809 | United Air Lines Inc. | Jul 2025 – Sep 2025 |
| Portland International Jetport → EL Paso International PWM–ELP | 1 | 133 | 70% | 2,117 | TEM Enterprises dba Avelo Airlines | Sep 2025 – Sep 2025 |
| Portland International Jetport → Fishers Island PWM–FID | 1 | 4 | 50% | 187 | Tradewind Aviation | Aug 2025 – Aug 2025 |
| Portland International Jetport → Francis S Gabreski PWM–FOK | 1 | 3 | 38% | 227 | Tradewind Aviation | Jul 2026 – Jul 2026 |
| Portland International Jetport → Republic PWM–FRG | 1 | 6 | 32% | 257 | CFM Inc d/b/a Contour... | Oct 2025 – Oct 2025 |
| Portland International Jetport → Fort Wayne International PWM–FWA | 1 | 0 | 0% | 783 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Portland International Jetport → Nuuk PWM–GOH international | 1 | 2 | 14% | 1,598 | VistaJet Limited | Aug 2025 – Aug 2025 |
| Portland International Jetport → Groton-New London PWM–GON | 1 | 16 | 100% | 183 | CFM Inc d/b/a Contour... | Aug 2025 – Aug 2025 |
| Portland International Jetport → New Castle PWM–ILG | 1 | 0 | 0% | 387 | TEM Enterprises dba Avelo Airlines | Mar 2026 – Mar 2026 |
| Portland International Jetport → Jacksonville International PWM–JAX | 1 | 126 | 92% | 1,102 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Portland International Jetport → Keflavik/Reykjavik PWM–KEF international | 1 | 7 | 78% | 2,320 | ADVANCED AIR, LLC | May 2026 – May 2026 |
| Portland International Jetport → Arnold Palmer Regional PWM–LBE | 1 | 0 | 0% | 523 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Portland International Jetport → Blue Grass PWM–LEX | 1 | 0 | 0% | 842 | SkyWest Airlines Inc. | Apr 2026 – Apr 2026 |
| Portland International Jetport → Marshfield PWM–MA4 | 1 | 4 | 50% | 108 | Tradewind Aviation | Nov 2025 – Nov 2025 |
| Portland International Jetport → Rangeley PWM–ME1 | 1 | 1 | 12% | 95 | Tradewind Aviation | Jul 2026 – Jul 2026 |
| Portland International Jetport → Manchester Boston Regional PWM–MHT | 1 | 0 | | 75 | Federal Express Corporation | Dec 2025 – Dec 2025 |
| Portland International Jetport → Dane County Rgnl/Truax Field PWM–MSN | 1 | 103 | 82% | 957 | United Air Lines Inc. | Sep 2025 – Sep 2025 |
| Portland International Jetport → Martin State PWM–MTN | 1 | 4 | 50% | 435 | Tradewind Aviation | Aug 2025 – Aug 2025 |
| Portland International Jetport → Norwood Memorial PWM–OWD | 1 | 6 | 75% | 110 | Tradewind Aviation | Nov 2025 – Nov 2025 |
| Portland International Jetport → Knox County Regional PWM–RKD | 1 | 4 | 50% | 67 | Tradewind Aviation | Dec 2025 – Dec 2025 |
| Portland International Jetport → Frederick Douglass/Greater Rochester International PWM–ROC | 1 | 0 | | 372 | Federal Express Corporation | Apr 2025 – Oct 2025 |
| Portland International Jetport → Savannah/Hilton Head International PWM–SAV | 1 | 107 | 99% | 991 | Breeze Aviation Group DBA Breeze | Aug 2025 – Aug 2025 |
| Portland International Jetport → St. Louis Lambert International PWM–STL | 1 | 140 | 81% | 1,096 | American Airlines Inc. | Jun 2026 – Jun 2026 |
| Portland International Jetport → Cyril E King PWM–STT | 1 | 12 | 80% | 1,771 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| Portland International Jetport → Cherry Capital PWM–TVC | 1 | 0 | 0% | 761 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Portland International Jetport → Quebec PWM–YQB international | 1 | 73 | 96% | 223 | Republic Airline | Dec 2025 – Dec 2025 |