| Manchester Boston Regional → Baltimore/Washington International Thurgood Marshall MHT–BWI | 1,734 | 187,500 | 69% | 377 | Southwest Airlines Co., Federal Express Corporation, Allegiant Air, Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Philadelphia International MHT–PHL | 1,399 | 49,296 | 83% | 289 | Piedmont Airlines, United Parcel Service, Federal Express Corporation, PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Ronald Reagan Washington Ntl MHT–DCA | 1,018 | 54,922 | 78% | 406 | PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Charlotte/Douglas International MHT–CLT | 920 | 57,159 | 85% | 738 | PSA Airlines Inc., Piedmont Airlines, American Airlines Inc. | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Orlando International MHT–MCO | 879 | 116,874 | 82% | 1,142 | Southwest Airlines Co., JetBlue Airways, Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Washington Dulles International MHT–IAD | 706 | 27,042 | 76% | 418 | CommuteAir LLC dba CommuteAir, PSA Airlines Inc., Breeze Aviation Group DBA Breeze, Southwest Airlines Co. | Mar 2025 – Jul 2026 |
| Manchester Boston Regional → Louisville Muhammad Ali International MHT–SDF | 592 | 0 | | 820 | United Parcel Service | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Chicago O'Hare International MHT–ORD | 589 | 31,800 | 79% | 843 | Envoy Air, Republic Airline, ABX Air Inc, Southwest Airlines Co. | May 2025 – Jul 2026 |
| Manchester Boston Regional → Chicago Midway International MHT–MDW | 516 | 54,039 | 67% | 838 | Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Chicago/Rockford International MHT–RFD | 363 | 0 | | 901 | United Parcel Service, ABX Air Inc | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Cincinnati/Northern Kentucky International MHT–CVG | 336 | 0 | | 741 | ABX Air Inc, Air Transport International | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Frederick W Smith Intl/Memphis MHT–MEM | 209 | 3 | 2% | 1,133 | Federal Express Corporation, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Bangor International MHT–BGR | 195 | 0 | | 184 | United Parcel Service | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Southwest Florida International MHT–RSW | 186 | 22,134 | 80% | 1,271 | Breeze Aviation Group DBA Breeze, JetBlue Airways | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Perot Fld/Fort Worth Alliance MHT–AFW | 156 | 0 | | 1,562 | ABX Air Inc, Air Transport International | Jan 2025 – Jan 2026 |
| Manchester Boston Regional → Raleigh-Durham International MHT–RDU | 151 | 14,695 | 76% | 625 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, United Parcel Service | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Fort Lauderdale/Hollywood International MHT–FLL | 107 | 10,551 | 61% | 1,262 | JetBlue Airways | Jan 2025 – May 2026 |
| Manchester Boston Regional → Charleston Afb/Intl MHT–CHS | 95 | 10,062 | 78% | 836 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Myrtle Beach International MHT–MYR | 82 | 10,344 | 82% | 756 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Apr 2025 – Jul 2026 |
| Manchester Boston Regional → Tampa International MHT–TPA | 63 | 7,388 | 74% | 1,204 | Southwest Airlines Co., JetBlue Airways | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Newark Liberty International MHT–EWR | 45 | 4 | 8% | 209 | Federal Express Corporation, United Parcel Service, GoJet Airlines LLC d/b/a... | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Wilmington International MHT–ILM | 42 | 4,625 | 77% | 692 | TEM Enterprises dba Avelo Airlines | Apr 2025 – Jan 2026 |
| Manchester Boston Regional → Concord MHT–USA | 38 | 4,571 | 82% | 719 | TEM Enterprises dba Avelo Airlines | Jan 2025 – Jan 2026 |
| Manchester Boston Regional → John F Kennedy International MHT–JFK | 34 | 1,420 | 27% | 199 | JetBlue Airways, United Parcel Service | Jan 2025 – Jan 2026 |
| Manchester Boston Regional → Atlantic City International MHT–ACY | 6 | 845 | 76% | 290 | Sun Country Airlines d/b/a... | Jun 2025 – Jul 2026 |
| Manchester Boston Regional → General Edward Lawrence Logan International MHT–BOS | 6 | 279 | 93% | 45 | Federal Express Corporation, JetBlue Airways | Feb 2025 – May 2026 |
| Manchester Boston Regional → Albany International MHT–ALB | 5 | 96 | 32% | 121 | United Parcel Service, PSA Airlines Inc., Eastern Air Express, LLC (EAX) | Aug 2025 – Mar 2026 |
| Manchester Boston Regional → Bradley International MHT–BDL | 5 | 201 | 89% | 94 | United Parcel Service, CommuteAir LLC dba CommuteAir, Southwest Airlines Co. | Apr 2025 – Jul 2026 |
| Manchester Boston Regional → Buffalo Niagara International MHT–BUF | 3 | 0 | 0% | 370 | United Parcel Service, Southwest Airlines Co. | Dec 2025 – Jul 2026 |
| Manchester Boston Regional → Jacksonville International MHT–JAX | 3 | 407 | 85% | 1,028 | Southwest Airlines Co., JetBlue Airways | May 2025 – Feb 2026 |
| Manchester Boston Regional → Teterboro MHT–TEB | 3 | 8 | 32% | 197 | Tradewind Aviation, Scott Aviation, LLC d/b/a... | Jan 2025 – Jul 2026 |
| Manchester Boston Regional → Hartsfield/Jackson Atlanta International MHT–ATL | 2 | 119 | 40% | 952 | JetBlue Airways, Breeze Aviation Group DBA Breeze | Sep 2025 – Sep 2025 |
| Manchester Boston Regional → Patrick Leahy Burlington International MHT–BTV | 2 | 95 | 83% | 137 | GoJet Airlines LLC d/b/a..., PSA Airlines Inc. | Mar 2025 – Mar 2026 |
| Manchester Boston Regional → George Bush Intcntl/Houston MHT–IAH | 2 | 1 | 1% | 1,594 | ABX Air Inc, PSA Airlines Inc. | Aug 2025 – Jun 2026 |
| Manchester Boston Regional → Harrisburg International MHT–MDT | 2 | 49 | 98% | 335 | United Parcel Service, Piedmont Airlines | Apr 2025 – Jan 2026 |
| Manchester Boston Regional → Moffett Federal Airfield MHT–NUQ | 2 | 11 | 48% | 2,665 | Scott Aviation, LLC d/b/a... | Sep 2025 – Jul 2026 |
| Manchester Boston Regional → Phoenix Sky Harbor International MHT–PHX | 2 | 62 | 17% | 2,280 | Allegiant Air, Southwest Airlines Co. | Dec 2025 – Jan 2026 |
| Manchester Boston Regional → Rhode Island TF Green International MHT–PVD | 2 | 76 | 29% | 84 | Envoy Air, Sun Country Airlines d/b/a... | Jul 2025 – Jul 2026 |
| Manchester Boston Regional → Syracuse Hancock International MHT–SYR | 2 | 0 | | 237 | United Parcel Service | Dec 2025 – Dec 2025 |
| Manchester Boston Regional → Montreal MHT–YUL international | 2 | 12 | 75% | 209 | Tradewind Aviation | Aug 2025 – Jan 2026 |
| Manchester Boston Regional → Nantucket Memorial MHT–ACK | 1 | 4 | 50% | 136 | Tradewind Aviation | Jun 2025 – Jun 2026 |
| Manchester Boston Regional → Lovell Field MHT–CHA | 1 | 110 | 61% | 918 | Allegiant Air | Oct 2025 – Oct 2025 |
| Manchester Boston Regional → Cleveland-Hopkins International MHT–CLE | 1 | 0 | | 545 | United Parcel Service | Nov 2025 – Nov 2025 |
| Manchester Boston Regional → Copenhagen MHT–CPH international | 1 | 4 | 29% | 3,658 | Air Hamburg... | Dec 2025 – Dec 2025 |
| Manchester Boston Regional → Des Moines International MHT–DSM | 1 | 124 | 91% | 1,141 | Southwest Airlines Co. | Jun 2026 – Jun 2026 |
| Manchester Boston Regional → Joe Foss Field MHT–FSD | 1 | 77 | 56% | 1,273 | Breeze Aviation Group DBA Breeze | Mar 2026 – Mar 2026 |
| Manchester Boston Regional → Groton-New London MHT–GON | 1 | 1 | 12% | 115 | Tradewind Aviation | Jul 2026 – Jul 2026 |
| Manchester Boston Regional → Gerald R Ford International MHT–GRR | 1 | 58 | 89% | 714 | Envoy Air | Aug 2025 – Aug 2025 |
| Manchester Boston Regional → Greenville Spartanburg International MHT–GSP | 1 | 72 | 95% | 802 | PSA Airlines Inc. | Jul 2026 – Jul 2026 |
| Manchester Boston Regional → Westchester County MHT–HPN | 1 | 0 | 0% | 174 | Glock Aviation GmbH | Jun 2026 – Jun 2026 |
| Manchester Boston Regional → Tweed/New Haven MHT–HVN | 1 | 148 | 80% | 137 | TEM Enterprises dba Avelo Airlines | Mar 2025 – Mar 2026 |
| Manchester Boston Regional → Indianapolis International MHT–IND | 1 | 33 | 51% | 803 | Envoy Air | Aug 2025 – Aug 2025 |
| Manchester Boston Regional → Lakeland Linder International MHT–LAL | 1 | 0 | | 1,188 | Air Transport International | Jan 2025 – Apr 2026 |
| Manchester Boston Regional → Lisbon MHT–LIS international | 1 | 1 | 7% | 3,201 | VistaJet Limited | Jun 2026 – Jun 2026 |
| Manchester Boston Regional → Nice MHT–NCE international | 1 | 7 | 50% | 3,806 | VistaJet Limited | Jul 2026 – Jul 2026 |
| Manchester Boston Regional → Albert J Ellis MHT–OAJ | 1 | 72 | 95% | 650 | PSA Airlines Inc. | Jun 2026 – Jun 2026 |
| Manchester Boston Regional → West Palm Beach/Palm Beach MHT–PBI | 1 | 142 | 81% | 1,222 | Southwest Airlines Co. | Aug 2025 – Aug 2025 |
| Manchester Boston Regional → Pittsburgh International MHT–PIT | 1 | 0 | | 485 | ABX Air Inc | Mar 2026 – Mar 2026 |
| Manchester Boston Regional → Salerno MHT–QSR international | 1 | 4 | 27% | 4,253 | FAI rent-a-jet AG | Jul 2026 – Jul 2026 |
| Manchester Boston Regional → Richmond International MHT–RIC | 1 | 37 | 57% | 486 | PSA Airlines Inc. | Jul 2025 – Aug 2025 |
| Manchester Boston Regional → Salisbury-Ocean City Wicomico Regional MHT–SBY | 1 | 46 | 92% | 382 | Piedmont Airlines | May 2026 – May 2026 |