| Wilkes-Barre/Scranton International → Chicago O'Hare International AVP–ORD | 1,485 | 65,506 | 76% | 632 | GoJet Airlines LLC d/b/a..., Envoy Air, SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Charlotte/Douglas International AVP–CLT | 973 | 73,791 | 84% | 509 | PSA Airlines Inc., American Airlines Inc., Piedmont Airlines, Envoy Air | Jan 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Washington Dulles International AVP–IAD | 775 | 29,511 | 76% | 189 | CommuteAir LLC dba CommuteAir, Republic Airline | Jan 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Orlando International AVP–MCO | 194 | 22,939 | 86% | 944 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Tampa International AVP–TPA | 97 | 11,565 | 88% | 999 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Myrtle Beach International AVP–MYR | 70 | 7,987 | 83% | 557 | Breeze Aviation Group DBA Breeze | May 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Southwest Florida International AVP–RSW | 62 | 6,555 | 77% | 1,077 | Breeze Aviation Group DBA Breeze | Jan 2025 – May 2026 |
| Wilkes-Barre/Scranton International → Newark Liberty International AVP–EWR | 11 | 751 | 86% | 93 | GoJet Airlines LLC d/b/a..., Republic Airline, United Air Lines Inc. | Mar 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Fort Lauderdale/Hollywood International AVP–FLL | 9 | 884 | 72% | 1,082 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Wilkes-Barre/Scranton International → Laguardia AVP–LGA | 6 | 452 | 82% | 104 | Republic Airline, Delta Air Lines Inc. | Feb 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Philadelphia International AVP–PHL | 4 | 172 | 82% | 104 | PSA Airlines Inc., Chartright Air Inc., Piedmont Airlines | Jan 2025 – Mar 2026 |
| Wilkes-Barre/Scranton International → Wilkes-Barre/Scranton International AVP–AVP | 3 | 0 | 0% | 0 | SkyWest Airlines Inc. | Apr 2026 – May 2026 |
| Wilkes-Barre/Scranton International → South Bend International AVP–SBN | 3 | 40 | 27% | 550 | SkyWest Airlines Inc., GoJet Airlines LLC d/b/a... | Jan 2025 – Mar 2026 |
| Wilkes-Barre/Scranton International → Syracuse Hancock International AVP–SYR | 3 | 180 | 83% | 124 | Envoy Air, PSA Airlines Inc. | Aug 2025 – Nov 2025 |
| Wilkes-Barre/Scranton International → Gerald R Ford International AVP–GRR | 2 | 73 | 63% | 515 | GoJet Airlines LLC d/b/a..., Envoy Air | Feb 2025 – May 2026 |
| Wilkes-Barre/Scranton International → Westchester County AVP–HPN | 2 | 137 | 64% | 107 | Envoy Air, Breeze Aviation Group DBA Breeze | Mar 2025 – May 2026 |
| Wilkes-Barre/Scranton International → Toronto AVP–YYZ international | 2 | 5 | 31% | 257 | Chartright Air Inc. | Jul 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Watertown International AVP–ART | 1 | 24 | 48% | 184 | Piedmont Airlines | Feb 2026 – Feb 2026 |
| Wilkes-Barre/Scranton International → Laurence G Hanscom Field AVP–BED | 1 | 1 | 12% | 241 | Tradewind Aviation | Nov 2025 – Nov 2025 |
| Wilkes-Barre/Scranton International → Nashville International AVP–BNA | 1 | 0 | 0% | 692 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| Wilkes-Barre/Scranton International → Akron-Canton Regional AVP–CAK | 1 | 0 | 0% | 300 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| Wilkes-Barre/Scranton International → Detroit Metro Wayne County AVP–DTW | 1 | 12 | 24% | 399 | GoJet Airlines LLC d/b/a... | Mar 2025 – Mar 2026 |
| Wilkes-Barre/Scranton International → Bishop International AVP–FNT | 1 | 0 | 0% | 427 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Wilkes-Barre/Scranton International → Francis S Gabreski AVP–FOK | 1 | 3 | 38% | 165 | Tradewind Aviation | Jul 2026 – Jul 2026 |
| Wilkes-Barre/Scranton International → Fort Wayne International AVP–FWA | 1 | 63 | 97% | 494 | Envoy Air | May 2025 – Jan 2026 |
| Wilkes-Barre/Scranton International → Delaware Coastal AVP–GED | 1 | 2 | 25% | 184 | Tradewind Aviation | Jul 2026 – Jul 2026 |
| Wilkes-Barre/Scranton International → Indianapolis International AVP–IND | 1 | 0 | 0% | 567 | SkyWest Airlines Inc. | Mar 2026 – Mar 2026 |
| Wilkes-Barre/Scranton International → Long Island Mac Arthur AVP–ISP | 1 | 117 | 85% | 142 | Breeze Aviation Group DBA Breeze | Mar 2026 – Mar 2026 |
| Wilkes-Barre/Scranton International → Ithaca Tompkins International AVP–ITH | 1 | 42 | 84% | 88 | CommuteAir LLC dba CommuteAir | Jun 2026 – Jun 2026 |
| Wilkes-Barre/Scranton International → Jacksonville International AVP–JAX | 1 | 127 | 93% | 819 | Breeze Aviation Group DBA Breeze | Aug 2025 – Aug 2025 |
| Wilkes-Barre/Scranton International → John F Kennedy International AVP–JFK | 1 | 127 | 99% | 113 | American Airlines Inc. | Jul 2025 – Jul 2026 |
| Wilkes-Barre/Scranton International → Mulhouse AVP–MLH international | 1 | 1 | 8% | 3,937 | Air Alsie A/S | Jun 2026 – Jun 2026 |
| Wilkes-Barre/Scranton International → Quad Cities International AVP–MLI | 1 | 42 | 84% | 768 | GoJet Airlines LLC d/b/a... | Sep 2025 – Sep 2025 |
| Wilkes-Barre/Scranton International → Naples AVP–NAP international | 1 | 2 | 14% | 4,460 | VistaJet Limited | Jul 2026 – Jul 2026 |
| Wilkes-Barre/Scranton International → Richmond International AVP–RIC | 1 | 48 | 96% | 277 | Piedmont Airlines | Aug 2025 – Aug 2025 |
| Wilkes-Barre/Scranton International → Frederick Douglass/Greater Rochester International AVP–ROC | 1 | 49 | 98% | 158 | Piedmont Airlines | Feb 2026 – Feb 2026 |
| Wilkes-Barre/Scranton International → Teterboro AVP–TEB | 1 | 0 | 0% | 93 | CFM Inc d/b/a Contour... | Jun 2026 – Jun 2026 |
| Wilkes-Barre/Scranton International → Tri-Cities AVP–TRI | 1 | 70 | 92% | 492 | PSA Airlines Inc. | Jul 2025 – Dec 2025 |
| Wilkes-Barre/Scranton International → MC Ghee Tyson AVP–TYS | 1 | 0 | 0% | 588 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Wilkes-Barre/Scranton International → Sault Ste. Marie AVP–YAM international | 1 | 0 | 0% | 564 | Chartright Air Inc. | Jul 2026 – Jul 2026 |