| Guam International → Seoul GUM–ICN international | 1,562 | 258,747 | 63% | 2,001 | Korean Air Lines Co. Ltd., Jin Air Co Ltd., Jeju Air Co Ltd., Atlas Air Inc. +1 | Jan 2025 – Jul 2026 |
| Guam International → Tokyo GUM–NRT international | 1,298 | 187,069 | 82% | 1,559 | United Air Lines Inc., Japan Air Lines Co. Ltd. | Jan 2025 – Jul 2026 |
| Guam International → Rota GUM–ROP | 790 | 1,425 | 27% | 56 | Star Marianas Air Inc., Lynden Air Cargo Airlines | Jan 2025 – Jul 2026 |
| Guam International → Manila GUM–MNL international | 677 | 96,140 | 74% | 1,597 | United Air Lines Inc., Philippine Airlines Inc., Silk Way Airlines, LLC | Jan 2025 – Jul 2026 |
| Guam International → Saipan GUM–SPN | 661 | 43,403 | 70% | 129 | United Air Lines Inc., Star Marianas Air Inc., Lynden Air Cargo Airlines, Asia Pacific +1 | Jan 2025 – Jul 2026 |
| Guam International → Busan GUM–PUS international | 482 | 45,880 | 52% | 1,792 | Jin Air Co Ltd., Korean Air Lines Co. Ltd. | Jan 2025 – Jul 2026 |
| Guam International → Daniel K Inouye International GUM–HNL | 447 | 95,134 | 76% | 3,801 | United Air Lines Inc., Asia Pacific, Omni Air International LLC | Jan 2025 – Jul 2026 |
| Guam International → Osaka GUM–KIX international | 361 | 42,081 | 70% | 1,561 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Guam International → Henderson Executive GUM–HND international | 357 | 43,281 | 73% | 1,550 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Guam International → Palau International GUM–ROR international | 328 | 18,863 | 38% | 814 | United Air Lines Inc., Asia Pacific | Jan 2025 – Jul 2026 |
| Guam International → Nagoya GUM–NGO international | 225 | 23,705 | 64% | 1,554 | United Air Lines Inc., Lynden Air Cargo Airlines | Jan 2025 – Jul 2026 |
| Guam International → Chuuk International GUM–TKK international | 209 | 23,613 | 70% | 633 | United Air Lines Inc., Asia Pacific | Jan 2025 – Jul 2026 |
| Guam International → Hong Kong GUM–HKG international | 202 | 0 | | 2,118 | Asia Pacific, United Parcel Service, National Air Cargo Group..., Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Guam International → Taipei GUM–TPE international | 107 | 12,430 | 71% | 1,729 | United Air Lines Inc., STARLUX AIRLINES, National Air Cargo Group..., Asia Pacific | Jan 2025 – Jul 2026 |
| Guam International → Yap GUM–YAP international | 102 | 6,931 | 41% | 531 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Guam International → Tinian GUM–TIQ | 95 | 305 | 46% | 118 | Star Marianas Air Inc., Lynden Air Cargo Airlines | Jan 2025 – Jul 2026 |
| Guam International → Amata Kabua International GUM–MAJ international | 74 | 0 | | 1,854 | Asia Pacific | Jan 2025 – Jul 2026 |
| Guam International → Pohnpei International GUM–PNI international | 59 | 5,836 | 61% | 1,016 | United Air Lines Inc., Asia Pacific | Jan 2025 – Jul 2026 |
| Guam International → Bucholz Aaf(Kwajalein Kmr)(Atoll) GUM–KWA international | 49 | 0 | | 1,590 | Asia Pacific | Jan 2025 – Jul 2026 |
| Guam International → Hampton Roads Executive GUM–PVG international | 49 | 0 | | 1,901 | Federal Express Corporation, Atlas Air Inc. | Jan 2025 – Jul 2026 |
| Guam International → Lapu-Lapu City GUM–CEB international | 30 | 1,184 | 14% | 1,426 | Philippine Airlines Inc. | Jan 2026 – Apr 2026 |
| Guam International → Ho Chi Minh City GUM–SGN international | 12 | 0 | | 2,584 | Asia Pacific | Sep 2025 – Oct 2025 |
| Guam International → Ted Stevens Anchorage International GUM–ANC | 6 | 112 | 15% | 4,586 | Omni Air International LLC, United Parcel Service, Federal Express Corporation | May 2025 – Jun 2026 |
| Guam International → Bangkok GUM–BKK international | 5 | 0 | | 2,958 | Asia Pacific, Silk Way Airlines, LLC | Mar 2025 – Nov 2025 |
| Guam International → Kuala Lumpur GUM–KUL international | 4 | 0 | | 3,036 | Asia Pacific, National Air Cargo Group... | Feb 2025 – Jun 2026 |
| Guam International → Vientiane GUM–VTE international | 4 | 793 | 67% | 2,824 | Omni Air International LLC | May 2025 – Jul 2026 |
| Guam International → Ta Khmau GUM–KTI international | 3 | 589 | 84% | 2,695 | Omni Air International LLC | Jan 2026 – Jun 2026 |
| Guam International → Jakarta GUM–CGK international | 2 | 0 | | 2,946 | Atlas Air Inc., Asia Pacific | Oct 2025 – Mar 2026 |
| Guam International → Guam International GUM–GUM | 2 | 0 | | 0 | Lynden Air Cargo Airlines, Asia Pacific | Feb 2026 – Apr 2026 |
| Guam International → Kosrae GUM–KSA international | 2 | 87 | 53% | 1,358 | Asia Pacific, United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Guam International → Alexandria International GUM–AEX | 1 | 48 | 13% | 7,547 | Omni Air International LLC | Jul 2026 – Jul 2026 |
| Guam International → Wake Island Airfield GUM–AWK | 1 | 0 | | 1,502 | Lynden Air Cargo Airlines | Aug 2025 – Aug 2025 |
| Guam International → Brisbane GUM–BNE international | 1 | 0 | | 2,864 | Asia Pacific | May 2025 – Oct 2025 |
| Guam International → Bandar Seri Begawan GUM–BWN international | 1 | 0 | | 2,120 | Asia Pacific | Sep 2025 – Sep 2025 |
| Guam International → Luzon Island GUM–CRK international | 1 | 102 | 62% | 1,628 | United Air Lines Inc. | Jan 2025 – Jul 2026 |
| Guam International → Sapporo GUM–CTS international | 1 | 0 | | 2,026 | Lynden Air Cargo Airlines | Jul 2026 – Jul 2026 |
| Guam International → Chicago O'Hare International GUM–ORD | 1 | 0 | | 7,360 | United Air Lines Inc. | Feb 2026 – Feb 2026 |
| Guam International → Port Hedland GUM–PHE international | 1 | 0 | | 2,930 | Asia Pacific | Apr 2026 – Apr 2026 |