| Portsmouth International AT Pease → Punta Gorda PSM–PGD | 235 | 35,577 | 86% | 1,279 | Allegiant Air | Jan 2025 – Jul 2026 |
| Portsmouth International AT Pease → Orlando Sanford International PSM–SFB | 135 | 19,701 | 82% | 1,144 | Allegiant Air | Jan 2025 – Jul 2026 |
| Portsmouth International AT Pease → Orlando International PSM–MCO | 72 | 7,279 | 74% | 1,167 | Breeze Aviation Group DBA Breeze | Jan 2025 – Jul 2026 |
| Portsmouth International AT Pease → Raleigh-Durham International PSM–RDU | 70 | 7,347 | 75% | 654 | Breeze Aviation Group DBA Breeze, TEM Enterprises dba Avelo Airlines | Aug 2025 – Jul 2026 |
| Portsmouth International AT Pease → Southwest Florida International PSM–RSW | 44 | 4,465 | 74% | 1,296 | Breeze Aviation Group DBA Breeze | Jan 2025 – May 2026 |
| Portsmouth International AT Pease → St. Pete-Clearwater International PSM–PIE | 43 | 6,290 | 80% | 1,239 | Allegiant Air | Apr 2025 – Jul 2026 |
| Portsmouth International AT Pease → Sarasota/Bradenton International PSM–SRQ | 14 | 1,859 | 74% | 1,266 | Allegiant Air | Jan 2025 – Nov 2025 |
| Portsmouth International AT Pease → Rzeszow PSM–RZE international | 9 | 0 | 0% | 4,154 | Antonov Company, Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Portsmouth International AT Pease → Westchester County PSM–HPN | 8 | 14 | 22% | 203 | Tradewind Aviation | Oct 2025 – Jul 2026 |
| Portsmouth International AT Pease → Valley International PSM–HRL | 5 | 371 | 42% | 1,905 | Global Crossing Airlines, Inc. | Jul 2025 – Nov 2025 |
| Portsmouth International AT Pease → Sofia PSM–SOF international | 5 | 706 | 70% | 4,499 | Omni Air International LLC, National Air Cargo Group... | Jan 2026 – Jul 2026 |
| Portsmouth International AT Pease → Alexandria International PSM–AEX | 4 | 521 | 64% | 1,440 | Eastern Air Express, LLC (EAX), Global Crossing Airlines, Inc., Omni Air International LLC | Jul 2025 – Feb 2026 |
| Portsmouth International AT Pease → General Edward Lawrence Logan International PSM–BOS | 3 | 130 | 34% | 50 | American Airlines Inc., Global Crossing Airlines, Inc., CFM Inc d/b/a Contour... | Oct 2025 – Apr 2026 |
| Portsmouth International AT Pease → Louis Armstrong New Orleans International PSM–MSY | 3 | 0 | | 1,402 | Antonov Company | May 2025 – May 2026 |
| Portsmouth International AT Pease → Nantucket Memorial PSM–ACK | 2 | 4 | 25% | 132 | Tradewind Aviation | Jun 2025 – Jul 2026 |
| Portsmouth International AT Pease → Atlantic City International PSM–ACY | 2 | 2 | 1% | 317 | Tradewind Aviation, TEM Enterprises dba Avelo Airlines | Sep 2025 – Jun 2026 |
| Portsmouth International AT Pease → Phoenix PSM–AZA | 2 | 40 | 15% | 2,297 | Antonov Company, Omni Air International LLC | Mar 2025 – Jan 2026 |
| Portsmouth International AT Pease → Chateauroux PSM–CHR international | 2 | 0 | | 3,437 | Antonov Company | Nov 2025 – Nov 2025 |
| Portsmouth International AT Pease → Eindhoven PSM–EIN international | 2 | 0 | | 3,465 | Antonov Company | Dec 2025 – Apr 2026 |
| Portsmouth International AT Pease → Jacksonville International PSM–JAX | 2 | 177 | 60% | 1,055 | Eastern Air Express, LLC (EAX), Breeze Aviation Group DBA Breeze | Aug 2025 – May 2026 |
| Portsmouth International AT Pease → John F Kennedy International PSM–JFK | 2 | 2 | 12% | 227 | Tradewind Aviation | Jun 2026 – Jun 2026 |
| Portsmouth International AT Pease → Midland International Air And Space Port PSM–MAF | 2 | 0 | | 1,873 | Antonov Company | Oct 2025 – Nov 2025 |
| Portsmouth International AT Pease → Miami International PSM–MIA | 2 | 0 | 0% | 1,306 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| Portsmouth International AT Pease → Philadelphia International PSM–PHL | 2 | 120 | 61% | 318 | Tradewind Aviation, TEM Enterprises dba Avelo Airlines | Oct 2025 – Jul 2026 |
| Portsmouth International AT Pease → Glasgow/Prestwick PSM–PIK international | 2 | 0 | | 2,990 | Antonov Company | Dec 2025 – Dec 2025 |
| Portsmouth International AT Pease → Providenciales PSM–PLS international | 2 | 7 | 25% | 1,470 | VistaJet Limited | Sep 2025 – Jan 2026 |
| Portsmouth International AT Pease → London PSM–STN international | 2 | 0 | | 3,247 | National Air Cargo Group..., Challenge Airlines (BE) S.A. | Jul 2025 – Jul 2026 |
| Portsmouth International AT Pease → Vandenberg Space Force Base PSM–VBG | 2 | 0 | | 2,702 | Atlas Air Inc., Antonov Company | Aug 2025 – Nov 2025 |
| Portsmouth International AT Pease → Titusville PSM–1FL | 1 | 0 | | 1,139 | Antonov Company | Jan 2025 – Jan 2026 |
| Portsmouth International AT Pease → Aurora Muni/Al Potter Field PSM–AUH international | 1 | 0 | | 6,640 | National Air Cargo Group... | Sep 2025 – Sep 2025 |
| Portsmouth International AT Pease → Austin-Bergstrom International PSM–AUS | 1 | 111 | 57% | 1,725 | Titan Airways | Jun 2026 – Jun 2026 |
| Portsmouth International AT Pease → Bergen PSM–BGO international | 1 | 0 | | 3,264 | Antonov Company | Jun 2026 – Jun 2026 |
| Portsmouth International AT Pease → Cairo PSM–CAI international | 1 | 90 | 33% | 5,397 | Omni Air International LLC | Jan 2026 – Jan 2026 |
| Portsmouth International AT Pease → Charlottesville-Albemarle PSM–CHO | 1 | 2 | 25% | 526 | Tradewind Aviation | Oct 2025 – Oct 2025 |
| Portsmouth International AT Pease → Casablanca PSM–CMN international | 1 | 0 | | 3,423 | Atlas Air Inc. | Mar 2026 – Mar 2026 |
| Portsmouth International AT Pease → Willemstad PSM–CUR international | 1 | 296 | 76% | 2,130 | Eastern Airlines f/k/a... | Apr 2026 – Apr 2026 |
| Portsmouth International AT Pease → Cincinnati/Northern Kentucky International PSM–CVG | 1 | 0 | 0% | 774 | Atlas Air Inc. | Jul 2026 – Jul 2026 |
| Portsmouth International AT Pease → Dover Air Force Base PSM–DOV | 1 | 0 | | 365 | Antonov Company | Aug 2025 – Aug 2025 |
| Portsmouth International AT Pease → EL Paso International PSM–ELP | 1 | 0 | | 2,085 | Antonov Company | Oct 2025 – Oct 2025 |
| Portsmouth International AT Pease → Derby PSM–EMA international | 1 | 0 | | 3,164 | Antonov Company | Oct 2025 – Oct 2025 |
| Portsmouth International AT Pease → Francis S Gabreski PSM–FOK | 1 | 3 | 38% | 180 | Tradewind Aviation | Dec 2025 – Dec 2025 |
| Portsmouth International AT Pease → Joe Foss Field PSM–FSD | 1 | 68 | 100% | 1,301 | Global Crossing Airlines, Inc. | Nov 2025 – Nov 2025 |
| Portsmouth International AT Pease → Floyd Bennett Memorial PSM–GFL | 1 | 2 | 25% | 142 | Tradewind Aviation | Jul 2026 – Jul 2026 |
| Portsmouth International AT Pease → Glasgow PSM–GLA international | 1 | 54 | 66% | 2,990 | Titan Airways | Jun 2026 – Jun 2026 |
| Portsmouth International AT Pease → Robert Gray Army Airfield PSM–GRK | 1 | 0 | 0% | 1,696 | Titan Airways | Jul 2026 – Jul 2026 |
| Portsmouth International AT Pease → Greenville Spartanburg International PSM–GSP | 1 | 0 | | 832 | National Air Cargo Group... | Nov 2025 – Nov 2025 |
| Portsmouth International AT Pease → Hahn PSM–HHN international | 1 | 0 | | 3,582 | Antonov Company | Sep 2025 – Sep 2025 |
| Portsmouth International AT Pease → East Hampton PSM–HTO | 1 | 2 | 25% | 164 | Tradewind Aviation | May 2025 – Aug 2025 |
| Portsmouth International AT Pease → George Bush Intcntl/Houston PSM–IAH | 1 | 0 | | 1,626 | Antonov Company | May 2026 – May 2026 |
| Portsmouth International AT Pease → Indianapolis International PSM–IND | 1 | 125 | 66% | 835 | TEM Enterprises dba Avelo Airlines | Sep 2025 – Sep 2025 |
| Portsmouth International AT Pease → Keflavik/Reykjavik PSM–KEF international | 1 | 0 | | 2,367 | Antonov Company | Jan 2025 – May 2026 |
