| Topeka Regional → Miami International FOE–MIA | 4 | 28 | 4% | 1,273 | Global Crossing Airlines, Inc. | Jan 2025 – Jan 2026 |
| Topeka Regional → Raleigh-Durham International FOE–RDU | 4 | 105 | 18% | 951 | Global Crossing Airlines, Inc. | Nov 2025 – Mar 2026 |
| Topeka Regional → Cincinnati/Northern Kentucky International FOE–CVG | 3 | 223 | 54% | 592 | Allegiant Air, SkyWest Airlines Inc. | Jan 2025 – Mar 2026 |
| Topeka Regional → Lubbock Preston Smith International FOE–LBB | 3 | 197 | 49% | 501 | JetBlue Airways, Global Crossing Airlines, Inc., SkyWest Airlines Inc. | Mar 2025 – Feb 2026 |
| Topeka Regional → Tucson International FOE–TUS | 3 | 181 | 41% | 980 | JetBlue Airways, Global Crossing Airlines, Inc., SkyWest Airlines Inc. | Mar 2025 – Feb 2026 |
| Topeka Regional → North Central West Virginia FOE–CKB | 2 | 189 | 50% | 829 | JetBlue Airways, Global Crossing Airlines, Inc. | Feb 2025 – Jan 2026 |
| Topeka Regional → Cancun FOE–CUN international | 2 | 0 | 0% | 1,340 | National Air Cargo Group... | Apr 2026 – Apr 2026 |
| Topeka Regional → John F Kennedy International FOE–JFK | 2 | 0 | 0% | 1,168 | National Air Cargo Group... | Apr 2026 – Apr 2026 |
| Topeka Regional → Harry Reid International FOE–LAS | 2 | 59 | 27% | 1,087 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| Topeka Regional → Orlando International FOE–MCO | 2 | 197 | 40% | 1,097 | JetBlue Airways, National Air Cargo Group... | Oct 2025 – Apr 2026 |
| Topeka Regional → Chicago O'Hare International FOE–ORD | 2 | 36 | 16% | 459 | Global Crossing Airlines, Inc., SkyWest Airlines Inc. | Dec 2025 – Mar 2026 |
| Topeka Regional → Orlando Sanford International FOE–SFB | 2 | 0 | 0% | 1,084 | Global Crossing Airlines, Inc. | Jan 2025 – Jan 2026 |
| Topeka Regional → Salt Lake City International FOE–SLC | 2 | 153 | 67% | 875 | Alaska Airlines Inc., SkyWest Airlines Inc. | Jan 2025 – Feb 2026 |
| Topeka Regional → Trenton Mercer FOE–TTN | 2 | 109 | 30% | 1,114 | Allegiant Air, Global Crossing Airlines, Inc. | Aug 2025 – Nov 2025 |
| Topeka Regional → Waco Regional FOE–ACT | 1 | 0 | 0% | 514 | Global Crossing Airlines, Inc. | Jan 2025 – Jan 2026 |
| Topeka Regional → Alexandria International FOE–AEX | 1 | 0 | 0% | 555 | Global Crossing Airlines, Inc. | Jan 2026 – Jan 2026 |
| Topeka Regional → Bradley International FOE–BDL | 1 | 60 | 48% | 1,225 | United Air Lines Inc. | Mar 2025 – Dec 2025 |
| Topeka Regional → Baltimore/Washington International Thurgood Marshall FOE–BWI | 1 | 0 | 0% | 1,020 | Global Crossing Airlines, Inc. | May 2025 – Nov 2025 |
| Topeka Regional → Bozeman Yellowstone International FOE–BZN | 1 | 0 | 0% | 920 | Global Crossing Airlines, Inc. | Jan 2026 – Jan 2026 |
| Topeka Regional → John Glenn Columbus International FOE–CMH | 1 | 0 | 0% | 686 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| Topeka Regional → Columbia Regional FOE–COU | 1 | 0 | 0% | 186 | Global Crossing Airlines, Inc. | Dec 2025 – Dec 2025 |
| Topeka Regional → Dallas Love Field FOE–DAL | 1 | 0 | 0% | 426 | Alaska Airlines Inc. | Nov 2025 – Nov 2025 |
| Topeka Regional → Denver International FOE–DEN | 1 | 0 | 0% | 486 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| Topeka Regional → Fresno Yosemite International FOE–FAT | 1 | 159 | 88% | 1,320 | Allegiant Air | Aug 2025 – Aug 2025 |
| Topeka Regional → William P Hobby FOE–HOU | 1 | 42 | 57% | 642 | CommuteAir LLC dba CommuteAir | Jan 2025 – Feb 2026 |
| Topeka Regional → Valley International FOE–HRL | 1 | 0 | 0% | 884 | Global Crossing Airlines, Inc. | Jan 2025 – Nov 2025 |
| Topeka Regional → Minneapolis-St Paul Intl/Wold-Chamberlain FOE–MSP | 1 | 0 | 0% | 428 | Global Crossing Airlines, Inc. | Dec 2025 – Dec 2025 |
| Topeka Regional → Oakland San Francisco Bay FOE–OAK | 1 | 0 | 0% | 1,440 | Global Crossing Airlines, Inc. | Feb 2026 – Feb 2026 |
| Topeka Regional → Phoenix Sky Harbor International FOE–PHX | 1 | 0 | 0% | 988 | Global Crossing Airlines, Inc. | Jan 2026 – Jan 2026 |
| Topeka Regional → Provo Municipal FOE–PVU | 1 | 50 | 46% | 861 | Breeze Aviation Group DBA Breeze | Feb 2025 – Jan 2026 |
| Topeka Regional → Southwest Florida International FOE–RSW | 1 | 60 | 33% | 1,175 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| Topeka Regional → San Diego International FOE–SAN | 1 | 126 | 71% | 1,278 | Eastern Air Express, LLC (EAX) | Mar 2026 – Mar 2026 |
| Topeka Regional → Stillwater Regional FOE–SWO | 1 | 136 | 76% | 208 | United Air Lines Inc. | Nov 2025 – Nov 2025 |