| Columbia Regional → Chicago O'Hare International COU–ORD | 1,947 | 78,745 | 67% | 315 | Envoy Air, SkyWest Airlines Inc., GoJet Airlines LLC d/b/a..., Global Crossing Airlines, Inc. +1 | Jan 2025 – Jul 2026 |
| Columbia Regional → Dallas-Fort Worth International COU–DFW | 1,205 | 63,250 | 73% | 490 | Envoy Air, SkyWest Airlines Inc., PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| Columbia Regional → Denver International COU–DEN | 305 | 17,762 | 83% | 671 | SkyWest Airlines Inc. | Sep 2025 – Jul 2026 |
| Columbia Regional → Charlotte/Douglas International COU–CLT | 71 | 4,695 | 87% | 670 | Envoy Air | May 2026 – Jul 2026 |
| Columbia Regional → Columbia Regional COU–COU | 24 | 0 | 0% | 0 | SkyWest Airlines Inc. | Feb 2025 – Jul 2026 |
| Columbia Regional → Orlando Sanford International COU–SFB | 17 | 2,310 | 84% | 936 | Allegiant Air | Jun 2026 – Jul 2026 |
| Columbia Regional → Eglin Afb/Destin-Ft Walton Beach COU–VPS | 17 | 2,653 | 87% | 659 | Allegiant Air | Jun 2026 – Jul 2026 |
| Columbia Regional → Minneapolis-St Paul Intl/Wold-Chamberlain COU–MSP | 5 | 39 | 4% | 421 | Sun Country Airlines d/b/a... | Oct 2025 – Dec 2025 |
| Columbia Regional → Jacksonville International COU–JAX | 4 | 336 | 46% | 828 | Sun Country Airlines d/b/a..., Allegiant Air | Dec 2025 – Dec 2025 |
| Columbia Regional → Hartsfield/Jackson Atlanta International COU–ATL | 3 | 0 | 0% | 563 | Delta Air Lines Inc. | Feb 2025 – Feb 2026 |
| Columbia Regional → Nashville International COU–BNA | 3 | 303 | 64% | 357 | Sun Country Airlines d/b/a..., Southwest Airlines Co., TEM Enterprises dba Avelo Airlines | Jan 2025 – May 2026 |
| Columbia Regional → Baton Rouge Metro, Ryan Field COU–BTR | 3 | 125 | 55% | 575 | Global Crossing Airlines, Inc., Breeze Aviation Group DBA Breeze, Air Wisconsin Airlines Corp | Jan 2025 – Apr 2026 |
| Columbia Regional → Fort Wayne International COU–FWA | 3 | 0 | 0% | 401 | SkyWest Airlines Inc. | Nov 2025 – Jul 2026 |
| Columbia Regional → Gainesville Regional COU–GNV | 3 | 58 | 22% | 847 | Breeze Aviation Group DBA Breeze, SkyWest Airlines Inc. | Jan 2025 – Mar 2026 |
| Columbia Regional → State College COU–SCE | 3 | 0 | 0% | 776 | SkyWest Airlines Inc. | Jun 2026 – Jun 2026 |
| Columbia Regional → Austin-Bergstrom International COU–AUS | 2 | 77 | 52% | 671 | CommuteAir LLC dba CommuteAir | Jan 2025 – Feb 2026 |
| Columbia Regional → Columbia Metro COU–CAE | 2 | 253 | 75% | 704 | Delta Air Lines Inc., Breeze Aviation Group DBA Breeze | Sep 2025 – Sep 2025 |
| Columbia Regional → Charlottesville-Albemarle COU–CHO | 2 | 0 | 0% | 747 | SkyWest Airlines Inc. | Apr 2026 – May 2026 |
| Columbia Regional → Easterwood Field COU–CLL | 2 | 228 | 88% | 614 | Ameristar Air Cargo, United Air Lines Inc. | Feb 2025 – Mar 2026 |
| Columbia Regional → Greenville Spartanburg International COU–GSP | 2 | 0 | 0% | 616 | Global Crossing Airlines, Inc. | Mar 2025 – Mar 2026 |
| Columbia Regional → Madrid COU–MAD international | 2 | 9 | 38% | 4,509 | Air Hamburg... | Feb 2025 – Jan 2026 |
| Columbia Regional → Mbs International COU–MBS | 2 | 0 | 0% | 534 | SkyWest Airlines Inc. | Nov 2025 – Mar 2026 |
| Columbia Regional → Kansas City International COU–MCI | 2 | 0 | 0% | 138 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| Columbia Regional → Montgomery Regional (Dannelly Field) COU–MGM | 2 | 235 | 80% | 556 | Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Oct 2025 – Oct 2025 |
| Columbia Regional → Quad Cities International COU–MLI | 2 | 71 | 56% | 202 | Envoy Air, SkyWest Airlines Inc. | May 2026 – Jun 2026 |
| Columbia Regional → Dane County Rgnl/Truax Field COU–MSN | 2 | 53 | 42% | 334 | Envoy Air, SkyWest Airlines Inc. | Nov 2025 – May 2026 |
| Columbia Regional → Okc Will Rogers International COU–OKC | 2 | 155 | 66% | 380 | SkyWest Airlines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Mar 2026 |
| Columbia Regional → South Bend International COU–SBN | 2 | 0 | 0% | 370 | SkyWest Airlines Inc. | May 2026 – Jun 2026 |
| Columbia Regional → Springfield-Branson Ntl COU–SGF | 2 | 83 | 59% | 126 | Envoy Air | Aug 2025 – Oct 2025 |
| Columbia Regional → Tuscaloosa Ntl COU–TCL | 2 | 200 | 80% | 464 | Delta Air Lines Inc., Air Wisconsin Airlines Corp | Jan 2025 – Jan 2026 |
| Columbia Regional → Teterboro COU–TEB | 2 | 0 | | 974 | Air Hamburg... | Sep 2025 – Nov 2025 |
| Columbia Regional → MC Ghee Tyson COU–TYS | 2 | 88 | 55% | 498 | Delta Air Lines Inc., Air Wisconsin Airlines Corp | Feb 2025 – May 2026 |
| Columbia Regional → Northwest Arkansas Ntl COU–XNA | 2 | 191 | 73% | 209 | Envoy Air, Sun Country Airlines d/b/a... | Feb 2025 – Jan 2026 |
| Columbia Regional → Westfield-Barnes Regional COU–BAF | 1 | 152 | 82% | 1,050 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Columbia Regional → Birmingham-Shuttlesworth International COU–BHM | 1 | 73 | 96% | 474 | Envoy Air | Oct 2025 – Oct 2025 |
| Columbia Regional → Monroe County COU–BMG | 1 | 8 | 89% | 302 | ADVANCED AIR, LLC | Nov 2025 – Nov 2025 |
| Columbia Regional → University Of Illinois/Willard COU–CMI | 1 | 40 | 37% | 227 | Breeze Aviation Group DBA Breeze | Dec 2025 – Dec 2025 |
| Columbia Regional → City Of Colorado Springs Municipal COU–COS | 1 | 0 | 0% | 673 | SkyWest Airlines Inc. | Oct 2025 – Oct 2025 |
| Columbia Regional → Columbus COU–CSG | 1 | 0 | 0% | 597 | SkyWest Airlines Inc. | Jan 2025 – Mar 2026 |
| Columbia Regional → James M Cox Dayton International COU–DAY | 1 | 60 | 92% | 435 | Envoy Air | Jan 2025 – Jun 2026 |
| Columbia Regional → Golden Triangle Regional COU–GTR | 1 | 149 | 83% | 422 | United Air Lines Inc. | Jan 2025 – Nov 2025 |
| Columbia Regional → William P Hobby COU–HOU | 1 | 43 | 72% | 656 | Ameristar Air Cargo | Feb 2025 – Jan 2026 |
| Columbia Regional → Huntsville Intl-Carl T Jones Field COU–HSV | 1 | 0 | 0% | 417 | SkyWest Airlines Inc. | Mar 2026 – Mar 2026 |
| Columbia Regional → Capital Region International COU–LAN | 1 | 20 | 31% | 484 | Envoy Air | Nov 2025 – Nov 2025 |
| Columbia Regional → Lawton-Fort Sill Regional COU–LAW | 1 | 72 | 95% | 452 | Envoy Air | Sep 2025 – Sep 2025 |
| Columbia Regional → Blue Grass COU–LEX | 1 | 0 | 0% | 416 | SkyWest Airlines Inc. | Mar 2025 – May 2026 |
| Columbia Regional → Lafayette Rgnl/Paul Fournet Field COU–LFT | 1 | 163 | 88% | 594 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Columbia Regional → Lille COU–LIL international | 1 | 4 | 29% | 4,433 | Air Hamburg... | Aug 2025 – Aug 2025 |
| Columbia Regional → Bill And Hillary Clinton Ntl/Adams Field COU–LIT | 1 | 0 | 0% | 282 | Sun Country Airlines d/b/a... | May 2025 – Nov 2025 |
| Columbia Regional → General Mitchell International COU–MKE | 1 | 32 | 49% | 363 | Envoy Air | Jan 2025 – Jan 2026 |
| Columbia Regional → Oakland San Francisco Bay COU–OAK | 1 | 33 | 22% | 1,626 | Global Crossing Airlines, Inc. | Dec 2025 – Dec 2025 |
| Columbia Regional → Olbia COU–OLB international | 1 | 0 | 0% | 5,063 | Concierge U Ltd. d/b/a Jet... | Aug 2025 – Aug 2025 |
| Columbia Regional → Page Municipal COU–PGA | 1 | 4 | 67% | 1,058 | Scott Aviation, LLC d/b/a... | Nov 2025 – Nov 2025 |
| Columbia Regional → General Downing - Peoria International COU–PIA | 1 | 0 | 0% | 185 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |
| Columbia Regional → Raleigh-Durham International COU–RDU | 1 | 27 | 90% | 766 | CFM Inc d/b/a Contour... | Feb 2025 – Nov 2025 |
| Columbia Regional → Sheppard Afb/Wichita Falls Municipal COU–SPS | 1 | 61 | 94% | 483 | Envoy Air | May 2026 – May 2026 |
| Columbia Regional → Cyril E King COU–STT | 1 | 114 | 63% | 2,160 | Allegiant Air | Mar 2026 – Mar 2026 |
| Columbia Regional → Tulsa International COU–TUL | 1 | 61 | 94% | 271 | Envoy Air | Dec 2025 – Dec 2025 |
| Columbia Regional → Tyler Pounds Regional COU–TYR | 1 | 61 | 94% | 481 | Envoy Air | Feb 2026 – Feb 2026 |
| Columbia Regional → University-Oxford COU–UOX | 1 | 0 | 0% | 340 | SkyWest Airlines Inc. | Jan 2025 – Jan 2026 |