| Portsmouth International AT Pease → Leipzig PSM–LEJ international | 1 | 0 | | 3,736 | Antonov Company | Apr 2026 – Apr 2026 |
| Portsmouth International AT Pease → Liege PSM–LGG international | 1 | 0 | | 3,489 | Antonov Company | Jan 2025 – Oct 2025 |
| Portsmouth International AT Pease → Milan PSM–LIN international | 1 | 2 | 14% | 3,805 | VistaJet Limited | May 2026 – May 2026 |
| Portsmouth International AT Pease → Lublin PSM–LUZ international | 1 | 0 | | 4,137 | Antonov Company | Jun 2025 – Sep 2025 |
| Portsmouth International AT Pease → Madrid PSM–MAD international | 1 | 2 | 25% | 3,383 | Gestair, S.A. | Mar 2026 – Mar 2026 |
| Portsmouth International AT Pease → Manchester Boston Regional PSM–MHT | 1 | 135 | 99% | 33 | Breeze Aviation Group DBA Breeze | Jul 2026 – Jul 2026 |
| Portsmouth International AT Pease → Mountain Home Air Force Base PSM–MUO | 1 | 0 | | 2,252 | Antonov Company | Oct 2025 – Oct 2025 |
| Portsmouth International AT Pease → Chicago O'Hare International PSM–ORD | 1 | 0 | | 874 | Western Global | Aug 2025 – Aug 2025 |
| Portsmouth International AT Pease → North Little Rock Municipal PSM–ORK international | 1 | 7 | 50% | 2,890 | Air Hamburg... | May 2026 – May 2026 |
| Portsmouth International AT Pease → Oslo PSM–OSL international | 1 | 0 | | 3,460 | Silk Way Airlines, LLC | Mar 2026 – Mar 2026 |
| Portsmouth International AT Pease → Bucharest PSM–OTP international | 1 | 219 | 81% | 4,530 | Omni Air International LLC | Jan 2026 – Jan 2026 |
| Portsmouth International AT Pease → Newport News/Williamsburg International PSM–PHF | 1 | 139 | 89% | 509 | Allegiant Air | Oct 2025 – Oct 2025 |
| Portsmouth International AT Pease → Pittsburgh International PSM–PIT | 1 | 4 | 50% | 517 | CFM Inc d/b/a Contour... | Apr 2026 – Apr 2026 |
| Portsmouth International AT Pease → Portsmouth International AT Pease PSM–PSM | 1 | 0 | 0% | 0 | Atlas Air Inc. | Feb 2025 – Jul 2026 |
| Portsmouth International AT Pease → Oakland County International PSM–PTK | 1 | 0 | | 640 | Gulf And Caribbean Cargo | Oct 2025 – Oct 2025 |
| Portsmouth International AT Pease → Riga PSM–RIX international | 1 | 0 | | 3,977 | Antonov Company | Sep 2025 – Sep 2025 |
| Portsmouth International AT Pease → Salt Lake City International PSM–SLC | 1 | 0 | | 2,105 | Antonov Company | Feb 2026 – Feb 2026 |
| Portsmouth International AT Pease → Wroclaw PSM–WRO international | 1 | 0 | | 3,925 | Antonov Company | May 2025 – Aug 2025 |
| Portsmouth International AT Pease → Westerly State PSM–WST | 1 | 6 | 75% | 129 | Tradewind Aviation | Aug 2025 – Aug 2025 |
| Portsmouth International AT Pease → Willow Run PSM–YIP | 1 | 67 | 42% | 649 | Eastern Air Express, LLC (EAX) | Feb 2025 – Sep 2025 |
| Portsmouth International AT Pease → Ottawa PSM–YOW international | 1 | 0 | 0% | 286 | Eastern Airlines f/k/a... | May 2026 – May 2026 |
| Portsmouth International AT Pease → Gander PSM–YQX international | 1 | 0 | | 879 | Antonov Company | Sep 2025 – Sep 2025 |
| Portsmouth International AT Pease → Toronto PSM–YTZ international | 1 | 1 | 12% | 433 | Tradewind Aviation | Jul 2026 – Jul 2026 |
| Portsmouth International AT Pease → Yuma PSM–YUM | 1 | 0 | | 2,469 | Antonov Company | Jun 2026 – Jun 2026 |
| Portsmouth International AT Pease → Calgary PSM–YYC international | 1 | 2 | 14% | 2,079 | VistaJet Limited | Mar 2026 – Mar 2026 |
| Portsmouth International AT Pease → Toronto PSM–YYZ international | 1 | 2 | 14% | 445 | VistaJet Limited | Jan 2026 – Jan 2026 |
| Portsmouth International AT Pease → Zaragoza PSM–ZAZ international | 1 | 0 | | 3,465 | Atlas Air Inc. | Jun 2026 – Jun 2026 |
| Portsmouth International AT Pease → North Kingstown PSM–ZXU | 1 | 2 | 25% | 107 | Tradewind Aviation | Jul 2026 – Jul 2026 |