| Cincinnati/Northern Kentucky International → Leipzig CVG–LEJ international | 613 | 0 | | 80,494,586 | 4,452 |
| Chicago O'Hare International → Frankfurt ORD–FRA international | 309 | 0 | | 47,113,658 | 4,343 |
| Hong Kong → Los Angeles International HKG–LAX international | 298 | 0 | | 54,267,928 | 7,260 |
| Shenzhen → Los Angeles International SZX–LAX international | 294 | 0 | | 58,375,651 | 7,248 |
| Los Angeles International → Leipzig LAX–LEJ international | 288 | 0 | | 34,199,421 | 5,838 |
| Los Angeles International → Cincinnati/Northern Kentucky International LAX–CVG | 281 | 0 | | 42,325,084 | 1,900 |
| Hartsfield/Jackson Atlanta International → Frankfurt ATL–FRA international | 244 | 0 | | 29,705,800 | 4,614 |
| Frankfurt → Hartsfield/Jackson Atlanta International FRA–ATL international | 241 | 0 | | 43,105,334 | 4,614 |
| Leipzig → Cincinnati/Northern Kentucky International LEJ–CVG international | 200 | 0 | | 35,477,652 | 4,452 |
| Los Angeles International → Frankfurt LAX–FRA international | 165 | 0 | | 22,835,983 | 5,805 |
| Brussels → Cincinnati/Northern Kentucky International BRU–CVG international | 146 | 0 | | 23,898,611 | 4,175 |
| Frankfurt → Chicago O'Hare International FRA–ORD international | 141 | 0 | | 27,923,507 | 4,343 |
| Frankfurt → John F Kennedy International FRA–JFK international | 137 | 0 | | 23,254,235 | 3,855 |
| John F Kennedy International → Frankfurt JFK–FRA international | 136 | 0 | | 16,510,049 | 3,855 |
| Cincinnati/Northern Kentucky International → Brussels CVG–BRU international | 132 | 0 | | 15,758,686 | 4,175 |
| Toronto → Chicago O'Hare International YYZ–ORD international | 131 | 0 | | 17,399,429 | 436 |
| Frankfurt → Los Angeles International FRA–LAX international | 109 | 0 | | 16,777,160 | 5,805 |
| Dallas-Fort Worth International → Frankfurt DFW–FRA international | 98 | 0 | | 13,656,581 | 5,142 |
| Hampton Roads Executive → Los Angeles International PVG–LAX international | 63 | 0 | | 12,853,008 | 6,485 |
| Hong Kong → Cincinnati/Northern Kentucky International HKG–CVG international | 62 | 0 | | 10,762,154 | 8,040 |
| Frankfurt → Dallas-Fort Worth International FRA–DFW international | 61 | 0 | | 11,058,292 | 5,142 |
| Dallas-Fort Worth International → George Bush Intcntl/Houston DFW–IAH | 57 | 0 | | 7,344,057 | 224 |
| Los Angeles International → Seattle-Tacoma International LAX–SEA | 54 | 0 | | 7,069,222 | 954 |
| Seattle-Tacoma International → Frankfurt SEA–FRA international | 54 | 0 | | 7,501,479 | 5,108 |
| George Bush Intcntl/Houston → Stavanger IAH–SVG international | 52 | 0 | | 9,338,591 | 4,844 |
| Tokyo → Cincinnati/Northern Kentucky International NRT–CVG international | 50 | 0 | | 9,671,842 | 6,537 |
| George Bush Intcntl/Houston → Dallas-Fort Worth International IAH–DFW | 48 | 0 | | 7,162,912 | 224 |
| Cincinnati/Northern Kentucky International → Derby CVG–EMA international | 47 | 0 | | 6,083,681 | 3,893 |
| Frankfurt → George Bush Intcntl/Houston FRA–IAH international | 47 | 0 | | 8,977,966 | 5,231 |
| Frankfurt → Seattle-Tacoma International FRA–SEA international | 47 | 0 | | 6,684,388 | 5,108 |
| Seattle-Tacoma International → Los Angeles International SEA–LAX | 47 | 0 | | 5,811,785 | 954 |
| Toronto → Dallas-Fort Worth International YYZ–DFW international | 47 | 0 | | 6,036,872 | 1,199 |
| Brussels → Chicago O'Hare International BRU–ORD international | 41 | 0 | | 7,970,743 | 4,160 |
| Derby → Cincinnati/Northern Kentucky International EMA–CVG international | 40 | 0 | | 7,156,778 | 3,893 |
| Ted Stevens Anchorage International → Chicago O'Hare International ANC–ORD | 29 | 0 | | 6,595,672 | 2,846 |
| Chicago O'Hare International → Leipzig ORD–LEJ international | 29 | 0 | | 2,950,215 | 4,422 |
| Shenzhen → Ted Stevens Anchorage International SZX–ANC international | 29 | 0 | | 6,595,672 | 5,065 |
| Los Angeles International → Hartsfield/Jackson Atlanta International LAX–ATL | 23 | 0 | | 1,611,212 | 1,947 |
| Hartsfield/Jackson Atlanta International → Leipzig ATL–LEJ international | 18 | 0 | | 1,623,406 | 4,717 |
| Ted Stevens Anchorage International → Cincinnati/Northern Kentucky International ANC–CVG | 16 | 0 | | 2,361,883 | 3,110 |
| Bangkok → Ted Stevens Anchorage International BKK–ANC international | 16 | 0 | | 2,361,894 | 6,016 |
| Cincinnati/Northern Kentucky International → Manama CVG–BAH international | 7 | 0 | | 1,038,257 | 7,094 |
| Hartsfield/Jackson Atlanta International → Cincinnati/Northern Kentucky International ATL–CVG | 5 | 0 | | 404,508 | 373 |
| George Bush Intcntl/Houston → Frankfurt IAH–FRA international | 5 | 0 | | 848,574 | 5,231 |
| Chicago O'Hare International → Shannon ORD–SNN international | 4 | 0 | | 643,192 | 3,590 |
| Seoul → Los Angeles International ICN–LAX international | 3 | 0 | | 615,402 | 5,995 |
| Chicago O'Hare International → Toronto ORD–YYZ international | 3 | 0 | | 436,487 | 436 |
| Frankfurt → Cincinnati/Northern Kentucky International FRA–CVG international | 2 | 0 | | 372,050 | 4,360 |
| Hartsfield/Jackson Atlanta International → Dallas-Fort Worth International ATL–DFW | 1 | 0 | | 116,794 | 731 |
| Birmingham-Shuttlesworth International → Hartsfield/Jackson Atlanta International BHM–ATL | 1 | 0 | | 0 | 134 |
| Buffalo Niagara International → Toronto BUF–YYZ international | 1 | 0 | | 161,383 | 68 |
| Cincinnati/Northern Kentucky International → Hartsfield/Jackson Atlanta International CVG–ATL | 1 | 0 | | 193,417 | 373 |
| Cincinnati/Northern Kentucky International → Cologne CVG–CGN international | 1 | 0 | | 83,085 | 4,278 |
| Cincinnati/Northern Kentucky International → Dubai CVG–DXB international | 1 | 0 | | 86,051 | 7,312 |
| Cincinnati/Northern Kentucky International → Chicago O'Hare International CVG–ORD | 1 | 0 | | 178,633 | 264 |
| Dallas-Fort Worth International → Hartsfield/Jackson Atlanta International DFW–ATL | 1 | 0 | | 148,038 | 731 |
| Derby → Miami International EMA–MIA international | 1 | 0 | | 146,216 | 4,374 |
| Frankfurt → Buffalo Niagara International FRA–BUF international | 1 | 0 | | 161,383 | 3,950 |
| Hong Kong → Minneapolis-St Paul Intl/Wold-Chamberlain HKG–MSP international | 1 | 0 | | 161,850 | 7,501 |
| John F Kennedy International → Hartsfield/Jackson Atlanta International JFK–ATL | 1 | 0 | | 138,772 | 760 |
| John F Kennedy International → Chicago O'Hare International JFK–ORD | 1 | 0 | | 70,233 | 740 |
| Los Angeles International → Portland International LAX–PDX | 1 | 0 | | 169,605 | 833 |
| Los Angeles International → Shannon LAX–SNN international | 1 | 0 | | 100,740 | 5,122 |
| Miami International → Hartsfield/Jackson Atlanta International MIA–ATL | 1 | 0 | | 132 | 594 |
| Minneapolis-St Paul Intl/Wold-Chamberlain → Cincinnati/Northern Kentucky International MSP–CVG | 1 | 0 | | 161,850 | 596 |
| Portland International → Frankfurt PDX–FRA international | 1 | 0 | | 153,010 | 5,226 |
| Toronto → George Bush Intcntl/Houston YYZ–IAH international | 1 | 0 | | 140,589 | 1,280 |
| Toronto → John F Kennedy International YYZ–JFK international | 1 | 0 | | 84,172 | 366 |