| Grand Junction Regional → Denver International GJT–DEN | 2,396 | 175,956 | 82% | 212 | SkyWest Airlines Inc., United Air Lines Inc., Delta Air Lines Inc., Southwest Airlines Co. +3 | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Dallas-Fort Worth International GJT–DFW | 1,036 | 61,709 | 82% | 772 | Envoy Air, SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Phoenix Sky Harbor International GJT–PHX | 980 | 56,998 | 81% | 438 | SkyWest Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Salt Lake City International GJT–SLC | 599 | 23,187 | 74% | 217 | SkyWest Airlines Inc., Delta Air Lines Inc., United Air Lines Inc., Federal Express Corporation | Jan 2025 – Jul 2026 |
| Grand Junction Regional → City Of Colorado Springs Municipal GJT–COS | 158 | 166 | 27% | 207 | Federal Express Corporation, SkyWest Airlines Inc., American Airlines Inc. | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Harry Reid International GJT–LAS | 126 | 11,235 | 65% | 420 | Breeze Aviation Group DBA Breeze, Mjet GmbH, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Grand Junction Regional → John Wayne/Orange County GJT–SNA | 109 | 9,812 | 66% | 642 | Breeze Aviation Group DBA Breeze | Apr 2025 – Jul 2026 |
| Grand Junction Regional → Frederick W Smith Intl/Memphis GJT–MEM | 92 | 0 | | 1,060 | Federal Express Corporation | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Aspen-Pitkin County/Sardy Field GJT–ASE | 55 | 157 | 4% | 89 | SkyWest Airlines Inc., CFM Inc d/b/a Contour... | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Grand Junction Regional GJT–GJT | 44 | 0 | 0% | 0 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Los Angeles International GJT–LAX | 37 | 308 | 11% | 656 | SkyWest Airlines Inc., Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Chicago O'Hare International GJT–ORD | 17 | 0 | 0% | 1,100 | SkyWest Airlines Inc. | Jan 2025 – Jun 2026 |
| Grand Junction Regional → Austin-Bergstrom International GJT–AUS | 12 | 0 | 0% | 870 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Grand Junction Regional → George Bush Intcntl/Houston GJT–IAH | 9 | 0 | 0% | 978 | SkyWest Airlines Inc. | Feb 2025 – Jul 2026 |
| Grand Junction Regional → Hartsfield/Jackson Atlanta International GJT–ATL | 8 | 0 | 0% | 1,390 | SkyWest Airlines Inc. | Jan 2025 – Mar 2026 |
| Grand Junction Regional → San Francisco International GJT–SFO | 7 | 0 | 0% | 759 | SkyWest Airlines Inc. | Feb 2025 – Jun 2026 |
| Grand Junction Regional → Charlotte/Douglas International GJT–CLT | 5 | 0 | 0% | 1,539 | SkyWest Airlines Inc. | Dec 2025 – Mar 2026 |
| Grand Junction Regional → Tucson International GJT–TUS | 5 | 0 | 0% | 501 | SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| Grand Junction Regional → Albuquerque International Sunport GJT–ABQ | 4 | 0 | 0% | 300 | Federal Express Corporation, SkyWest Airlines Inc. | Sep 2025 – Jun 2026 |
| Grand Junction Regional → Casper/Natrona County International GJT–CPR | 4 | 0 | | 282 | Federal Express Corporation | Apr 2025 – May 2026 |
| Grand Junction Regional → Lubbock Preston Smith International GJT–LBB | 4 | 75 | 36% | 530 | SkyWest Airlines Inc., Federal Express Corporation, Envoy Air | Jul 2025 – Jun 2026 |
| Grand Junction Regional → Yampa Valley GJT–HDN | 2 | 253 | 75% | 117 | American Airlines Inc., United Air Lines Inc. | Jan 2025 – Feb 2026 |
| Grand Junction Regional → Abilene Regional GJT–ABI | 1 | 72 | 95% | 678 | Envoy Air | May 2025 – Aug 2025 |
| Grand Junction Regional → Waco Regional GJT–ACT | 1 | 0 | 0% | 820 | SkyWest Airlines Inc. | Mar 2025 – Jun 2026 |
| Grand Junction Regional → Rick Husband Amarillo International GJT–AMA | 1 | 74 | 97% | 462 | Envoy Air | Sep 2025 – Sep 2025 |
| Grand Junction Regional → Carlsbad GJT–CLD | 1 | 0 | 0% | 641 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| Grand Junction Regional → Clovis Regional GJT–CVN | 1 | 2 | 13% | 442 | Jet Aviation Flight Services, Inc. | May 2026 – May 2026 |
| Grand Junction Regional → Dallas Love Field GJT–DAL | 1 | 13 | 81% | 783 | Jet Aviation Flight Services, Inc. | Jan 2026 – Jan 2026 |
| Grand Junction Regional → Durango-La Plata County GJT–DRO | 1 | 0 | 0% | 142 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Grand Junction Regional → Northern Colorado Regional GJT–FNL | 1 | 0 | 0% | 208 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Grand Junction Regional → Laughlin/Bullhead International GJT–IFP | 1 | 138 | 74% | 431 | Sun Country Airlines d/b/a... | Mar 2026 – Mar 2026 |
| Grand Junction Regional → Lawton-Fort Sill Regional GJT–LAW | 1 | 73 | 96% | 641 | Envoy Air | Sep 2025 – Sep 2025 |
| Grand Junction Regional → Minneapolis-St Paul Intl/Wold-Chamberlain GJT–MSP | 1 | 0 | 0% | 880 | Sun Country Airlines d/b/a... | Mar 2026 – Mar 2026 |
| Grand Junction Regional → Montrose Regional GJT–MTJ | 1 | 147 | 89% | 54 | United Air Lines Inc. | Feb 2026 – Feb 2026 |
| Grand Junction Regional → Okc Will Rogers International GJT–OKC | 1 | 0 | 0% | 654 | SkyWest Airlines Inc. | Jul 2026 – Jul 2026 |
| Grand Junction Regional → Palm Springs International GJT–PSP | 1 | 0 | 0% | 575 | SkyWest Airlines Inc. | Jul 2026 – Jul 2026 |
| Grand Junction Regional → Provo Municipal GJT–PVU | 1 | 0 | 0% | 187 | SkyWest Airlines Inc. | Mar 2025 – Mar 2026 |
| Grand Junction Regional → Rapid City Regional GJT–RAP | 1 | 91 | 58% | 442 | Allegiant Air | Oct 2025 – Oct 2025 |
| Grand Junction Regional → Southwest Wyoming Regional GJT–RKS | 1 | 0 | 0% | 173 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| Grand Junction Regional → San Diego International GJT–SAN | 1 | 23 | 77% | 655 | CFM Inc d/b/a Contour... | Jan 2025 – Jan 2026 |
| Grand Junction Regional → St. George Regional GJT–SGU | 1 | 0 | 0% | 308 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| Grand Junction Regional → Mineta San Jose International GJT–SJC | 1 | 2 | 29% | 739 | Scott Aviation, LLC d/b/a... | Dec 2025 – Dec 2025 |
| Grand Junction Regional → San Angelo Rgnl/Mathis Field GJT–SJT | 1 | 0 | 0% | 701 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |