| Roanoke/Blacksburg Regional (Woodrum Field) → Charlotte/Douglas International ROA–CLT | 2,628 | 111,242 | 84% | 155 | Piedmont Airlines, PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Chicago O'Hare International ROA–ORD | 1,424 | 68,665 | 79% | 530 | GoJet Airlines LLC d/b/a..., SkyWest Airlines Inc., Republic Airline, Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Hartsfield/Jackson Atlanta International ROA–ATL | 1,400 | 102,485 | 83% | 357 | Endeavor Air Inc., Delta Air Lines Inc., SkyWest Airlines Inc., JetBlue Airways +2 | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Washington Dulles International ROA–IAD | 1,022 | 40,265 | 78% | 177 | CommuteAir LLC dba CommuteAir, GoJet Airlines LLC d/b/a..., Mesa Airlines Inc., Global Crossing Airlines, Inc. +1 | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Laguardia ROA–LGA | 622 | 26,763 | 60% | 405 | Republic Airline, Endeavor Air Inc. | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Philadelphia International ROA–PHL | 616 | 23,425 | 76% | 311 | Piedmont Airlines, United Parcel Service, Breeze Aviation Group DBA Breeze, Republic Airline | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Louisville Muhammad Ali International ROA–SDF | 245 | 150 | 81% | 321 | United Parcel Service, Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Frederick W Smith Intl/Memphis ROA–MEM | 158 | 0 | 0% | 580 | Federal Express Corporation, Republic Airline | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Orlando Sanford International ROA–SFB | 116 | 16,803 | 82% | 594 | Allegiant Air | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → St. Pete-Clearwater International ROA–PIE | 110 | 15,962 | 83% | 668 | Allegiant Air | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Sarasota/Bradenton International ROA–SRQ | 75 | 7,895 | 58% | 701 | Allegiant Air | Feb 2025 – Apr 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Dallas-Fort Worth International ROA–DFW | 53 | 3,667 | 92% | 1,012 | PSA Airlines Inc. | Jun 2026 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → MC Ghee Tyson ROA–TYS | 45 | 45 | 90% | 247 | Federal Express Corporation, United Parcel Service, CommuteAir LLC dba CommuteAir | Jan 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Fort Wayne International ROA–FWA | 41 | 0 | | 377 | Federal Express Corporation | Jul 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Roanoke/Blacksburg Regional (Woodrum Field) ROA–ROA | 9 | 0 | 0% | 0 | SkyWest Airlines Inc. | Jan 2025 – May 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Atlantic City International ROA–ACY | 8 | 726 | 55% | 328 | Sun Country Airlines d/b/a..., CFM Inc d/b/a Contour... | Apr 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Richmond International ROA–RIC | 7 | 237 | 37% | 147 | United Parcel Service, Sun Country Airlines d/b/a..., Republic Airline | Sep 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Columbia Metro ROA–CAE | 4 | 42 | 84% | 242 | United Parcel Service, Piedmont Airlines | Jul 2025 – Jan 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → West Virginia International Yeager ROA–CRW | 4 | 116 | 50% | 114 | SkyWest Airlines Inc., Endeavor Air Inc., PSA Airlines Inc. | Sep 2025 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Gulfport-Biloxi International ROA–GPT | 4 | 440 | 59% | 707 | Sun Country Airlines d/b/a... | Feb 2025 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Raleigh-Durham International ROA–RDU | 4 | 75 | 52% | 120 | United Parcel Service, Global Crossing Airlines, Inc., Republic Airline | Jul 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Nashville International ROA–BNA | 3 | 177 | 45% | 381 | Delta Air Lines Inc., CFM Inc d/b/a Contour..., Sun Country Airlines d/b/a... | May 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Piedmont Triad International ROA–GSO | 3 | 0 | | 84 | United Parcel Service, Federal Express Corporation | Feb 2025 – Dec 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Greenville Spartanburg International ROA–GSP | 3 | 90 | 90% | 209 | Piedmont Airlines, United Parcel Service | Jan 2025 – Dec 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Miami International ROA–MIA | 3 | 234 | 46% | 795 | American Airlines Inc., Global Crossing Airlines, Inc. | Jan 2025 – Jan 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Charlottesville-Albemarle ROA–CHO | 2 | 39 | 39% | 101 | SkyWest Airlines Inc., Piedmont Airlines | May 2025 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Denver International ROA–DEN | 2 | 180 | 72% | 1,344 | Delta Air Lines Inc., SkyWest Airlines Inc. | Oct 2025 – May 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Francis S Gabreski ROA–FOK | 2 | 4 | 25% | 463 | CFM Inc d/b/a Contour... | Mar 2026 – Apr 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Gerald R Ford International ROA–GRR | 2 | 50 | 50% | 483 | GoJet Airlines LLC d/b/a... | Mar 2026 – May 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Westchester County ROA–HPN | 2 | 8 | 50% | 424 | CFM Inc d/b/a Contour..., Tradewind Aviation | Jun 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Tri-State/Milton J Ferguson Field ROA–HTS | 2 | 41 | 82% | 158 | Federal Express Corporation, Piedmont Airlines | Jan 2025 – May 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Laredo International ROA–LRD | 2 | 0 | | 1,319 | Tatonduk Outfitters... | Nov 2025 – Apr 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → General Mitchell International ROA–MKE | 2 | 45 | 45% | 571 | GoJet Airlines LLC d/b/a..., SkyWest Airlines Inc. | Sep 2025 – Feb 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → South Bend International ROA–SBN | 2 | 48 | 48% | 454 | GoJet Airlines LLC d/b/a..., SkyWest Airlines Inc. | Jan 2025 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Augusta Regional AT Bush Field ROA–AGS | 1 | 0 | 0% | 295 | CFM Inc d/b/a Contour... | Jun 2025 – Apr 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Austin-Bergstrom International ROA–AUS | 1 | 100 | 64% | 1,128 | Allegiant Air | Mar 2026 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → General Edward Lawrence Logan International ROA–BOS | 1 | 37 | 26% | 590 | JetBlue Airways | Mar 2026 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Baltimore/Washington International Thurgood Marshall ROA–BWI | 1 | 53 | 82% | 221 | Republic Airline | Nov 2025 – Nov 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Akron-Canton Regional ROA–CAK | 1 | 0 | 0% | 260 | Sun Country Airlines d/b/a... | Oct 2025 – Oct 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Lovell Field ROA–CHA | 1 | 0 | | 332 | Federal Express Corporation | Jan 2025 – Sep 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → The Eastern Iowa ROA–CID | 1 | 18 | 36% | 700 | GoJet Airlines LLC d/b/a... | Mar 2026 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Cleveland-Hopkins International ROA–CLE | 1 | 0 | | 299 | United Parcel Service | Jan 2026 – Jan 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Easterwood Field ROA–CLL | 1 | 65 | 86% | 1,047 | PSA Airlines Inc. | Jun 2026 – Jun 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Cincinnati/Northern Kentucky International ROA–CVG | 1 | 0 | | 282 | Federal Express Corporation | Jan 2025 – Nov 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Dallas Love Field ROA–DAL | 1 | 0 | 0% | 1,003 | SkyWest Airlines Inc. | Feb 2025 – Nov 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Ronald Reagan Washington Ntl ROA–DCA | 1 | 42 | 55% | 192 | Republic Airline | May 2025 – Oct 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Decatur ROA–DEC | 1 | 0 | 0% | 511 | SkyWest Airlines Inc. | Mar 2026 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Detroit Metro Wayne County ROA–DTW | 1 | 0 | | 382 | Federal Express Corporation | Oct 2025 – Oct 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Erie Intl/Tom Ridge Field ROA–ERI | 1 | 44 | 88% | 328 | Piedmont Airlines | Jul 2025 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Kalispell ROA–FCA | 1 | 0 | 0% | 1,880 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Frederick Municipal ROA–FDK | 1 | 8 | 100% | 202 | Tradewind Aviation | Nov 2025 – Nov 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Fort Lauderdale/Hollywood International ROA–FLL | 1 | 49 | 98% | 775 | Air Wisconsin Airlines Corp | Nov 2025 – Nov 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Delaware Coastal ROA–GED | 1 | 9 | 69% | 269 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Wilmington International ROA–ILM | 1 | 8 | 100% | 241 | CFM Inc d/b/a Contour... | Jun 2025 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Indianapolis International ROA–IND | 1 | 0 | | 380 | Federal Express Corporation | Aug 2025 – Aug 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Los Angeles International ROA–LAX | 1 | 54 | 29% | 2,161 | Sun Country Airlines d/b/a... | May 2026 – May 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Rickenbacker International ROA–LCK | 1 | 0 | | 234 | United Parcel Service | Jul 2026 – Jul 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Lynchburg Rgnl/Preston Glenn Field ROA–LYH | 1 | 46 | 92% | 43 | Piedmont Airlines | Feb 2025 – Nov 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Harrisburg International ROA–MDT | 1 | 0 | | 263 | Federal Express Corporation | Mar 2025 – Sep 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Louis Armstrong New Orleans International ROA–MSY | 1 | 169 | 91% | 778 | Sun Country Airlines d/b/a... | Jun 2026 – Jun 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Nassau ROA–NAS international | 1 | 52 | 48% | 860 | Breeze Aviation Group DBA Breeze | Nov 2025 – Nov 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Oakland San Francisco Bay ROA–OAK | 1 | 0 | 0% | 2,300 | Global Crossing Airlines, Inc. | Jan 2026 – Jan 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Okc Will Rogers International ROA–OKC | 1 | 0 | 0% | 990 | Global Crossing Airlines, Inc. | Mar 2026 – Mar 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Savannah/Hilton Head International ROA–SAV | 1 | 2 | 25% | 365 | CFM Inc d/b/a Contour... | Jun 2026 – Jun 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Mineta San Jose International ROA–SJC | 1 | 59 | 32% | 2,290 | Sun Country Airlines d/b/a... | Feb 2026 – Feb 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → St. Louis Lambert International ROA–STL | 1 | 36 | 72% | 575 | GoJet Airlines LLC d/b/a... | Apr 2026 – Apr 2026 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Tallahassee International ROA–TLH | 1 | 161 | 80% | 540 | JetBlue Airways | Nov 2025 – Nov 2025 |
| Roanoke/Blacksburg Regional (Woodrum Field) → Tupelo Regional ROA–TUP | 1 | 96 | 52% | 537 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |