| Manhattan Regional → Dallas-Fort Worth International MHK–DFW | 1,061 | 57,186 | 74% | 431 | Envoy Air, SkyWest Airlines Inc., American Airlines Inc. | Jan 2025 – Jul 2026 |
| Manhattan Regional → Chicago O'Hare International MHK–ORD | 553 | 23,590 | 64% | 501 | Envoy Air, SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Manhattan Regional → March Arb MHK–RIV | 4 | 430 | 62% | 1,199 | Allegiant Air | Feb 2025 – Jan 2026 |
| Manhattan Regional → Tucson International MHK–TUS | 3 | 257 | 53% | 936 | Global Crossing Airlines, Inc., Breeze Aviation Group DBA Breeze, United Air Lines Inc. | Sep 2025 – May 2026 |
| Manhattan Regional → City Of Colorado Springs Municipal MHK–COS | 2 | 0 | 0% | 433 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Manhattan Regional → Denver International MHK–DEN | 2 | 191 | 76% | 430 | SkyWest Airlines Inc., United Air Lines Inc. | Jan 2025 – Nov 2025 |
| Manhattan Regional → Harry Reid International MHK–LAS | 2 | 0 | 0% | 1,034 | Global Crossing Airlines, Inc., SkyWest Airlines Inc. | Jan 2026 – Mar 2026 |
| Manhattan Regional → Lubbock Preston Smith International MHK–LBB | 2 | 261 | 85% | 474 | Breeze Aviation Group DBA Breeze, United Air Lines Inc. | Jan 2025 – Feb 2026 |
| Manhattan Regional → Manhattan Regional MHK–MHK | 2 | 0 | 0% | 0 | SkyWest Airlines Inc. | Jun 2025 – Aug 2025 |
| Manhattan Regional → Provo Municipal MHK–PVU | 2 | 49 | 26% | 805 | Breeze Aviation Group DBA Breeze, SkyWest Airlines Inc. | Feb 2025 – Feb 2026 |
| Manhattan Regional → Salt Lake City International MHK–SLC | 2 | 212 | 67% | 820 | Breeze Aviation Group DBA Breeze, United Air Lines Inc. | Jun 2025 – Jan 2026 |
| Manhattan Regional → Abilene Regional MHK–ABI | 1 | 75 | 99% | 494 | Envoy Air | Jun 2026 – Jun 2026 |
| Manhattan Regional → Waco Regional MHK–ACT | 1 | 175 | 98% | 521 | United Air Lines Inc. | Jan 2025 – Oct 2025 |
| Manhattan Regional → Alexandria International MHK–AEX | 1 | 0 | 0% | 587 | Global Crossing Airlines, Inc. | Feb 2025 – Jan 2026 |
| Manhattan Regional → Birmingham-Shuttlesworth International MHK–BHM | 1 | 0 | 0% | 673 | SkyWest Airlines Inc. | Sep 2025 – Sep 2025 |
| Manhattan Regional → Nashville International MHK–BNA | 1 | 0 | 0% | 586 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Manhattan Regional → Columbia Metro MHK–CAE | 1 | 0 | 0% | 935 | CommuteAir LLC dba CommuteAir | Apr 2026 – Apr 2026 |
| Manhattan Regional → North Central West Virginia MHK–CKB | 1 | 0 | 0% | 881 | Global Crossing Airlines, Inc. | Jan 2026 – Jan 2026 |
| Manhattan Regional → Easterwood Field MHK–CLL | 1 | 0 | 0% | 590 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Manhattan Regional → Cincinnati/Northern Kentucky International MHK–CVG | 1 | 46 | 26% | 645 | Allegiant Air | Mar 2025 – Feb 2026 |
| Manhattan Regional → Mahlon Sweet Field MHK–EUG | 1 | 170 | 96% | 1,410 | Alaska Airlines Inc. | Apr 2025 – Apr 2026 |
| Manhattan Regional → Newark Liberty International MHK–EWR | 1 | 36 | 26% | 1,197 | Breeze Aviation Group DBA Breeze | Feb 2025 – Dec 2025 |
| Manhattan Regional → Fort Worth Meacham International MHK–FTW | 1 | 0 | 0% | 438 | Global Crossing Airlines, Inc. | Jan 2025 – Feb 2026 |
| Manhattan Regional → Grand Forks International MHK–GFK | 1 | 142 | 79% | 608 | Allegiant Air | Aug 2025 – Aug 2025 |
| Manhattan Regional → William P Hobby MHK–HOU | 1 | 0 | 0% | 659 | CommuteAir LLC dba CommuteAir | Mar 2026 – Mar 2026 |
| Manhattan Regional → Huntsville Intl-Carl T Jones Field MHK–HSV | 1 | 0 | 0% | 629 | SkyWest Airlines Inc. | Nov 2025 – Nov 2025 |
| Manhattan Regional → Los Angeles International MHK–LAX | 1 | 0 | 0% | 1,258 | Alaska Airlines Inc. | Oct 2025 – Oct 2025 |
| Manhattan Regional → Lincoln MHK–LNK | 1 | 0 | 0% | 118 | SkyWest Airlines Inc. | Jul 2026 – Jul 2026 |
| Manhattan Regional → Kansas City International MHK–MCI | 1 | 2 | 3% | 105 | SkyWest Airlines Inc. | Mar 2025 – Nov 2025 |
| Manhattan Regional → Miami International MHK–MIA | 1 | 0 | 0% | 1,323 | Global Crossing Airlines, Inc. | Jan 2025 – Feb 2026 |
| Manhattan Regional → General Mitchell International MHK–MKE | 1 | 0 | 0% | 528 | Air Wisconsin Airlines Corp | Jan 2025 – Oct 2025 |
| Manhattan Regional → Quad Cities International MHK–MLI | 1 | 57 | 88% | 362 | Envoy Air | Mar 2026 – Mar 2026 |
| Manhattan Regional → Okc Will Rogers International MHK–OKC | 1 | 166 | 93% | 264 | United Air Lines Inc. | Nov 2025 – Nov 2025 |
| Manhattan Regional → Eppley Airfield MHK–OMA | 1 | 20 | 31% | 155 | Envoy Air | Jan 2026 – Jan 2026 |
| Manhattan Regional → Phoenix Sky Harbor International MHK–PHX | 1 | 0 | 0% | 941 | SkyWest Airlines Inc. | Feb 2025 – Mar 2026 |
| Manhattan Regional → Seattle-Tacoma International MHK–SEA | 1 | 0 | 0% | 1,406 | Alaska Airlines Inc. | Apr 2025 – Apr 2026 |
| Manhattan Regional → Orlando Sanford International MHK–SFB | 1 | 188 | 94% | 1,136 | JetBlue Airways | Feb 2025 – Sep 2025 |
| Manhattan Regional → Sheppard Afb/Wichita Falls Municipal MHK–SPS | 1 | 0 | 0% | 369 | SkyWest Airlines Inc. | Jul 2025 – Sep 2025 |
| Manhattan Regional → New York Stewart International MHK–SWF | 1 | 170 | 95% | 1,199 | United Air Lines Inc. | Sep 2025 – Sep 2025 |
| Manhattan Regional → Stillwater Regional MHK–SWO | 1 | 0 | 0% | 207 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |