| Wilmington International → Charlotte/Douglas International ILM–CLT | 2,904 | 256,002 | 80% | 185 | American Airlines Inc., Piedmont Airlines, PSA Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Wilmington International → Laguardia ILM–LGA | 1,722 | 91,870 | 73% | 500 | Republic Airline, Endeavor Air Inc. | Jan 2025 – Jul 2026 |
| Wilmington International → Hartsfield/Jackson Atlanta International ILM–ATL | 1,368 | 125,688 | 88% | 377 | Delta Air Lines Inc., Endeavor Air Inc., TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Wilmington International → Philadelphia International ILM–PHL | 1,222 | 51,125 | 81% | 414 | Piedmont Airlines, PSA Airlines Inc., Republic Airline, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Wilmington International → Ronald Reagan Washington Ntl ILM–DCA | 819 | 37,813 | 67% | 320 | PSA Airlines Inc., Republic Airline, American Airlines Inc. | Jan 2025 – Jul 2026 |
| Wilmington International → Newark Liberty International ILM–EWR | 687 | 34,226 | 78% | 488 | Republic Airline, GoJet Airlines LLC d/b/a... | Jan 2025 – Jul 2026 |
| Wilmington International → Dallas-Fort Worth International ILM–DFW | 679 | 70,366 | 83% | 1,106 | American Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Wilmington International → Chicago O'Hare International ILM–ORD | 528 | 34,231 | 88% | 760 | Envoy Air, SkyWest Airlines Inc., Republic Airline, American Airlines Inc. | May 2025 – Jul 2026 |
| Wilmington International → Miami International ILM–MIA | 451 | 26,673 | 61% | 601 | Envoy Air, American Airlines Inc., Republic Airline, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Wilmington International → General Edward Lawrence Logan International ILM–BOS | 428 | 35,305 | 79% | 672 | JetBlue Airways, Republic Airline, Envoy Air, CFM Inc d/b/a Contour... | Apr 2025 – Jul 2026 |
| Wilmington International → Raleigh-Durham International ILM–RDU | 259 | 738 | 83% | 122 | Federal Express Corporation, American Airlines Inc., Endeavor Air Inc., Alaska Airlines Inc. +3 | Jan 2025 – Jul 2026 |
| Wilmington International → Orlando International ILM–MCO | 257 | 26,993 | 77% | 450 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Wilmington International → Tampa International ILM–TPA | 202 | 21,701 | 71% | 513 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Wilmington International → Long Island Mac Arthur ILM–ISP | 154 | 16,911 | 78% | 522 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jun 2025 – Jul 2026 |
| Wilmington International → Tweed/New Haven ILM–HVN | 153 | 18,928 | 77% | 555 | TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Wilmington International → Fort Lauderdale/Hollywood International ILM–FLL | 136 | 14,300 | 74% | 580 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, American Airlines Inc. | Jan 2025 – Jul 2026 |
| Wilmington International → Southwest Florida International ILM–RSW | 132 | 12,711 | 69% | 580 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines, Envoy Air | Jan 2025 – Jul 2026 |
| Wilmington International → Bradley International ILM–BDL | 123 | 12,801 | 76% | 600 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Wilmington International → Rhode Island TF Green International ILM–PVD | 104 | 9,381 | 66% | 623 | Breeze Aviation Group DBA Breeze | Feb 2025 – Jul 2026 |
| Wilmington International → Baltimore/Washington International Thurgood Marshall ILM–BWI | 99 | 11,087 | 68% | 345 | TEM Enterprises dba Avelo Airlines, Endeavor Air Inc., Breeze Aviation Group DBA Breeze | Apr 2025 – Jul 2026 |
| Wilmington International → Frederick Douglass/Greater Rochester International ILM–ROC | 81 | 8,949 | 69% | 611 | TEM Enterprises dba Avelo Airlines | Apr 2025 – Jul 2026 |
| Wilmington International → Akron-Canton Regional ILM–CAK | 77 | 6,890 | 65% | 498 | Breeze Aviation Group DBA Breeze | Nov 2025 – Jul 2026 |
| Wilmington International → Nashville International ILM–BNA | 73 | 7,860 | 66% | 513 | TEM Enterprises dba Avelo Airlines | Apr 2025 – Jul 2026 |
| Wilmington International → Shannon ILM–SNN international | 58 | 0 | | 3,541 | Air Transport International | Aug 2025 – Jul 2026 |
| Wilmington International → Minneapolis-St Paul Intl/Wold-Chamberlain ILM–MSP | 53 | 6,704 | 84% | 1,094 | Delta Air Lines Inc., Sun Country Airlines d/b/a... | Apr 2025 – Jul 2026 |
| Wilmington International → Manchester Boston Regional ILM–MHT | 42 | 4,674 | 77% | 692 | TEM Enterprises dba Avelo Airlines | Apr 2025 – Jan 2026 |
| Wilmington International → New Castle ILM–ILG | 41 | 5,528 | 73% | 394 | TEM Enterprises dba Avelo Airlines | Apr 2025 – Jul 2026 |
| Wilmington International → Detroit Metro Wayne County ILM–DTW | 38 | 3,380 | 61% | 623 | TEM Enterprises dba Avelo Airlines, Sun Country Airlines d/b/a... | Jun 2025 – Feb 2026 |
| Wilmington International → Washington Dulles International ILM–IAD | 22 | 1,688 | 60% | 324 | TEM Enterprises dba Avelo Airlines, GoJet Airlines LLC d/b/a..., Republic Airline, PSA Airlines Inc. | Apr 2025 – May 2026 |
| Wilmington International → West Palm Beach/Palm Beach ILM–PBI | 21 | 1,573 | 49% | 539 | TEM Enterprises dba Avelo Airlines, American Airlines Inc. | Nov 2025 – Jan 2026 |
| Wilmington International → William P Hobby ILM–HOU | 16 | 784 | 34% | 1,068 | TEM Enterprises dba Avelo Airlines | Jun 2025 – Sep 2025 |
| Wilmington International → Denver International ILM–DEN | 13 | 831 | 88% | 1,522 | SkyWest Airlines Inc. | May 2025 – Jul 2026 |
| Wilmington International → Atlantic City International ILM–ACY | 10 | 816 | 44% | 403 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Wilmington International → Wilmington Air Park ILM–ILN | 7 | 0 | | 483 | Air Transport International | Aug 2025 – Jul 2026 |
| Wilmington International → Paulding Northwest Atlanta ILM–PUJ international | 7 | 415 | 36% | 1,230 | TEM Enterprises dba Avelo Airlines | Dec 2025 – Jan 2026 |
| Wilmington International → Norfolk International ILM–ORF | 5 | 345 | 73% | 205 | PSA Airlines Inc., Delta Air Lines Inc., SkyWest Airlines Inc., Republic Airline | Jun 2025 – Jul 2026 |
| Wilmington International → Wilmington International ILM–ILM | 4 | 0 | 0% | 0 | SkyWest Airlines Inc. | Feb 2025 – Jul 2026 |
| Wilmington International → Lovell Field ILM–CHA | 3 | 167 | 73% | 419 | Delta Air Lines Inc., CFM Inc d/b/a Contour... | Apr 2025 – Jun 2026 |
| Wilmington International → Charleston Afb/Intl ILM–CHS | 3 | 377 | 88% | 155 | Delta Air Lines Inc., TEM Enterprises dba Avelo Airlines | Jun 2025 – Jul 2026 |
| Wilmington International → Coastal Carolina Regional ILM–EWN | 3 | 109 | 73% | 74 | Piedmont Airlines | Oct 2025 – May 2026 |
| Wilmington International → General Mitchell International ILM–MKE | 3 | 70 | 40% | 806 | Air Wisconsin Airlines Corp, Envoy Air | Dec 2025 – Mar 2026 |
| Wilmington International → Louis Armstrong New Orleans International ILM–MSY | 3 | 255 | 60% | 781 | American Airlines Inc., Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Apr 2026 – Jun 2026 |
| Wilmington International → Naples Municipal ILM–APF | 2 | 5 | 31% | 605 | CFM Inc d/b/a Contour..., Tradewind Aviation | Jan 2026 – Jul 2026 |
| Wilmington International → Florence Regional ILM–FLO | 2 | 80 | 80% | 104 | Piedmont Airlines | May 2026 – May 2026 |
| Wilmington International → Page Field ILM–FMY | 2 | 3 | 18% | 579 | CFM Inc d/b/a Contour... | Jan 2026 – Jul 2026 |
| Wilmington International → Westchester County ILM–HPN | 2 | 0 | 0% | 522 | CFM Inc d/b/a Contour... | Mar 2026 – Jun 2026 |
| Wilmington International → Indianapolis International ILM–IND | 2 | 0 | 0% | 597 | Republic Airline | Jul 2025 – Jul 2026 |
| Wilmington International → John F Kennedy International ILM–JFK | 2 | 288 | 95% | 494 | JetBlue Airways | Oct 2025 – Jul 2026 |
| Wilmington International → Myrtle Beach International ILM–MYR | 2 | 193 | 91% | 71 | Envoy Air, Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Wilmington International → Okc Will Rogers International ILM–OKC | 2 | 0 | 0% | 1,121 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Wilmington International → Miami-Opa Locka Executive ILM–OPF | 2 | 2 | 25% | 593 | Air Transport International, CFM Inc d/b/a Contour... | Mar 2025 – Apr 2026 |
| Wilmington International → Hattiesburg/Laurel Regional ILM–PIB | 2 | 0 | 0% | 692 | TEM Enterprises dba Avelo Airlines | Oct 2025 – Nov 2025 |
| Wilmington International → Savannah/Hilton Head International ILM–SAV | 2 | 0 | 0% | 241 | SkyWest Airlines Inc. | Jul 2025 – Jun 2026 |
| Wilmington International → Luis Munoz Marin International ILM–SJU | 2 | 316 | 65% | 1,314 | American Airlines Inc., Omni Air International LLC | Dec 2025 – Apr 2026 |
| Wilmington International → Concord ILM–USA | 2 | 287 | 78% | 177 | TEM Enterprises dba Avelo Airlines | Jan 2025 – May 2026 |
| Wilmington International → Nantucket Memorial ILM–ACK | 1 | 0 | 0% | 645 | ACM AIR CHARTER GmbH | Jun 2026 – Jun 2026 |
| Wilmington International → Perot Fld/Fort Worth Alliance ILM–AFW | 1 | 0 | 0% | 1,121 | Omni Air International LLC | Mar 2026 – Mar 2026 |
| Wilmington International → Augusta Regional AT Bush Field ILM–AGS | 1 | 68 | 89% | 242 | Endeavor Air Inc. | Jan 2026 – Jan 2026 |
| Wilmington International → Athens/Ben Epps ILM–AHN | 1 | 0 | 0% | 312 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Wilmington International → Asheville Regional ILM–AVL | 1 | 47 | 44% | 276 | Breeze Aviation Group DBA Breeze | Apr 2026 – Apr 2026 |
| Wilmington International → Wilkes-Barre/Scranton International ILM–AVP | 1 | 55 | 85% | 502 | Republic Airline | Feb 2025 – Dec 2025 |
| Wilmington International → Boca Raton ILM–BCT | 1 | 3 | 38% | 560 | Tradewind Aviation | Oct 2025 – Oct 2025 |
| Wilmington International → Columbia Metro ILM–CAE | 1 | 47 | 94% | 186 | Piedmont Airlines | Jun 2025 – Jan 2026 |
| Wilmington International → Cleveland-Hopkins International ILM–CLE | 1 | 0 | 0% | 538 | Republic Airline | Jun 2025 – Aug 2025 |
| Wilmington International → John Glenn Columbus International ILM–CMH | 1 | 0 | 0% | 481 | Ameristar Air Cargo | Mar 2026 – Mar 2026 |
| Wilmington International → Cancun ILM–CUN international | 1 | 0 | 0% | 1,063 | TEM Enterprises dba Avelo Airlines | Nov 2025 – Nov 2025 |
| Wilmington International → Cincinnati/Northern Kentucky International ILM–CVG | 1 | 0 | 0% | 500 | Republic Airline | Jul 2026 – Jul 2026 |
| Wilmington International → Edinburgh ILM–EDI international | 1 | 10 | 71% | 3,729 | VistaJet Limited | Aug 2025 – Aug 2025 |
| Wilmington International → Fayetteville Rgnl/Grannis Field ILM–FAY | 1 | 94 | 51% | 75 | Sun Country Airlines d/b/a... | Feb 2025 – Apr 2026 |
| Wilmington International → Northern Colorado Regional ILM–FNL | 1 | 0 | 0% | 1,545 | Eastern Air Express, LLC (EAX) | Mar 2026 – Mar 2026 |
| Wilmington International → Gulfport-Biloxi International ILM–GPT | 1 | 70 | 38% | 705 | Sun Country Airlines d/b/a... | Jun 2025 – Feb 2026 |
| Wilmington International → Robert Gray Army Airfield ILM–GRK | 1 | 73 | 96% | 1,180 | Envoy Air | Aug 2025 – Aug 2025 |
| Wilmington International → Piedmont Triad International ILM–GSO | 1 | 21 | 32% | 171 | PSA Airlines Inc. | May 2026 – May 2026 |
| Wilmington International → Gary/Chicago International ILM–GYY | 1 | 37 | 74% | 725 | Air Wisconsin Airlines Corp | Dec 2025 – Dec 2025 |
| Wilmington International → Heraklion ILM–HER international | 1 | 4 | 27% | 5,542 | FAI rent-a-jet AG | Jun 2026 – Jun 2026 |
| Wilmington International → Hilton Head ILM–HHH | 1 | 0 | 0% | 214 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Wilmington International → Brooksville ILM–JZQ | 1 | 0 | 0% | 481 | CFM Inc d/b/a Contour... | Apr 2025 – Jul 2026 |
| Wilmington International → Blue Grass ILM–LEX | 1 | 59 | 78% | 456 | Envoy Air | Mar 2026 – Mar 2026 |
| Wilmington International → Lafayette Rgnl/Paul Fournet Field ILM–LFT | 1 | 37 | 74% | 870 | Air Wisconsin Airlines Corp | Apr 2025 – Dec 2025 |
| Wilmington International → Bill And Hillary Clinton Ntl/Adams Field ILM–LIT | 1 | 128 | 100% | 817 | American Airlines Inc. | Jun 2026 – Jun 2026 |
| Wilmington International → London/Corbin/Magee ILM–LOZ | 1 | 8 | 57% | 398 | Air Hamburg... | Aug 2025 – Aug 2025 |
| Wilmington International → Harrisburg International ILM–MDT | 1 | 26 | 34% | 413 | Endeavor Air Inc. | Dec 2025 – Dec 2025 |
| Wilmington International → Frederick W Smith Intl/Memphis ILM–MEM | 1 | 122 | 95% | 689 | American Airlines Inc. | Jun 2026 – Jun 2026 |
| Wilmington International → Smyrna ILM–MQY | 1 | 0 | 0% | 502 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Wilmington International → Monroe ILM–N2C | 1 | 7 | 88% | 163 | CFM Inc d/b/a Contour... | Jun 2026 – Jun 2026 |
| Wilmington International → Norfolk NS (Chambers Field) ILM–NGU | 1 | 0 | | 205 | Air Transport International | Apr 2026 – Apr 2026 |
| Wilmington International → Albert J Ellis ILM–OAJ | 1 | 45 | 90% | 42 | Piedmont Airlines | May 2025 – May 2026 |
| Wilmington International → Ocala Intl-Jim Taylor Field ILM–OCF | 1 | 0 | 0% | 433 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| Wilmington International → Pitt-Greenville ILM–PGV | 1 | 45 | 90% | 99 | Piedmont Airlines | Jun 2025 – Feb 2026 |
| Wilmington International → Pittsburgh International ILM–PIT | 1 | 0 | 0% | 448 | Sun Country Airlines d/b/a... | Jun 2026 – Jun 2026 |
| Wilmington International → Portland International Jetport ILM–PWM | 1 | 7 | 88% | 765 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| Wilmington International → Richmond International ILM–RIC | 1 | 53 | 82% | 226 | Republic Airline | Mar 2026 – Mar 2026 |
| Wilmington International → March Arb ILM–RIV | 1 | 0 | 0% | 2,243 | TEM Enterprises dba Avelo Airlines | Aug 2025 – Aug 2025 |
| Wilmington International → Roanoke/Blacksburg Regional (Woodrum Field) ILM–ROA | 1 | 8 | 100% | 241 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Wilmington International → Louisville Muhammad Ali International ILM–SDF | 1 | 0 | | 514 | Air Transport International | Jul 2025 – Apr 2026 |
| Wilmington International → Tulsa International ILM–TUL | 1 | 172 | 100% | 1,025 | American Airlines Inc. | Jul 2026 – Jul 2026 |
| Wilmington International → Leesburg ILM–VA4 | 1 | 0 | 0% | 332 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| Wilmington International → Hamilton ILM–YHM international | 1 | 2 | 22% | 624 | Hamilton Jetport Limited | Jan 2026 – Jan 2026 |