| St. Louis Downtown → Minneapolis-St Paul Intl/Wold-Chamberlain CPS–MSP | 18 | 462 | 18% | 463 | Sun Country Airlines d/b/a..., Delta Air Lines Inc., KaiserAir, Inc., NEW PACIFIC AIRLINES +1 | Jan 2025 – May 2026 |
| St. Louis Downtown → Dallas Love Field CPS–DAL | 13 | 1,115 | 72% | 545 | Air Canada, Allegiant Air, NEW PACIFIC AIRLINES, Delta Air Lines Inc. | Jan 2025 – Jun 2026 |
| St. Louis Downtown → Hartsfield/Jackson Atlanta International CPS–ATL | 8 | 99 | 8% | 467 | Delta Air Lines Inc. | Apr 2025 – Jul 2026 |
| St. Louis Downtown → John Glenn Columbus International CPS–CMH | 5 | 168 | 38% | 402 | Republic Airline, KaiserAir, Inc., NEW PACIFIC AIRLINES, JetBlue Airways | Jan 2025 – Mar 2026 |
| St. Louis Downtown → Chicago Midway International CPS–MDW | 5 | 102 | 22% | 256 | Delta Air Lines Inc., KaiserAir, Inc., Sun Country Airlines d/b/a... | Feb 2025 – May 2026 |
| St. Louis Downtown → Denver International CPS–DEN | 4 | 213 | 54% | 783 | Air Canada, Delta Air Lines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jun 2026 |
| St. Louis Downtown → Westchester County CPS–HPN | 4 | 88 | 42% | 891 | CFM Inc d/b/a Contour..., Jet Aviation Flight Services, Inc., Delta Air Lines Inc. | Dec 2025 – Apr 2026 |
| St. Louis Downtown → Kansas City Downtown/Wheeler Field CPS–MKC | 4 | 128 | 25% | 242 | Delta Air Lines Inc., Sun Country Airlines d/b/a..., United Air Lines Inc. | May 2026 – Jul 2026 |
| St. Louis Downtown → Pittsburgh International CPS–PIT | 4 | 196 | 38% | 546 | Delta Air Lines Inc., Allegiant Air, Republic Airline | Feb 2025 – Apr 2026 |
| St. Louis Downtown → Seattle-Tacoma International CPS–SEA | 4 | 102 | 25% | 1,725 | Delta Air Lines Inc., Sun Country Airlines d/b/a... | Aug 2025 – Jun 2026 |
| St. Louis Downtown → Salt Lake City International CPS–SLC | 4 | 108 | 22% | 1,170 | Delta Air Lines Inc. | Jan 2025 – Jun 2026 |
| St. Louis Downtown → Charlotte/Douglas International CPS–CLT | 3 | 106 | 63% | 560 | CFM Inc d/b/a Contour..., Breeze Aviation Group DBA Breeze | Jan 2025 – Mar 2026 |
| St. Louis Downtown → James M Cox Dayton International CPS–DAY | 3 | 53 | 41% | 332 | CFM Inc d/b/a Contour..., Republic Airline | Jan 2025 – Feb 2026 |
| St. Louis Downtown → Newark Liberty International CPS–EWR | 3 | 48 | 9% | 864 | Sun Country Airlines d/b/a..., Global Crossing Airlines, Inc. | Mar 2025 – Apr 2026 |
| St. Louis Downtown → Indianapolis International CPS–IND | 3 | 0 | 0% | 222 | Delta Air Lines Inc. | Aug 2025 – May 2026 |
| St. Louis Downtown → Los Angeles International CPS–LAX | 3 | 146 | 32% | 1,603 | Sun Country Airlines d/b/a..., NEW PACIFIC AIRLINES | Sep 2025 – Jul 2026 |
| St. Louis Downtown → Chicago O'Hare International CPS–ORD | 3 | 162 | 75% | 263 | Delta Air Lines Inc. | Feb 2025 – Dec 2025 |
| St. Louis Downtown → San Francisco International CPS–SFO | 3 | 207 | 96% | 1,748 | Delta Air Lines Inc. | Sep 2025 – Apr 2026 |
| St. Louis Downtown → Allegheny County CPS–AGC | 2 | 55 | 92% | 560 | CFM Inc d/b/a Contour... | Dec 2025 – Jan 2026 |
| St. Louis Downtown → Buffalo Niagara International CPS–BUF | 2 | 120 | 62% | 670 | Jet Aviation Flight Services, Inc., Allegiant Air | Sep 2025 – Mar 2026 |
| St. Louis Downtown → Cincinnati/Northern Kentucky International CPS–CVG | 2 | 124 | 86% | 298 | Delta Air Lines Inc. | Apr 2025 – May 2026 |
| St. Louis Downtown → Detroit Metro Wayne County CPS–DTW | 2 | 64 | 44% | 438 | Delta Air Lines Inc. | Jul 2025 – Apr 2026 |
| St. Louis Downtown → Washington Dulles International CPS–IAD | 2 | 117 | 45% | 686 | Delta Air Lines Inc., Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| St. Louis Downtown → Harry Reid International CPS–LAS | 2 | 52 | 37% | 1,383 | Air Canada, Delta Air Lines Inc. | Aug 2025 – Jan 2026 |
| St. Louis Downtown → Long Beach (Daugherty Field) CPS–LGB | 2 | 92 | 66% | 1,592 | Air Canada | Mar 2026 – Apr 2026 |
| St. Louis Downtown → Frederick W Smith Intl/Memphis CPS–MEM | 2 | 0 | 0% | 244 | Delta Air Lines Inc. | Jan 2025 – Jan 2026 |
| St. Louis Downtown → General Mitchell International CPS–MKE | 2 | 70 | 26% | 324 | Delta Air Lines Inc. | Jun 2025 – Mar 2026 |
| St. Louis Downtown → Smyrna CPS–MQY | 2 | 0 | 0% | 267 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| St. Louis Downtown → Okc Will Rogers International CPS–OKC | 2 | 0 | 0% | 466 | Delta Air Lines Inc. | May 2025 – Apr 2026 |
| St. Louis Downtown → San Diego International CPS–SAN | 2 | 121 | 47% | 1,567 | Delta Air Lines Inc., Sun Country Airlines d/b/a... | Jul 2025 – May 2026 |
| St. Louis Downtown → Winnipeg CPS–YWG international | 2 | 101 | 40% | 857 | Air Canada, Global Crossing Airlines, Inc. | Jan 2025 – Apr 2026 |
| St. Louis Downtown → Toronto CPS–YYZ international | 2 | 69 | 48% | 652 | Delta Air Lines Inc. | Oct 2025 – Jul 2026 |
| St. Louis Downtown → North Kingstown CPS–ZXU | 2 | 53 | 88% | 1,013 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| St. Louis Downtown → Athens/Ben Epps CPS–AHN | 1 | 0 | 0% | 497 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| St. Louis Downtown → Austin-Bergstrom International CPS–AUS | 1 | 59 | 32% | 719 | Sun Country Airlines d/b/a... | May 2026 – May 2026 |
| St. Louis Downtown → Boeing Fld/King County International CPS–BFI | 1 | 56 | 80% | 1,726 | Air Canada | Feb 2025 – Feb 2026 |
| St. Louis Downtown → Burke Lakefront CPS–BKL | 1 | 0 | 0% | 493 | Delta Air Lines Inc. | Jun 2025 – Jul 2026 |
| St. Louis Downtown → Nashville International CPS–BNA | 1 | 68 | 94% | 255 | Delta Air Lines Inc. | Jan 2025 – Dec 2025 |
| St. Louis Downtown → General Edward Lawrence Logan International CPS–BOS | 1 | 0 | 0% | 1,040 | Delta Air Lines Inc. | Apr 2025 – Apr 2026 |
| St. Louis Downtown → Southeast Iowa Regional CPS–BRL | 1 | 0 | 0% | 161 | CFM Inc d/b/a Contour... | Jan 2026 – Jan 2026 |
| St. Louis Downtown → Dallas-Fort Worth International CPS–DFW | 1 | 42 | 23% | 550 | Sun Country Airlines d/b/a... | Apr 2026 – Apr 2026 |
| St. Louis Downtown → Republic CPS–FRG | 1 | 48 | 35% | 904 | JetBlue Airways | Mar 2026 – Mar 2026 |
| St. Louis Downtown → William P Hobby CPS–HOU | 1 | 66 | 92% | 681 | Delta Air Lines Inc. | Jul 2025 – Apr 2026 |
| St. Louis Downtown → John F Kennedy International CPS–JFK | 1 | 65 | 90% | 884 | Delta Air Lines Inc. | Apr 2025 – Jun 2026 |
| St. Louis Downtown → Laredo International CPS–LRD | 1 | 0 | 0% | 931 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| St. Louis Downtown → Miami International CPS–MIA | 1 | 63 | 88% | 1,052 | Delta Air Lines Inc. | Jul 2025 – Aug 2025 |
| St. Louis Downtown → Veterans Airport Of Southern Illinois CPS–MWA | 1 | 0 | 0% | 84 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| St. Louis Downtown → Barkley Regional CPS–PAH | 1 | 0 | 0% | 129 | CFM Inc d/b/a Contour... | Jan 2026 – Jan 2026 |
| St. Louis Downtown → Phoenix Sky Harbor International CPS–PHX | 1 | 38 | 53% | 1,271 | Delta Air Lines Inc. | May 2025 – Jul 2026 |
| St. Louis Downtown → St. Pete-Clearwater International CPS–PIE | 1 | 69 | 96% | 852 | Delta Air Lines Inc. | Jun 2026 – Jun 2026 |
| St. Louis Downtown → Portland International Jetport CPS–PWM | 1 | 1 | 12% | 1,090 | Jet Aviation Flight Services, Inc. | May 2026 – May 2026 |
| St. Louis Downtown → Richmond International CPS–RIC | 1 | 29 | 97% | 703 | CFM Inc d/b/a Contour... | Jan 2025 – Jan 2026 |
| St. Louis Downtown → Mineta San Jose International CPS–SJC | 1 | 60 | 83% | 1,728 | Delta Air Lines Inc. | Nov 2025 – Nov 2025 |
| St. Louis Downtown → St. Louis Lambert International CPS–STL | 1 | 0 | 0% | 17 | Delta Air Lines Inc. | Nov 2025 – Nov 2025 |
| St. Louis Downtown → Nashville CPS–TN8 | 1 | 0 | 0% | 244 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| St. Louis Downtown → Tampa International CPS–TPA | 1 | 59 | 82% | 852 | Delta Air Lines Inc. | Aug 2025 – Aug 2025 |
| St. Louis Downtown → Quincy Rgnl-Baldwin Field CPS–UIN | 1 | 0 | 0% | 110 | CFM Inc d/b/a Contour... | Dec 2025 – Dec 2025 |
| St. Louis Downtown → Concord CPS–USA | 1 | 129 | 68% | 567 | TEM Enterprises dba Avelo Airlines | Oct 2025 – Oct 2025 |
| St. Louis Downtown → Edmonton CPS–YEG international | 1 | 50 | 71% | 1,507 | Air Canada | Mar 2026 – Mar 2026 |
| St. Louis Downtown → Ottawa CPS–YOW international | 1 | 49 | 70% | 878 | Air Canada | Jan 2025 – Oct 2025 |
| St. Louis Downtown → Calgary CPS–YYC international | 1 | 52 | 74% | 1,447 | Air Canada | Nov 2025 – Nov 2025 |