| Akron-Canton Regional → Chicago O'Hare International CAK–ORD | 1,929 | 79,417 | 76% | 344 | SkyWest Airlines Inc., PSA Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Charlotte/Douglas International CAK–CLT | 1,385 | 75,850 | 77% | 394 | PSA Airlines Inc., Piedmont Airlines | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Orlando International CAK–MCO | 359 | 43,812 | 89% | 861 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Charleston Afb/Intl CAK–CHS | 317 | 34,395 | 80% | 558 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Ronald Reagan Washington Ntl CAK–DCA | 302 | 8,517 | 43% | 274 | PSA Airlines Inc. | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Myrtle Beach International CAK–MYR | 271 | 29,693 | 77% | 518 | Breeze Aviation Group DBA Breeze, Allegiant Air | Apr 2025 – Jul 2026 |
| Akron-Canton Regional → Jacksonville International CAK–JAX | 261 | 29,835 | 72% | 719 | Allegiant Air, Breeze Aviation Group DBA Breeze | May 2025 – Jul 2026 |
| Akron-Canton Regional → Sarasota/Bradenton International CAK–SRQ | 237 | 34,905 | 88% | 934 | Allegiant Air, Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Southwest Florida International CAK–RSW | 211 | 24,088 | 83% | 991 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Raleigh-Durham International CAK–RDU | 191 | 16,661 | 64% | 376 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Savannah/Hilton Head International CAK–SAV | 186 | 23,709 | 83% | 606 | Allegiant Air, Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Harry Reid International CAK–LAS | 158 | 18,070 | 83% | 1,846 | Breeze Aviation Group DBA Breeze, Allegiant Air | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Punta Gorda CAK–PGD | 151 | 23,275 | 88% | 965 | Allegiant Air | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Fort Lauderdale/Hollywood International CAK–FLL | 145 | 18,298 | 80% | 1,026 | Breeze Aviation Group DBA Breeze, Allegiant Air | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Tampa International CAK–TPA | 141 | 16,021 | 83% | 894 | Breeze Aviation Group DBA Breeze, Allegiant Air | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → St. Pete-Clearwater International CAK–PIE | 132 | 20,188 | 90% | 899 | Allegiant Air | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Orlando Sanford International CAK–SFB | 121 | 17,559 | 84% | 837 | Allegiant Air | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Norfolk International CAK–ORF | 104 | 7,367 | 52% | 396 | Breeze Aviation Group DBA Breeze | Apr 2025 – Jul 2026 |
| Akron-Canton Regional → West Palm Beach/Palm Beach CAK–PBI | 97 | 9,171 | 69% | 984 | Breeze Aviation Group DBA Breeze | Sep 2025 – Jul 2026 |
| Akron-Canton Regional → Wilmington International CAK–ILM | 77 | 7,745 | 73% | 498 | Breeze Aviation Group DBA Breeze | Nov 2025 – Jul 2026 |
| Akron-Canton Regional → Daytona Beach International CAK–DAB | 70 | 5,743 | 60% | 809 | Breeze Aviation Group DBA Breeze | Sep 2025 – May 2026 |
| Akron-Canton Regional → Eglin Afb/Destin-Ft Walton Beach CAK–VPS | 70 | 9,046 | 77% | 774 | Allegiant Air | May 2025 – Jul 2026 |
| Akron-Canton Regional → Nashville International CAK–BNA | 58 | 5,900 | 63% | 436 | Allegiant Air | Mar 2025 – Jul 2026 |
| Akron-Canton Regional → Akron-Canton Regional CAK–CAK | 29 | 0 | 0% | 0 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Laurence G Hanscom Field CAK–BED | 27 | 973 | 24% | 536 | Eastern Air Express, LLC (EAX), Air Wisconsin Airlines Corp | Apr 2026 – Jul 2026 |
| Akron-Canton Regional → Richmond International CAK–RIC | 26 | 1,386 | 34% | 322 | Eastern Air Express, LLC (EAX), Breeze Aviation Group DBA Breeze | Apr 2026 – Jul 2026 |
| Akron-Canton Regional → Alexandria International CAK–AEX | 21 | 617 | 19% | 906 | Eastern Air Express, LLC (EAX) | May 2026 – Jul 2026 |
| Akron-Canton Regional → Indianapolis International CAK–IND | 16 | 552 | 22% | 269 | Eastern Air Express, LLC (EAX) | May 2026 – Jul 2026 |
| Akron-Canton Regional → Gulfport-Biloxi International CAK–GPT | 14 | 2,179 | 84% | 842 | Sun Country Airlines d/b/a... | Jan 2025 – Jul 2026 |
| Akron-Canton Regional → Atlantic City International CAK–ACY | 10 | 1,465 | 79% | 377 | Sun Country Airlines d/b/a... | Feb 2025 – Jul 2026 |
| Akron-Canton Regional → Los Angeles International CAK–LAX | 10 | 1,001 | 66% | 2,073 | Breeze Aviation Group DBA Breeze, American Airlines Inc. | May 2025 – Aug 2025 |
| Akron-Canton Regional → Portland International Jetport CAK–PWM | 9 | 1,029 | 83% | 600 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Akron-Canton Regional → John Glenn Columbus International CAK–CMH | 4 | 72 | 16% | 99 | Breeze Aviation Group DBA Breeze, PSA Airlines Inc., SkyWest Airlines Inc., Sun Country Airlines d/b/a... | Apr 2025 – Jun 2026 |
| Akron-Canton Regional → Bishop International CAK–FNT | 4 | 0 | 0% | 185 | SkyWest Airlines Inc., Sun Country Airlines d/b/a... | Aug 2025 – Apr 2026 |
| Akron-Canton Regional → Laughlin/Bullhead International CAK–IFP | 4 | 693 | 93% | 1,838 | Sun Country Airlines d/b/a... | Apr 2025 – May 2026 |
| Akron-Canton Regional → Harrisburg International CAK–MDT | 4 | 121 | 20% | 251 | Eastern Air Express, LLC (EAX) | Jul 2026 – Jul 2026 |
| Akron-Canton Regional → Detroit Metro Wayne County CAK–DTW | 3 | 167 | 27% | 133 | Sun Country Airlines d/b/a..., Delta Air Lines Inc. | Jan 2025 – Mar 2026 |
| Akron-Canton Regional → Newark Liberty International CAK–EWR | 3 | 47 | 10% | 382 | Eastern Air Express, LLC (EAX) | May 2026 – Jul 2026 |
| Akron-Canton Regional → Minneapolis-St Paul Intl/Wold-Chamberlain CAK–MSP | 3 | 68 | 16% | 657 | Sun Country Airlines d/b/a..., SkyWest Airlines Inc. | Jul 2025 – Apr 2026 |
| Akron-Canton Regional → Pittsburgh International CAK–PIT | 3 | 106 | 64% | 70 | PSA Airlines Inc., SkyWest Airlines Inc., Piedmont Airlines | Jun 2025 – Apr 2026 |
| Akron-Canton Regional → South Bend International CAK–SBN | 3 | 0 | 0% | 260 | SkyWest Airlines Inc. | Mar 2025 – Jun 2026 |
| Akron-Canton Regional → Westfield-Barnes Regional CAK–BAF | 2 | 292 | 78% | 460 | Sun Country Airlines d/b/a... | Oct 2025 – Nov 2025 |
| Akron-Canton Regional → Baltimore/Washington International Thurgood Marshall CAK–BWI | 2 | 71 | 24% | 280 | Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Jun 2025 – Jun 2026 |
| Akron-Canton Regional → Houghton County Memorial CAK–CMX | 2 | 0 | 0% | 556 | SkyWest Airlines Inc. | Mar 2026 – Jun 2026 |
| Akron-Canton Regional → James M Cox Dayton International CAK–DAY | 2 | 2 | 1% | 162 | Scott Aviation, LLC d/b/a..., Sun Country Airlines d/b/a... | Aug 2025 – Apr 2026 |
| Akron-Canton Regional → Duluth International CAK–DLH | 2 | 0 | 0% | 674 | SkyWest Airlines Inc. | Aug 2025 – Jul 2026 |
| Akron-Canton Regional → Erie Intl/Tom Ridge Field CAK–ERI | 2 | 104 | 32% | 104 | Breeze Aviation Group DBA Breeze, Sun Country Airlines d/b/a... | Nov 2025 – May 2026 |
| Akron-Canton Regional → Fort Wayne International CAK–FWA | 2 | 0 | 0% | 196 | SkyWest Airlines Inc. | May 2026 – Jul 2026 |
| Akron-Canton Regional → Gerald R Ford International CAK–GRR | 2 | 33 | 13% | 250 | PSA Airlines Inc., Sun Country Airlines d/b/a... | Jul 2025 – Feb 2026 |
| Akron-Canton Regional → Mbs International CAK–MBS | 2 | 0 | 0% | 226 | SkyWest Airlines Inc., Sun Country Airlines d/b/a... | Oct 2025 – Apr 2026 |
| Akron-Canton Regional → Kansas City International CAK–MCI | 2 | 59 | 18% | 711 | Eastern Air Express, LLC (EAX) | May 2026 – Jul 2026 |
| Akron-Canton Regional → General Mitchell International CAK–MKE | 2 | 0 | 0% | 361 | SkyWest Airlines Inc., Sun Country Airlines d/b/a... | Apr 2026 – May 2026 |
| Akron-Canton Regional → Okc Will Rogers International CAK–OKC | 2 | 167 | 73% | 957 | Allegiant Air, Air Wisconsin Airlines Corp | Oct 2025 – Jul 2026 |
| Akron-Canton Regional → Philadelphia International CAK–PHL | 2 | 110 | 72% | 335 | PSA Airlines Inc. | Apr 2026 – Jul 2026 |
| Akron-Canton Regional → Augusta Regional AT Bush Field CAK–AGS | 1 | 2 | 22% | 521 | Jet Aviation Flight Services, Inc. | Aug 2025 – Aug 2025 |
| Akron-Canton Regional → Hartsfield/Jackson Atlanta International CAK–ATL | 1 | 0 | 0% | 528 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Akron-Canton Regional → Wilkes-Barre/Scranton International CAK–AVP | 1 | 121 | 88% | 300 | Breeze Aviation Group DBA Breeze | Feb 2026 – Feb 2026 |
| Akron-Canton Regional → Bradley International CAK–BDL | 1 | 33 | 24% | 460 | Breeze Aviation Group DBA Breeze | Mar 2026 – Mar 2026 |
| Akron-Canton Regional → Birmingham-Shuttlesworth International CAK–BHM | 1 | 131 | 73% | 585 | Allegiant Air | Sep 2025 – Sep 2025 |
| Akron-Canton Regional → Buffalo Niagara International CAK–BUF | 1 | 18 | 11% | 198 | Eastern Air Express, LLC (EAX) | May 2025 – May 2026 |
| Akron-Canton Regional → Columbia Metro CAK–CAE | 1 | 122 | 89% | 482 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Akron-Canton Regional → Cleveland-Hopkins International CAK–CLE | 1 | 0 | 0% | 40 | Sun Country Airlines d/b/a... | Mar 2025 – Dec 2025 |
| Akron-Canton Regional → City Of Colorado Springs Municipal CAK–COS | 1 | 0 | 0% | 1,242 | SkyWest Airlines Inc. | Dec 2025 – Dec 2025 |
| Akron-Canton Regional → West Virginia International Yeager CAK–CRW | 1 | 110 | 80% | 175 | Breeze Aviation Group DBA Breeze | Jul 2025 – Sep 2025 |
| Akron-Canton Regional → Fayetteville Rgnl/Grannis Field CAK–FAY | 1 | 0 | 0% | 432 | Sun Country Airlines d/b/a... | Jun 2026 – Jun 2026 |
| Akron-Canton Regional → Francis S Gabreski CAK–FOK | 1 | 2 | 25% | 461 | CFM Inc d/b/a Contour... | Jul 2026 – Jul 2026 |
| Akron-Canton Regional → Green Bay/Austin Straubel International CAK–GRB | 1 | 0 | 0% | 420 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Akron-Canton Regional → Washington Dulles International CAK–IAD | 1 | 11 | 17% | 251 | PSA Airlines Inc. | May 2026 – May 2026 |
| Akron-Canton Regional → George Bush Intcntl/Houston CAK–IAH | 1 | 17 | 11% | 1,085 | Eastern Air Express, LLC (EAX) | May 2026 – May 2026 |
| Akron-Canton Regional → John Murtha Johnstown/Cambria County CAK–JST | 1 | 0 | 0% | 143 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Akron-Canton Regional → Laramie Regional CAK–LAR | 1 | 152 | 84% | 1,261 | Allegiant Air | Aug 2025 – Aug 2025 |
| Akron-Canton Regional → Lubbock Preston Smith International CAK–LBB | 1 | 149 | 83% | 1,225 | Allegiant Air | Sep 2025 – Sep 2025 |
| Akron-Canton Regional → Arnold Palmer Regional CAK–LBE | 1 | 0 | 0% | 116 | Sun Country Airlines d/b/a... | Jan 2025 – Sep 2025 |
| Akron-Canton Regional → Paris CAK–LBG international | 1 | 9 | 64% | 3,938 | VistaJet Limited | Sep 2025 – Sep 2025 |
| Akron-Canton Regional → Lafayette Rgnl/Paul Fournet Field CAK–LFT | 1 | 16 | 10% | 946 | Eastern Air Express, LLC (EAX) | May 2026 – May 2026 |
| Akron-Canton Regional → Lincoln CAK–LNK | 1 | 136 | 76% | 801 | Allegiant Air | Sep 2025 – Sep 2025 |
| Akron-Canton Regional → Lawson Army Airfield (Fort Benning) CAK–LSF | 1 | 16 | 10% | 624 | Eastern Air Express, LLC (EAX) | May 2026 – May 2026 |
| Akron-Canton Regional → Minot International CAK–MOT | 1 | 0 | 0% | 1,098 | Sun Country Airlines d/b/a... | May 2026 – May 2026 |
| Akron-Canton Regional → Dane County Rgnl/Truax Field CAK–MSN | 1 | 0 | 0% | 434 | SkyWest Airlines Inc. | Jan 2026 – Jan 2026 |
| Akron-Canton Regional → Monroe CAK–N2C | 1 | 0 | 0% | 409 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Akron-Canton Regional → Miami-Opa Locka Executive CAK–OPF | 1 | 16 | 10% | 1,037 | Eastern Air Express, LLC (EAX) | Jun 2026 – Jun 2026 |
| Akron-Canton Regional → Provo Municipal CAK–PVU | 1 | 99 | 72% | 1,586 | Breeze Aviation Group DBA Breeze | Mar 2026 – Mar 2026 |
| Akron-Canton Regional → Reno/Tahoe International CAK–RNO | 1 | 146 | 78% | 2,014 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Akron-Canton Regional → Frederick Douglass/Greater Rochester International CAK–ROC | 1 | 0 | 0% | 246 | Sun Country Airlines d/b/a... | Jul 2026 – Jul 2026 |
| Akron-Canton Regional → State College CAK–SCE | 1 | 0 | 0% | 188 | Air Wisconsin Airlines Corp | Jul 2026 – Jul 2026 |
| Akron-Canton Regional → Louisville Muhammad Ali International CAK–SDF | 1 | 0 | 0% | 297 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |
| Akron-Canton Regional → Springfield-Branson Ntl CAK–SGF | 1 | 0 | 0% | 690 | Sun Country Airlines d/b/a... | Feb 2025 – Mar 2026 |
| Akron-Canton Regional → Salina Regional CAK–SLN | 1 | 17 | 89% | 873 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| Akron-Canton Regional → Teterboro CAK–TEB | 1 | 0 | 0% | 386 | CFM Inc d/b/a Contour... | Feb 2026 – Feb 2026 |
| Akron-Canton Regional → Tallahassee International CAK–TLH | 1 | 147 | 82% | 743 | Allegiant Air | Sep 2025 – Sep 2025 |
| Akron-Canton Regional → Tel Aviv CAK–TLV international | 1 | 6 | 43% | 5,982 | VistaJet Limited | Jan 2025 – Oct 2025 |
| Akron-Canton Regional → Willow Run CAK–YIP | 1 | 29 | 18% | 141 | Eastern Air Express, LLC (EAX) | Jul 2026 – Jul 2026 |
| Akron-Canton Regional → Youngstown/Warren Regional CAK–YNG | 1 | 0 | 0% | 46 | Eastern Air Express, LLC (EAX) | Apr 2026 – Apr 2026 |
| Akron-Canton Regional → Toronto CAK–YYZ international | 1 | 0 | 0% | 212 | Sun Country Airlines d/b/a... | Aug 2025 – Aug 2025 |