| Spokane International → Seattle-Tacoma International GEG–SEA | 6,194 | 500,797 | 79% | 224 | SkyWest Airlines Inc., Alaska Airlines Inc., Horizon Air, Delta Air Lines Inc. +3 | Jan 2025 – Jul 2026 |
| Spokane International → Denver International GEG–DEN | 2,039 | 259,650 | 81% | 836 | Southwest Airlines Co., United Air Lines Inc., SkyWest Airlines Inc., Frontier Airlines Inc. +1 | Jan 2025 – Jul 2026 |
| Spokane International → Portland International GEG–PDX | 1,748 | 149,103 | 80% | 279 | Horizon Air, Alaska Airlines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → Salt Lake City International GEG–SLC | 1,662 | 147,411 | 79% | 546 | Delta Air Lines Inc., SkyWest Airlines Inc., United Air Lines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Spokane International → Boise Air Trml/Gowen Field GEG–BOI | 1,303 | 69,869 | 70% | 287 | Horizon Air, SkyWest Airlines Inc., Delta Air Lines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Spokane International → Phoenix Sky Harbor International GEG–PHX | 1,250 | 148,565 | 77% | 1,020 | Southwest Airlines Co., American Airlines Inc., Frontier Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Spokane International → Los Angeles International GEG–LAX | 1,232 | 86,976 | 76% | 945 | SkyWest Airlines Inc., Horizon Air, Alaska Airlines Inc., Allegiant Air +2 | Jan 2025 – Jul 2026 |
| Spokane International → San Francisco International GEG–SFO | 1,042 | 61,924 | 77% | 733 | SkyWest Airlines Inc., Horizon Air, United Air Lines Inc., Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → Harry Reid International GEG–LAS | 857 | 107,344 | 76% | 806 | Southwest Airlines Co., Allegiant Air, United Parcel Service | Jan 2025 – Jul 2026 |
| Spokane International → Minneapolis-St Paul Intl/Wold-Chamberlain GEG–MSP | 807 | 115,089 | 84% | 1,175 | Delta Air Lines Inc., Sun Country Airlines d/b/a..., SkyWest Airlines Inc., American Airlines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → Yakima Air Trml/Mcallister Field GEG–YKM | 762 | 0 | | 159 | Federal Express Corporation, Empire Airlines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → Chicago O'Hare International GEG–ORD | 696 | 64,324 | 84% | 1,498 | SkyWest Airlines Inc., American Airlines Inc., United Air Lines Inc., Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → Sacramento International GEG–SMF | 606 | 63,121 | 66% | 649 | Southwest Airlines Co., Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → Louisville Muhammad Ali International GEG–SDF | 553 | 0 | | 1,725 | United Parcel Service | Jan 2025 – Jul 2026 |
| Spokane International → Dallas-Fort Worth International GEG–DFW | 539 | 87,661 | 89% | 1,477 | American Airlines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → Hartsfield/Jackson Atlanta International GEG–ATL | 531 | 78,759 | 84% | 1,969 | Delta Air Lines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → San Diego International GEG–SAN | 416 | 56,322 | 79% | 1,027 | Alaska Airlines Inc., Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Spokane International → Oakland San Francisco Bay GEG–OAK | 404 | 47,130 | 75% | 723 | Southwest Airlines Co., Federal Express Corporation, United Parcel Service, Allegiant Air | Jan 2025 – Jul 2026 |
| Spokane International → Ontario International GEG–ONT | 350 | 123 | 90% | 936 | United Parcel Service, Southwest Airlines Co. | Jan 2025 – Jul 2026 |
| Spokane International → San Bernardino International GEG–SBD | 346 | 0 | | 933 | Sun Country Airlines d/b/a..., Air Transport International, ABX Air Inc | Jan 2025 – Jul 2026 |
| Spokane International → Frederick W Smith Intl/Memphis GEG–MEM | 302 | 0 | | 1,662 | Federal Express Corporation | Jan 2025 – Jul 2026 |
| Spokane International → Mineta San Jose International GEG–SJC | 242 | 26,015 | 68% | 742 | Southwest Airlines Co., SkyWest Airlines Inc., Horizon Air | Jan 2025 – Jul 2026 |
| Spokane International → John Wayne/Orange County GEG–SNA | 234 | 17,376 | 85% | 962 | Horizon Air, Allegiant Air | May 2025 – Jul 2026 |
| Spokane International → Phoenix GEG–AZA | 98 | 15,836 | 90% | 1,034 | Allegiant Air | Jan 2025 – Jul 2026 |
| Spokane International → Chicago Midway International GEG–MDW | 85 | 13,290 | 93% | 1,511 | Southwest Airlines Co. | Jun 2025 – Jul 2026 |
| Spokane International → Reno/Tahoe International GEG–RNO | 48 | 69 | 91% | 572 | Federal Express Corporation, United Parcel Service, Horizon Air | Feb 2025 – Jul 2026 |
| Spokane International → Spokane International GEG–GEG | 36 | 0 | 0% | 0 | SkyWest Airlines Inc., Empire Airlines Inc., Alaska Airlines Inc. | Jan 2025 – Jul 2026 |
| Spokane International → Boeing Fld/King County International GEG–BFI | 18 | 5 | 42% | 223 | United Parcel Service, Kenmore Air Harbor | Jan 2025 – May 2026 |
| Spokane International → Dallas Love Field GEG–DAL | 18 | 2,531 | 91% | 1,486 | Southwest Airlines Co. | Jun 2025 – Jul 2026 |
| Spokane International → Ted Stevens Anchorage International GEG–ANC | 17 | 1,416 | 96% | 1,584 | Horizon Air, Alaska Airlines Inc. | May 2025 – Jul 2026 |
| Spokane International → Tri-Cities GEG–PSC | 11 | 308 | 55% | 120 | SkyWest Airlines Inc., Empire Airlines Inc., Federal Express Corporation, Horizon Air +1 | Feb 2025 – Jul 2026 |
| Spokane International → George Bush Intcntl/Houston GEG–IAH | 10 | 537 | 71% | 1,695 | SkyWest Airlines Inc. | May 2026 – Jul 2026 |
| Spokane International → Missoula Montana GEG–MSO | 7 | 609 | 74% | 169 | United Air Lines Inc., SkyWest Airlines Inc., Envoy Air, Horizon Air | Apr 2025 – Jul 2026 |
| Spokane International → General Edward Lawrence Logan International GEG–BOS | 6 | 845 | 75% | 2,274 | Delta Air Lines Inc., Alaska Airlines Inc. | Nov 2025 – Jun 2026 |
| Spokane International → Laughlin/Bullhead International GEG–IFP | 6 | 554 | 50% | 874 | Sun Country Airlines d/b/a... | Jan 2025 – May 2026 |
| Spokane International → John F Kennedy International GEG–JFK | 6 | 848 | 76% | 2,198 | Alaska Airlines Inc., Delta Air Lines Inc. | Nov 2025 – Nov 2025 |
| Spokane International → Okc Will Rogers International GEG–OKC | 5 | 750 | 92% | 1,328 | American Airlines Inc., CommuteAir LLC dba CommuteAir | Mar 2025 – Jul 2026 |
| Spokane International → Albuquerque International Sunport GEG–ABQ | 4 | 0 | | 1,035 | United Parcel Service, Federal Express Corporation | Jun 2025 – Dec 2025 |
| Spokane International → City Of Colorado Springs Municipal GEG–COS | 4 | 382 | 87% | 887 | Southwest Airlines Co., Federal Express Corporation, United Air Lines Inc. | Mar 2025 – May 2026 |
| Spokane International → Great Falls International GEG–GTF | 4 | 0 | 0% | 288 | Federal Express Corporation, Sun Country Airlines d/b/a... | Jun 2025 – Jun 2026 |
| Spokane International → Newark Liberty International GEG–EWR | 3 | 387 | 72% | 2,178 | Alaska Airlines Inc. | Mar 2025 – Nov 2025 |
| Spokane International → Kalispell GEG–FCA | 3 | 280 | 87% | 160 | Delta Air Lines Inc., Federal Express Corporation, United Air Lines Inc. | May 2025 – May 2026 |
| Spokane International → Washington Dulles International GEG–IAD | 3 | 388 | 83% | 2,082 | Allegiant Air, Delta Air Lines Inc. | Apr 2025 – Apr 2026 |
| Spokane International → Eppley Airfield GEG–OMA | 3 | 344 | 78% | 1,151 | Delta Air Lines Inc., Breeze Aviation Group DBA Breeze, Southwest Airlines Co. | Aug 2025 – Feb 2026 |
| Spokane International → Rick Husband Amarillo International GEG–AMA | 2 | 275 | 96% | 1,182 | American Airlines Inc., Southwest Airlines Co. | Oct 2025 – Jul 2026 |
| Spokane International → Billings Logan International GEG–BIL | 2 | 50 | 19% | 445 | Horizon Air, Sun Country Airlines d/b/a... | Oct 2025 – Jan 2026 |
| Spokane International → Bellingham International GEG–BLI | 2 | 0 | 0% | 245 | Sun Country Airlines d/b/a... | Jul 2025 – Mar 2026 |
| Spokane International → Detroit Metro Wayne County GEG–DTW | 2 | 109 | 61% | 1,703 | Alaska Airlines Inc., Federal Express Corporation | Nov 2025 – Dec 2025 |
| Spokane International → General Mitchell International GEG–MKE | 2 | 0 | 0% | 1,471 | SkyWest Airlines Inc. | Mar 2025 – Jul 2026 |
| Spokane International → Seattle Paine Field International GEG–PAE | 2 | 16 | 100% | 222 | Kenmore Air Harbor | Apr 2025 – Mar 2026 |
| Spokane International → Palm Springs International GEG–PSP | 2 | 0 | 0% | 953 | SkyWest Airlines Inc. | Feb 2025 – Jul 2026 |
| Spokane International → San Antonio International GEG–SAT | 2 | 278 | 85% | 1,610 | American Airlines Inc., Allegiant Air | Aug 2025 – Aug 2025 |
| Spokane International → Joslin Fld/Magic Valley Regional GEG–TWF | 2 | 198 | 99% | 385 | Delta Air Lines Inc., SkyWest Airlines Inc. | Aug 2025 – Feb 2026 |
| Spokane International → Willow Run GEG–YIP | 2 | 0 | 0% | 1,695 | Ameristar Air Cargo, Global Crossing Airlines, Inc. | Mar 2025 – Mar 2026 |
| Spokane International → Vancouver GEG–YVR international | 2 | 118 | 37% | 282 | Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Mar 2026 – Jun 2026 |
| Spokane International → Calgary GEG–YYC international | 2 | 129 | 38% | 290 | Flair Airlines Ltd., United Air Lines Inc. | Jan 2025 – Mar 2026 |
| Spokane International → Waterloo Regional GEG–ALO | 1 | 122 | 78% | 1,272 | Allegiant Air | Sep 2025 – Sep 2025 |
| Spokane International → Austin-Bergstrom International GEG–AUS | 1 | 139 | 73% | 1,600 | American Airlines Inc. | Feb 2025 – Jun 2026 |
| Spokane International → Bozeman Yellowstone International GEG–BZN | 1 | 0 | 0% | 329 | SkyWest Airlines Inc. | Apr 2025 – Mar 2026 |
| Spokane International → The Eastern Iowa GEG–CID | 1 | 71 | 55% | 1,324 | American Airlines Inc. | Apr 2026 – Apr 2026 |
| Spokane International → Mahlon Sweet Field GEG–EUG | 1 | 1 | 17% | 365 | Kenmore Air Harbor | Nov 2025 – Nov 2025 |
| Spokane International → Northern Colorado Regional GEG–FNL | 1 | 123 | 68% | 795 | Allegiant Air | Nov 2025 – Nov 2025 |
| Spokane International → Joe Foss Field GEG–FSD | 1 | 0 | 0% | 1,042 | SkyWest Airlines Inc. | Apr 2026 – Apr 2026 |
| Spokane International → Grand Junction Regional GEG–GJT | 1 | 164 | 99% | 741 | United Air Lines Inc. | Jun 2025 – Jun 2026 |
| Spokane International → Helena Regional GEG–HLN | 1 | 67 | 88% | 271 | Horizon Air | May 2026 – May 2026 |
| Spokane International → Huntsville Intl-Carl T Jones Field GEG–HSV | 1 | 127 | 71% | 1,821 | Delta Air Lines Inc. | Jun 2025 – Mar 2026 |
| Spokane International → Wichita Dwight D Eisenhower Ntl GEG–ICT | 1 | 173 | 99% | 1,228 | Southwest Airlines Co. | Mar 2025 – Aug 2025 |
| Spokane International → Lubbock Preston Smith International GEG–LBB | 1 | 160 | 93% | 1,264 | American Airlines Inc. | Jun 2026 – Jun 2026 |
| Spokane International → Long Beach (Daugherty Field) GEG–LGB | 1 | 74 | 54% | 953 | Breeze Aviation Group DBA Breeze | Nov 2025 – Nov 2025 |
| Spokane International → Lincoln GEG–LNK | 1 | 0 | 0% | 1,128 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Spokane International → Quad Cities International GEG–MLI | 1 | 121 | 78% | 1,393 | Allegiant Air | Sep 2025 – Sep 2025 |
| Spokane International → Dane County Rgnl/Truax Field GEG–MSN | 1 | 0 | 0% | 1,398 | SkyWest Airlines Inc. | Jul 2026 – Jul 2026 |
| Spokane International → Montrose Regional GEG–MTJ | 1 | 163 | 93% | 795 | Southwest Airlines Co. | Dec 2025 – Dec 2025 |
| Spokane International → Ogden-Hinckley GEG–OGD | 1 | 123 | 79% | 521 | Allegiant Air | Oct 2025 – Oct 2025 |
| Spokane International → Pullman/Moscow Regional GEG–PUW | 1 | 0 | 0% | 64 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Spokane International → Chicago/Rockford International GEG–RFD | 1 | 0 | | 1,436 | United Parcel Service | Sep 2025 – Sep 2025 |
| Spokane International → Frederick Douglass/Greater Rochester International GEG–ROC | 1 | 0 | 0% | 1,943 | SkyWest Airlines Inc. | Jun 2026 – Jun 2026 |
| Spokane International → San Luis Obispo County Regional GEG–SBP | 1 | 149 | 83% | 869 | Allegiant Air | Nov 2025 – Nov 2025 |
| Spokane International → Sheppard Afb/Wichita Falls Municipal GEG–SPS | 1 | 165 | 87% | 1,365 | American Airlines Inc. | Jun 2026 – Jun 2026 |
| Spokane International → Tampa International GEG–TPA | 1 | 160 | 82% | 2,315 | Delta Air Lines Inc. | Apr 2025 – Nov 2025 |
| Spokane International → Tucson International GEG–TUS | 1 | 96 | 55% | 1,124 | Southwest Airlines Co. | Jul 2025 – Mar 2026 |
| Spokane International → Van Nuys GEG–VNY | 1 | 2 | 29% | 927 | Scott Aviation, LLC d/b/a... | Dec 2025 – Dec 2025 |
| Spokane International → Edmonton GEG–YEG international | 1 | 77 | 41% | 430 | Flair Airlines Ltd. | Nov 2025 – Nov 2025 |