| Pitt-Greenville → Charlotte/Douglas International PGV–CLT | 1,049 | 35,794 | 68% | 203 | Piedmont Airlines | Jan 2025 – Jul 2026 |
| Pitt-Greenville → Atlantic City International PGV–ACY | 4 | 538 | 72% | 305 | Sun Country Airlines d/b/a... | Jan 2025 – May 2026 |
| Pitt-Greenville → Frederick W Smith Intl/Memphis PGV–MEM | 3 | 244 | 53% | 712 | Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Nov 2025 – Mar 2026 |
| Pitt-Greenville → Louis Armstrong New Orleans International PGV–MSY | 3 | 341 | 72% | 843 | Allegiant Air, Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Jan 2025 – Dec 2025 |
| Pitt-Greenville → Gulfport-Biloxi International PGV–GPT | 2 | 178 | 48% | 767 | Sun Country Airlines d/b/a... | Feb 2025 – Mar 2026 |
| Pitt-Greenville → San Antonio International PGV–SAT | 2 | 296 | 82% | 1,297 | Allegiant Air | Nov 2025 – Nov 2025 |
| Pitt-Greenville → Coastal Carolina Regional PGV–EWN | 1 | 13 | 26% | 43 | Piedmont Airlines | Feb 2026 – Feb 2026 |
| Pitt-Greenville → Fort Lauderdale/Hollywood International PGV–FLL | 1 | 170 | 94% | 679 | Allegiant Air | Nov 2025 – Nov 2025 |
| Pitt-Greenville → Moss Town PGV–GGT international | 1 | 117 | 78% | 836 | Global Crossing Airlines, Inc. | May 2026 – May 2026 |
| Pitt-Greenville → Piedmont Triad International PGV–GSO | 1 | 39 | 78% | 147 | Piedmont Airlines | Feb 2025 – Jun 2026 |
| Pitt-Greenville → William P Hobby PGV–HOU | 1 | 0 | 0% | 1,120 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |
| Pitt-Greenville → Huntsville Intl-Carl T Jones Field PGV–HSV | 1 | 0 | 0% | 536 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |
| Pitt-Greenville → George Bush Intcntl/Houston PGV–IAH | 1 | 0 | 0% | 1,113 | SkyWest Airlines Inc. | Jan 2026 – Jan 2026 |
| Pitt-Greenville → Arnold Palmer Regional PGV–LBE | 1 | 0 | 0% | 338 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |
| Pitt-Greenville → Laredo International PGV–LRD | 1 | 0 | | 1,412 | Ameristar Air Cargo | Aug 2025 – Aug 2025 |
| Pitt-Greenville → General Mitchell International PGV–MKE | 1 | 0 | 0% | 755 | Air Wisconsin Airlines Corp | May 2025 – May 2026 |
| Pitt-Greenville → Chicago O'Hare International PGV–ORD | 1 | 0 | 0% | 716 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |
| Pitt-Greenville → Philadelphia International PGV–PHL | 1 | 163 | 91% | 315 | Allegiant Air | Oct 2025 – Oct 2025 |
| Pitt-Greenville → Pittsburgh International PGV–PIT | 1 | 0 | 0% | 369 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Pitt-Greenville → Provo Municipal PGV–PVU | 1 | 163 | 83% | 1,890 | American Airlines Inc. | Sep 2025 – Sep 2025 |
| Pitt-Greenville → Raleigh-Durham International PGV–RDU | 1 | 0 | 0% | 80 | Sun Country Airlines d/b/a... | May 2026 – May 2026 |
| Pitt-Greenville → Richmond International PGV–RIC | 1 | 73 | 96% | 130 | PSA Airlines Inc. | Jul 2026 – Jul 2026 |
| Pitt-Greenville → Louisville Muhammad Ali International PGV–SDF | 1 | 0 | 0% | 494 | Sun Country Airlines d/b/a... | Oct 2025 – Oct 2025 |
| Pitt-Greenville → New York Stewart International PGV–SWF | 1 | 165 | 92% | 442 | United Air Lines Inc. | Sep 2025 – Sep 2025 |
| Pitt-Greenville → Tulsa International PGV–TUL | 1 | 161 | 87% | 1,037 | Sun Country Airlines d/b/a... | Oct 2025 – Oct 2025 |
| Pitt-Greenville → Toronto PGV–YTZ international | 1 | 4 | 67% | 562 | Hamilton Jetport Limited | May 2026 – May 2026 |
| Pitt-Greenville → Montreal PGV–YUL international | 1 | 0 | 0% | 705 | Sun Country Airlines d/b/a... | Oct 2025 – Oct 2025 |
| Pitt-Greenville → Toronto PGV–YYZ international | 1 | 0 | 0% | 567 | Chartright Air Inc. | Nov 2025 – Nov 2025 |