| Orlando Sanford International → Lehigh Valley International SFB–ABE | 640 | 103,407 | 90% | 882 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → MC Ghee Tyson SFB–TYS | 636 | 96,029 | 84% | 511 | Allegiant Air, Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Asheville Regional SFB–AVL | 514 | 74,894 | 81% | 465 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Gerald R Ford International SFB–GRR | 400 | 64,429 | 89% | 1,001 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Cincinnati/Northern Kentucky International SFB–CVG | 354 | 55,142 | 88% | 735 | Allegiant Air, JetBlue Airways, National Air Cargo Group... | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Bishop International SFB–FNT | 322 | 50,360 | 86% | 988 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Bangor International SFB–BGR | 282 | 41,812 | 81% | 1,299 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Harrisburg International SFB–MDT | 277 | 43,511 | 89% | 827 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Appleton International SFB–ATW | 248 | 39,948 | 89% | 1,141 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → South Bend International SFB–SBN | 247 | 38,308 | 87% | 936 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Indianapolis International SFB–IND | 226 | 35,417 | 88% | 807 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Blue Grass SFB–LEX | 217 | 33,252 | 86% | 667 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Des Moines International SFB–DSM | 205 | 32,690 | 88% | 1,124 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Concord SFB–USA | 192 | 27,908 | 81% | 457 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Fort Wayne International SFB–FWA | 183 | 26,244 | 79% | 870 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Pittsburgh International SFB–PIT | 173 | 28,200 | 90% | 810 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → The Eastern Iowa SFB–CID | 169 | 26,062 | 85% | 1,078 | Allegiant Air, TEM Enterprises dba Avelo Airlines | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Scott Afb/Midamerica St. Louis SFB–BLV | 165 | 25,225 | 88% | 835 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Rickenbacker International SFB–LCK | 162 | 24,590 | 86% | 767 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Elmira/Corning Regional SFB–ELM | 159 | 25,259 | 87% | 954 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Springfield-Branson Ntl SFB–SGF | 158 | 23,937 | 85% | 914 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Chicago/Rockford International SFB–RFD | 152 | 23,598 | 87% | 1,025 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Tri-State/Milton J Ferguson Field SFB–HTS | 142 | 21,808 | 85% | 665 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → General Downing - Peoria International SFB–PIA | 142 | 21,453 | 85% | 949 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Plattsburgh International SFB–PBG | 140 | 21,746 | 86% | 1,175 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Portsmouth International AT Pease SFB–PSM | 135 | 19,586 | 81% | 1,144 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Tri-Cities SFB–TRI | 134 | 19,379 | 81% | 535 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Northwest Arkansas Ntl SFB–XNA | 134 | 20,080 | 89% | 920 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Greenville Spartanburg International SFB–GSP | 132 | 18,241 | 76% | 426 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Evansville Regional SFB–EVV | 127 | 18,847 | 83% | 734 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Central IL Rgnl/Bloomington-Normal SFB–BMI | 125 | 19,131 | 85% | 917 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Louisville Muhammad Ali International SFB–SDF | 125 | 19,254 | 87% | 698 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Nashville International SFB–BNA | 124 | 18,642 | 89% | 598 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Akron-Canton Regional SFB–CAK | 122 | 17,186 | 82% | 837 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Lovell Field SFB–CHA | 121 | 16,964 | 80% | 490 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Hagerstown Rgnl/Richard A Henson Field SFB–HGR | 121 | 17,964 | 85% | 780 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Key West International SFB–EYW | 115 | 11,661 | 64% | 292 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Roanoke/Blacksburg Regional (Woodrum Field) SFB–ROA | 115 | 16,945 | 84% | 594 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Paulding Northwest Atlanta SFB–PUJ international | 114 | 12,931 | 61% | 1,075 | Arajet S.A. | Oct 2025 – Jul 2026 |
| Orlando Sanford International → Eugene F Kranz Toledo Express SFB–TOL | 111 | 17,174 | 86% | 895 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Joe Foss Field SFB–FSD | 110 | 17,475 | 87% | 1,334 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → MC Allen International SFB–MFE | 110 | 17,842 | 88% | 1,059 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Tulsa International SFB–TUL | 108 | 16,180 | 84% | 995 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → North Central West Virginia SFB–CKB | 107 | 15,757 | 83% | 727 | Allegiant Air, Global Crossing Airlines, Inc. | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Albany International SFB–ALB | 104 | 16,341 | 86% | 1,049 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Eppley Airfield SFB–OMA | 100 | 16,440 | 90% | 1,195 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Syracuse Hancock International SFB–SYR | 100 | 15,956 | 88% | 1,029 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Quad Cities International SFB–MLI | 96 | 14,648 | 84% | 1,018 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Cherry Capital SFB–TVC | 92 | 13,816 | 83% | 1,127 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Frederick W Smith Intl/Memphis SFB–MEM | 91 | 12,785 | 81% | 671 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → New York Stewart International SFB–SWF | 87 | 12,764 | 84% | 965 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → James M Cox Dayton International SFB–DAY | 81 | 12,298 | 87% | 785 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Hector International SFB–FAR | 75 | 12,045 | 87% | 1,508 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Wichita Dwight D Eisenhower Ntl SFB–ICT | 74 | 10,435 | 82% | 1,117 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Columbia Metro SFB–CAE | 72 | 4,612 | 39% | 356 | Allegiant Air | May 2025 – Apr 2026 |
| Orlando Sanford International → Atlantic City International SFB–ACY | 71 | 9,966 | 78% | 829 | Allegiant Air, Sun Country Airlines d/b/a... | Apr 2025 – Jul 2026 |
| Orlando Sanford International → Bill And Hillary Clinton Ntl/Adams Field SFB–LIT | 54 | 7,800 | 83% | 765 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Huntsville Intl-Carl T Jones Field SFB–HSV | 48 | 5,609 | 69% | 519 | Allegiant Air | Feb 2026 – Jul 2026 |
| Orlando Sanford International → Niagara Falls International SFB–IAG | 42 | 6,144 | 83% | 996 | Allegiant Air | Feb 2025 – May 2026 |
| Orlando Sanford International → Rapid City Regional SFB–RAP | 30 | 4,623 | 82% | 1,600 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Austin-Bergstrom International SFB–AUS | 25 | 4,179 | 91% | 994 | Allegiant Air, Sun Country Airlines d/b/a... | May 2025 – Jul 2026 |
| Orlando Sanford International → Shreveport Regional SFB–SHV | 23 | 3,114 | 83% | 791 | Allegiant Air | May 2025 – Jul 2026 |
| Orlando Sanford International → Okc Will Rogers International SFB–OKC | 22 | 3,558 | 89% | 1,061 | Allegiant Air | Jan 2025 – Jul 2026 |
| Orlando Sanford International → Harry Reid International SFB–LAS | 21 | 2,794 | 84% | 2,034 | Allegiant Air | Mar 2026 – Jul 2026 |
| Orlando Sanford International → LA Crosse Regional SFB–LSE | 21 | 2,666 | 72% | 1,180 | Allegiant Air | May 2026 – Jul 2026 |
| Orlando Sanford International → Columbia Regional SFB–COU | 17 | 2,115 | 77% | 936 | Allegiant Air | Jun 2026 – Jul 2026 |
| Orlando Sanford International → Bismarck Municipal SFB–BIS | 15 | 2,094 | 81% | 1,628 | Allegiant Air | Jan 2025 – Apr 2026 |
| Orlando Sanford International → Provo Municipal SFB–PVU | 15 | 2,474 | 92% | 1,898 | Allegiant Air | Jan 2025 – Feb 2026 |
| Orlando Sanford International → Richmond International SFB–RIC | 14 | 1,600 | 68% | 643 | Allegiant Air | Jan 2025 – Jan 2026 |
| Orlando Sanford International → Gulfport-Biloxi International SFB–GPT | 13 | 1,766 | 73% | 484 | Sun Country Airlines d/b/a... | Jan 2025 – Jun 2026 |
| Orlando Sanford International → Miami International SFB–MIA | 6 | 0 | 0% | 213 | Global Crossing Airlines, Inc. | Feb 2025 – Jul 2026 |
| Orlando Sanford International → Baltimore/Washington International Thurgood Marshall SFB–BWI | 5 | 572 | 69% | 763 | Allegiant Air, Sun Country Airlines d/b/a... | Apr 2025 – Apr 2026 |
| Orlando Sanford International → Dallas Love Field SFB–DAL | 5 | 712 | 82% | 969 | Allegiant Air, Global Crossing Airlines, Inc. | Apr 2026 – Jun 2026 |
| Orlando Sanford International → Norfolk International SFB–ORF | 4 | 599 | 93% | 631 | Allegiant Air | Feb 2025 – Aug 2025 |
| Orlando Sanford International → Charleston Afb/Intl SFB–CHS | 3 | 313 | 57% | 293 | Allegiant Air, Sun Country Airlines d/b/a... | May 2025 – Jul 2026 |
| Orlando Sanford International → Topeka Regional SFB–FOE | 3 | 52 | 12% | 1,084 | Global Crossing Airlines, Inc. | Jan 2026 – Jan 2026 |
| Orlando Sanford International → Valley International SFB–HRL | 3 | 0 | 0% | 1,022 | Global Crossing Airlines, Inc. | Feb 2025 – May 2026 |
| Orlando Sanford International → Miami-Opa Locka Executive SFB–OPF | 3 | 0 | 0% | 206 | Global Crossing Airlines, Inc. | Mar 2026 – May 2026 |
| Orlando Sanford International → Waco Regional SFB–ACT | 2 | 197 | 79% | 976 | JetBlue Airways, SkyWest Airlines Inc. | Jan 2025 – Feb 2026 |
| Orlando Sanford International → Alexandria International SFB–AEX | 2 | 0 | 0% | 700 | Global Crossing Airlines, Inc. | Apr 2026 – May 2026 |
| Orlando Sanford International → Fort Lauderdale/Hollywood International SFB–FLL | 2 | 119 | 70% | 198 | Allegiant Air, CFM Inc d/b/a Contour... | Jan 2025 – Jun 2026 |
| Orlando Sanford International → Washington Dulles International SFB–IAD | 2 | 303 | 97% | 734 | Allegiant Air | Apr 2026 – May 2026 |
| Orlando Sanford International → Jacksonville International SFB–JAX | 2 | 0 | 0% | 122 | Sun Country Airlines d/b/a... | Feb 2025 – Feb 2026 |
| Orlando Sanford International → Lubbock Preston Smith International SFB–LBB | 2 | 223 | 83% | 1,262 | JetBlue Airways, Sun Country Airlines d/b/a... | Nov 2025 – Jan 2026 |
| Orlando Sanford International → Minneapolis-St Paul Intl/Wold-Chamberlain SFB–MSP | 2 | 115 | 31% | 1,291 | Sun Country Airlines d/b/a... | Oct 2025 – Jun 2026 |
| Orlando Sanford International → West Palm Beach/Palm Beach SFB–PBI | 2 | 0 | 0% | 160 | Sun Country Airlines d/b/a... | Apr 2025 – Apr 2026 |
| Orlando Sanford International → Sarasota/Bradenton International SFB–SRQ | 2 | 0 | 0% | 125 | CFM Inc d/b/a Contour..., Sun Country Airlines d/b/a... | Dec 2025 – May 2026 |
| Orlando Sanford International → Tallahassee International SFB–TLH | 2 | 2 | 1% | 218 | Sun Country Airlines d/b/a..., Tradewind Aviation | Nov 2025 – Jun 2026 |
| Orlando Sanford International → Athens/Ben Epps SFB–AHN | 1 | 10 | 67% | 377 | CFM Inc d/b/a Contour... | May 2026 – May 2026 |
| Orlando Sanford International → Athens SFB–ATH international | 1 | 7 | 50% | 5,774 | GainJet Ireland Ltd | Feb 2025 – Feb 2026 |
| Orlando Sanford International → Laurence G Hanscom Field SFB–BED | 1 | 103 | 55% | 1,096 | Sun Country Airlines d/b/a... | Sep 2025 – Sep 2025 |
| Orlando Sanford International → Birmingham-Shuttlesworth International SFB–BHM | 1 | 184 | 99% | 464 | Sun Country Airlines d/b/a... | Aug 2025 – Aug 2025 |
| Orlando Sanford International → Biggs Army Airfield (Fort Bliss) SFB–BIF | 1 | 24 | 14% | 1,514 | Allegiant Air | Jul 2025 – Jan 2026 |
| Orlando Sanford International → Baton Rouge Metro, Ryan Field SFB–BTR | 1 | 138 | 77% | 608 | Allegiant Air | Oct 2025 – Oct 2025 |
| Orlando Sanford International → Daytona Beach International SFB–DAB | 1 | 0 | 0% | 30 | Sun Country Airlines d/b/a... | Jul 2025 – Sep 2025 |
| Orlando Sanford International → Dallas-Fort Worth International SFB–DFW | 1 | 0 | 0% | 980 | SkyWest Airlines Inc. | Feb 2026 – Feb 2026 |
| Orlando Sanford International → Republic SFB–FRG | 1 | 10 | 62% | 935 | CFM Inc d/b/a Contour... | Mar 2026 – Mar 2026 |
| Orlando Sanford International → Gainesville Regional SFB–GNV | 1 | 0 | 0% | 89 | Sun Country Airlines d/b/a... | Oct 2025 – Oct 2025 |
| Orlando Sanford International → Gary/Chicago International SFB–GYY | 1 | 97 | 54% | 951 | Allegiant Air | Nov 2025 – Nov 2025 |
| Orlando Sanford International → William P Hobby SFB–HOU | 1 | 176 | 95% | 850 | Sun Country Airlines d/b/a... | Nov 2025 – Nov 2025 |
| Orlando Sanford International → Laughlin/Bullhead International SFB–IFP | 1 | 163 | 88% | 1,996 | Sun Country Airlines d/b/a... | Jan 2025 – Mar 2026 |
| Orlando Sanford International → Wilmington International SFB–ILM | 1 | 0 | 0% | 426 | Sun Country Airlines d/b/a... | May 2026 – May 2026 |
| Orlando Sanford International → Jackson-Medgar Wiley Evers International SFB–JAN | 1 | 129 | 83% | 580 | Allegiant Air | Nov 2025 – Nov 2025 |
| Orlando Sanford International → Lakeland Linder International SFB–LAL | 1 | 0 | 0% | 72 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| Orlando Sanford International → Kansas City International SFB–MCI | 1 | 43 | 28% | 1,058 | Caribbean Sun Airlines,... | Jan 2025 – Mar 2026 |
| Orlando Sanford International → Orlando International SFB–MCO | 1 | 0 | 0% | 24 | National Air Cargo Group... | Aug 2025 – Aug 2025 |
| Orlando Sanford International → Montgomery Regional (Dannelly Field) SFB–MGM | 1 | 140 | 90% | 392 | Allegiant Air | Oct 2025 – Oct 2025 |
| Orlando Sanford International → Manhattan Regional SFB–MHK | 1 | 184 | 92% | 1,136 | JetBlue Airways | Feb 2025 – Sep 2025 |
| Orlando Sanford International → Melbourne Orlando International SFB–MLB | 1 | 0 | 0% | 59 | Sun Country Airlines d/b/a... | Mar 2026 – Mar 2026 |
| Orlando Sanford International → Minot International SFB–MOT | 1 | 177 | 98% | 1,717 | Allegiant Air | Jan 2025 – Jun 2026 |
| Orlando Sanford International → Louis Armstrong New Orleans International SFB–MSY | 1 | 138 | 74% | 550 | Sun Country Airlines d/b/a... | May 2026 – May 2026 |
| Orlando Sanford International → Norfolk NS (Chambers Field) SFB–NGU | 1 | 0 | 0% | 631 | National Air Cargo Group... | Oct 2025 – Oct 2025 |
| Orlando Sanford International → Philadelphia International SFB–PHL | 1 | 0 | 0% | 838 | Southwest Airlines Co. | Mar 2026 – Mar 2026 |
| Orlando Sanford International → Southwest Florida International SFB–RSW | 1 | 0 | 0% | 158 | Sun Country Airlines d/b/a... | Jan 2025 – Jun 2026 |
| Orlando Sanford International → San Diego International SFB–SAN | 1 | 107 | 59% | 2,146 | Allegiant Air | Nov 2025 – Nov 2025 |
| Orlando Sanford International → Savannah/Hilton Head International SFB–SAV | 1 | 0 | 0% | 231 | Sun Country Airlines d/b/a... | Jun 2025 – Mar 2026 |
| Orlando Sanford International → Orlando Sanford International SFB–SFB | 1 | 0 | | 0 | Global Crossing Airlines, Inc. | Feb 2025 – Sep 2025 |
| Orlando Sanford International → Salt Lake City International SFB–SLC | 1 | 197 | 98% | 1,921 | JetBlue Airways | Nov 2025 – Nov 2025 |
| Orlando Sanford International → Stillwater Regional SFB–SWO | 1 | 0 | 0% | 1,055 | SkyWest Airlines Inc. | Mar 2025 – Mar 2026 |
| Orlando Sanford International → Tucson International SFB–TUS | 1 | 45 | 75% | 1,783 | Ameristar Air Cargo | Jan 2026 – Jan 2026 |