| San Luis Obispo County Regional → Phoenix Sky Harbor International SBP–PHX | 1,245 | 93,484 | 75% | 509 | American Airlines Inc., SkyWest Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → San Francisco International SBP–SFO | 1,132 | 64,469 | 70% | 191 | SkyWest Airlines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → Denver International SBP–DEN | 712 | 68,173 | 83% | 931 | United Air Lines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → San Diego International SBP–SAN | 697 | 38,766 | 73% | 263 | SkyWest Airlines Inc., Horizon Air, Allegiant Air | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → Los Angeles International SBP–LAX | 634 | 29,258 | 66% | 155 | SkyWest Airlines Inc., United Air Lines Inc. | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → Seattle-Tacoma International SBP–SEA | 457 | 38,424 | 77% | 847 | Horizon Air, Alaska Airlines Inc., SkyWest Airlines Inc. | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → Ontario International SBP–ONT | 448 | 0 | | 191 | Federal Express Corporation | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → Portland International SBP–PDX | 442 | 25,988 | 77% | 722 | Horizon Air, SkyWest Airlines Inc., Allegiant Air | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → Dallas-Fort Worth International SBP–DFW | 351 | 46,974 | 86% | 1,360 | American Airlines Inc., Envoy Air | Jan 2025 – Jul 2026 |
| San Luis Obispo County Regional → Harry Reid International SBP–LAS | 164 | 7,885 | 63% | 314 | SkyWest Airlines Inc., Horizon Air | Jan 2025 – Apr 2026 |
| San Luis Obispo County Regional → San Luis Obispo County Regional SBP–SBP | 24 | 0 | 0% | 0 | SkyWest Airlines Inc. | Feb 2025 – Jul 2026 |
| San Luis Obispo County Regional → Santa Maria Pub/Capt G Allan Hancock Field SBP–SMX | 12 | 0 | | 25 | Federal Express Corporation | Mar 2025 – Jun 2026 |
| San Luis Obispo County Regional → Fresno Yosemite International SBP–FAT | 3 | 0 | 0% | 118 | SkyWest Airlines Inc. | Sep 2025 – Jul 2026 |
| San Luis Obispo County Regional → Grand Junction Regional SBP–GJT | 3 | 244 | 74% | 720 | United Air Lines Inc., SkyWest Airlines Inc. | Apr 2025 – Jun 2026 |
| San Luis Obispo County Regional → Palm Springs International SBP–PSP | 3 | 0 | 0% | 255 | SkyWest Airlines Inc. | Oct 2025 – Jan 2026 |
| San Luis Obispo County Regional → San Antonio International SBP–SAT | 3 | 452 | 88% | 1,351 | American Airlines Inc. | Aug 2025 – Jun 2026 |
| San Luis Obispo County Regional → City Of Colorado Springs Municipal SBP–COS | 2 | 198 | 72% | 914 | United Air Lines Inc. | Dec 2025 – Jul 2026 |
| San Luis Obispo County Regional → Jackson Hole SBP–JAC | 2 | 3 | 19% | 783 | Scott Aviation, LLC d/b/a... | Feb 2026 – Mar 2026 |
| San Luis Obispo County Regional → Salt Lake City International SBP–SLC | 2 | 137 | 59% | 608 | Allegiant Air, SkyWest Airlines Inc. | Feb 2025 – Sep 2025 |
| San Luis Obispo County Regional → Bozeman Yellowstone International SBP–BZN | 1 | 148 | 82% | 881 | Allegiant Air | Oct 2025 – Oct 2025 |
| San Luis Obispo County Regional → Carlsbad SBP–CLD | 1 | 2 | 25% | 241 | Scott Aviation, LLC d/b/a... | Dec 2025 – Dec 2025 |
| San Luis Obispo County Regional → EL Paso International SBP–ELP | 1 | 125 | 73% | 856 | American Airlines Inc. | May 2026 – May 2026 |
| San Luis Obispo County Regional → Flagstaff Pulliam SBP–FLG | 1 | 129 | 73% | 508 | Allegiant Air | Nov 2025 – Nov 2025 |
| San Luis Obispo County Regional → Spokane International SBP–GEG | 1 | 147 | 82% | 869 | Allegiant Air | Nov 2025 – Nov 2025 |
| San Luis Obispo County Regional → East Texas Regional SBP–GGG | 1 | 118 | 76% | 1,500 | Allegiant Air | Sep 2025 – Sep 2025 |
| San Luis Obispo County Regional → Jack Northrop Fld/Hawthorne Municipal SBP–HHR | 1 | 8 | 89% | 160 | ADVANCED AIR, LLC | Jun 2025 – Oct 2025 |
| San Luis Obispo County Regional → Laramie Regional SBP–LAR | 1 | 0 | 0% | 914 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| San Luis Obispo County Regional → Laguardia SBP–LGA | 1 | 50 | 28% | 2,550 | Allegiant Air | Jul 2026 – Jul 2026 |
| San Luis Obispo County Regional → Missoula Montana SBP–MSO | 1 | 138 | 88% | 875 | Allegiant Air | Oct 2025 – Oct 2025 |
| San Luis Obispo County Regional → Kahului SBP–OGG | 1 | 7 | 39% | 2,381 | Scott Aviation, LLC d/b/a... | Nov 2025 – Nov 2025 |
| San Luis Obispo County Regional → Pocatello Regional SBP–PIH | 1 | 129 | 72% | 682 | Allegiant Air | Nov 2025 – Nov 2025 |
| San Luis Obispo County Regional → Mineta San Jose International SBP–SJC | 1 | 0 | 0% | 163 | SkyWest Airlines Inc. | Aug 2025 – Aug 2025 |
| San Luis Obispo County Regional → Charles M Schulz/Sonoma County SBP–STS | 1 | 0 | 0% | 256 | SkyWest Airlines Inc. | May 2026 – May 2026 |
| San Luis Obispo County Regional → Van Nuys SBP–VNY | 1 | 3 | 50% | 141 | Scott Aviation, LLC d/b/a... | Aug 2025 – Aug 2025 |
| San Luis Obispo County Regional → Yuma SBP–YUM | 1 | 0 | 0% | 389 | SkyWest Airlines Inc. | Jul 2026 – Jul 2026 |