| Gainesville Regional → Hartsfield/Jackson Atlanta International GNV–ATL | 1,693 | 155,293 | 85% | 300 | Delta Air Lines Inc., Endeavor Air Inc. | Jan 2025 – Jul 2026 |
| Gainesville Regional → Charlotte/Douglas International GNV–CLT | 1,543 | 63,841 | 81% | 388 | Piedmont Airlines, PSA Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Gainesville Regional → Dallas-Fort Worth International GNV–DFW | 700 | 43,514 | 82% | 900 | Envoy Air, SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Gainesville Regional → Miami International GNV–MIA | 385 | 18,809 | 64% | 294 | Envoy Air, Tradewind Aviation | Jan 2025 – Jul 2026 |
| Gainesville Regional → Chicago O'Hare International GNV–ORD | 54 | 0 | 0% | 904 | SkyWest Airlines Inc. | May 2025 – Jun 2026 |
| Gainesville Regional → Denver International GNV–DEN | 33 | 0 | 0% | 1,448 | SkyWest Airlines Inc. | May 2025 – Jun 2026 |
| Gainesville Regional → Salt Lake City International GNV–SLC | 13 | 0 | 0% | 1,834 | SkyWest Airlines Inc. | Dec 2025 – Apr 2026 |
| Gainesville Regional → Los Angeles International GNV–LAX | 10 | 0 | 0% | 2,135 | SkyWest Airlines Inc. | Jan 2026 – Mar 2026 |
| Gainesville Regional → Gainesville Regional GNV–GNV | 9 | 0 | 0% | 0 | SkyWest Airlines Inc. | Aug 2025 – Jun 2026 |
| Gainesville Regional → Gulfport-Biloxi International GNV–GPT | 8 | 1,139 | 77% | 410 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Gainesville Regional → Austin-Bergstrom International GNV–AUS | 7 | 758 | 70% | 924 | American Airlines Inc., Delta Air Lines Inc., Global Crossing Airlines, Inc., Envoy Air +2 | Apr 2025 – Feb 2026 |
| Gainesville Regional → Nashville International GNV–BNA | 7 | 155 | 30% | 512 | SkyWest Airlines Inc., Envoy Air, Breeze Aviation Group DBA Breeze, Republic Airline | Jan 2025 – Jun 2026 |
| Gainesville Regional → Easterwood Field GNV–CLL | 7 | 540 | 68% | 845 | Breeze Aviation Group DBA Breeze, Ameristar Air Cargo, Delta Air Lines Inc., Envoy Air | Jan 2025 – Apr 2026 |
| Gainesville Regional → Phoenix Sky Harbor International GNV–PHX | 6 | 0 | 0% | 1,767 | SkyWest Airlines Inc. | Mar 2026 – Jun 2026 |
| Gainesville Regional → Tallahassee International GNV–TLH | 5 | 120 | 55% | 134 | Piedmont Airlines, Federal Express Corporation, Global Crossing Airlines, Inc. | Jun 2025 – Jun 2026 |
| Gainesville Regional → MC Ghee Tyson GNV–TYS | 5 | 430 | 79% | 433 | Delta Air Lines Inc., Endeavor Air Inc., Breeze Aviation Group DBA Breeze, Air Wisconsin Airlines Corp | Jan 2025 – Mar 2026 |
| Gainesville Regional → Melbourne Orlando International GNV–MLB | 4 | 65 | 10% | 147 | Sun Country Airlines d/b/a..., PSA Airlines Inc. | Mar 2026 – Jul 2026 |
| Gainesville Regional → Okc Will Rogers International GNV–OKC | 4 | 57 | 18% | 976 | SkyWest Airlines Inc., Breeze Aviation Group DBA Breeze | Dec 2025 – Apr 2026 |
| Gainesville Regional → Baton Rouge Metro, Ryan Field GNV–BTR | 3 | 305 | 73% | 535 | Breeze Aviation Group DBA Breeze, Delta Air Lines Inc. | Jan 2025 – May 2026 |
| Gainesville Regional → Columbia Regional GNV–COU | 3 | 89 | 33% | 847 | Breeze Aviation Group DBA Breeze, SkyWest Airlines Inc. | Jan 2025 – Mar 2026 |
| Gainesville Regional → Fort Lauderdale/Hollywood International GNV–FLL | 3 | 190 | 47% | 281 | Delta Air Lines Inc., Tropic Ocean Airways LLC | Jan 2025 – Oct 2025 |
| Gainesville Regional → Greenville Spartanburg International GNV–GSP | 3 | 155 | 75% | 359 | Piedmont Airlines, Breeze Aviation Group DBA Breeze | Mar 2025 – May 2026 |
| Gainesville Regional → Blue Grass GNV–LEX | 3 | 309 | 74% | 591 | Breeze Aviation Group DBA Breeze, Delta Air Lines Inc. | Jan 2025 – Mar 2026 |
| Gainesville Regional → Witham Field GNV–SUA | 3 | 6 | 25% | 213 | Tradewind Aviation | Jul 2025 – Nov 2025 |
| Gainesville Regional → Tucson International GNV–TUS | 3 | 0 | 0% | 1,707 | SkyWest Airlines Inc. | Jan 2026 – Mar 2026 |
| Gainesville Regional → Northwest Arkansas Ntl GNV–XNA | 3 | 210 | 65% | 833 | Breeze Aviation Group DBA Breeze | Jan 2025 – Mar 2026 |
| Gainesville Regional → City Of Colorado Springs Municipal GNV–COS | 2 | 56 | 41% | 1,424 | Ameristar Air Cargo, SkyWest Airlines Inc. | May 2025 – Jun 2026 |
| Gainesville Regional → Daytona Beach International GNV–DAB | 2 | 61 | 23% | 81 | PSA Airlines Inc., Sun Country Airlines d/b/a... | Mar 2025 – Dec 2025 |
| Gainesville Regional → George Bush Intcntl/Houston GNV–IAH | 2 | 76 | 48% | 785 | Delta Air Lines Inc., SkyWest Airlines Inc. | May 2025 – May 2026 |
| Gainesville Regional → Jacksonville International GNV–JAX | 2 | 74 | 28% | 65 | Envoy Air, Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Gainesville Regional → Frederick W Smith Intl/Memphis GNV–MEM | 2 | 312 | 82% | 582 | Delta Air Lines Inc., Allegiant Air | Nov 2025 – Nov 2025 |
| Gainesville Regional → St. Pete-Clearwater International GNV–PIE | 2 | 0 | 0% | 125 | Sun Country Airlines d/b/a... | Oct 2025 – Nov 2025 |
| Gainesville Regional → San Diego International GNV–SAN | 2 | 0 | 0% | 2,069 | SkyWest Airlines Inc. | Jan 2026 – Mar 2026 |
| Gainesville Regional → San Francisco International GNV–SFO | 2 | 0 | 0% | 2,356 | SkyWest Airlines Inc. | Mar 2025 – Dec 2025 |
| Gainesville Regional → Tampa International GNV–TPA | 2 | 217 | 80% | 119 | Delta Air Lines Inc., Envoy Air | Dec 2025 – Jul 2026 |
| Gainesville Regional → Tupelo Regional GNV–TUP | 2 | 0 | 0% | 495 | SkyWest Airlines Inc. | Mar 2025 – Apr 2026 |
| Gainesville Regional → Tyler Pounds Regional GNV–TYR | 2 | 139 | 91% | 800 | Envoy Air | Feb 2026 – Jun 2026 |
| Gainesville Regional → Abilene Regional GNV–ABI | 1 | 63 | 83% | 1,048 | Envoy Air | Aug 2025 – Aug 2025 |
| Gainesville Regional → Albuquerque International Sunport GNV–ABQ | 1 | 0 | 0% | 1,466 | SkyWest Airlines Inc. | Jan 2026 – Jan 2026 |
| Gainesville Regional → Addison GNV–ADS | 1 | 0 | 0% | 890 | Ameristar Air Cargo | Jun 2026 – Jun 2026 |
| Gainesville Regional → Birmingham-Shuttlesworth International GNV–BHM | 1 | 106 | 96% | 375 | Delta Air Lines Inc. | Mar 2025 – Mar 2026 |
| Gainesville Regional → Boise Air Trml/Gowen Field GNV–BOI | 1 | 0 | 0% | 2,096 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |
| Gainesville Regional → Columbus GNV–CSG | 1 | 0 | 0% | 251 | Global Crossing Airlines, Inc. | Feb 2025 – Jan 2026 |
| Gainesville Regional → Newark Liberty International GNV–EWR | 1 | 55 | 51% | 885 | Breeze Aviation Group DBA Breeze | Dec 2025 – Dec 2025 |
| Gainesville Regional → Florence Regional GNV–FLO | 1 | 49 | 98% | 344 | Piedmont Airlines | Jul 2025 – Mar 2026 |
| Gainesville Regional → Gerald R Ford International GNV–GRR | 1 | 0 | 0% | 927 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Gainesville Regional → Piedmont Triad International GNV–GSO | 1 | 37 | 74% | 462 | Piedmont Airlines | Mar 2025 – May 2026 |
| Gainesville Regional → Golden Triangle Regional GNV–GTR | 1 | 163 | 91% | 454 | United Air Lines Inc. | Feb 2025 – Oct 2025 |
| Gainesville Regional → Washington Dulles International GNV–IAD | 1 | 2 | 25% | 695 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| Gainesville Regional → Indianapolis International GNV–IND | 1 | 0 | 0% | 728 | Sun Country Airlines d/b/a... | Aug 2025 – Aug 2025 |
| Gainesville Regional → Long Island Mac Arthur GNV–ISP | 1 | 132 | 71% | 924 | Sun Country Airlines d/b/a... | Aug 2025 – Aug 2025 |
| Gainesville Regional → Smyrna GNV–MQY | 1 | 0 | 0% | 500 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| Gainesville Regional → West Palm Beach/Palm Beach GNV–PBI | 1 | 1 | 12% | 246 | Tradewind Aviation | Jan 2026 – Jan 2026 |
| Gainesville Regional → Dekalb-Peachtree GNV–PDK | 1 | 6 | 75% | 312 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Gainesville Regional → Portland International GNV–PDX | 1 | 0 | 0% | 2,435 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |
| Gainesville Regional → Pensacola International GNV–PNS | 1 | 59 | 91% | 299 | PSA Airlines Inc. | Dec 2025 – Dec 2025 |
| Gainesville Regional → Tri-Cities GNV–PSC | 1 | 0 | 0% | 2,284 | SkyWest Airlines Inc. | Jan 2026 – Jan 2026 |
| Gainesville Regional → Seattle-Tacoma International GNV–SEA | 1 | 0 | 0% | 2,453 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |
| Gainesville Regional → Orlando Sanford International GNV–SFB | 1 | 0 | 0% | 89 | Sun Country Airlines d/b/a... | Jan 2026 – Jan 2026 |
| Gainesville Regional → Sarasota/Bradenton International GNV–SRQ | 1 | 3 | 38% | 159 | Tradewind Aviation | Nov 2025 – Nov 2025 |
| Gainesville Regional → Tuscaloosa Ntl GNV–TCL | 1 | 60 | 56% | 398 | Breeze Aviation Group DBA Breeze | Jan 2025 – Feb 2026 |
| Gainesville Regional → University-Oxford GNV–UOX | 1 | 30 | 100% | 535 | CFM Inc d/b/a Contour... | Mar 2025 – Feb 2026 |
| Gainesville Regional → St. Augustine GNV–UST | 1 | 0 | 0% | 59 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |